NO760914L - - Google Patents

Info

Publication number: NO760914L
Authority: NO; Norway
Prior art keywords: albumin; polymers; preparation; approx; polymer
Prior art date: 1975-04-08

Application number

NO760914A

Other languages

English (en)

Norwegian (no)

Inventor

R Reckel

Original Assignee

Ortho Diagnostics

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-04-08

Filing date

1976-03-16

Publication date

1976-10-11

1976-03-16 Application filed by Ortho Diagnostics filed Critical Ortho Diagnostics

1976-10-11 Publication of NO760914L publication Critical patent/NO760914L/no

Links

102000009027 Albumins Human genes 0.000 claims description 135
108010088751 Albumins Proteins 0.000 claims description 135
229920000642 polymer Polymers 0.000 claims description 102
238000002360 preparation method Methods 0.000 claims description 83
239000000203 mixture Substances 0.000 claims description 56
239000000178 monomer Substances 0.000 claims description 40
239000003153 chemical reaction reagent Substances 0.000 claims description 33
108010071390 Serum Albumin Proteins 0.000 claims description 32
102000007562 Serum Albumin Human genes 0.000 claims description 32
230000000405 serological effect Effects 0.000 claims description 29
238000001514 detection method Methods 0.000 claims description 20
210000003743 erythrocyte Anatomy 0.000 claims description 19
238000000034 method Methods 0.000 claims description 18
238000006116 polymerization reaction Methods 0.000 claims description 17
210000002966 serum Anatomy 0.000 claims description 17
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 13
150000001718 carbodiimides Chemical class 0.000 claims description 12
239000002253 acid Substances 0.000 claims description 10
125000000217 alkyl group Chemical group 0.000 claims description 10
239000003795 chemical substances by application Substances 0.000 claims description 10
239000000725 suspension Substances 0.000 claims description 9
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 7
150000003839 salts Chemical class 0.000 claims description 7
239000002244 precipitate Substances 0.000 claims description 6
125000004432 carbon atom Chemical group C* 0.000 claims description 5
239000001257 hydrogen Substances 0.000 claims description 5
229910052739 hydrogen Inorganic materials 0.000 claims description 5
229910052500 inorganic mineral Inorganic materials 0.000 claims description 4
239000011707 mineral Substances 0.000 claims description 4
238000002156 mixing Methods 0.000 claims description 4
229910017464 nitrogen compound Inorganic materials 0.000 claims description 4
150000002830 nitrogen compounds Chemical class 0.000 claims description 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 3
125000000278 alkyl amino alkyl group Chemical group 0.000 claims description 3
229910052799 carbon Inorganic materials 0.000 claims description 3
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims description 3
229910052757 nitrogen Inorganic materials 0.000 claims description 3
125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims description 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 2
125000005936 piperidyl group Chemical group 0.000 claims 2
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
125000004433 nitrogen atom Chemical group N* 0.000 claims 1
239000000126 substance Substances 0.000 claims 1
239000000243 solution Substances 0.000 description 48
238000006243 chemical reaction Methods 0.000 description 31
108091003079 Bovine Serum Albumin Proteins 0.000 description 30
229940098773 bovine serum albumin Drugs 0.000 description 23
230000004520 agglutination Effects 0.000 description 17
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 16
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
-1 dextran Chemical class 0.000 description 12
238000010790 dilution Methods 0.000 description 12
239000012895 dilution Substances 0.000 description 12
239000000539 dimer Substances 0.000 description 12
239000013638 trimer Substances 0.000 description 12
238000004519 manufacturing process Methods 0.000 description 11
230000003389 potentiating effect Effects 0.000 description 11
238000003756 stirring Methods 0.000 description 11
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 10
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 10
210000004369 blood Anatomy 0.000 description 10
239000008280 blood Substances 0.000 description 10
239000011541 reaction mixture Substances 0.000 description 10
238000004448 titration Methods 0.000 description 9
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
239000000427 antigen Substances 0.000 description 8
102000036639 antigens Human genes 0.000 description 7
108091007433 antigens Proteins 0.000 description 7
QYSGYZVSCZSLHT-UHFFFAOYSA-N octafluoropropane Chemical compound FC(F)(F)C(F)(F)C(F)(F)F QYSGYZVSCZSLHT-UHFFFAOYSA-N 0.000 description 7
239000002504 physiological saline solution Substances 0.000 description 7
239000000047 product Substances 0.000 description 7
239000000644 isotonic solution Substances 0.000 description 6
229920002401 polyacrylamide Polymers 0.000 description 6
238000012360 testing method Methods 0.000 description 6
DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 6
239000004471 Glycine Substances 0.000 description 5
230000015572 biosynthetic process Effects 0.000 description 5
239000006227 byproduct Substances 0.000 description 5
210000004027 cell Anatomy 0.000 description 5
238000001962 electrophoresis Methods 0.000 description 5
230000035931 haemagglutination Effects 0.000 description 5
239000013067 intermediate product Substances 0.000 description 5
CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical class C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 description 5
239000002609 medium Substances 0.000 description 5
238000000926 separation method Methods 0.000 description 5
239000011780 sodium chloride Substances 0.000 description 5
FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 4
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
238000004458 analytical method Methods 0.000 description 4
239000007864 aqueous solution Substances 0.000 description 4
239000000499 gel Substances 0.000 description 4
229920002959 polymer blend Polymers 0.000 description 4
235000018102 proteins Nutrition 0.000 description 4
102000004169 proteins and genes Human genes 0.000 description 4
108090000623 proteins and genes Proteins 0.000 description 4
LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Substances CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 3
241000283690 Bos taurus Species 0.000 description 3
229920002307 Dextran Polymers 0.000 description 3
150000001450 anions Chemical class 0.000 description 3
239000004202 carbamide Substances 0.000 description 3
239000012153 distilled water Substances 0.000 description 3
238000001556 precipitation Methods 0.000 description 3
238000012545 processing Methods 0.000 description 3
230000002441 reversible effect Effects 0.000 description 3
HEUACNVDCAMJLS-UHFFFAOYSA-N 1,2-oxazol-2-ium-2-sulfonate Chemical compound [O-]S(=O)(=O)[N+]1=CC=CO1 HEUACNVDCAMJLS-UHFFFAOYSA-N 0.000 description 2
AQGZJQNZNONGKY-UHFFFAOYSA-N 1-[4-(2,5-dioxopyrrol-1-yl)phenyl]pyrrole-2,5-dione Chemical compound O=C1C=CC(=O)N1C1=CC=C(N2C(C=CC2=O)=O)C=C1 AQGZJQNZNONGKY-UHFFFAOYSA-N 0.000 description 2
NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 2
108060003951 Immunoglobulin Proteins 0.000 description 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
229920005654 Sephadex Polymers 0.000 description 2
239000012507 Sephadex™ Substances 0.000 description 2
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
150000007513 acids Chemical class 0.000 description 2
230000032683 aging Effects 0.000 description 2
150000001298 alcohols Chemical class 0.000 description 2
229910000147 aluminium phosphate Inorganic materials 0.000 description 2
125000003277 amino group Chemical group 0.000 description 2
125000000129 anionic group Chemical group 0.000 description 2
GZUXJHMPEANEGY-UHFFFAOYSA-N bromomethane Chemical compound BrC GZUXJHMPEANEGY-UHFFFAOYSA-N 0.000 description 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
238000005119 centrifugation Methods 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
239000000470 constituent Substances 0.000 description 2
239000003085 diluting agent Substances 0.000 description 2
238000009826 distribution Methods 0.000 description 2
230000000694 effects Effects 0.000 description 2
DNJIEGIFACGWOD-UHFFFAOYSA-N ethyl mercaptane Natural products CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 description 2
238000002474 experimental method Methods 0.000 description 2
230000002349 favourable effect Effects 0.000 description 2
238000005194 fractionation Methods 0.000 description 2
102000018358 immunoglobulin Human genes 0.000 description 2
230000005764 inhibitory process Effects 0.000 description 2
150000002500 ions Chemical class 0.000 description 2
GBCAVSYHPPARHX-UHFFFAOYSA-M n'-cyclohexyl-n-[2-(4-methylmorpholin-4-ium-4-yl)ethyl]methanediimine;4-methylbenzenesulfonate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1.C1CCCCC1N=C=NCC[N+]1(C)CCOCC1 GBCAVSYHPPARHX-UHFFFAOYSA-M 0.000 description 2
230000000379 polymerizing effect Effects 0.000 description 2
108090000765 processed proteins & peptides Proteins 0.000 description 2
WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical compound CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 description 2
238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 2
238000003860 storage Methods 0.000 description 2
125000003396 thiol group Chemical group [H]S* 0.000 description 2
XINQFOMFQFGGCQ-UHFFFAOYSA-L (2-dodecoxy-2-oxoethyl)-[6-[(2-dodecoxy-2-oxoethyl)-dimethylazaniumyl]hexyl]-dimethylazanium;dichloride Chemical compound [Cl-].[Cl-].CCCCCCCCCCCCOC(=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(=O)OCCCCCCCCCCCC XINQFOMFQFGGCQ-UHFFFAOYSA-L 0.000 description 1
MWOOKDULMBMMPN-UHFFFAOYSA-N 3-(2-ethyl-1,2-oxazol-2-ium-5-yl)benzenesulfonate Chemical compound O1[N+](CC)=CC=C1C1=CC=CC(S([O-])(=O)=O)=C1 MWOOKDULMBMMPN-UHFFFAOYSA-N 0.000 description 1
101710186708 Agglutinin Proteins 0.000 description 1
MBTOCBINXNCWRM-UHFFFAOYSA-N Cl.N=C=NCCN1CCOCC1 Chemical compound Cl.N=C=NCCN1CCOCC1 MBTOCBINXNCWRM-UHFFFAOYSA-N 0.000 description 1
