NO802092L - Reagenspreparat for bestemmelse av lipaseaktivitet i biologiske vaesker, fremgangsmaate for bestemmelse av lipaseaktivitet, samt testesett - Google Patents

Reagenspreparat for bestemmelse av lipaseaktivitet i biologiske vaesker, fremgangsmaate for bestemmelse av lipaseaktivitet, samt testesett

Info

Publication number: NO802092L
Authority: NO; Norway
Prior art keywords: reagent; pseudocholinesterase; inhibitor; mixture; cholinesterase
Prior art date: 1979-07-13

Application number

NO802092A

Other languages

English (en)

Norwegian (no)

Inventor

Cleo Le-O Huang

Original Assignee

Dow Chemical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-07-13

Filing date

1980-07-11

Publication date

1981-01-14

1980-07-11 Application filed by Dow Chemical Co filed Critical Dow Chemical Co

1981-01-14 Publication of NO802092L publication Critical patent/NO802092L/no

Links

239000003153 chemical reaction reagent Substances 0.000 title claims description 51
238000000034 method Methods 0.000 title claims description 29
235000019626 lipase activity Nutrition 0.000 title claims description 22
238000012360 testing method Methods 0.000 title claims description 13
238000002360 preparation method Methods 0.000 title claims 5
239000007788 liquid Substances 0.000 title description 5
102100032404 Cholinesterase Human genes 0.000 claims description 43
239000000203 mixture Substances 0.000 claims description 42
108010053652 Butyrylcholinesterase Proteins 0.000 claims description 34
108090001060 Lipase Proteins 0.000 claims description 26
102000004882 Lipase Human genes 0.000 claims description 26
239000004367 Lipase Substances 0.000 claims description 26
235000019421 lipase Nutrition 0.000 claims description 26
239000000758 substrate Substances 0.000 claims description 23
238000011534 incubation Methods 0.000 claims description 21
239000003112 inhibitor Substances 0.000 claims description 21
239000003774 sulfhydryl reagent Substances 0.000 claims description 20
239000000243 solution Substances 0.000 claims description 16
108090000322 Cholinesterases Proteins 0.000 claims description 15
229940048961 cholinesterase Drugs 0.000 claims description 15
239000002736 nonionic surfactant Substances 0.000 claims description 14
PIJVFDBKTWXHHD-HIFRSBDPSA-N physostigmine Chemical group C12=CC(OC(=O)NC)=CC=C2N(C)[C@@H]2[C@@]1(C)CCN2C PIJVFDBKTWXHHD-HIFRSBDPSA-N 0.000 claims description 11
102000009027 Albumins Human genes 0.000 claims description 10
108010088751 Albumins Proteins 0.000 claims description 10
239000000872 buffer Substances 0.000 claims description 9
238000006243 chemical reaction Methods 0.000 claims description 9
HZOTZTANVBDFOF-PBCQUBLHSA-N physostigmine salicylate Chemical group OC(=O)C1=CC=CC=C1O.C12=CC(OC(=O)NC)=CC=C2N(C)[C@@H]2[C@@]1(C)CCN2C HZOTZTANVBDFOF-PBCQUBLHSA-N 0.000 claims description 9
UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical class NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims description 9
239000013060 biological fluid Substances 0.000 claims description 8
PIJVFDBKTWXHHD-UHFFFAOYSA-N Physostigmine Natural products C12=CC(OC(=O)NC)=CC=C2N(C)C2C1(C)CCN2C PIJVFDBKTWXHHD-UHFFFAOYSA-N 0.000 claims description 7
229960001697 physostigmine Drugs 0.000 claims description 7
238000005259 measurement Methods 0.000 claims description 6
239000004094 surface-active agent Substances 0.000 claims description 6
239000000544 cholinesterase inhibitor Substances 0.000 claims description 5
230000000694 effects Effects 0.000 claims description 5
239000007787 solid Substances 0.000 claims description 5
