NO333128B1 - Fremgangsmate for fremstilling av ¿ krystallinsk form av perindopril erbumin og fremgangsmate for fremstilling av et medikament inneholdende nevnte forbindelse - Google Patents

Fremgangsmate for fremstilling av ¿ krystallinsk form av perindopril erbumin og fremgangsmate for fremstilling av et medikament inneholdende nevnte forbindelse Download PDF

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Publication number
NO333128B1
NO333128B1 NO20060256A NO20060256A NO333128B1 NO 333128 B1 NO333128 B1 NO 333128B1 NO 20060256 A NO20060256 A NO 20060256A NO 20060256 A NO20060256 A NO 20060256A NO 333128 B1 NO333128 B1 NO 333128B1
Authority
NO
Norway
Prior art keywords
crystalline form
water
perindopril erbumine
tert
methyl ether
Prior art date
Application number
NO20060256A
Other languages
English (en)
Norwegian (no)
Other versions
NO20060256L (no
Inventor
Christoph Strassler
Vit Lellek
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of NO20060256L publication Critical patent/NO20060256L/no
Publication of NO333128B1 publication Critical patent/NO333128B1/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
NO20060256A 2003-06-24 2006-01-18 Fremgangsmate for fremstilling av ¿ krystallinsk form av perindopril erbumin og fremgangsmate for fremstilling av et medikament inneholdende nevnte forbindelse NO333128B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH11092003 2003-06-24
PCT/CH2004/000374 WO2004113293A1 (fr) 2003-06-24 2004-06-18 Nouvelles formes cristallines de perindopril erbumine

Publications (2)

Publication Number Publication Date
NO20060256L NO20060256L (no) 2006-01-18
NO333128B1 true NO333128B1 (no) 2013-03-11

Family

ID=33520350

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20060256A NO333128B1 (no) 2003-06-24 2006-01-18 Fremgangsmate for fremstilling av ¿ krystallinsk form av perindopril erbumin og fremgangsmate for fremstilling av et medikament inneholdende nevnte forbindelse

Country Status (21)

Country Link
US (2) US7705046B2 (fr)
EP (1) EP1636185B1 (fr)
JP (1) JP2007507418A (fr)
KR (1) KR20060035636A (fr)
CN (2) CN101333181A (fr)
AT (1) ATE540924T1 (fr)
AU (1) AU2004249345B8 (fr)
BR (1) BRPI0411966A (fr)
CA (1) CA2530550C (fr)
CY (1) CY1112597T1 (fr)
DK (1) DK1636185T3 (fr)
EA (1) EA008603B1 (fr)
ES (1) ES2382171T3 (fr)
MX (1) MXPA05013811A (fr)
NO (1) NO333128B1 (fr)
NZ (1) NZ544160A (fr)
PL (1) PL1636185T3 (fr)
PT (1) PT1636185E (fr)
SI (1) SI1636185T1 (fr)
WO (1) WO2004113293A1 (fr)
ZA (1) ZA200600655B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG125976A1 (en) * 2005-03-11 2006-10-30 Servier Lab New gama crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it
SG125975A1 (en) * 2005-03-11 2006-10-30 Servier Lab New alpha crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it
WO2007017893A2 (fr) * 2005-05-05 2007-02-15 Arch Pharmalabs Limited Preparation d'une nouvelle forme cristalline de perindopril erbumine monohydrate
WO2007017894A2 (fr) * 2005-05-05 2007-02-15 Arch Pharmalabs Limited Preparation d'une nouvelle forme cristalline $g(h)(eta) de perindopril erbumine
US20090099370A1 (en) * 2005-08-12 2009-04-16 Sandoz Ag Crystalline Form of Perindopril Erbumine
EP1943267B1 (fr) * 2005-08-12 2011-03-16 LEK Pharmaceuticals d.d. Procede de preparation de perindopril erbumine
EP1815857A1 (fr) 2006-02-02 2007-08-08 LEK Pharmaceuticals D.D. Composition pharmaceutique comprenant du perindopril
WO2007092758A2 (fr) * 2006-02-03 2007-08-16 Dr. Reddy's Laboratories Ltd. Formes cristallines de périndopril erbumine
EA200600630A1 (ru) * 2006-04-20 2007-02-27 ИСМАГИЛОВ, Искандар Халиуллович ζ-ЗЕТА ФОРМА ПЕРИНДОПРИЛ ЭРБУМИНА
WO2008050185A2 (fr) * 2006-10-26 2008-05-02 Glenmark Pharmaceuticals Limited Nouveaux polymorphes de la périndopril erbumine
WO2008114270A1 (fr) * 2007-03-22 2008-09-25 Aarti Healthcare Limited Procédé de préparation d'un sel de périndopril erbumine et son ou ses nouveaux polymorphes
SI22543A (sl) 2007-06-27 2008-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nove soli perindoprila
PT105315B (pt) 2010-09-29 2013-01-16 Inst Superior Tecnico Uma nova forma cristalina hidratada de erbumina de perindopril, métodos para a sua preparação e sua utilização em preparações farmacêuticas

