NO782128L - Fremgangsmaate for fremstilling av fysiologisk aktive isonikotinsyrederivater - Google Patents

Fremgangsmaate for fremstilling av fysiologisk aktive isonikotinsyrederivater

Info

Publication number: NO782128L
Authority: NO; Norway
Prior art keywords: group; compound; general formula; acid; hydrogen
Prior art date: 1977-06-20

Application number

NO782128A

Other languages

English (en)

Norwegian (no)

Inventor

Povl Krogsgaard-Larsen

Erik Falch

Original Assignee

Krogsgaard Larsen Povl

Erik Falch

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-06-20

Filing date

1978-06-19

Publication date

1978-12-21

1978-06-19 Application filed by Krogsgaard Larsen Povl, Erik Falch filed Critical Krogsgaard Larsen Povl

1978-12-21 Publication of NO782128L publication Critical patent/NO782128L/no

Links

238000002360 preparation method Methods 0.000 title claims description 23
239000002253 acid Substances 0.000 title claims description 14
238000000034 method Methods 0.000 title claims description 9
150000001875 compounds Chemical class 0.000 claims description 80
150000003839 salts Chemical class 0.000 claims description 37
229910052739 hydrogen Inorganic materials 0.000 claims description 32
239000001257 hydrogen Substances 0.000 claims description 31
229940125890 compound Ia Drugs 0.000 claims description 22
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 19
-1 formic acid ester Chemical class 0.000 claims description 19
125000000217 alkyl group Chemical group 0.000 claims description 17
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 16
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 16
229910052736 halogen Inorganic materials 0.000 claims description 13
150000002367 halogens Chemical class 0.000 claims description 13
150000002431 hydrogen Chemical class 0.000 claims description 12
BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 12
125000003545 alkoxy group Chemical group 0.000 claims description 11
125000003884 phenylalkyl group Chemical group 0.000 claims description 10
238000006243 chemical reaction Methods 0.000 claims description 9
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 8
125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims description 8
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 7
235000019253 formic acid Nutrition 0.000 claims description 6
125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims description 5
125000003710 aryl alkyl group Chemical group 0.000 claims description 5
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125000003118 aryl group Chemical group 0.000 claims description 4
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125000005843 halogen group Chemical group 0.000 claims 3
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238000000354 decomposition reaction Methods 0.000 description 5
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230000008499 blood brain barrier function Effects 0.000 description 4
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MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
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LKVYWSOUXPAASC-UHFFFAOYSA-N propan-2-yl 1,2,3,6-tetrahydropyridine-4-carboxylate Chemical compound CC(C)OC(=O)C1=CCNCC1 LKVYWSOUXPAASC-UHFFFAOYSA-N 0.000 description 1
QFPHZWKUUXPCHL-UHFFFAOYSA-N propanoyloxymethyl 1,2,3,6-tetrahydropyridine-4-carboxylate Chemical compound CCC(=O)OCOC(=O)C1=CCNCC1 QFPHZWKUUXPCHL-UHFFFAOYSA-N 0.000 description 1
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IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
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QGMRQYFBGABWDR-UHFFFAOYSA-N sodium;5-ethyl-5-pentan-2-yl-1,3-diazinane-2,4,6-trione Chemical compound [Na+].CCCC(C)C1(CC)C(=O)NC(=O)NC1=O QGMRQYFBGABWDR-UHFFFAOYSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pyridine Compounds (AREA)
Hydrogenated Pyridines (AREA)

NO782128A 1977-06-20 1978-06-19 Fremgangsmaate for fremstilling av fysiologisk aktive isonikotinsyrederivater NO782128L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB2574077		1977-06-20

Publications (1)

Publication Number	Publication Date
NO782128L true NO782128L (no)	1978-12-21

Family

ID=10232513

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
NO782128A NO782128L (no)	1977-06-20	1978-06-19	Fremgangsmaate for fremstilling av fysiologisk aktive isonikotinsyrederivater
NO782127A NO152049C (no)	1977-06-20	1978-06-19	Analogifremgangsmaate for fremstilling av den farmasoeytisk anvendelige forbindelse 4,5,6,7-tetrahydroisoksazolo (5,4-c)pyridin-3-ol
NO792839A NO792839L (no)	1977-06-20	1979-09-03	Mellomprodukt for anvendelse ved fremstilling av fysiologisk aktive isonikotinsyrederivater

