NO744336L - - Google Patents

Info

Publication number: NO744336L
Authority: NO; Norway
Prior art keywords: volumes; buffer solution; stated; passed; ion exchanger
Prior art date: 1973-12-19

Application number

NO744336A

Other languages

English (en)

Norwegian (no)

Inventor

Donald William Mercer

Original Assignee

Donald William Mercer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1973-12-19

Filing date

1974-12-02

Publication date

1975-07-14

1974-12-02 Application filed by Donald William Mercer filed Critical Donald William Mercer

1975-07-14 Publication of NO744336L publication Critical patent/NO744336L/no

Links

150000002500 ions Chemical group 0.000 claims description 45
238000000034 method Methods 0.000 claims description 38
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 28
239000007853 buffer solution Substances 0.000 claims description 20
239000011780 sodium chloride Substances 0.000 claims description 14
239000000243 solution Substances 0.000 claims description 13
210000002381 plasma Anatomy 0.000 claims description 11
102000004169 proteins and genes Human genes 0.000 claims description 9
108090000623 proteins and genes Proteins 0.000 claims description 9
238000010521 absorption reaction Methods 0.000 claims description 4
150000001450 anions Chemical class 0.000 claims description 3
238000002798 spectrophotometry method Methods 0.000 claims description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
230000031700 light absorption Effects 0.000 claims 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
108010044467 Isoenzymes Proteins 0.000 description 67
102000004420 Creatine Kinase Human genes 0.000 description 41
108010042126 Creatine kinase Proteins 0.000 description 41
210000002966 serum Anatomy 0.000 description 33
208000010125 myocardial infarction Diseases 0.000 description 22
102000003855 L-lactate dehydrogenase Human genes 0.000 description 21
108700023483 L-lactate dehydrogenases Proteins 0.000 description 21
238000010586 diagram Methods 0.000 description 13
235000002639 sodium chloride Nutrition 0.000 description 11
229960002668 sodium chloride Drugs 0.000 description 10
102000004190 Enzymes Human genes 0.000 description 9
108090000790 Enzymes Proteins 0.000 description 9
210000005013 brain tissue Anatomy 0.000 description 9
239000003708 ampul Substances 0.000 description 7
239000000872 buffer Substances 0.000 description 7
238000005342 ion exchange Methods 0.000 description 7
206010061216 Infarction Diseases 0.000 description 5
230000000694 effects Effects 0.000 description 5
230000007574 infarction Effects 0.000 description 5
238000000926 separation method Methods 0.000 description 5
210000001519 tissue Anatomy 0.000 description 5
208000029549 Muscle injury Diseases 0.000 description 4
239000003153 chemical reaction reagent Substances 0.000 description 4
201000010099 disease Diseases 0.000 description 4
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
239000000284 extract Substances 0.000 description 4
210000005003 heart tissue Anatomy 0.000 description 4
210000002027 skeletal muscle Anatomy 0.000 description 4
238000004587 chromatography analysis Methods 0.000 description 3
230000006378 damage Effects 0.000 description 3
238000001962 electrophoresis Methods 0.000 description 3
210000002216 heart Anatomy 0.000 description 3
208000006454 hepatitis Diseases 0.000 description 3
231100000283 hepatitis Toxicity 0.000 description 3
208000014674 injury Diseases 0.000 description 3
210000003205 muscle Anatomy 0.000 description 3
238000012360 testing method Methods 0.000 description 3
208000007848 Alcoholism Diseases 0.000 description 2
201000002481 Myositis Diseases 0.000 description 2
208000027418 Wounds and injury Diseases 0.000 description 2
239000002253 acid Substances 0.000 description 2
238000004458 analytical method Methods 0.000 description 2
210000004369 blood Anatomy 0.000 description 2
239000008280 blood Substances 0.000 description 2
208000026106 cerebrovascular disease Diseases 0.000 description 2
238000000502 dialysis Methods 0.000 description 2
208000003532 hypothyroidism Diseases 0.000 description 2
230000002989 hypothyroidism Effects 0.000 description 2
239000007927 intramuscular injection Substances 0.000 description 2
238000010255 intramuscular injection Methods 0.000 description 2
239000000203 mixture Substances 0.000 description 2
238000012549 training Methods 0.000 description 2
LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
208000012260 Accidental injury Diseases 0.000 description 1
102000013563 Acid Phosphatase Human genes 0.000 description 1
108010051457 Acid Phosphatase Proteins 0.000 description 1
102000002260 Alkaline Phosphatase Human genes 0.000 description 1
108020004774 Alkaline Phosphatase Proteins 0.000 description 1
206010008479 Chest Pain Diseases 0.000 description 1
206010067125 Liver injury Diseases 0.000 description 1
208000019693 Lung disease Diseases 0.000 description 1
208000001647 Renal Insufficiency Diseases 0.000 description 1
229920005654 Sephadex Polymers 0.000 description 1
239000012507 Sephadex™ Substances 0.000 description 1
239000007983 Tris buffer Substances 0.000 description 1
229920004482 WACKER® Polymers 0.000 description 1
-1 anionic ion Chemical class 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
210000000601 blood cell Anatomy 0.000 description 1
208000029028 brain injury Diseases 0.000 description 1
230000003683 cardiac damage Effects 0.000 description 1
238000013194 cardioversion Methods 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
238000004440 column chromatography Methods 0.000 description 1
238000001514 detection method Methods 0.000 description 1
238000003745 diagnosis Methods 0.000 description 1
238000002405 diagnostic procedure Methods 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
239000011521 glass Substances 0.000 description 1
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
150000004676 glycans Chemical class 0.000 description 1
208000019622 heart disease Diseases 0.000 description 1
231100000234 hepatic damage Toxicity 0.000 description 1
201000006370 kidney failure Diseases 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
230000008818 liver damage Effects 0.000 description 1
238000005259 measurement Methods 0.000 description 1
238000012544 monitoring process Methods 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
229920001282 polysaccharide Polymers 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
230000002980 postoperative effect Effects 0.000 description 1
229910000160 potassium phosphate Inorganic materials 0.000 description 1
235000011009 potassium phosphates Nutrition 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
238000012545 processing Methods 0.000 description 1
238000011084 recovery Methods 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
238000010186 staining Methods 0.000 description 1
239000000758 substrate Substances 0.000 description 1
230000000451 tissue damage Effects 0.000 description 1
231100000827 tissue damage Toxicity 0.000 description 1
230000008733 trauma Effects 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/007—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving isoenzyme profiles
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange

