NO334437B1 - Mikroporering av menneskehud for medikamentavlevering og overvåkningsanvendelser - Google Patents

Mikroporering av menneskehud for medikamentavlevering og overvåkningsanvendelser Download PDF

Info

Publication number
NO334437B1
NO334437B1 NO19980878A NO980878A NO334437B1 NO 334437 B1 NO334437 B1 NO 334437B1 NO 19980878 A NO19980878 A NO 19980878A NO 980878 A NO980878 A NO 980878A NO 334437 B1 NO334437 B1 NO 334437B1
Authority
NO
Norway
Prior art keywords
skin
stratum corneum
energy
micropore
tissue
Prior art date
Application number
NO19980878A
Other languages
English (en)
Norwegian (no)
Other versions
NO980878D0 (no
NO980878L (no
Inventor
Jonathan A Eppstein
Michael R Hatch
Difei Yang
Original Assignee
Spectrx Inc
Altea Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spectrx Inc, Altea Therapeutics Corp filed Critical Spectrx Inc
Publication of NO980878D0 publication Critical patent/NO980878D0/no
Publication of NO980878L publication Critical patent/NO980878L/no
Publication of NO334437B1 publication Critical patent/NO334437B1/no

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14507Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0045Devices for taking samples of body liquids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0047Sonopheresis, i.e. ultrasonically-enhanced transdermal delivery, electroporation of a pharmacologically active agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B17/32Surgical cutting instruments
    • A61B17/3203Fluid jet cutting instruments
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/203Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B2017/00017Electrical control of surgical instruments
    • A61B2017/00137Details of operation mode
    • A61B2017/00154Details of operation mode pulsed
    • A61B2017/00172Pulse trains, bursts, intermittent continuous operation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B2017/00743Type of operation; Specification of treatment sites
    • A61B2017/00747Dermatology
    • A61B2017/00761Removing layer of skin tissue, e.g. wrinkles, scars or cancerous tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B2017/00743Type of operation; Specification of treatment sites
    • A61B2017/00747Dermatology
    • A61B2017/00765Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00452Skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00452Skin
    • A61B2018/0047Upper parts of the skin, e.g. skin peeling or treatment of wrinkles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1486Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Optics & Photonics (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Surgical Instruments (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Laser Surgery Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO19980878A 1995-08-29 1998-02-27 Mikroporering av menneskehud for medikamentavlevering og overvåkningsanvendelser NO334437B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US52054795A 1995-08-29 1995-08-29
US804395P 1995-10-30 1995-10-30
PCT/US1996/013865 WO1997007734A1 (fr) 1995-08-29 1996-08-29 Realisation de micropores sur la peau humaine pour l'administration de medicaments et les applications de monitorage

Publications (3)

Publication Number Publication Date
NO980878D0 NO980878D0 (no) 1998-02-27
NO980878L NO980878L (no) 1998-04-27
NO334437B1 true NO334437B1 (no) 2014-03-03

Family

ID=26677684

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19980878A NO334437B1 (no) 1995-08-29 1998-02-27 Mikroporering av menneskehud for medikamentavlevering og overvåkningsanvendelser

Country Status (13)

Country Link
EP (1) EP0858285A4 (fr)
JP (2) JP3899427B2 (fr)
CN (1) CN1174713C (fr)
AU (1) AU707065B2 (fr)
BR (1) BR9610012A (fr)
CA (1) CA2199002C (fr)
ES (1) ES2536459T3 (fr)
GB (1) GB2307414B (fr)
IL (1) IL123379A (fr)
NO (1) NO334437B1 (fr)
PT (1) PT1563788E (fr)
TR (1) TR199800347T1 (fr)
WO (1) WO1997007734A1 (fr)