239000000126 substance Substances 0.000 claims description 5
KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims description 4
102000013392 Carboxylesterase Human genes 0.000 claims description 4
108010051152 Carboxylesterase Proteins 0.000 claims description 4
239000003929 acidic solution Substances 0.000 claims description 4
150000003839 salts Chemical class 0.000 claims description 4
XDVMCVGTDUKDHL-UHFFFAOYSA-N [amino(2-azaniumylethylsulfanyl)methylidene]azanium;dibromide Chemical compound Br.Br.NCCSC(N)=N XDVMCVGTDUKDHL-UHFFFAOYSA-N 0.000 claims description 3
239000000693 micelle Substances 0.000 claims description 3
229940122274 Carboxylesterase inhibitor Drugs 0.000 claims description 2
102000003914 Cholinesterases Human genes 0.000 claims 6
229940122041 Cholinesterase inhibitor Drugs 0.000 claims 1
239000012442 inert solvent Substances 0.000 claims 1
238000002835 absorbance Methods 0.000 description 24
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 19
210000002966 serum Anatomy 0.000 description 18
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 12
YBYRMVIVWMBXKQ-UHFFFAOYSA-N phenylmethanesulfonyl fluoride Chemical group FS(=O)(=O)CC1=CC=CC=C1 YBYRMVIVWMBXKQ-UHFFFAOYSA-N 0.000 description 10
NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 description 8
KIUMMUBSPKGMOY-UHFFFAOYSA-N 3,3'-Dithiobis(6-nitrobenzoic acid) Chemical compound C1=C([N+]([O-])=O)C(C(=O)O)=CC(SSC=2C=C(C(=CC=2)[N+]([O-])=O)C(O)=O)=C1 KIUMMUBSPKGMOY-UHFFFAOYSA-N 0.000 description 7
238000002405 diagnostic procedure Methods 0.000 description 6
239000012153 distilled water Substances 0.000 description 6
239000012086 standard solution Substances 0.000 description 6
239000000839 emulsion Substances 0.000 description 5
230000007062 hydrolysis Effects 0.000 description 5
238000006460 hydrolysis reaction Methods 0.000 description 5
230000002401 inhibitory effect Effects 0.000 description 5
GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 5
108010022752 Acetylcholinesterase Proteins 0.000 description 4
102100033639 Acetylcholinesterase Human genes 0.000 description 4
229920002307 Dextran Polymers 0.000 description 4
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
229940022698 acetylcholinesterase Drugs 0.000 description 4
239000004615 ingredient Substances 0.000 description 4
230000005764 inhibitory process Effects 0.000 description 4
125000003396 thiol group Chemical group [H]S* 0.000 description 4
231100000331 toxic Toxicity 0.000 description 4
230000002588 toxic effect Effects 0.000 description 4
QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 3
230000002159 abnormal effect Effects 0.000 description 3
239000002253 acid Substances 0.000 description 3
239000003945 anionic surfactant Substances 0.000 description 3
108010009043 arylesterase Proteins 0.000 description 3
102000028848 arylesterase Human genes 0.000 description 3
238000005119 centrifugation Methods 0.000 description 3
150000001875 compounds Chemical class 0.000 description 3
238000004108 freeze drying Methods 0.000 description 3
102000004169 proteins and genes Human genes 0.000 description 3
108090000623 proteins and genes Proteins 0.000 description 3
230000035945 sensitivity Effects 0.000 description 3
230000003381 solubilizing effect Effects 0.000 description 3
239000003381 stabilizer Substances 0.000 description 3
238000012546 transfer Methods 0.000 description 3
PMNLUUOXGOOLSP-UHFFFAOYSA-N 2-mercaptopropanoic acid Chemical compound CC(S)C(O)=O PMNLUUOXGOOLSP-UHFFFAOYSA-N 0.000 description 2
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