KIWBPDUYBMNFTB-UHFFFAOYSA-N Ethyl hydrogen sulfate Chemical compound CCOS(O)(=O)=O KIWBPDUYBMNFTB-UHFFFAOYSA-N 0.000 description 1
102000006395 Globulins Human genes 0.000 description 1
108010044091 Globulins Proteins 0.000 description 1
101710146024 Horcolin Proteins 0.000 description 1
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
101710189395 Lectin Proteins 0.000 description 1
241000124008 Mammalia Species 0.000 description 1
101710179758 Mannose-specific lectin Proteins 0.000 description 1
101710150763 Mannose-specific lectin 1 Proteins 0.000 description 1
101710150745 Mannose-specific lectin 2 Proteins 0.000 description 1
GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical class [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
239000000910 agglutinin Substances 0.000 description 1
235000004279 alanine Nutrition 0.000 description 1
230000001476 alcoholic effect Effects 0.000 description 1
150000003973 alkyl amines Chemical class 0.000 description 1
125000005600 alkyl phosphonate group Chemical group 0.000 description 1
150000001408 amides Chemical class 0.000 description 1
150000003862 amino acid derivatives Chemical class 0.000 description 1
235000019270 ammonium chloride Nutrition 0.000 description 1
125000003118 aryl group Chemical group 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
AGEZXYOZHKGVCM-UHFFFAOYSA-N benzyl bromide Chemical compound BrCC1=CC=CC=C1 AGEZXYOZHKGVCM-UHFFFAOYSA-N 0.000 description 1
150000001768 cations Chemical class 0.000 description 1
238000002405 diagnostic procedure Methods 0.000 description 1
239000012897 dilution medium Substances 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
150000002019 disulfides Chemical class 0.000 description 1
VRZVPALEJCLXPR-UHFFFAOYSA-N ethyl 4-methylbenzenesulfonate Chemical compound CCOS(=O)(=O)C1=CC=C(C)C=C1 VRZVPALEJCLXPR-UHFFFAOYSA-N 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
238000013213 extrapolation Methods 0.000 description 1
238000002523 gelfiltration Methods 0.000 description 1
150000004820 halides Chemical class 0.000 description 1
125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
230000001900 immune effect Effects 0.000 description 1
229940072221 immunoglobulins Drugs 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
239000007924 injection Substances 0.000 description 1
238000002347 injection Methods 0.000 description 1
INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 description 1
229960000310 isoleucine Drugs 0.000 description 1
AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
230000002045 lasting effect Effects 0.000 description 1
229920002521 macromolecule Polymers 0.000 description 1
125000005528 methosulfate group Chemical group 0.000 description 1
VUQUOGPMUUJORT-UHFFFAOYSA-N methyl 4-methylbenzenesulfonate Chemical compound COS(=O)(=O)C1=CC=C(C)C=C1 VUQUOGPMUUJORT-UHFFFAOYSA-N 0.000 description 1
229940102396 methyl bromide Drugs 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
JZMJDSHXVKJFKW-UHFFFAOYSA-M methyl sulfate(1-) Chemical compound COS([O-])(=O)=O JZMJDSHXVKJFKW-UHFFFAOYSA-M 0.000 description 1
DEQXHPXOGUSHDX-UHFFFAOYSA-N methylaminomethanetriol;hydrochloride Chemical compound Cl.CNC(O)(O)O DEQXHPXOGUSHDX-UHFFFAOYSA-N 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
YQQNBLKGZRCEDI-UHFFFAOYSA-N n-ethyl-n'-(2-morpholin-4-ylethyl)methanediimine;sulfuric acid Chemical compound OS(O)(=O)=O.CCN=C=NCCN1CCOCC1 YQQNBLKGZRCEDI-UHFFFAOYSA-N 0.000 description 1
125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
229910017604 nitric acid Inorganic materials 0.000 description 1
238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
229920006316 polyvinylpyrrolidine Polymers 0.000 description 1
239000011148 porous material Substances 0.000 description 1
230000001376 precipitating effect Effects 0.000 description 1
235000004252 protein component Nutrition 0.000 description 1
150000003242 quaternary ammonium salts Chemical class 0.000 description 1
238000005956 quaternization reaction Methods 0.000 description 1
150000003254 radicals Chemical group 0.000 description 1
238000011896 sensitive detection Methods 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
230000001235 sensitizing effect Effects 0.000 description 1
238000009589 serological test Methods 0.000 description 1
239000007787 solid Substances 0.000 description 1
238000010186 staining Methods 0.000 description 1
239000007858 starting material Substances 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
150000003871 sulfonates Chemical class 0.000 description 1
150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
125000001302 tertiary amino group Chemical group 0.000 description 1
RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
229940033663 thimerosal Drugs 0.000 description 1
238000012546 transfer Methods 0.000 description 1
238000000108 ultra-filtration Methods 0.000 description 1
238000005199 ultracentrifugation Methods 0.000 description 1
239000004474 valine Substances 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/823—Immunogenic carrier or carrier per se
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/826—Additives, e.g. buffers, diluents, preservatives