Families Citing this family (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6251100B1 (en) 1993-09-24 2001-06-26 Transmedica International, Inc. Laser assisted topical anesthetic permeation
EP0914178B1 (fr) 1996-06-18 2003-03-12 Alza Corporation Dispositif d'amelioration d'apport ou d'echantillonnage d'agents transdermiques
CA2259437C (fr) * 1996-07-03 2006-12-05 Altea Technologies, Inc. Microporation mecanique multiple de la peau ou de la muqueuse
ATE231015T1 (de) * 1996-09-17 2003-02-15 Deka Products Lp System zur medikamentenabgabe durch transport
US6797276B1 (en) 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
US20060002949A1 (en) 1996-11-14 2006-01-05 Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. Transcutaneous immunization without heterologous adjuvant
US5980898A (en) 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
ES2289192T3 (es) * 1996-12-31 2008-02-01 Altea Therapeutics Corporation Microporacion de tejido para suministro de agentes bioactivos.
US6527716B1 (en) 1997-12-30 2003-03-04 Altea Technologies, Inc. Microporation of tissue for delivery of bioactive agents
US6027496A (en) * 1997-03-25 2000-02-22 Abbott Laboratories Removal of stratum corneum by means of light
EP1017320A1 (fr) 1997-10-21 2000-07-12 Townsend Engineering Company Appareil et procede pour la collecte de fluides interstitiels
US6155992A (en) * 1997-12-02 2000-12-05 Abbott Laboratories Method and apparatus for obtaining interstitial fluid for diagnostic tests
US6918901B1 (en) 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
DE69839969D1 (de) 1997-12-11 2008-10-16 Alza Corp Vorrichtung zur verbesserung des transdermalen flusses von medikamenten
JP4061022B2 (ja) * 1997-12-11 2008-03-12 アルザ・コーポレーション 経皮輸送剤の流量促進装置
CA2313698C (fr) * 1997-12-11 2008-04-15 Alza Corporation Dispositif renforcant le flux d'agents transdermiques
US6530915B1 (en) 1998-03-06 2003-03-11 Spectrx, Inc. Photothermal structure for biomedical applications, and method therefor
US6173202B1 (en) * 1998-03-06 2001-01-09 Spectrx, Inc. Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue
EP1059938A1 (fr) * 1998-03-06 2000-12-20 Spectrx, Inc. Structure photothermique pour applications biomedicales, et procede associe
US6091975A (en) * 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
US6569157B1 (en) * 1998-05-18 2003-05-27 Abbott Laboratories Removal of stratum corneum by means of light
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US7344499B1 (en) 1998-06-10 2008-03-18 Georgia Tech Research Corporation Microneedle device for extraction and sensing of bodily fluids
US6077660A (en) * 1998-06-10 2000-06-20 Abbott Laboratories Diagnostic assay requiring a small sample of biological fluid
EP1124607B1 (fr) 1998-07-14 2008-11-12 Altea Therapeutics Corporation Elimination conrôlée d'une membrane biologique par une charge pyrotechnique en vue d'un transport transmembranaire
US7384396B2 (en) 1998-07-21 2008-06-10 Spectrx Inc. System and method for continuous analyte monitoring
AU5004299A (en) * 1998-07-21 2000-02-14 Altea Technologies, Inc. System and method for continuous analyte monitoring
IL141774A0 (en) * 1998-09-04 2002-03-10 Powderject Res Ltd Monitoring methods using particle delivery methods
US6468229B1 (en) 1998-10-20 2002-10-22 Abbott Laboratories Apparatus and method for the collection of interstitial fluids
US6148232A (en) 1998-11-09 2000-11-14 Elecsys Ltd. Transdermal drug delivery and analyte extraction
US6597946B2 (en) 1998-11-09 2003-07-22 Transpharma Ltd. Electronic card for transdermal drug delivery and analyte extraction
US6708060B1 (en) 1998-11-09 2004-03-16 Transpharma Ltd. Handheld apparatus and method for transdermal drug delivery and analyte extraction
US6611706B2 (en) 1998-11-09 2003-08-26 Transpharma Ltd. Monopolar and bipolar current application for transdermal drug delivery and analyte extraction
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
ATE324922T1 (de) * 1999-06-08 2006-06-15 Altea Therapeutics Corp Vorrichtung zur mikroporation eines biologischen gewebes mittels einer filmgewebe schnittstellenvorrichtung und verfahren