239000002202 Polyethylene glycol Substances 0.000 description 2
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
239000012445 acidic reagent Substances 0.000 description 2
238000004458 analytical method Methods 0.000 description 2
239000008346 aqueous phase Substances 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
238000007796 conventional method Methods 0.000 description 2
MUCZHBLJLSDCSD-UHFFFAOYSA-N diisopropyl fluorophosphate Chemical compound CC(C)OP(F)(=O)OC(C)C MUCZHBLJLSDCSD-UHFFFAOYSA-N 0.000 description 2
229960002362 neostigmine Drugs 0.000 description 2
LULNWZDBKTWDGK-UHFFFAOYSA-M neostigmine bromide Chemical compound [Br-].CN(C)C(=O)OC1=CC=CC([N+](C)(C)C)=C1 LULNWZDBKTWDGK-UHFFFAOYSA-M 0.000 description 2
230000007935 neutral effect Effects 0.000 description 2
UYDLBVPAAFVANX-UHFFFAOYSA-N octylphenoxy polyethoxyethanol Chemical compound CC(C)(C)CC(C)(C)C1=CC=C(OCCOCCOCCOCCO)C=C1 UYDLBVPAAFVANX-UHFFFAOYSA-N 0.000 description 2
125000004430 oxygen atom Chemical group O* 0.000 description 2
229920001223 polyethylene glycol Polymers 0.000 description 2
238000001556 precipitation Methods 0.000 description 2
239000011541 reaction mixture Substances 0.000 description 2
235000019333 sodium laurylsulphate Nutrition 0.000 description 2
229910052717 sulfur Inorganic materials 0.000 description 2
125000004434 sulfur atom Chemical group 0.000 description 2
235000015112 vegetable and seed oil Nutrition 0.000 description 2
239000008158 vegetable oil Substances 0.000 description 2
JWSLMDWREGSKAJ-UHFFFAOYSA-N (1-benzylpyridin-1-ium-3-yl) n,n-dimethylcarbamate Chemical compound CN(C)C(=O)OC1=CC=C[N+](CC=2C=CC=CC=2)=C1 JWSLMDWREGSKAJ-UHFFFAOYSA-N 0.000 description 1
WGJCBBASTRWVJL-UHFFFAOYSA-N 1,3-thiazolidine-2-thione Chemical compound SC1=NCCS1 WGJCBBASTRWVJL-UHFFFAOYSA-N 0.000 description 1
CMCBDXRRFKYBDG-UHFFFAOYSA-N 1-dodecoxydodecane Chemical compound CCCCCCCCCCCCOCCCCCCCCCCCC CMCBDXRRFKYBDG-UHFFFAOYSA-N 0.000 description 1
JPJDHKGZXKMWDY-UHFFFAOYSA-N 2,3-bis(sulfanyl)propan-1-ol;butanoic acid Chemical compound CCCC(O)=O.CCCC(O)=O.CCCC(O)=O.OCC(S)CS JPJDHKGZXKMWDY-UHFFFAOYSA-N 0.000 description 1
KWVPFECTOKLOBL-KTKRTIGZSA-N 2-[(z)-octadec-9-enoxy]ethanol Chemical compound CCCCCCCC\C=C/CCCCCCCCOCCO KWVPFECTOKLOBL-KTKRTIGZSA-N 0.000 description 1
HQAPREJURVMGMB-UHFFFAOYSA-M 2-acetylsulfanylethyl(trimethyl)azanium;bromide Chemical compound [Br-].CC(=O)SCC[N+](C)(C)C HQAPREJURVMGMB-UHFFFAOYSA-M 0.000 description 1
SLAMLWHELXOEJZ-UHFFFAOYSA-N 2-nitrobenzoic acid Chemical compound OC(=O)C1=CC=CC=C1[N+]([O-])=O SLAMLWHELXOEJZ-UHFFFAOYSA-N 0.000 description 1
GNFTZDOKVXKIBK-UHFFFAOYSA-N 3-(2-methoxyethoxy)benzohydrazide Chemical compound COCCOC1=CC=CC(C(=O)NN)=C1 GNFTZDOKVXKIBK-UHFFFAOYSA-N 0.000 description 1
VFVHNRJEYQGRGE-UHFFFAOYSA-N 3-acetylsulfanyl-2-methylpropanoic acid Chemical compound OC(=O)C(C)CSC(C)=O VFVHNRJEYQGRGE-UHFFFAOYSA-N 0.000 description 1
239000004382 Amylase Substances 0.000 description 1
102000013142 Amylases Human genes 0.000 description 1
108010065511 Amylases Proteins 0.000 description 1
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
108090000371 Esterases Proteins 0.000 description 1
KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 description 1
239000005949 Malathion Substances 0.000 description 1
IGFHQQFPSIBGKE-UHFFFAOYSA-N Nonylphenol Natural products CCCCCCCCCC1=CC=C(O)C=C1 IGFHQQFPSIBGKE-UHFFFAOYSA-N 0.000 description 1
206010033645 Pancreatitis Diseases 0.000 description 1
229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
