NO790252L - Spesifikke bindings-proevings teknikker - Google Patents

Spesifikke bindings-proevings teknikker

Info

Publication number: NO790252L
Authority: NO; Norway
Prior art keywords: ige; labeled; ligand; amount; radiolabeled
Prior art date: 1978-01-26

Application number

NO790252A

Other languages

English (en)

Norwegian (no)

Inventor

Keith G Huggins

Ivan M Roitt

Original Assignee

Miles Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-01-26

Filing date

1979-01-25

Publication date

1979-07-27

1979-01-25 Application filed by Miles Lab filed Critical Miles Lab

1979-07-27 Publication of NO790252L publication Critical patent/NO790252L/no

Links

238000000034 method Methods 0.000 title claims description 97
230000009870 specific binding Effects 0.000 title claims description 34
238000012360 testing method Methods 0.000 title claims description 24
239000003446 ligand Substances 0.000 claims description 75
239000000758 substrate Substances 0.000 claims description 47
238000009739 binding Methods 0.000 claims description 45
230000027455 binding Effects 0.000 claims description 44
102000004169 proteins and genes Human genes 0.000 claims description 37
108090000623 proteins and genes Proteins 0.000 claims description 37
210000002966 serum Anatomy 0.000 claims description 36
239000000126 substance Substances 0.000 claims description 36
239000013566 allergen Substances 0.000 claims description 35
239000007790 solid phase Substances 0.000 claims description 23
229940074608 allergen extract Drugs 0.000 claims description 20
238000002372 labelling Methods 0.000 claims description 20
239000013558 reference substance Substances 0.000 claims description 20
238000000159 protein binding assay Methods 0.000 claims description 15
230000005764 inhibitory process Effects 0.000 claims description 10
238000010998 test method Methods 0.000 claims description 10
108090000790 Enzymes Proteins 0.000 claims description 7
102000004190 Enzymes Human genes 0.000 claims description 7
238000006243 chemical reaction Methods 0.000 claims description 7
238000010790 dilution Methods 0.000 claims description 6
239000012895 dilution Substances 0.000 claims description 6
230000002285 radioactive effect Effects 0.000 claims description 6
239000005515 coenzyme Substances 0.000 claims description 5
230000007423 decrease Effects 0.000 claims description 5
239000002532 enzyme inhibitor Substances 0.000 claims description 5
230000036541 health Effects 0.000 claims description 5
230000008520 organization Effects 0.000 claims description 5
241001515965 unidentified phage Species 0.000 claims description 5
230000006957 competitive inhibition Effects 0.000 claims description 3
239000012925 reference material Substances 0.000 claims 2
238000009738 saturating Methods 0.000 claims 2
241000894007 species Species 0.000 claims 1
239000000427 antigen Substances 0.000 description 44
102000036639 antigens Human genes 0.000 description 44
108091007433 antigens Proteins 0.000 description 44
206010003645 Atopy Diseases 0.000 description 17
239000003153 chemical reaction reagent Substances 0.000 description 13
230000005855 radiation Effects 0.000 description 13
239000000284 extract Substances 0.000 description 11
239000000047 product Substances 0.000 description 11
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 9
239000000203 mixture Substances 0.000 description 9
239000002953 phosphate buffered saline Substances 0.000 description 9
239000000243 solution Substances 0.000 description 9
206010020751 Hypersensitivity Diseases 0.000 description 8
239000000463 material Substances 0.000 description 7
239000008363 phosphate buffer Substances 0.000 description 7
238000002360 preparation method Methods 0.000 description 7
229960004784 allergens Drugs 0.000 description 6
208000026935 allergic disease Diseases 0.000 description 6
238000004448 titration Methods 0.000 description 6
108091003079 Bovine Serum Albumin Proteins 0.000 description 5
230000007815 allergy Effects 0.000 description 5
229940098773 bovine serum albumin Drugs 0.000 description 5
238000011088 calibration curve Methods 0.000 description 5
238000002405 diagnostic procedure Methods 0.000 description 5
238000011534 incubation Methods 0.000 description 5
239000004094 surface-active agent Substances 0.000 description 5
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
210000001124 body fluid Anatomy 0.000 description 4
239000010839 body fluid Substances 0.000 description 4
229940088598 enzyme Drugs 0.000 description 4
238000000338 in vitro Methods 0.000 description 4
238000004519 manufacturing process Methods 0.000 description 4
239000002504 physiological saline solution Substances 0.000 description 4
206010028980 Neoplasm Diseases 0.000 description 3
241001494479 Pecora Species 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
230000000172 allergic effect Effects 0.000 description 3
208000010668 atopic eczema Diseases 0.000 description 3
230000015572 biosynthetic process Effects 0.000 description 3
239000000872 buffer Substances 0.000 description 3
239000007795 chemical reaction product Substances 0.000 description 3
230000000694 effects Effects 0.000 description 3
238000002474 experimental method Methods 0.000 description 3
239000012634 fragment Substances 0.000 description 3
238000001727 in vivo Methods 0.000 description 3
238000002347 injection Methods 0.000 description 3
239000007924 injection Substances 0.000 description 3
230000026045 iodination Effects 0.000 description 3
238000006192 iodination reaction Methods 0.000 description 3
239000007791 liquid phase Substances 0.000 description 3
238000000163 radioactive labelling Methods 0.000 description 3
238000005406 washing Methods 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
108700004676 Bence Jones Proteins 0.000 description 2
241000209210 Dactylis Species 0.000 description 2