US20030078499A1 (en) 1999-08-12 2003-04-24 Eppstein Jonathan A. Microporation of tissue for delivery of bioactive agents
US6355054B1 (en) * 1999-11-05 2002-03-12 Ceramoptec Industries, Inc. Laser system for improved transbarrier therapeutic radiation delivery
DE19963034A1 (de) 1999-12-24 2001-06-28 Roche Diagnostics Gmbh System zur verbesserten Bestimmung des Glukosespiegels anhand von Messungen in interstitieller Flüssigkeit
IL136008A0 (en) 2000-05-07 2001-05-20 Elecsys Ltd Electrically-mediated transdermal drug injection
US6706032B2 (en) 2000-06-08 2004-03-16 Massachusetts Institute Of Technology Localized molecular and ionic transport to and from tissues
US7597692B2 (en) 2000-06-08 2009-10-06 Massachusetts Institute Of Technology Microscission processes and procedures
AUPR044000A0 (en) * 2000-09-28 2000-10-26 Norwood Abbey Ltd Diagnostic device
US6537243B1 (en) 2000-10-12 2003-03-25 Abbott Laboratories Device and method for obtaining interstitial fluid from a patient for diagnostic tests
US6882884B1 (en) 2000-10-13 2005-04-19 Soundskin, L.L.C. Process for the stimulation of production of extracellular dermal proteins in human tissue
US6733493B2 (en) * 2000-11-16 2004-05-11 Innotech Usa, Inc. Laser skin perforator
US9302903B2 (en) 2000-12-14 2016-04-05 Georgia Tech Research Corporation Microneedle devices and production thereof
WO2002050584A2 (fr) 2000-12-21 2002-06-27 Biovalve Technologies, Inc. Systemes de reseaux de micro-aiguilles
ES2310201T3 (es) 2001-02-13 2009-01-01 Government Of The United States Of America, As Represented By The Secretary Of The Army Vacuna para inmunizacion transcutanea contra la diarrea de los viajeros.
JP4704583B2 (ja) * 2001-02-28 2011-06-15 有限会社開発顧問室 パッチテスト用シート
US6790179B2 (en) 2001-08-01 2004-09-14 Johnson & Johnson Consumer Companies, Inc. Method of examining and diagnosing skin health
US6855117B2 (en) 2001-08-01 2005-02-15 Johnson & Johnson Consumer Companies, Inc. Method of treating the skin of a subject
US6840910B2 (en) 2001-08-01 2005-01-11 Johnson & Johnson Consumer Companies, Inc. Method of distributing skin care products
WO2003024507A2 (fr) 2001-09-19 2003-03-27 Biovalve Technologies, Inc. Microaiguilles, jeux de microaiguilles, et systemes et procedes associes
AU2002330083A1 (en) 2001-09-21 2003-04-01 Biovalve Technologies, Inc. Gas pressure actuated microneedle arrays, and systems and methods relating to same
AU2002353444A1 (en) 2001-11-07 2003-05-19 Transpharma Medical Ltd. Integrated transdermal drug delivery system
CA2478822C (fr) 2002-03-11 2016-07-12 Passport Technologies, Inc. Systeme therapeutique transdermique de liberation de medicaments, son procede de fabrication et son procede d'utilisation
US9918665B2 (en) 2002-03-11 2018-03-20 Nitto Denko Corporation Transdermal porator and patch system and method for using same
WO2003089043A2 (fr) 2002-04-19 2003-10-30 Transpharma Medical Ltd. Administration de medicaments et extraction d'analyte par voie transdermique a l'aide d'un appareil tenu a la main
US7662404B2 (en) 2002-10-31 2010-02-16 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized peptides and polypeptides
US7383084B2 (en) 2002-10-31 2008-06-03 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
US8133505B2 (en) 2002-10-31 2012-03-13 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
IL152574A (en) 2002-10-31 2009-09-22 Transpharma Medical Ltd A system for passing through the skin of dry items or dried medicines
IL152575A (en) 2002-10-31 2008-12-29 Transpharma Medical Ltd A skin-to-skin transmission system of water-insoluble drugs
IL152573A (en) 2002-10-31 2009-11-18 Transpharma Medical Ltd A system for the transmission through the skin of a medical preparation against vomiting and nausea
US7258673B2 (en) 2003-06-06 2007-08-21 Lifescan, Inc Devices, systems and methods for extracting bodily fluid and monitoring an analyte therein
CN1897899A (zh) * 2003-10-24 2007-01-17 阿尔扎公司 促进透皮药物传递的装置和方法
EP1675539A4 (fr) * 2003-10-24 2007-09-12 Alza Corp Procede et systeme de pretraitement permettant d'ameliorer l'administration transdermique de medicaments