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
US4508729A (en) * 1979-12-07 1985-04-02 Adir Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
DE69333521T2 (de) * 1993-01-08 2004-09-23 Kanegafuchi Kagaku Kogyo K.K. Verfahren zur Kristallisierung von N2-((S)-1-ethoxycarbonyl-3-phenylpropyl)-N6-trifluoroacetyl-L-lysyl-L-prolin
FR2807431B1 (fr) 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2811319B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811320B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811318B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2827860B1 (fr) 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
GB2395195A (en) * 2002-11-18 2004-05-19 Cipla Ltd Preparation of perindopril from carboxy-protected precursor, & perindopril monohydrates for use as angiotensin converting enzyme (ACE) inhibitors
US20070178166A1 (en) * 2005-12-15 2007-08-02 Acusphere, Inc. Processes for making particle-based pharmaceutical formulations for pulmonary or nasal administration

Also Published As

Publication number Publication date
CN101333181A (zh) 2008-12-31
JP2007507418A (ja) 2007-03-29
WO2004113293A1 (fr) 2004-12-29
US7981921B2 (en) 2011-07-19
DK1636185T3 (da) 2012-05-07
AU2004249345B8 (en) 2009-06-25
EA200501859A1 (ru) 2006-06-30
CA2530550C (fr) 2017-04-04
AU2004249345A1 (en) 2004-12-29
CY1112597T1 (el) 2016-02-10
EA008603B1 (ru) 2007-06-29
EP1636185A1 (fr) 2006-03-22
MXPA05013811A (es) 2006-06-27
KR20060035636A (ko) 2006-04-26
ATE540924T1 (de) 2012-01-15
NO20060256L (no) 2006-01-18
PL1636185T3 (pl) 2012-12-31
CN100395235C (zh) 2008-06-18
US20100160404A1 (en) 2010-06-24
PT1636185E (pt) 2012-04-16
EP1636185B1 (fr) 2012-01-11
AU2004249345B2 (en) 2009-02-26
NZ544160A (en) 2008-07-31
BRPI0411966A (pt) 2006-08-29
US20070135512A1 (en) 2007-06-14
HK1093984A1 (zh) 2007-03-16
ZA200600655B (en) 2007-05-30
SI1636185T1 (sl) 2012-06-29
CN1812971A (zh) 2006-08-02
CA2530550A1 (fr) 2004-12-08
ES2382171T3 (es) 2012-06-06
US7705046B2 (en) 2010-04-27

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CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: LES LABORATOIRES SERVIER

Free format text: NEW ADDRESS: 35 RUE DE VERDUN, FR-92284 SURESNES CEDEX, FR

MM1K Lapsed by not paying the annual fees