229920001219 Polysorbate 40 Polymers 0.000 description 1
229920001214 Polysorbate 60 Polymers 0.000 description 1
VNYBTNPBYXSMOO-UHFFFAOYSA-M Pyridostigmine bromide Chemical compound [Br-].CN(C)C(=O)OC1=CC=C[N+](C)=C1 VNYBTNPBYXSMOO-UHFFFAOYSA-M 0.000 description 1
102000007562 Serum Albumin Human genes 0.000 description 1
108010071390 Serum Albumin Proteins 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
230000004913 activation Effects 0.000 description 1
125000000217 alkyl group Chemical group 0.000 description 1
-1 alkylphenyl ether Chemical compound 0.000 description 1
DXUUXWKFVDVHIK-UHFFFAOYSA-N ambenonium chloride Chemical compound [Cl-].[Cl-].C=1C=CC=C(Cl)C=1C[N+](CC)(CC)CCNC(=O)C(=O)NCC[N+](CC)(CC)CC1=CC=CC=C1Cl DXUUXWKFVDVHIK-UHFFFAOYSA-N 0.000 description 1
229960004302 ambenonium chloride Drugs 0.000 description 1
235000019418 amylase Nutrition 0.000 description 1
125000000129 anionic group Chemical group 0.000 description 1
239000011260 aqueous acid Substances 0.000 description 1
239000012062 aqueous buffer Substances 0.000 description 1
238000003149 assay kit Methods 0.000 description 1
238000011088 calibration curve Methods 0.000 description 1
125000004432 carbon atom Chemical group C* 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
238000011161 development Methods 0.000 description 1
JXSJBGJIGXNWCI-UHFFFAOYSA-N diethyl 2-[(dimethoxyphosphorothioyl)thio]succinate Chemical compound CCOC(=O)CC(SP(=S)(OC)OC)C(=O)OCC JXSJBGJIGXNWCI-UHFFFAOYSA-N 0.000 description 1
MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
230000002255 enzymatic effect Effects 0.000 description 1
229940088598 enzyme Drugs 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
239000012530 fluid Substances 0.000 description 1
229960005051 fluostigmine Drugs 0.000 description 1
239000003517 fume Substances 0.000 description 1
230000014509 gene expression Effects 0.000 description 1
150000004820 halides Chemical class 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
229910000040 hydrogen fluoride Inorganic materials 0.000 description 1
230000000749 insecticidal effect Effects 0.000 description 1
229960000453 malathion Drugs 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 description 1
229960001428 mercaptopurine Drugs 0.000 description 1
OSZNNLWOYWAHSS-UHFFFAOYSA-M neostigmine methyl sulfate Chemical compound COS([O-])(=O)=O.CN(C)C(=O)OC1=CC=CC([N+](C)(C)C)=C1 OSZNNLWOYWAHSS-UHFFFAOYSA-M 0.000 description 1
SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical compound CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 description 1
230000020477 pH reduction Effects 0.000 description 1
LCCNCVORNKJIRZ-UHFFFAOYSA-N parathion Chemical compound CCOP(=S)(OCC)OC1=CC=C([N+]([O-])=O)C=C1 LCCNCVORNKJIRZ-UHFFFAOYSA-N 0.000 description 1
239000008389 polyethoxylated castor oil Substances 0.000 description 1
229920000136 polysorbate Polymers 0.000 description 1
229960002151 pyridostigmine bromide Drugs 0.000 description 1
230000009257 reactivity Effects 0.000 description 1
238000007430 reference method Methods 0.000 description 1
229960001860 salicylate Drugs 0.000 description 1
YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
238000000926 separation method Methods 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000011593 sulfur Substances 0.000 description 1
238000010998 test method Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Physics & Mathematics (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Biophysics (AREA)
Analytical Chemistry (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)