US8016811B2 (en) 2003-10-24 2011-09-13 Altea Therapeutics Corporation Method for transdermal delivery of permeant substances
CA2584800A1 (fr) 2004-10-21 2006-05-04 Bayer Healthcare Llc Procede pour determiner la concentration d'un analyte dans un fluide corporel et systeme associe
JP2006326147A (ja) * 2005-05-30 2006-12-07 Shingo Wakamatsu レーザー治療装置
TWI419717B (zh) * 2005-06-17 2013-12-21 Altea Therapeutics Corp 滲透傳送系統及其使用方法
JP5011936B2 (ja) * 2006-10-11 2012-08-29 パナソニック株式会社 血液検査装置
JP5011935B2 (ja) * 2006-10-11 2012-08-29 パナソニック株式会社 血液検査装置
CN101534895B (zh) * 2006-11-14 2012-10-03 国立大学法人鹿儿岛大学 药物注入装置
RU2328739C1 (ru) * 2007-02-26 2008-07-10 Айрат Анварович Халиков Способ определения целостности клеточных мембран биологической ткани трупа
JP2010525881A (ja) * 2007-04-27 2010-07-29 エコー セラピューティクス, インコーポレイテッド 被検体の検知または経皮的薬物送達のための皮膚透過装置
CA2704740C (fr) 2007-10-09 2016-05-17 Transpharma Ltd. Fixation magnetique d'un timbre transdermique
CA2696227A1 (fr) 2007-10-17 2009-04-23 Transpharma Medical Ltd. Verification de la vitesse de dissolution
JP5407868B2 (ja) * 2007-11-06 2014-02-05 コニカミノルタ株式会社 微小開口形成装置およびそれを用いる体液収集システム
JP2011505899A (ja) 2007-12-05 2011-03-03 シネロン メディカル リミテッド 使い捨て可能な電磁気エネルギーアプリケータ及びそれを使用する方法
GB0811856D0 (en) 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
US8606366B2 (en) 2009-02-18 2013-12-10 Syneron Medical Ltd. Skin treatment apparatus for personal use and method for using same
US20100256466A1 (en) * 2009-04-02 2010-10-07 Avraham Shekalim Metabolite Management System
JP5774001B2 (ja) 2009-07-27 2015-09-02 ノヴォクセル リミテッド 組織焼灼のための方法および装置
PT105635B (pt) 2011-04-19 2014-04-11 Univ De Coimbra Dispositivo para a administração eficiente de compostos na pele ou barreiras biológicas, ou através dessas, usando filmes finos absorventes de luz
CN105939684B (zh) 2013-12-18 2020-06-09 诺服塞尔有限公司 汽化组织的设备及方法
WO2016042547A1 (fr) * 2014-09-15 2016-03-24 Novoxel Ltd. Procédés et dispositifs pour la vaporisation et l'incision de tissus par chirurgie thermique
PL3193761T3 (pl) 2014-09-15 2021-10-18 Novoxel Ltd. Sposoby wytwarzania urządzeń do cieplnego parowania i uciskania tkanki
KR20170134478A (ko) * 2015-03-03 2017-12-06 가이디드 테라피 시스템스, 엘.엘.씨. 인조 마이크로채널을 통해 불투막 또는 반투막을 통과하여 물질을 이동하기 위한 방법 및 시스템
JP6876045B2 (ja) * 2015-12-15 2021-05-26 コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. 表面処理装置及び方法
US20190029654A1 (en) * 2016-01-15 2019-01-31 University Of Cincinnati Advanced electroporation devices and methods for analyte access in biofluids
CN109640858B (zh) * 2016-06-20 2022-02-01 北德克萨斯大学 非整体复合骨材料的激光辅助加工(lam)
FI127811B (en) * 2016-11-21 2019-03-15 Helsingin Yliopisto Device for sampling one or more analytes
HUE069886T2 (hu) * 2017-02-14 2025-04-28 Hoffmann La Roche Számítógéppel megvalósított eljárás és hordozható eszköz testfolyadék glükózszintjére vonatkozó glükózmonitorozási adatok elemzésére, valamint számítógéppel olvasható tartós adathordozó
US11441994B2 (en) * 2017-07-27 2022-09-13 Tata Consultancy Services Limited Method and system for in-silico design of skin electroporation
WO2019025610A1 (fr) * 2017-08-03 2019-02-07 Fibrotx Oü Dosage d'écoulement latéral et dispositif pour application de soins de la peau
CN109157280A (zh) * 2018-08-10 2019-01-08 重庆大学 不可逆电穿孔组织消融效果动态实时评估设备
DK3804648T3 (da) * 2018-08-23 2022-04-11 Novocure Gmbh Anvendelse af elektriske vekseltrømsfelter til forøgelse af permeabilitet af blodhjernebarrieren
CN114375181B (zh) * 2019-06-28 2025-10-31 帕斯帕特技术有限公司 用于控制向细丝装置递送能量的方法和系统
TWI729670B (zh) * 2019-08-02 2021-06-01 華廣生技股份有限公司 生物感測器之植入裝置
CN110613893A (zh) * 2019-10-31 2019-12-27 南京工业职业技术学院 一种新型励磁线圈
CN111693434B (zh) * 2020-06-19 2024-01-19 中建路桥集团有限公司 一种测试混凝土抗渗性能的实验装置
CN114504373A (zh) * 2020-11-16 2022-05-17 澳美力科技(成都)有限公司 一种新型射频变频美容仪
CN112957124B (zh) * 2021-01-30 2023-08-22 南京理工大学 一种能量靶向调控的离体激光生物组织焊接缝合方法
CN115670642A (zh) * 2021-05-20 2023-02-03 黄虹凤 保证高精度和高速度的激光切线装置
CN114343839B (zh) * 2021-12-30 2024-07-23 德州环球之光医疗科技股份有限公司 一种基于可调的螺旋线型激光光斑的治疗图形转换方法
CN116999687B (zh) * 2023-07-19 2024-11-12 河南翔宇医疗设备股份有限公司 一种超声渗透仪以及超声渗透仪输出参数设置装置、介质