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
102000009438 IgE Receptors Human genes 0.000 description 2
108010073816 IgE Receptors Proteins 0.000 description 2
108060003951 Immunoglobulin Proteins 0.000 description 2
241000283973 Oryctolagus cuniculus Species 0.000 description 2
108090000526 Papain Proteins 0.000 description 2
239000004365 Protease Substances 0.000 description 2
229920005654 Sephadex Polymers 0.000 description 2
239000012507 Sephadex™ Substances 0.000 description 2
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
239000008351 acetate buffer Substances 0.000 description 2
150000001413 amino acids Chemical group 0.000 description 2
239000003708 ampul Substances 0.000 description 2
238000003556 assay Methods 0.000 description 2
230000004071 biological effect Effects 0.000 description 2
201000011510 cancer Diseases 0.000 description 2
VDQQXEISLMTGAB-UHFFFAOYSA-N chloramine T Chemical compound [Na+].CC1=CC=C(S(=O)(=O)[N-]Cl)C=C1 VDQQXEISLMTGAB-UHFFFAOYSA-N 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 2
238000001514 detection method Methods 0.000 description 2
238000003745 diagnosis Methods 0.000 description 2
238000000605 extraction Methods 0.000 description 2
229940046528 grass pollen Drugs 0.000 description 2
102000018358 immunoglobulin Human genes 0.000 description 2
239000007788 liquid Substances 0.000 description 2
230000010807 negative regulation of binding Effects 0.000 description 2
229910052757 nitrogen Inorganic materials 0.000 description 2
229940055729 papain Drugs 0.000 description 2
235000019834 papain Nutrition 0.000 description 2
238000003127 radioimmunoassay Methods 0.000 description 2
239000011541 reaction mixture Substances 0.000 description 2
230000004044 response Effects 0.000 description 2
HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 2
229940001584 sodium metabisulfite Drugs 0.000 description 2
235000010262 sodium metabisulphite Nutrition 0.000 description 2
238000003756 stirring Methods 0.000 description 2
238000003860 storage Methods 0.000 description 2
208000035285 Allergic Seasonal Rhinitis Diseases 0.000 description 1
206010002199 Anaphylactic shock Diseases 0.000 description 1
RZZPDXZPRHQOCG-OJAKKHQRSA-O CDP-choline(1+) Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OCC[N+](C)(C)C)O[C@H]1N1C(=O)N=C(N)C=C1 RZZPDXZPRHQOCG-OJAKKHQRSA-O 0.000 description 1
241000282693 Cercopithecidae Species 0.000 description 1
240000004585 Dactylis glomerata Species 0.000 description 1
208000010201 Exanthema Diseases 0.000 description 1
239000004471 Glycine Substances 0.000 description 1
108091006905 Human Serum Albumin Proteins 0.000 description 1
102000008100 Human Serum Albumin Human genes 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
108010045503 Myeloma Proteins Proteins 0.000 description 1
102000005717 Myeloma Proteins Human genes 0.000 description 1
206010035226 Plasma cell myeloma Diseases 0.000 description 1
208000024780 Urticaria Diseases 0.000 description 1
PNDPGZBMCMUPRI-XXSWNUTMSA-N [125I][125I] Chemical compound [125I][125I] PNDPGZBMCMUPRI-XXSWNUTMSA-N 0.000 description 1
238000009825 accumulation Methods 0.000 description 1
230000002009 allergenic effect Effects 0.000 description 1
208000030961 allergic reaction Diseases 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
208000003455 anaphylaxis Diseases 0.000 description 1
208000006673 asthma Diseases 0.000 description 1
208000010216 atopic IgE responsiveness Diseases 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
230000000903 blocking effect Effects 0.000 description 1
210000000988 bone and bone Anatomy 0.000 description 1
210000001185 bone marrow Anatomy 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
239000000470 constituent Substances 0.000 description 1
238000010908 decantation Methods 0.000 description 1
238000000586 desensitisation Methods 0.000 description 1
230000029087 digestion Effects 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
231100000673 dose–response relationship Toxicity 0.000 description 1
238000005530 etching Methods 0.000 description 1
201000005884 exanthem Diseases 0.000 description 1
238000005227 gel permeation chromatography Methods 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
150000002496 iodine Chemical class 0.000 description 1
229940044173 iodine-125 Drugs 0.000 description 1
238000004255 ion exchange chromatography Methods 0.000 description 1
230000001788 irregular Effects 0.000 description 1
150000002540 isothiocyanates Chemical class 0.000 description 1
208000019420 lymphoid neoplasm Diseases 0.000 description 1
238000005259 measurement Methods 0.000 description 1
238000010907 mechanical stirring Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
201000000050 myeloid neoplasm Diseases 0.000 description 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
239000002420 orchard Substances 0.000 description 1
230000036961 partial effect Effects 0.000 description 1
230000001575 pathological effect Effects 0.000 description 1
229920000136 polysorbate Polymers 0.000 description 1
230000008569 process Effects 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
239000012857 radioactive material Substances 0.000 description 1
206010037844 rash Diseases 0.000 description 1
230000009257 reactivity Effects 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000000284 resting effect Effects 0.000 description 1
230000002441 reversible effect Effects 0.000 description 1
239000001022 rhodamine dye Substances 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
238000013207 serial dilution Methods 0.000 description 1
238000004088 simulation Methods 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
239000012224 working solution Substances 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
- G01N33/6857—Antibody fragments
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/804—Radioisotope, e.g. radioimmunoassay