NO802092A 1979-07-13 1980-07-11 Reagenspreparat for bestemmelse av lipaseaktivitet i biologiske vaesker, fremgangsmaate for bestemmelse av lipaseaktivitet, samt testesett NO802092L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/057,525 US4279994A (en)	1979-07-13	1979-07-13	Lipase determination method and reagent

Publications (1)

Publication Number	Publication Date
NO802092L true NO802092L (no)	1981-01-14

Family

ID=22011108

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO802092A NO802092L (no)	1979-07-13	1980-07-11	Reagenspreparat for bestemmelse av lipaseaktivitet i biologiske vaesker, fremgangsmaate for bestemmelse av lipaseaktivitet, samt testesett

Country Status (13)

Country	Link
US (1)	US4279994A (fr)
JP (1)	JPS5615698A (fr)
BE (1)	BE883387A (fr)
CA (1)	CA1128843A (fr)
DE (1)	DE3020072A1 (fr)
DK (1)	DK221380A (fr)
FI (1)	FI801799A7 (fr)
FR (1)	FR2461007A1 (fr)
GB (1)	GB2065881B (fr)
IT (1)	IT1209237B (fr)
NL (1)	NL8003138A (fr)
NO (1)	NO802092L (fr)
SE (1)	SE8003518L (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4483922A (en) *	1982-05-14	1984-11-20	Amf Inc.	Inactivation of enzymes
US4757001A (en) *	1984-02-16	1988-07-12	Fujirebio Kabushiki Kaisha	Method of measuring biological ligand by utilizing amylase
US6218163B1 (en)	1995-08-07	2001-04-17	Thermogen, Inc.	Stable biocatalysts for ester hydrolysis
EP0952847A4 (fr) *	1996-01-11	2003-09-03	Thermogen Inc	Biocatalyseurs stables pour l'hydrolyse d'esters
JP4220603B2 (ja) *	1998-12-02	2009-02-04	アルフレッサファーマ株式会社	血小板活性化因子アセチルヒドロラーゼ活性の測定方法
CN113533012B (zh) *	2020-04-22	2024-03-12	上海云泽生物科技有限公司	用于伏立康唑血药浓度检测的样本前处理液

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3119668A (en) *	1959-01-26	1964-01-28	Dow Chemical Co	Sulfhydryl tests and compounds therefor
FR1472956A (fr) *	1964-07-20	1967-06-01
US3867259A (en) *	1973-11-08	1975-02-18	American Cyanamid Co	Lactate dehydrogenase test material
US3875014A (en) *	1973-12-14	1975-04-01	American Cyanamid Co	Glutamic oxaloacetic transaminase test material
US3917515A (en) *	1974-03-13	1975-11-04	Jack M Goldberg	Serum lipase method and medium
US3986930A (en) *	1974-05-28	1976-10-19	Dainippon Pharmaceutical Co., Ltd.	Lipase activity determining method and reagent