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775361A (en) * 1986-04-10 1988-10-04 The General Hospital Corporation Controlled removal of human stratum corneum by pulsed laser to enhance percutaneous transport
US4863970A (en) * 1986-11-14 1989-09-05 Theratech, Inc. Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols
EP0398960B1 (fr) * 1988-01-21 1995-12-06 Massachusetts Institute Of Technology Transport de molecules a travers les tissus par electroporation
US5139023A (en) 1989-06-02 1992-08-18 Theratech Inc. Apparatus and method for noninvasive blood glucose monitoring
US5016615A (en) * 1990-02-20 1991-05-21 Riverside Research Institute Local application of medication with ultrasound
US5115805A (en) * 1990-02-23 1992-05-26 Cygnus Therapeutic Systems Ultrasound-enhanced delivery of materials into and through the skin
GB9014307D0 (en) * 1990-06-27 1990-08-15 Scient Generics Ltd Method of treatment and compositions therefor
JP3189337B2 (ja) * 1991-11-08 2001-07-16 日本電気株式会社 皮膚角層の除去器具および除去方法
US5344418A (en) * 1991-12-12 1994-09-06 Shahriar Ghaffari Optical system for treatment of vascular lesions
US5165418B1 (en) 1992-03-02 1999-12-14 Nikola I Tankovich Blood sampling device and method using a laser
US5246437A (en) * 1992-04-10 1993-09-21 Abela George S Cell treatment apparatus and method
US5643252A (en) * 1992-10-28 1997-07-01 Venisect, Inc. Laser perforator
US5279552A (en) * 1993-01-11 1994-01-18 Anton Magnet Intradermal injection device
US5267985A (en) * 1993-02-11 1993-12-07 Trancell, Inc. Drug delivery by multiple frequency phonophoresis
US5582184A (en) * 1993-10-13 1996-12-10 Integ Incorporated Interstitial fluid collection and constituent measurement
US5445611A (en) * 1993-12-08 1995-08-29 Non-Invasive Monitoring Company (Nimco) Enhancement of transdermal delivery with ultrasound and chemical enhancers
US5458140A (en) 1993-11-15 1995-10-17 Non-Invasive Monitoring Company (Nimco) Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers
DE69624668T2 (de) * 1995-07-25 2003-08-28 Massachusetts Institute Of Technology, Cambridge Verbesserter transdermaler transport unter verwendung von ultraschall

