PL1636185T3 - Nowe formy krystaliczne peryndoprylu erbuminy - Google Patents

Nowe formy krystaliczne peryndoprylu erbuminy

Info

Publication number: PL1636185T3
Authority: PL; Poland
Prior art keywords: crystalline form; stirring; water; perindopril erbumine; tert
Prior art date: 2003-06-24

Application number

PL04737029T

Other languages

English (en)

Inventor

Christoph Strässler

Vit Lellek

Roger Fässler

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-06-24

Filing date

2004-06-18

Publication date

2012-12-31

2004-06-18 Application filed by Servier Lab filed Critical Servier Lab

2012-12-31 Publication of PL1636185T3 publication Critical patent/PL1636185T3/pl

Links

229960003929 perindopril erbumine Drugs 0.000 title abstract 3
IYNMDWMQHSMDDE-MHXJNQAMSA-N perindopril erbumine Chemical compound CC(C)(C)N.C1CCC[C@@H]2N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H](C(O)=O)C[C@@H]21 IYNMDWMQHSMDDE-MHXJNQAMSA-N 0.000 title abstract 3
238000003756 stirring Methods 0.000 abstract 5
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 5
BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 abstract 4
238000002425 crystallisation Methods 0.000 abstract 2
230000008025 crystallization Effects 0.000 abstract 2
238000010899 nucleation Methods 0.000 abstract 2
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
239000013543 active substance Substances 0.000 abstract 1
238000010533 azeotropic distillation Methods 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Cardiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Epidemiology (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

PL04737029T 2003-06-24 2004-06-18 Nowe formy krystaliczne peryndoprylu erbuminy PL1636185T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
CH11092003		2003-06-24
EP04737029A EP1636185B1 (de)	2003-06-24	2004-06-18	Neue kristalline formen von perindopril erbumine
PCT/CH2004/000374 WO2004113293A1 (de)	2003-06-24	2004-06-18	Neue kristalline formen von perindopril erbumine

Publications (1)

Publication Number	Publication Date
PL1636185T3 true PL1636185T3 (pl)	2012-12-31

Family

ID=33520350

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL04737029T PL1636185T3 (pl)	2003-06-24	2004-06-18	Nowe formy krystaliczne peryndoprylu erbuminy

Country Status (21)

Country	Link
US (2)	US7705046B2 (pl)
EP (1)	EP1636185B1 (pl)
JP (1)	JP2007507418A (pl)
KR (1)	KR20060035636A (pl)
CN (2)	CN101333181A (pl)
AT (1)	ATE540924T1 (pl)
AU (1)	AU2004249345B8 (pl)
BR (1)	BRPI0411966A (pl)
CA (1)	CA2530550C (pl)
CY (1)	CY1112597T1 (pl)
DK (1)	DK1636185T3 (pl)
EA (1)	EA008603B1 (pl)
ES (1)	ES2382171T3 (pl)
MX (1)	MXPA05013811A (pl)
NO (1)	NO333128B1 (pl)
NZ (1)	NZ544160A (pl)
PL (1)	PL1636185T3 (pl)
PT (1)	PT1636185E (pl)
SI (1)	SI1636185T1 (pl)
WO (1)	WO2004113293A1 (pl)
ZA (1)	ZA200600655B (pl)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SG125976A1 (en) *	2005-03-11	2006-10-30	Servier Lab	New gama crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it
SG125975A1 (en) *	2005-03-11	2006-10-30	Servier Lab	New alpha crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it
WO2007017893A2 (en) *	2005-05-05	2007-02-15	Arch Pharmalabs Limited	Preparation of novel crystalline form of perindopril erbumine monohydrate
WO2007017894A2 (en) *	2005-05-05	2007-02-15	Arch Pharmalabs Limited	PREPARATION OF NOVEL CRYSTALLINE η(ETA) FORM OF PERINDOPRIL ERBUMINE
US20090099370A1 (en) *	2005-08-12	2009-04-16	Sandoz Ag	Crystalline Form of Perindopril Erbumine
EP1943267B1 (en) *	2005-08-12	2011-03-16	LEK Pharmaceuticals d.d.	A process for the preparation of perindopril erbumine
EP1815857A1 (en)	2006-02-02	2007-08-08	LEK Pharmaceuticals D.D.	A pharmaceutical composition comprising perindopril
WO2007092758A2 (en) *	2006-02-03	2007-08-16	Dr. Reddy's Laboratories Ltd.	Crystalline forms of perindopril erbumine
EA200600630A1 (ru) *	2006-04-20	2007-02-27	ИСМАГИЛОВ, Искандар Халиуллович	ζ-ЗЕТА ФОРМА ПЕРИНДОПРИЛ ЭРБУМИНА
WO2008050185A2 (en) *	2006-10-26	2008-05-02	Glenmark Pharmaceuticals Limited	Novel polymorphs of perindopril erbumine
WO2008114270A1 (en) *	2007-03-22	2008-09-25	Aarti Healthcare Limited	Process for the preparation of perindopril erbumine salt and novel polymorph (s) thereof
SI22543A (sl)	2007-06-27	2008-12-31	Krka, Tovarna Zdravil, D.D., Novo Mesto	Nove soli perindoprila
PT105315B (pt)	2010-09-29	2013-01-16	Inst Superior Tecnico	Uma nova forma cristalina hidratada de erbumina de perindopril, métodos para a sua preparação e sua utilização em preparações farmacêuticas

