NO821645L - Analogifremgangsmaate for fremstilling av farmakologisk aktive benzoazepinderivater - Google Patents

Analogifremgangsmaate for fremstilling av farmakologisk aktive benzoazepinderivater

Info

Publication number: NO821645L
Authority: NO; Norway
Prior art keywords: preparation; pharmacologically active; analogue procedure; benzoazepine derivatives; benzoazepine
Prior art date: 1981-05-19

Application number

NO821645A

Other languages

English (en)

Other versions

NO159166C (no

NO159166B (no

Inventor

Manfred Reiffen

Joachim Heider

Norbert Hauel

Volkhard Austel

Wolfgang Eberlein

Klaus Noll

Helmut Pieper

Gerd Krueger

Johannes Keck

Walter Kobinger

Christian Lillie

Original Assignee

Thomae Gmbh Dr K

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-05-19

Filing date

1982-05-18

Publication date

1982-11-22

1982-05-18 Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K

1982-11-22 Publication of NO821645L publication Critical patent/NO821645L/no

1988-08-29 Publication of NO159166B publication Critical patent/NO159166B/no

1988-12-07 Publication of NO159166C publication Critical patent/NO159166C/no

Links

150000008038 benzoazepines Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Cardiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

NO821645A 1981-05-19 1982-05-18 Analogifremgangsmaate for fremstilling av farmakologisk aktive benzoazepinderivater. NO159166C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19813119874 DE3119874A1 (de)	1981-05-19	1981-05-19	"benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"

Publications (3)

Publication Number	Publication Date
NO821645L true NO821645L (no)	1982-11-22
NO159166B NO159166B (no)	1988-08-29
NO159166C NO159166C (no)	1988-12-07

Family

ID=6132690

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO821645A NO159166C (no)	1981-05-19	1982-05-18	Analogifremgangsmaate for fremstilling av farmakologisk aktive benzoazepinderivater.

Country Status (29)