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Food Science & Technology (AREA)
Biochemistry (AREA)
Cell Biology (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Investigating Or Analysing Biological Materials (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

NO790252A 1978-01-26 1979-01-25 Spesifikke bindings-proevings teknikker NO790252L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/872,668 US4211762A (en)	1978-01-26	1978-01-26	Specific binding assay techniques

Publications (1)

Publication Number	Publication Date
NO790252L true NO790252L (no)	1979-07-27

Family

ID=25360070

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO790252A NO790252L (no)	1978-01-26	1979-01-25	Spesifikke bindings-proevings teknikker

Country Status (10)

Country	Link
US (1)	US4211762A (da)
AU (1)	AU513556B2 (da)
CA (1)	CA1114290A (da)
DE (1)	DE2900546C3 (da)
DK (1)	DK32579A (da)
FI (1)	FI790228A7 (da)
FR (1)	FR2445966A1 (da)
GB (1)	GB2013337B (da)
NO (1)	NO790252L (da)
SE (1)	SE7900343L (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2953610C1 (de) *	1979-03-19	1985-04-11	International Diagnostic Technology, Inc., Santa Clara, Calif.	Verfahren zum Bestimmen eines immunologisch aktiven Stoffs
DE3168691D1 (en) *	1980-11-07	1985-03-14	Technicon Instr	Immunoassay of proteins
US4444879A (en) *	1981-01-29	1984-04-24	Science Research Center, Inc.	Immunoassay with article having support film and immunological counterpart of analyte
FR2502786B1 (fr) *	1981-03-24	1985-06-21	Stallergenes Laboratoire	Procede de fixation d'antigenes et d'anticorps sur support de polysaccharides, et utilisation du produit ainsi obtenu pour les dosages immunologiques
FR2503578B1 (fr) *	1981-04-13	1987-07-17	Guinard Separation	Installation de filtration a coursiers passant entre des plateaux de serrage
JPH0672881B2 (ja) *	1982-10-13	1994-09-14	バイオウィッテッカー・インコーポレーテッド	アレルギー反応の蛍光分析法
US4845027B1 (en) *	1982-10-13	1994-05-10	Biowhittaker Inc	Fluorometric assay of allergic reactions
US4528267A (en) *	1982-11-26	1985-07-09	Axionics, Inc.	Fluorometirc enzyme inhibition immunoassay for measuring potency of allergen extracts
US4849337A (en) *	1983-01-31	1989-07-18	Minnesota Mining And Manufacturing Company	Assaying allergen specific IgE levels with fluorogenic enzyme labeled antibody
US4558013A (en) *	1983-04-08	1985-12-10	Mast Immunosystems, Ltd.	Calibrated reaction measurement system
JPS59208462A (ja) *	1983-04-29	1984-11-26	バイオウィッテッカー・インコーポレーテッド	キモパパインの分析法
US4649039A (en) *	1984-07-03	1987-03-10	E. I. Du Pont De Nemours And Company	Radiolabeling of methionine-containing proteins and peptides
DE3800048A1 (de) *	1987-05-14	1988-11-24	Boehringer Mannheim Gmbh	Verfahren zur bestimmung eines antikoerpers in menschlichen koerperfluessigkeiten
US5231344A (en) *	1990-01-17	1993-07-27	Hitachi Ltd.	Control apparatus for electric generator
JP2009521666A (ja) *	2005-10-12	2009-06-04	アラーガン、インコーポレイテッド	共鳴エネルギー移動後の偏光解消（ｄａｒｅｔ）を用いる分子または細胞より小さい部分の相互作用力のアッセイ