Also Published As

Publication number Publication date
JP2006192285A (ja) 2006-07-27
CA2199002A1 (fr) 1997-03-01
PT1563788E (pt) 2015-06-02
CA2199002C (fr) 1999-02-23
GB2307414A (en) 1997-05-28
HK1009321A1 (en) 1999-05-28
CN1195276A (zh) 1998-10-07
TR199800347T1 (xx) 1998-05-21
AU6863196A (en) 1997-03-19
IL123379A (en) 2002-04-21
WO1997007734A1 (fr) 1997-03-06
BR9610012A (pt) 1999-12-21
GB9702766D0 (en) 1997-04-02
JPH11511360A (ja) 1999-10-05
JP3899427B2 (ja) 2007-03-28
EP0858285A4 (fr) 2000-05-17
GB2307414B (en) 1998-03-11
ES2536459T3 (es) 2015-05-25
AU707065B2 (en) 1999-07-01
NO980878D0 (no) 1998-02-27
NO980878L (no) 1998-04-27
IL123379A0 (en) 1998-09-24
CN1174713C (zh) 2004-11-10
EP0858285A1 (fr) 1998-08-19

Similar Documents

Publication Publication Date Title
US6142939A (en) Microporation of human skin for drug delivery and monitoring applications
AU707065B2 (en) Microporation of human skin for drug delivery and monitoring applications
US6527716B1 (en) Microporation of tissue for delivery of bioactive agents
US7758561B2 (en) Microporation of tissue for delivery of bioactive agents
CA2789115C (fr) Formation de micropores sur un tissu pour l'administration d'agents bioactifs
US20020169394A1 (en) Integrated tissue poration, fluid harvesting and analysis device, and method therefor
US6419642B1 (en) Irradiation enhanced permeation and delivery
CA2329167C (fr) Technique et appareil permettant d'accroitre les debits d'un fluide dans un tissu biologique rendu microporeux
US20010050083A1 (en) Irradiation enhanced permeation and delivery
EP1563788B1 (fr) Microporation de la peau humaine pour l'administration des médicaments et applications de surveillance
RU2209031C2 (ru) Формирование микропор в коже человека для доставки лекарственных препаратов и мониторинга
WO2002026148A1 (fr) Permeation et prelevement ameliores par irradiation
WO2002026149A1 (fr) Penetration et administration ameliorees par irradiation

Legal Events

Date Code Title Description
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: NITTO DENKO CORPORATION, JP

MK1K Patent expired