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
NO782127A NO152049C (no)	1977-06-20	1978-06-19	Analogifremgangsmaate for fremstilling av den farmasoeytisk anvendelige forbindelse 4,5,6,7-tetrahydroisoksazolo (5,4-c)pyridin-3-ol
NO792839A NO792839L (no)	1977-06-20	1979-09-03	Mellomprodukt for anvendelse ved fremstilling av fysiologisk aktive isonikotinsyrederivater

Country Status (14)

Country	Link
US (2)	US4278676A (de)
EP (4)	EP0027279A1 (de)
JP (2)	JPS5436275A (de)
AT (1)	AT368505B (de)
AU (2)	AU3724478A (de)
CA (1)	CA1107736A (de)
DK (2)	DK270378A (de)
ES (2)	ES470912A1 (de)
FI (2)	FI781955A7 (de)
IE (1)	IE47200B1 (de)
IT (2)	IT1159739B (de)
NO (3)	NO782128L (de)
NZ (1)	NZ187615A (de)
ZA (2)	ZA783492B (de)

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EP2314289A1 (de)	2005-10-31	2011-04-27	Braincells, Inc.	Gaba-rezeptor-vermittelte modulation von neurogenese
US20070203216A1 (en) *	2006-02-14	2007-08-30	Bjarke Ebert	Method of treating inflammatory diseases
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
US7678808B2 (en)	2006-05-09	2010-03-16	Braincells, Inc.	5 HT receptor mediated neurogenesis
EP2021000A2 (de)	2006-05-09	2009-02-11	Braincells, Inc.	Neurogenese mittels angiotensin-modulation
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1978
- 1978-06-15 DK DK270378A patent/DK270378A/da unknown
- 1978-06-15 DK DK270278A patent/DK270278A/da unknown
- 1978-06-19 ES ES470912A patent/ES470912A1/es not_active Expired
- 1978-06-19 US US05/917,118 patent/US4278676A/en not_active Expired - Lifetime
- 1978-06-19 NO NO782128A patent/NO782128L/no unknown
- 1978-06-19 EP EP80106497A patent/EP0027279A1/de not_active Withdrawn
- 1978-06-19 EP EP80106498A patent/EP0028017A1/de not_active Withdrawn
- 1978-06-19 IE IE1234/78A patent/IE47200B1/en unknown
- 1978-06-19 FI FI781955A patent/FI781955A7/fi not_active Application Discontinuation
- 1978-06-19 ZA ZA00783492A patent/ZA783492B/xx unknown
- 1978-06-19 FI FI781954A patent/FI64376C/fi not_active IP Right Cessation
- 1978-06-19 ZA ZA00783493A patent/ZA783493B/xx unknown
- 1978-06-19 NO NO782127A patent/NO152049C/no unknown
- 1978-06-19 NZ NZ187615A patent/NZ187615A/xx unknown
- 1978-06-19 EP EP78100191A patent/EP0000338B1/de not_active Expired
- 1978-06-19 EP EP78100190A patent/EP0000167A1/de not_active Withdrawn
- 1978-06-19 ES ES470913A patent/ES470913A1/es not_active Expired
- 1978-06-19 AU AU37244/78A patent/AU3724478A/en active Pending
- 1978-06-20 JP JP7479978A patent/JPS5436275A/ja active Pending
- 1978-06-20 IT IT68450/78A patent/IT1159739B/it active
- 1978-06-20 AT AT0448678A patent/AT368505B/de not_active IP Right Cessation
- 1978-06-20 JP JP7480078A patent/JPS5436290A/ja active Pending
- 1978-06-20 AU AU37298/78A patent/AU521040B2/en not_active Expired
- 1978-06-20 IT IT7868449A patent/IT7868449A0/it unknown
- 1978-06-20 CA CA305,798A patent/CA1107736A/en not_active Expired
1979
- 1979-09-03 NO NO792839A patent/NO792839L/no unknown
- 1979-12-17 US US06/104,080 patent/US4301287A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ES470912A1 (es)	1979-02-01
EP0028017A1 (de)	1981-05-06
DK270278A (da)	1978-12-21
EP0000338A3 (en)	1979-06-27
EP0027279A1 (de)	1981-04-22
NO152049C (no)	1985-07-24
ZA783493B (en)	1979-06-27
AU3729878A (en)	1980-01-03
AT368505B (de)	1982-10-25
AU521040B2 (en)	1982-03-11
NO152049B (no)	1985-04-15
EP0000338A2 (de)	1979-01-24
EP0000167A1 (de)	1979-01-10
US4301287A (en)	1981-11-17
IT7868450A0 (it)	1978-06-20
ATA448678A (de)	1982-02-15
NZ187615A (en)	1981-12-15
IT1159739B (it)	1987-03-04
JPS5436290A (en)	1979-03-16
CA1107736A (en)	1981-08-25
FI781955A7 (fi)	1978-12-21
FI781954A7 (fi)	1978-12-21
FI64376B (fi)	1983-07-29
DK270378A (da)	1978-12-21
NO782127L (no)	1978-12-21
NO792839L (no)	1978-12-21
FI64376C (fi)	1983-11-10
IT7868449A0 (it)	1978-06-20
JPS5436275A (en)	1979-03-16
IE781234L (en)	1978-12-20
ZA783492B (en)	1979-06-27
ES470913A1 (es)	1979-02-01
EP0000338B1 (de)	1981-11-25
IE47200B1 (en)	1984-01-11
AU3724478A (en)	1980-01-03
US4278676A (en)	1981-07-14