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3720760A (en) *	1968-09-06	1973-03-13	Pharmacia Ab	Method for determining the presence of reagin-immunoglobulins(reagin-ig)directed against certain allergens,in aqueous samples
US3941876A (en) *	1973-04-25	1976-03-02	Gte New Ventures Corporation	In vitro method for determining allergic hypersensitivity

1978
- 1978-01-26 US US05/872,668 patent/US4211762A/en not_active Expired - Lifetime
- 1978-12-14 CA CA317,964A patent/CA1114290A/en not_active Expired
1979
- 1979-01-08 DE DE2900546A patent/DE2900546C3/de not_active Expired
- 1979-01-15 SE SE7900343A patent/SE7900343L/xx not_active Application Discontinuation
- 1979-01-15 GB GB7901472A patent/GB2013337B/en not_active Expired
- 1979-01-24 FI FI790228A patent/FI790228A7/fi not_active IP Right Cessation
- 1979-01-25 NO NO790252A patent/NO790252L/no unknown
- 1979-01-25 DK DK32579A patent/DK32579A/da unknown
- 1979-01-25 AU AU43668/79A patent/AU513556B2/en not_active Ceased
- 1979-01-25 FR FR7901965A patent/FR2445966A1/fr active Pending

Also Published As

Publication number	Publication date
FR2445966A1 (fr)	1980-08-01
FI790228A7 (fi)	1979-07-27
DE2900546C3 (de)	1981-05-21
GB2013337B (en)	1982-11-17
DE2900546B2 (de)	1980-09-11
CA1114290A (en)	1981-12-15
US4211762A (en)	1980-07-08
SE7900343L (sv)	1979-07-27
DK32579A (da)	1979-07-27
AU4366879A (en)	1979-08-02
GB2013337A (en)	1979-08-08
DE2900546A1 (de)	1979-08-30
AU513556B2 (en)	1980-12-11

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EP0111211B1 (en)	1986-05-21	Immunoassay for nonenzymatically glucosylated proteins and protein fragments - an index of glycemia
US4478744A (en)	1984-10-23	Method of obtaining antibodies
US4247533A (en)	1981-01-27	Hemoglobin A1c radioimmunoassay
Bodenheimer Jr et al.	1983	Elevated circulating immune complexes in primary sclerosing cholangitis
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McDuffie et al.	1956	A comparative study of methods used for analysis of specific precipitates in quantitative immunochemistry
US20240361342A1 (en)	2024-10-31	Lateral flow immunoassay method of simultaneously detecting hemoglobin s, hemoglobin c, and hemoglobin a in newborns, infants, children, and adults
Koopman et al.	1980	A sensitive radioimmunoassay for quantitation of IgM rheumatoid factor
Fauci et al.	1970	The relationship between antibody affinity and the efficiency of complement fixation
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DE3800048A1 (de)	1988-11-24	Verfahren zur bestimmung eines antikoerpers in menschlichen koerperfluessigkeiten
Mann et al.	1969	Use of insoluble antibody for quantitative determination of small amounts of immunoglobulin
AU715797B2 (en)	2000-02-10	Methods for determining the presence of brain protein S-100
JPS63292061A (ja)	1988-11-29	完全無傷なプラコラーゲンペプチド（３型）およびプロコラーゲン（３型）の選択的な免疫学的測定法
Hamilton et al.	1980	Serological analysis of human IgG and IgE anti-insulin antibodies by solid-phase radioimmunoassays
TAKEDA et al.	1977	Radiometric measurement of thyroglobulin-antithyroglobulin immune complex in human serum
Ishizaka et al.	1969	Physicochemical Properties of Human Reaginic Antibodies: VIII. Effect of Reduction and Alkylation on γE Antibodies
Karol et al.	1977	Evolution of an idiotypic determinant: anti-Val.
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JPS58122459A (ja)	1983-07-21	酵素の会合を利用した測定方法
JPH0326787B2 (da)	1991-04-11
YUZURIHA et al.	1978	Studies on biotransformation of lysozyme. IV. Radioimmunoassay of lysozyme and its evaluation
GB1580318A (en)	1980-12-03	Antibodies active against human hemoglobin a1c
Franchimont et al.	1969	Radioimmunoassay of rheumatoid factor