Landscapes

Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Analytical Chemistry (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Physics & Mathematics (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Hematology (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Microbiology (AREA)
Pathology (AREA)
General Physics & Mathematics (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Cell Biology (AREA)
Genetics & Genomics (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
General Engineering & Computer Science (AREA)
Investigating Or Analysing Biological Materials (AREA)
Enzymes And Modification Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

NO744336A 1973-12-19 1974-12-02 NO744336L (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US42600273A	1973-12-19	1973-12-19
US47343874A	1974-05-28	1974-05-28

Publications (1)

Publication Number	Publication Date
NO744336L true NO744336L (fr)	1975-07-14

Family

ID=27026882

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO744336A NO744336L (fr)	1973-12-19	1974-12-02

Country Status (7)

Country	Link
JP (1)	JPS5093693A (fr)
CH (1)	CH595634A5 (fr)
DE (1)	DE2437785A1 (fr)
FR (1)	FR2255601B1 (fr)
GB (1)	GB1481463A (fr)
NO (1)	NO744336L (fr)
SE (1)	SE7408786L (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2005830B (en) *	1977-10-11	1982-05-26	American Hospital Supply Corp	Isoenzyme determination
US4200691A (en)	1978-02-15	1980-04-29	E. I. Du Pont De Nemours And Company	Method for isolating MB creatine kinase