Publication	Publication Date	Title
NO792839L (no)	1978-12-21	Mellomprodukt for anvendelse ved fremstilling av fysiologisk aktive isonikotinsyrederivater
KR880000042B1 (ko)	1988-02-20	신규 유기 아마이드 화합물의 제법
JP2022174114A (ja)	2022-11-22	Ａｌｋタンパク質分解剤及びそれらの癌療法における使用
EP0595610B1 (de)	1997-05-07	Benzokondensierte Lactame
CA2807511A1 (en)	2012-02-09	Processes for preparing tubulysins
KR102842676B1 (ko)	2025-08-04	Khk 억제 효과를 갖는 화합물
SK283233B6 (sk)	2003-04-01	Deriváty benzazepinon-N-octovej kyseliny substituované kyselinou fosfónovou, ako aj spôsob ich výroby a liečivá obsahujúce tieto zlúčeniny
SE445352B (sv)	1986-06-16	Forfarande for framstellning av dipeptider, vilka inhiberar overforing av angiotensin i till angiotensin ii
JPS6058751B2 (ja)	1985-12-21	プロリン関連化合物ならびにその製法
HU223752B1 (hu)	2005-01-28	A gasztrointesztinális keringést elősegítő gyógyászati készítmény
CS621585A2 (en)	1989-08-14	Method of analynprolinone derivatives production
AU2008320718B2 (en)	2013-09-19	Indol-2-one derivatives disubstituted in the 3-position, preparation thereof and therapeutic use thereof
AU2024251729A1 (en)	2025-11-13	Synthesis of ras inhibitors
FR2701708A1 (fr)	1994-08-26	Dérivés de 2-amido-4-phénylthiazoles polysubstitués, procédé de préparation, composition pharmaceutique et utilisation de ces dérivés pour la préparation d'un médicament.
IE47481B1 (en)	1984-04-04	1-piperidinophthalazine cardiac stimulants
JP2020500907A (ja)	2020-01-16	細胞外クエン酸の取込みの阻害剤としてのスルホンアミド
US4968670A (en)	1990-11-06	Pyridine-2,4- and 2,5-dicarboxylic acid derivatives, a process for their preparation, the use thereof, and medicaments based on these compounds
MXPA99003106A (es)	2004-12-02	Compuestos azaheterociclicos n-sustituidos.
CA3155114A1 (en)	2021-05-06	Semicarbazide-sensitive amino oxidase inhibitors and use thereof
HU198937B (en)	1989-12-28	Process for producing indolopyrazino benzodiazepine derivatives and pharmaceutical compositions comprising same
US4138482A (en)	1979-02-06	3-Cyano-N-(N,N-dimethylaminopropyl)-iminodibenzyl and salts thereof
EP0145304B1 (de)	1988-04-20	Tetrahydro-beta-carbolinderivate und Verfahren zu ihrer Herstellung
IE904434A1 (en)	1991-06-19	"New thiophene derivatives, the process for the preparation thereof and the pharmaceutical compositions containing them"
CS236782B2 (en)	1985-05-15	Processing of 5 s-(2r-butyl)peptidergotalkaloid
ITMI951257A1 (it)	1996-12-14	Derivati dell'acido fosfinico ad attivita' inibitrice delle metallopeptidasi