Country	Link
EP (1)	EP0065229B1 (no)
JP (1)	JPS57193462A (no)
KR (3)	KR890001544B1 (no)
AR (1)	AR231130A1 (no)
AT (1)	ATE14725T1 (no)
AU (1)	AU551509B2 (no)
BG (1)	BG60412B2 (no)
CA (1)	CA1185239A (no)
CS (2)	CS251760B2 (no)
DD (1)	DD202872A5 (no)
DE (2)	DE3119874A1 (no)
DK (1)	DK156720C (no)
ES (5)	ES512285A0 (no)
FI (1)	FI77856C (no)
GB (1)	GB2099425B (no)
GR (1)	GR76458B (no)
HK (1)	HK43388A (no)
HU (1)	HU186584B (no)
IE (1)	IE53016B1 (no)
IL (1)	IL65814A (no)
MX (1)	MX9202743A (no)
NO (1)	NO159166C (no)
NZ (1)	NZ200659A (no)
PL (1)	PL136914B1 (no)
PT (1)	PT74919B (no)
SU (1)	SU1160935A3 (no)
UA (1)	UA8038A1 (no)
YU (1)	YU44674B (no)
ZA (1)	ZA823413B (no)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3242599A1 (de) *	1982-11-18	1984-05-24	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel
DE3343801A1 (de) *	1983-12-03	1985-06-13	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue indolderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3418271A1 (de) *	1984-05-17	1985-11-21	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3418270A1 (de) *	1984-05-17	1985-11-21	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0204349A3 (de) *	1985-06-01	1990-01-03	Dr. Karl Thomae GmbH	Neue heteroaromatische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE3717561A1 (de) *	1987-05-25	1988-12-08	Thomae Gmbh Dr K	Indol-, isochinolin- und benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3541811A1 (de) *	1985-11-27	1987-06-04	Thomae Gmbh Dr K	Neue cyclische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3736866A1 (de) *	1987-10-30	1989-05-11	Thomae Gmbh Dr K	Mittel zur behandlung des bluthochdrucks und der herzinsuffizienz
FR2624117B1 (fr) *	1987-12-08	1991-02-22	Synthelabo	Derives de hydroxy-3 (methoxy-4 phenyl)-2 (methylamino-2 ethyl)-5 dihydro-2,3 5h-benzothiazepine-1,5 one-4, leur preparation et leur application en therapeutique
JP2699511B2 (ja) *	1988-01-29	1998-01-19	武田薬品工業株式会社	置換アミン類
JP2807577B2 (ja) *	1990-06-15	1998-10-08	エーザイ株式会社	環状アミド誘導体
FR2681862B1 (fr) *	1991-09-27	1993-11-12	Adir Cie	Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
JPH09501405A (ja) *	1993-05-27	1997-02-10	スミスクライン・ビーチャム・ラボラトワール・ファルマソーティク	抗不整脈用ｎ−置換３−ベンズアゼピンまたはイソキノリン
FR2705675B1 (fr) *	1993-05-27	1996-05-03	Smithkline Beecham Labo Pharma	Nouveaux composés, leur procédé de préparation et leur utilisation en tant que médicaments.
SE9303274D0 (sv) *	1993-10-07	1993-10-07	Astra Ab	Novel phenylethyl and phenylproplamines
DE10018401A1 (de)	2000-04-13	2001-10-25	Boehringer Ingelheim Pharma	Verwendung von Bradycardica bei der Behandlung von mit Hypertrophie einhergehenden Myocarderkrankungen und neue Arzneimittelkombinationen
IL159105A0 (en)	2001-06-07	2004-05-12	Neuro3D	Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses thereof
EP1661886B1 (en) *	2003-08-29	2016-08-10	Mitsui Chemicals Agro, Inc.	Insecticide for agricultural or horticultural use and method of use thereof
FR2868776B1 (fr) *	2004-04-13	2008-04-18	Servier Lab	Nouveau procede de synthese de derives de la 1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868775B1 (fr) *	2004-04-13	2008-04-11	Servier Lab	Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868777B1 (fr)	2004-04-13	2006-05-26	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2870537A1 (fr) *	2004-05-19	2005-11-25	Servier Lab	Nouveau procede de synthese du (1s)-4,5-dimethoxy-1-(methyl aminomethyl-)-benzocyclobutane et de ses sels d'addition, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2882555B1 (fr) *	2005-02-28	2007-05-04	Servier Lab	Forme cristalline gamma du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882553B1 (fr) *	2005-02-28	2007-05-04	Servier Lab	Forme cristalline beta du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882556B1 (fr) *	2005-02-28	2007-05-04	Servier Lab	Forme cristalline gamma d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882554B1 (fr) *	2005-02-28	2007-05-04	Servier Lab	Forme critalline beta d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
EP1762179A1 (en)	2005-09-07	2007-03-14	Boehringer Ingelheim Vetmedica Gmbh	Method for improving diagnostic quality in echocardiography
FR2891826B1 (fr) *	2005-10-11	2007-12-28	Servier Lab	Forme cristalline 6 du chlorhydrate de l'ivabradine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2891827B1 (fr) *	2005-10-11	2007-12-28	Servier Lab	Forme cristalline deltad du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2920773B1 (fr) *	2007-09-11	2009-10-23	Servier Lab	Derives de 1,2,4,5-tetrahydro-3h-benzazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2935381B1 (fr) *	2008-08-29	2010-12-17	Servier Lab	Nouveau procede de resolution des enantiomerees du (3,4-dimethoxy-bicyclo°4.2.0!octa-1,3,5-trien-7-yl)nitrile et application a la synthese de l'ivabradine
FR2941695B1 (fr) *	2009-02-04	2011-02-18	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
ME00987B (me) *	2009-03-31	2012-06-20	Servier Lab	Novi postupak sinteze ivabradina i njegovih soli sa farmaceutski prihvatljivom kiselinom
ME00986B (me) *	2009-03-31	2012-06-20	Servier Lab	Novi postupak sinteze ivabradina i njegovih adicionih soli sa farmaceutski prihvatljivom kiselinom
FR2956401B1 (fr) *	2010-02-17	2012-02-03	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
AR089645A1 (es)	2011-08-12	2014-09-10	Boehringer Ingelheim Vetmed	Particula multicapas de sabor enmascarado, metodo, uso, composicion farmaceutica
WO2014122248A1 (en)	2013-02-11	2014-08-14	Boehringer Ingelheim Vetmedica Gmbh	Kit-of-parts
FR3003859B1 (fr) *	2013-03-26	2015-03-13	Servier Lab	"procede de synthese de derives de la 7,8-dimethoxy-1,3-dihydro-2h-3-benzazepin-2-one et application a la synthese de l'ivabradine"
HU230826B1 (hu) *	2014-11-19	2018-07-30	Richter Gedeon Nyrt.	Eljárás benzazepin származékok előállítására

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3474090A (en) *	1966-12-22	1969-10-21	American Cyanamid Co	3-aminoalkyl-1,3-benzodiazepin-2-ones
US3780023A (en) *	1972-06-30	1973-12-18	J Suh	2-aralkylamino-4,5-dihydro-3h-1,3-benzodiazepines
US4210749A (en) *	1974-11-12	1980-07-01	Pennwalt Corporation	Substituted 1,2,4,5-tetrahydro-3H,3 benzazepines
DE2639718C2 (de) *	1976-09-03	1987-03-05	Dr. Karl Thomae Gmbh, 7950 Biberach	1-[6,7-Dimethoxy-3,4-dihydro-2H-isochinolin-1-on-2-yl]-3-[N-methyl-N-(2-(3,4-dimethoxy-phenyl)-äthyl)-amino]-propan, dessen physiologisch verträgliche Säureadditionssalze und diese Verbindungen enthaltende Arzneimittel
ZA786230B (en) *	1977-12-21	1979-10-31	Smithkline Corp	8 and/or 9 substituted 2-benzazepine compounds
ZA792785B (en)	1978-07-07	1980-08-27	Smithkline Corp	Mercapto substituted-2,3,4,5-tetrahydro-1h-3-benzazepines
ES484553A1 (es) *	1978-10-05	1980-05-16	Hoechst Ag	Un metodo para preparar 4-fenil-1,3-benzodiazepinas
DE2850078A1 (de) *	1978-11-18	1980-05-29	Basf Ag	Aminopropanolderivate des 6-hydroxy-2,3,4,5-tetrahydro-1h-1- benzazepin-2-ons