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
Urology & Nephrology (AREA)
Biotechnology (AREA)
Pathology (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Microbiology (AREA)
Cell Biology (AREA)
General Physics & Mathematics (AREA)
Food Science & Technology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
Peptides Or Proteins (AREA)
Compositions Of Macromolecular Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

NO760914A 1975-04-08 1976-03-16 NO760914L (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/566,641 US4046871A (en)	1975-04-08	1975-04-08	Compositions and serological methods including bovine serum albumin polymers

Publications (1)

Publication Number	Publication Date
NO760914L true NO760914L (de)	1976-10-11

Family

ID=24263762

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO760914A NO760914L (de)	1975-04-08	1976-03-16

Country Status (11)

Country	Link
US (1)	US4046871A (de)
JP (1)	JPS51123817A (de)
AT (1)	AT357270B (de)
DE (1)	DE2614865A1 (de)
DK (1)	DK146576A (de)
FI (1)	FI55345C (de)
FR (1)	FR2307269A1 (de)
GB (1)	GB1537871A (de)
IL (1)	IL49358A (de)
NO (1)	NO760914L (de)
SE (1)	SE7602536L (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4596792A (en) *	1981-09-04	1986-06-24	The Regents Of The University Of California	Safe vaccine for hepatitis containing polymerized serum albumin
AU554859B2 (en) *	1981-09-04	1986-09-04	Regents Of The University Of California, The	Polymerized albumin vaccine
US4452886A (en) *	1981-09-21	1984-06-05	Henry Robert P	Novel photon absorbing or emitting polymers and their use as reagents in immunoassay systems
US4765980A (en) *	1986-04-28	1988-08-23	International Minerals & Chemical Corp.	Stabilized porcine growth hormone
US5274081A (en) *	1989-09-20	1993-12-28	Immuno A.G.	Complex suitable for carrying out a method of purifying pre-S hepatitis B surface antigen
US5576175A (en) *	1989-09-20	1996-11-19	Immuno Aktiengesellschaft	Complex suitable for carrying out a method of purifying pre-S hepatitis B surface antigen
EP1089769A1 (de) *	1998-06-23	2001-04-11	Surgical Sealants, Incorporated	Carbodiimide vernetztes albumin für bioadhäsive, chirurgische dichtmittel und implantierbare vorrichtungen
US7015198B1 (en) *	1999-05-11	2006-03-21	Orentreich Foundation For The Advancement Of Science, Inc.	Materials for soft tissue augmentation and methods of making and using same
US7056747B2 (en) *	2004-08-13	2006-06-06	Dade Behring Inc.	Process for removing endogenous Vitamin B12 and folate from albumin preparations
FR3150705B1 (fr)	2023-07-07	2026-04-24	Biotech Dental	Nouveau systeme de regeneration osseuse

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL89406C (de) *	1951-07-28
US2938892A (en) *	1958-10-10	1960-05-31	Little Inc A	Amides and process of preparing same with a monocarbodhmide
CH564031A5 (de) *	1968-03-29	1975-07-15	Anvar