1979
- 1979-07-13 US US06/057,525 patent/US4279994A/en not_active Expired - Lifetime
1980
- 1980-05-02 CA CA351,122A patent/CA1128843A/fr not_active Expired
- 1980-05-09 SE SE8003518A patent/SE8003518L/xx not_active Application Discontinuation
- 1980-05-20 GB GB8016588A patent/GB2065881B/en not_active Expired
- 1980-05-20 BE BE0/200684A patent/BE883387A/fr not_active IP Right Cessation
- 1980-05-21 DK DK221380A patent/DK221380A/da not_active Application Discontinuation
- 1980-05-27 JP JP7071980A patent/JPS5615698A/ja active Pending
- 1980-05-27 DE DE19803020072 patent/DE3020072A1/de not_active Withdrawn
- 1980-05-29 NL NL8003138A patent/NL8003138A/nl not_active Application Discontinuation
- 1980-06-04 FI FI801799A patent/FI801799A7/fi not_active Application Discontinuation
- 1980-06-26 IT IT8023006A patent/IT1209237B/it active
- 1980-07-07 FR FR8015088A patent/FR2461007A1/fr active Granted
- 1980-07-11 NO NO802092A patent/NO802092L/no unknown

Also Published As

Publication number	Publication date
JPS5615698A (en)	1981-02-14
DK221380A (da)	1981-01-14
FR2461007A1 (fr)	1981-01-30
FI801799A7 (fi)	1981-01-01
GB2065881B (en)	1983-06-22
DE3020072A1 (de)	1981-02-05
FR2461007B1 (fr)	1984-09-14
GB2065881A (en)	1981-07-01
IT1209237B (it)	1989-07-16
BE883387A (fr)	1980-11-20
US4279994A (en)	1981-07-21
CA1128843A (fr)	1982-08-03
IT8023006A0 (it)	1980-06-26
SE8003518L (sv)	1981-01-14
NL8003138A (nl)	1981-01-15

Publication	Publication Date	Title
Noe et al.	1984	Direct spectrophotometry of serum hemoglobin: an Allen correction compared with a three-wavelength polychromatic analysis.
McGowan et al.	1983	A peroxidase-coupled method for the colorimetric determination of serum triglycerides.
EP0080304B1 (fr)	1986-05-21	Stabilisation d'oxydase
Rautela et al.	1978	Automated enzymic measurement of total cholesterol in serum.
US8883439B2 (en)	2014-11-11	Blood component measurement method utilizing hemolyzed whole blood, and kit for the method
CS228127B2 (en)	1984-05-14	Reagencni cinidlo
US4211844A (en)	1980-07-08	Bilirubin-specific fungal enzyme preparation
US4000042A (en)	1976-12-28	Diagnostic reagent for the determination of amylase
Gardiner	1979	A rapid and sensitive fluorimetric assay for adenosine, inosine, and hypoxanthine
NO162120B (no)	1989-07-31	Preparat, proeveinnte fovisning a v esteraseaktivitet i en vaeskeproeve.
NO802092L (no)	1981-01-14	Reagenspreparat for bestemmelse av lipaseaktivitet i biologiske vaesker, fremgangsmaate for bestemmelse av lipaseaktivitet, samt testesett
US5962248A (en)	1999-10-05	Quantitative determination method for chloride ions
McGowan et al.	1983	Enzymatic colorimetry of lecithin and sphingomyelin in aqueous solution.
EP0091026B1 (fr)	1987-02-11	Composition liquide stabilisée pour le dosage du cholestérol
Appel	1974	Amino acid arylamidases (“leucine-nitroanilidase”)
JPH1014596A (ja)	1998-01-20	体液中の成分の測定法およびその試薬
JP4542541B2 (ja)	2010-09-15	安定化コリンエステラーゼ基質溶液
JP4013108B2 (ja)	2007-11-28	リパーゼの安定化方法
WO1993013219A1 (fr)	1993-07-08	Composition de determination d'ions calcium
US3799843A (en)	1974-03-26	Determination of acid phosphatase
Osawa et al.	2005	Development and application of serum cholinesterase activity measurement using benzoylthiocholine iodide
EP0486997B1 (fr)	1996-01-31	Réactif pour déterminer de niveau d'ion de calcium
JPH0367600A (ja)	1991-03-22	リパーゼ定量用単一試薬系およびその製造方法
JPH02276597A (ja)	1990-11-13	体液中のカルシウム測定方法
JPH07303497A (ja)	1995-11-21	生体成分の測定方法および測定用試薬組成物