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2503155A2 (fr)	1980-10-02	1982-10-08	Science Union & Cie	Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
US4508729A (en) *	1979-12-07	1985-04-02	Adir	Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
FR2620709B1 (fr) *	1987-09-17	1990-09-07	Adir	Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
DE69333521T2 (de) *	1993-01-08	2004-09-23	Kanegafuchi Kagaku Kogyo K.K.	Verfahren zur Kristallisierung von N2-((S)-1-ethoxycarbonyl-3-phenylpropyl)-N6-trifluoroacetyl-L-lysyl-L-prolin
FR2807431B1 (fr)	2000-04-06	2002-07-19	Adir	Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2811319B1 (fr) *	2000-07-06	2002-08-23	Adir	Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811320B1 (fr) *	2000-07-06	2002-08-23	Adir	Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811318B1 (fr) *	2000-07-06	2002-08-23	Adir	Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2827860B1 (fr)	2001-07-24	2004-12-10	Servier Lab	Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
GB2395195A (en) *	2002-11-18	2004-05-19	Cipla Ltd	Preparation of perindopril from carboxy-protected precursor, & perindopril monohydrates for use as angiotensin converting enzyme (ACE) inhibitors
US20070178166A1 (en) *	2005-12-15	2007-08-02	Acusphere, Inc.	Processes for making particle-based pharmaceutical formulations for pulmonary or nasal administration

2004
- 2004-06-18 CA CA2530550A patent/CA2530550C/en not_active Expired - Fee Related
- 2004-06-18 KR KR1020057024852A patent/KR20060035636A/ko not_active Ceased
- 2004-06-18 WO PCT/CH2004/000374 patent/WO2004113293A1/de not_active Ceased
- 2004-06-18 NZ NZ544160A patent/NZ544160A/en not_active IP Right Cessation
- 2004-06-18 BR BRPI0411966-5A patent/BRPI0411966A/pt not_active Application Discontinuation
- 2004-06-18 PT PT04737029T patent/PT1636185E/pt unknown
- 2004-06-18 US US10/560,464 patent/US7705046B2/en not_active Expired - Fee Related
- 2004-06-18 EP EP04737029A patent/EP1636185B1/de not_active Expired - Lifetime
- 2004-06-18 CN CNA2008100912488A patent/CN101333181A/zh active Pending
- 2004-06-18 AU AU2004249345A patent/AU2004249345B8/en not_active Ceased
- 2004-06-18 MX MXPA05013811A patent/MXPA05013811A/es active IP Right Grant
- 2004-06-18 SI SI200431851T patent/SI1636185T1/sl unknown
- 2004-06-18 EA EA200501859A patent/EA008603B1/ru not_active IP Right Cessation
- 2004-06-18 ES ES04737029T patent/ES2382171T3/es not_active Expired - Lifetime
- 2004-06-18 JP JP2006515624A patent/JP2007507418A/ja active Pending
- 2004-06-18 AT AT04737029T patent/ATE540924T1/de active
- 2004-06-18 DK DK04737029.1T patent/DK1636185T3/da active
- 2004-06-18 CN CNB2004800178672A patent/CN100395235C/zh not_active Expired - Fee Related
- 2004-06-18 PL PL04737029T patent/PL1636185T3/pl unknown
2006
- 2006-01-18 NO NO20060256A patent/NO333128B1/no not_active IP Right Cessation
- 2006-01-23 ZA ZA200600655A patent/ZA200600655B/en unknown
2010
- 2010-03-09 US US12/720,250 patent/US7981921B2/en not_active Expired - Fee Related
2012
- 2012-04-04 CY CY20121100334T patent/CY1112597T1/el unknown