1974
- 1974-07-03 SE SE7408786A patent/SE7408786L/xx unknown
- 1974-08-06 DE DE2437785A patent/DE2437785A1/de active Pending
- 1974-08-13 CH CH1105374A patent/CH595634A5/xx not_active IP Right Cessation
- 1974-10-15 GB GB44671/74A patent/GB1481463A/en not_active Expired
- 1974-10-23 JP JP49121526A patent/JPS5093693A/ja active Pending
- 1974-10-24 FR FR7435751A patent/FR2255601B1/fr not_active Expired
- 1974-12-02 NO NO744336A patent/NO744336L/no unknown

Also Published As

Publication number	Publication date
FR2255601A1 (fr)	1975-07-18
GB1481463A (en)	1977-07-27
DE2437785A1 (de)	1975-06-26
CH595634A5 (fr)	1978-02-15
FR2255601B1 (fr)	1978-11-24
JPS5093693A (fr)	1975-07-25
AU7087174A (en)	1976-01-08
SE7408786L (fr)	1975-06-23

Publication	Publication Date	Title
Tsung et al.	1986	Creatine kinase isoenzymes in extracts of various human skeletal muscles.
Spillane et al.	1979	Accelerated ageing or selective neuronal loss as an important cause of dementia?
Varat et al.	1975	Cardiac specific creatine phosphokinase isoenzyme in the diagnosis of acute myocardial infarction.
Smith	1967	Diagnostic value of serum-creatine-kinase in a coronary-care unit
Wu et al.	1992	Creatine kinase MB isoforms in patients with skeletal muscle injury: ramifications for early detection of acute myocardial infarction
Nealon et al.	1975	Separation of creatine kinase isoenzymes in serum by ion-exchange column chromatography (Mercer's method, modified to increase sensitivity)
US3932221A (en)	1976-01-13	Immunological isozyme determination method
Howe et al.	1945	Cytochrome oxidase in normal and regenerating neurons
Parks Jr et al.	1971	Erythrocytic nucleoside diphosphokinase. IV. Evidence for electrophoretic heterogeneity
Green et al.	1972	Normal serum alkaline phosphatase isoenzymes examined by acrylamide and starch gel electrophoresis and by isoenzyme analysis using organ-specific inhibitors
US4046634A (en)	1977-09-06	Assay of isoenzymes by ion exchange chromatography
Shell et al.	1979	Sensitivity and specificity of MB creatine kinase activity determined with column chromatography
Hungund et al.	2023	Efficacy of nonsurgical periodontal therapy affecting salivary biomarkers in non-diabetic and type 2 diabetic periodontitis patients. An observational study
Hamburg et al.	1991	Metabolic and diagnostic significance of creatine kinase isoenzymes
Keiichi et al.	1977	Serum creatine kinase isoenzymes in Duchenne muscular dystrophy
Dunér et al.	1958	Determination of Histamine in Blood and Urine by Absorption on Amberlite Irc–-50: With Special Reference to the Normal Values for Histamine in Human Blood and an Analysis of the Specificity of the Method
Shay et al.	1931	II. The galactose tolerance test in the differential diagnosis of jaundice
US7198905B2 (en)	2007-04-03	Method of screening methods prediabetic state and screening reagent
Bayer et al.	1976	Creatine kinase isoenzymes in cerebrospinal fluid in a case of brain damage.
Nordby et al.	1975	Creatine kinase and lactate dehydrogenase in the cerebrospinal fluid in patients with head injuries
Bogoch et al.	2017	Brain proteins in the sphingolipidosis: Tay-Sachs disease protein
US4013513A (en)	1977-03-22	Ion exchange chromatographic isoenzyme separation and isolation
Weaver et al.	1982	Aged amylase: a valuable test for detecting and tracking pancreatic pseudocysts
Griffiths	1986	CK-MB: a valuable test?
CA1038195A (fr)	1978-09-12	Separation des isoenzymes par echange d'ions