1975
- 1975-04-08 US US05/566,641 patent/US4046871A/en not_active Expired - Lifetime
1976
- 1976-02-26 SE SE7602536A patent/SE7602536L/xx unknown
- 1976-03-04 FR FR7606193A patent/FR2307269A1/fr active Granted
- 1976-03-16 NO NO760914A patent/NO760914L/no unknown
- 1976-03-25 GB GB12133/76A patent/GB1537871A/en not_active Expired
- 1976-03-30 DK DK146576A patent/DK146576A/da not_active IP Right Cessation
- 1976-04-06 JP JP51037869A patent/JPS51123817A/ja active Pending
- 1976-04-06 IL IL49358A patent/IL49358A/xx unknown
- 1976-04-06 DE DE19762614865 patent/DE2614865A1/de not_active Withdrawn
- 1976-04-07 AT AT252976A patent/AT357270B/de not_active IP Right Cessation
- 1976-04-07 FI FI760934A patent/FI55345C/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
IL49358A0 (en)	1976-06-30
SE7602536L (sv)	1976-10-09
FI55345B (fi)	1979-03-30
AT357270B (de)	1980-06-25
JPS51123817A (en)	1976-10-28
FI55345C (fi)	1979-07-10
FR2307269A1 (fr)	1976-11-05
GB1537871A (en)	1979-01-04
FI760934A7 (de)	1976-10-09
DK146576A (da)	1976-10-09
US4046871A (en)	1977-09-06
DE2614865A1 (de)	1976-10-21
ATA252976A (de)	1979-11-15
FR2307269B1 (de)	1980-06-06
IL49358A (en)	1979-09-30

Publication	Publication Date	Title
Putnam et al.	1944	The precipitation of proteins by synthetic detergents1a
Wofsy et al.	1963	Effects of the amidination reaction on antibody activity and on the physical properties of some proteins
Staros	1982	N-hydroxysulfosuccinimide active esters: bis (N-hydroxysulfosuccinimide) esters of two dicarboxylic acids are hydrophilic, membrane-impermeant, protein cross-linkers
Ada et al.	1964	ANTIGENS IN IMMUNITY: I. PREPARATION AND PROPERTIES OF FLAGELLAR ANTIGENS FROM SALMONELLA ADELAIDE
Edelman et al.	1961	Studies on structural units of the γ-globulins
Grabar	1959	Immunoelectrophoretic analysis
Pappenheimer Jr et al.	1940	Studies on the molecular weight of diphtheria toxin, antitoxin, and their reaction products
Luetscher	1940	Electrophoretic analysis of plasma and urinary proteins
Scanu	1966	Forms of human serum high density lipoprotein protein
Scanu et al.	1968	Molecular weight and subunit structure of human serum high density lipoprotein after chemical modification by succinic anhydride
US4046871A (en)	1977-09-06	Compositions and serological methods including bovine serum albumin polymers
Mueller-Eckhardt et al.	1978	Studies on the platelet radioactive anti-immunoglobulin test
JP4106111B2 (ja)	2008-06-25	イムノアッセイ用較正／対照用配合物
Chavin et al.	1969	Studies on antigen-binding activity of macroglobulin antibody subunits and their enzymatic fragments
Gitlin et al.	1951	Experimental hypersensitivity in the rabbit: disappearance rates of native and labelled heterologous proteins from the serum after intravenous injection
Kochwa et al.	1966	Aggregation of IgG globulin in vivo. II. Physicochemical properties of the isolated protein
Roy et al.	1984	Nondisulfide polymerization of gamma-and beta-crystallins in the human lens.
Šťastný et al.	1961	The interaction of acridine dyes with blood plasma proteins
Karlsson et al.	1980	A comparative study of three approaches to the routine quantitative determination of spinal fluid total proteins
Lebreton et al.	1975	Immunochemical and biochemical study of a human Fcμ fragment (μ‐chain disease)
Banovitz et al.	1959	Precipitin Production in Chickens: XVIII. Physical Chemical Studies on Complexes of Bovine Serum Albumin and Its Chicken Antibodies
Shulman et al.	1966	Precipitation of auto-antibody in serum from patients with myasthenia gravis
FI72822B (fi)	1987-03-31	Immunologisk reagens foer bestaemning av graviditet, foerfarande foer framstaellning av detta och foerfarande foer bestaemning av graviditet.
Bhakdi et al.	1981	A simple method for isolating specific antibodies to complement components
Rappaport et al.	1970	Conformational changes in the antigenic determinant of tobacco mosaic virus protein resulting from polymerization of the subunits