NO780197L - Fremgangsmaate for fremstilling av lysin-saltet av alfa-metyl-(2-isopropyl-5-indanyl)eddiksyre - Google Patents

Fremgangsmaate for fremstilling av lysin-saltet av alfa-metyl-(2-isopropyl-5-indanyl)eddiksyre

Info

Publication number: NO780197L
Authority: NO; Norway
Prior art keywords: isopropyl; acetic acid; indanyl; methyl; salt
Prior art date: 1977-02-02

Application number

NO780197A

Other languages

English (en)

Norwegian (no)

Inventor

Jean-Marie Teulon

Original Assignee

Hexachimie

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-02-02

Filing date

1978-01-19

Publication date

1978-08-03

1978-01-19 Application filed by Hexachimie filed Critical Hexachimie

1978-08-03 Publication of NO780197L publication Critical patent/NO780197L/no

Links

238000002360 preparation method Methods 0.000 title claims description 4
238000000034 method Methods 0.000 title claims 5
MRASYQFTHLLRCS-UHFFFAOYSA-N 2-(2-propan-2-yl-2,3-dihydro-1h-inden-5-yl)acetic acid Chemical compound C1=C(CC(O)=O)C=C2CC(C(C)C)CC2=C1 MRASYQFTHLLRCS-UHFFFAOYSA-N 0.000 title 1
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical class NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 title 1
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 14
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 12
RYDUZJFCKYTEHX-UHFFFAOYSA-N 2-(2-propan-2-yl-2,3-dihydro-1h-inden-5-yl)propanoic acid Chemical compound C1=C(C(C)C(O)=O)C=C2CC(C(C)C)CC2=C1 RYDUZJFCKYTEHX-UHFFFAOYSA-N 0.000 claims description 8
239000004472 Lysine Substances 0.000 claims description 8
239000002904 solvent Substances 0.000 claims description 8
150000003839 salts Chemical class 0.000 claims description 7
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 6
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims description 3
230000001476 alcoholic effect Effects 0.000 claims description 2
RNFNDJAIBTYOQL-UHFFFAOYSA-N chloral hydrate Chemical compound OC(O)C(Cl)(Cl)Cl RNFNDJAIBTYOQL-UHFFFAOYSA-N 0.000 claims description 2
229960002327 chloral hydrate Drugs 0.000 claims description 2
239000003960 organic solvent Substances 0.000 claims description 2
238000004519 manufacturing process Methods 0.000 claims 1
239000000243 solution Substances 0.000 description 13
239000000047 product Substances 0.000 description 5
241001465754 Metazoa Species 0.000 description 3
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
239000002253 acid Substances 0.000 description 3
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
230000000202 analgesic effect Effects 0.000 description 2
230000003110 anti-inflammatory effect Effects 0.000 description 2
239000001110 calcium chloride Substances 0.000 description 2
229910001628 calcium chloride Inorganic materials 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
239000013078 crystal Substances 0.000 description 2
239000012153 distilled water Substances 0.000 description 2
239000011521 glass Substances 0.000 description 2
230000002757 inflammatory effect Effects 0.000 description 2
230000005764 inhibitory process Effects 0.000 description 2
230000008018 melting Effects 0.000 description 2
238000002844 melting Methods 0.000 description 2
125000000896 monocarboxylic acid group Chemical group 0.000 description 2
230000000144 pharmacologic effect Effects 0.000 description 2
239000002244 precipitate Substances 0.000 description 2
238000005303 weighing Methods 0.000 description 2
RLQZIECDMISZHS-UHFFFAOYSA-N 2-phenylcyclohexa-2,5-diene-1,4-dione Chemical compound O=C1C=CC(=O)C(C=2C=CC=CC=2)=C1 RLQZIECDMISZHS-UHFFFAOYSA-N 0.000 description 1
206010018910 Haemolysis Diseases 0.000 description 1
206010061218 Inflammation Diseases 0.000 description 1
241000699666 Mus <mouse, genus> Species 0.000 description 1
241000699670 Mus sp. Species 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
241000700159 Rattus Species 0.000 description 1
239000000730 antalgic agent Substances 0.000 description 1
239000002260 anti-inflammatory agent Substances 0.000 description 1
229940121363 anti-inflammatory agent Drugs 0.000 description 1
230000003356 anti-rheumatic effect Effects 0.000 description 1
239000003435 antirheumatic agent Substances 0.000 description 1
239000007982 barbital buffer Substances 0.000 description 1
229960000796 barbital sodium Drugs 0.000 description 1
FTOAOBMCPZCFFF-UHFFFAOYSA-N barbitone sodium Natural products CCC1(CC)C(=O)NC(=O)NC1=O FTOAOBMCPZCFFF-UHFFFAOYSA-N 0.000 description 1
239000008280 blood Substances 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
239000002775 capsule Substances 0.000 description 1
239000000679 carrageenan Substances 0.000 description 1
235000010418 carrageenan Nutrition 0.000 description 1
229940113118 carrageenan Drugs 0.000 description 1
229920001525 carrageenan Polymers 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
230000003480 fibrinolytic effect Effects 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
230000008588 hemolysis Effects 0.000 description 1
210000000548 hind-foot Anatomy 0.000 description 1
125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
230000004054 inflammatory process Effects 0.000 description 1
238000007918 intramuscular administration Methods 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000001103 potassium chloride Substances 0.000 description 1
235000011164 potassium chloride Nutrition 0.000 description 1
210000000664 rectum Anatomy 0.000 description 1
RGHFKWPGWBFQLN-UHFFFAOYSA-M sodium;5,5-diethylpyrimidin-3-ide-2,4,6-trione Chemical compound [Na+].CCC1(CC)C([O-])=NC(=O)NC1=O RGHFKWPGWBFQLN-UHFFFAOYSA-M 0.000 description 1
230000003637 steroidlike Effects 0.000 description 1
238000003756 stirring Methods 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
239000000829 suppository Substances 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
- C07C59/50—Mandelic acid

