NO773225L - Fremgangsmaate for fremstilling av en polymorf form av cimetidin - Google Patents

Fremgangsmaate for fremstilling av en polymorf form av cimetidin

Info

Publication number: NO773225L
Authority: NO; Norway
Prior art keywords: cimetidine; suspension; procedure; stated; solvent
Prior art date: 1976-09-21

Application number

NO773225A

Other languages

English (en)

Norwegian (no)

Inventor

Patrick Michael Guy Bavin

James Christopher Phillips Sly

Geoffrey David Tovey

Richard John Ward

Original Assignee

Smith Kline French Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-09-21

Filing date

1977-09-20

Publication date

1978-03-22

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10407431&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO773225(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1976-09-21 Priority claimed from GB3906576A external-priority patent/GB1543238A/en

1977-09-20 Application filed by Smith Kline French Lab filed Critical Smith Kline French Lab

1978-03-22 Publication of NO773225L publication Critical patent/NO773225L/no

Links

CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 title claims description 45
229960001380 cimetidine Drugs 0.000 title claims description 44
238000000034 method Methods 0.000 title claims description 15
239000000725 suspension Substances 0.000 claims description 17
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 10
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 6
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 6
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 6
238000001816 cooling Methods 0.000 claims description 5
238000002329 infrared spectrum Methods 0.000 claims description 5
239000002904 solvent Substances 0.000 claims description 5
238000005119 centrifugation Methods 0.000 claims description 3
230000035515 penetration Effects 0.000 claims description 3
NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 claims description 2
UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 claims description 2
238000013019 agitation Methods 0.000 claims description 2
239000003125 aqueous solvent Substances 0.000 claims description 2
239000007788 liquid Substances 0.000 claims description 2
238000004519 manufacturing process Methods 0.000 description 5
239000007787 solid Substances 0.000 description 5
238000002425 crystallisation Methods 0.000 description 4
230000008025 crystallization Effects 0.000 description 4
239000000047 product Substances 0.000 description 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 2
NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
230000001276 controlling effect Effects 0.000 description 2
238000004090 dissolution Methods 0.000 description 2
230000010355 oscillation Effects 0.000 description 2
239000000843 powder Substances 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 1
238000005147 X-ray Weissenberg Methods 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
239000005557 antagonist Substances 0.000 description 1
230000004071 biological effect Effects 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
238000007906 compression Methods 0.000 description 1
230000006835 compression Effects 0.000 description 1
238000010586 diagram Methods 0.000 description 1
SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 1
239000003937 drug carrier Substances 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
238000001914 filtration Methods 0.000 description 1
239000012530 fluid Substances 0.000 description 1
239000007903 gelatin capsule Substances 0.000 description 1
230000014509 gene expression Effects 0.000 description 1
238000005469 granulation Methods 0.000 description 1
230000003179 granulation Effects 0.000 description 1
238000000227 grinding Methods 0.000 description 1
229960001340 histamine Drugs 0.000 description 1
239000007791 liquid phase Substances 0.000 description 1
238000002156 mixing Methods 0.000 description 1
239000000203 mixture Substances 0.000 description 1
239000008188 pellet Substances 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

NO773225A 1976-09-21 1977-09-20 Fremgangsmaate for fremstilling av en polymorf form av cimetidin NO773225L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB3906576A GB1543238A (en)	1976-09-21	1976-09-21	Polymorph of cimetidine

Publications (1)

Publication Number	Publication Date
NO773225L true NO773225L (no)	1978-03-22

Family

ID=10407431

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO773225A NO773225L (no)	1976-09-21	1977-09-20	Fremgangsmaate for fremstilling av en polymorf form av cimetidin

Country Status (18)

Country	Link
JP (1)	JPS60185767A (da)
AR (1)	AR218267A1 (da)
BG (1)	BG28050A3 (da)
CS (1)	CS207482B1 (da)
DD (1)	DD129906A5 (da)
DK (1)	DK417677A (da)
ES (1)	ES462517A1 (da)
FI (1)	FI772542A7 (da)
GR (1)	GR61173B (da)
IT (1)	IT1086352B (da)
MY (1)	MY8400026A (da)
NL (1)	NL7710354A (da)
NO (1)	NO773225L (da)
PL (1)	PL103681B1 (da)
PT (1)	PT66927B (da)
SE (1)	SE7710518L (da)
ZA (1)	ZA774857B (da)
ZM (1)	ZM7077A1 (da)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1338169A (en) *	1971-03-09	1973-11-21	Smith Kline French Lab	Ureas thioureas and guanidines
GB1397436A (en) *	1972-09-05	1975-06-11	Smith Kline French Lab	Heterocyclic n-cyanoguinidines
GB1531221A (en) *	1974-09-02	1978-11-08	Smith Kline French Lab	Process for preparing guanidine derivatives

1977
- 1977-04-18 DD DD7700198451A patent/DD129906A5/xx unknown
- 1977-05-13 GR GR53452A patent/GR61173B/el unknown
- 1977-05-17 BG BG036338A patent/BG28050A3/xx unknown
- 1977-08-11 ZA ZA00774857A patent/ZA774857B/xx unknown
- 1977-08-16 PT PT66927A patent/PT66927B/pt unknown
- 1977-08-26 FI FI772542A patent/FI772542A7/fi unknown
- 1977-09-08 IT IT27402/77A patent/IT1086352B/it active
- 1977-09-12 ZM ZM7770A patent/ZM7077A1/xx unknown
- 1977-09-19 AR AR269254A patent/AR218267A1/es active
- 1977-09-20 SE SE7710518A patent/SE7710518L/xx not_active Application Discontinuation
- 1977-09-20 NO NO773225A patent/NO773225L/no unknown
- 1977-09-20 PL PL1977200960A patent/PL103681B1/pl unknown
- 1977-09-21 DK DK417677A patent/DK417677A/da not_active Application Discontinuation
- 1977-09-21 CS CS611677A patent/CS207482B1/cs unknown
- 1977-09-21 ES ES462517A patent/ES462517A1/es not_active Expired
- 1977-09-21 NL NL7710354A patent/NL7710354A/xx not_active Application Discontinuation
1984
- 1984-07-31 JP JP59162761A patent/JPS60185767A/ja active Granted
- 1984-12-30 MY MY26/84A patent/MY8400026A/xx unknown

Also Published As

Publication number	Publication date
ES462517A1 (es)	1978-07-01
PT66927A (en)	1977-09-01
JPS6234759B2 (da)	1987-07-28
GR61173B (en)	1978-10-03
NL7710354A (nl)	1978-03-23
CS207482B1 (en)	1981-07-31
AR218267A1 (es)	1980-05-30
PT66927B (en)	1979-03-13
DD129906A5 (de)	1978-02-15
PL200960A1 (pl)	1978-05-22
FI772542A7 (da)	1977-08-29
MY8400026A (en)	1984-12-31
PL103681B1 (pl)	1979-07-31
JPS60185767A (ja)	1985-09-21
ZM7077A1 (en)	1978-08-21
BG28050A3 (bg)	1980-02-25
SE7710518L (sv)	1978-03-22
ZA774857B (en)	1978-06-28
IT1086352B (it)	1985-05-28
DK417677A (da)	1978-03-22

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