Also Published As

Publication number	Publication date
CN101333181A (zh)	2008-12-31
JP2007507418A (ja)	2007-03-29
WO2004113293A1 (de)	2004-12-29
US7981921B2 (en)	2011-07-19
DK1636185T3 (da)	2012-05-07
AU2004249345B8 (en)	2009-06-25
EA200501859A1 (ru)	2006-06-30
CA2530550C (en)	2017-04-04
AU2004249345A1 (en)	2004-12-29
CY1112597T1 (el)	2016-02-10
EA008603B1 (ru)	2007-06-29
EP1636185A1 (de)	2006-03-22
MXPA05013811A (es)	2006-06-27
NO333128B1 (no)	2013-03-11
KR20060035636A (ko)	2006-04-26
ATE540924T1 (de)	2012-01-15
NO20060256L (no)	2006-01-18
CN100395235C (zh)	2008-06-18
US20100160404A1 (en)	2010-06-24
PT1636185E (pt)	2012-04-16
EP1636185B1 (de)	2012-01-11
AU2004249345B2 (en)	2009-02-26
NZ544160A (en)	2008-07-31
BRPI0411966A (pt)	2006-08-29
US20070135512A1 (en)	2007-06-14
HK1093984A1 (zh)	2007-03-16
ZA200600655B (en)	2007-05-30
SI1636185T1 (sl)	2012-06-29
CN1812971A (zh)	2006-08-02
CA2530550A1 (en)	2004-12-08
ES2382171T3 (es)	2012-06-06
US7705046B2 (en)	2010-04-27

Publication	Publication Date	Title
CY1112597T1 (el)	2016-02-10	Νεες κρυσταλλικες μορφες της ερβουμινικης περινδοπριλης
ATE506948T1 (de)	2011-05-15	Verwendung von igf-1-serumspiegel-erhöhenden indolessigsäure-derivaten zur herstellung eines arzneimittels zur behandlung von verschiedenen krankheiten
AU2002359164A1 (en)	2003-07-09	Use of oxindole derivatives in the treatment of dementia related diseases, alzheimer's disease and conditions associated with glycogen synthase kinase-3
WO2008035686A1 (en)	2008-03-27	Agent for improving insulin resistance
FI91156B (fi)	1994-02-15	Menetelmä uusien terapeuttisesti käyttökelpoisten neplanosiinijohdannaisten valmistamiseksi
JPH02777A (ja)	1990-01-05	新規化合物、その製法及びそれを含む医薬組成物
JP2005229812A (ja)	2005-09-02	安定化されたｓａｍを含有する乾燥微生物又は微生物抽出物、及びその製造方法
WO2008039087A3 (en)	2008-08-14	Indoline derivatives and uses thereof
JP2022537518A (ja)	2022-08-26	脳神経または心臓保護剤としてのアミノチオール系化合物の使用
JPH04230628A (ja)	1992-08-19	脂質調節薬としての１０員環ラクトンの使用
CN100475804C (zh)	2009-04-08	一类异色满酮-4衍生物、其制备方法及其医疗用途
FR2533566A1 (fr)	1984-03-30	Imino- et amino-acides acyloxycetone-substitues a action therapeutique
ATE38470T1 (de)	1988-11-15	Pharmazeutisches produkt zur behandlung der hypertonie und thromboembolischer krankheiten.
EP0207483A3 (en)	1988-03-16	Benzimidazoles, process for their preparation, medicaments containing them and intermediates
GEP20043408B (en)	2004-06-10	Process For Preparing 6-(4-Chlorophenyl)- 2,2-Dimethyl-7-Phenyl-2,3-Dihydro-1H-Pyrrolizin-5-YL-Acetic Acid, Pharmaceutical Composition Containing Them and Use Thereof for Treatment of Disorders of the Rheumatic Type
KR20010086473A (ko)	2001-09-12	류코트리엔 생성 저해활성을 가지는 정유 성분
CN108929320A (zh)	2018-12-04	3r-吲哚甲基-6r-恶唑烷酮修饰的哌嗪-2,5-二酮，其合成，活性和应用
JPH08283150A (ja)	1996-10-29	抗炎症剤
CA1322531C (en)	1993-09-28	Phenolic thioethers as inhibitors of 5-lipoxygenase
Von Korff et al.	1958	A DIFFERENCE IN BOVINE AND HUMAN FIBRINO-PEPTIDES WITH RESPECT TO THE OCCURRENCE OF TYROSINE-O-SULFATE
CN101307080A (zh)	2008-11-19	具有镇静活性的5-(4-β-D-吡喃阿洛糖苷-苯基)-3-芳基-4,5-二氢吡唑-1-硫代酰胺类化合物的制备
EP0261891A3 (en)	1990-09-05	Pharmaceutical compositions containing etiochiolandione
JPS62132878A (ja)	1987-06-16	新生理活性物質モナコリンｍ及びその製造法
JPS61106564A (ja)	1986-05-24	不飽和脂肪酸アミド誘導体およびこれを含有する血小板凝集抑制剤
JP4452078B2 (ja)	2010-04-21	ヒドロペリレン誘導体