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO780197A 1977-02-02 1978-01-19 Fremgangsmaate for fremstilling av lysin-saltet av alfa-metyl-(2-isopropyl-5-indanyl)eddiksyre NO780197L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB422677		1977-02-02

Publications (1)

Publication Number	Publication Date
NO780197L true NO780197L (no)	1978-08-03

Family

ID=9773125

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO780197A NO780197L (no)	1977-02-02	1978-01-19	Fremgangsmaate for fremstilling av lysin-saltet av alfa-metyl-(2-isopropyl-5-indanyl)eddiksyre

Country Status (16)

Country	Link
JP (1)	JPS5396313A (de)
AT (1)	ATA52878A (de)
AU (1)	AU3272178A (de)
BE (1)	BE862834A (de)
DD (1)	DD133940A5 (de)
DE (1)	DE2803205A1 (de)
DK (1)	DK47278A (de)
ES (1)	ES466481A1 (de)
FR (1)	FR2379511A1 (de)
GR (1)	GR62849B (de)
NL (1)	NL7801204A (de)
NO (1)	NO780197L (de)
PT (1)	PT67572B (de)
SE (1)	SE7801087L (de)
SU (1)	SU667130A3 (de)
ZA (1)	ZA78403B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3328401A1 (de) *	1983-08-05	1985-02-21	Merckle GmbH, 7902 Blaubeuren	Injizierbare loesung zur behandlung von entzuendungen
IT1197289B (it) *	1986-09-26	1988-11-30	S I F I Societa Ind Farmaceuti	Sale di lisina dell'acido 4-bifenilacetico e sue composizioni oftalmiche

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH592598A5 (de) *	1973-10-30	1977-10-31	Hexachimie
IT1059677B (it) *	1974-03-22	1982-06-21	Neopharmed Spa	Sale di lisina ad azione terapeutica

1978
- 1978-01-09 FR FR7800450A patent/FR2379511A1/fr not_active Withdrawn
- 1978-01-12 BE BE2056598A patent/BE862834A/xx unknown
- 1978-01-19 NO NO780197A patent/NO780197L/no unknown
- 1978-01-23 ZA ZA00780403A patent/ZA78403B/xx unknown
- 1978-01-23 GR GR55241A patent/GR62849B/el unknown
- 1978-01-24 PT PT67572A patent/PT67572B/pt unknown
- 1978-01-25 DE DE19782803205 patent/DE2803205A1/de active Pending
- 1978-01-25 AU AU32721/78A patent/AU3272178A/en active Pending
- 1978-01-25 AT AT52878A patent/ATA52878A/de not_active IP Right Cessation
- 1978-01-27 JP JP818678A patent/JPS5396313A/ja active Pending
- 1978-01-30 SE SE7801087A patent/SE7801087L/xx unknown
- 1978-01-30 ES ES466481A patent/ES466481A1/es not_active Expired
- 1978-01-31 DD DD78203487A patent/DD133940A5/de unknown
- 1978-02-01 DK DK47278A patent/DK47278A/da unknown
- 1978-02-01 SU SU782571854A patent/SU667130A3/ru active
- 1978-02-02 NL NL7801204A patent/NL7801204A/xx not_active Application Discontinuation

Also Published As

Publication number	Publication date
GR62849B (en)	1979-06-20
FR2379511A1 (fr)	1978-09-01
PT67572A (fr)	1978-02-01
DE2803205A1 (de)	1978-08-03
ATA52878A (de)	1979-02-15
BE862834A (fr)	1978-07-12
ZA78403B (en)	1979-01-31
DD133940A5 (de)	1979-01-31
NL7801204A (nl)	1978-08-04
JPS5396313A (en)	1978-08-23
PT67572B (fr)	1979-06-20
SU667130A3 (ru)	1979-06-05
SE7801087L (sv)	1978-08-03
DK47278A (da)	1978-08-03
ES466481A1 (es)	1979-06-01
AU3272178A (en)	1979-08-02

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