1981
- 1981-05-19 DE DE19813119874 patent/DE3119874A1/de not_active Withdrawn
1982
- 1982-05-06 DE DE8282103931T patent/DE3265206D1/de not_active Expired
- 1982-05-06 EP EP82103931A patent/EP0065229B1/de not_active Expired
- 1982-05-06 AT AT82103931T patent/ATE14725T1/de not_active IP Right Cessation
- 1982-05-12 CS CS823456A patent/CS251760B2/cs unknown
- 1982-05-13 SU SU823435639A patent/SU1160935A3/ru active
- 1982-05-13 UA UA3435639A patent/UA8038A1/uk unknown
- 1982-05-17 FI FI821724A patent/FI77856C/fi not_active IP Right Cessation
- 1982-05-17 DK DK222382A patent/DK156720C/da not_active IP Right Cessation
- 1982-05-17 PL PL1982236474A patent/PL136914B1/pl unknown
- 1982-05-17 DD DD82239912A patent/DD202872A5/de not_active IP Right Cessation
- 1982-05-18 IE IE1194/82A patent/IE53016B1/en not_active IP Right Cessation
- 1982-05-18 HU HU821581A patent/HU186584B/hu unknown
- 1982-05-18 AU AU83794/82A patent/AU551509B2/en not_active Expired
- 1982-05-18 NZ NZ200659A patent/NZ200659A/en unknown
- 1982-05-18 JP JP57083915A patent/JPS57193462A/ja active Granted
- 1982-05-18 NO NO821645A patent/NO159166C/no not_active IP Right Cessation
- 1982-05-18 ES ES512285A patent/ES512285A0/es active Granted
- 1982-05-18 CA CA000403172A patent/CA1185239A/en not_active Expired
- 1982-05-18 ZA ZA823413A patent/ZA823413B/xx unknown
- 1982-05-18 PT PT74919A patent/PT74919B/pt unknown
- 1982-05-18 YU YU1051/82A patent/YU44674B/xx unknown
- 1982-05-18 GB GB8214503A patent/GB2099425B/en not_active Expired
- 1982-05-18 IL IL65814A patent/IL65814A/xx not_active IP Right Cessation
- 1982-05-18 AR AR289434A patent/AR231130A1/es active
- 1982-05-19 GR GR68197A patent/GR76458B/el unknown
- 1982-05-19 KR KR8202240A patent/KR890001544B1/ko not_active Expired
- 1982-05-19 KR KR1019890001999A patent/KR890001545B1/ko not_active Expired
- 1982-11-29 ES ES517756A patent/ES517756A0/es active Granted
- 1982-11-29 ES ES517758A patent/ES517758A0/es active Granted
- 1982-11-29 ES ES517753A patent/ES517753A0/es active Granted
- 1982-11-29 ES ES517757A patent/ES517757A0/es active Granted
1988
- 1988-06-09 HK HK433/88A patent/HK43388A/xx not_active IP Right Cessation
1989
- 1989-02-20 KR KR1019890001998A patent/KR890001550B1/ko not_active Expired
1991
- 1991-12-27 CS CS914102A patent/CS410291A3/cs unknown
1992
- 1992-06-09 MX MX9202743A patent/MX9202743A/es unknown
1994
- 1994-01-25 BG BG098418A patent/BG60412B2/bg unknown

Also Published As

Publication number	Publication date
ATE14725T1 (de)	1985-08-15
CA1185239A (en)	1985-04-09
UA8038A1 (uk)	1995-12-26
KR890001550B1 (ko)	1989-05-08
DK156720C (da)	1990-02-19
DD202872A5 (de)	1983-10-05
BG60412B2 (bg)	1995-02-28
GR76458B (no)	1984-08-10
EP0065229A1 (de)	1982-11-24
MX9202743A (es)	1992-06-30
KR890001544B1 (ko)	1989-05-08
ES8308312A1 (es)	1983-08-16
PT74919B (de)	1985-05-16
DK156720B (da)	1989-09-25
AR231130A1 (es)	1984-09-28
JPS57193462A (en)	1982-11-27
AU551509B2 (en)	1986-05-01
YU44674B (en)	1990-12-31
GB2099425A (en)	1982-12-08
IE821194L (en)	1982-11-19
ES517758A0 (es)	1983-08-16
ES8308309A1 (es)	1983-08-16
ES517753A0 (es)	1983-08-16
KR890001545B1 (ko)	1989-05-08
NO159166C (no)	1988-12-07
PL236474A1 (en)	1983-06-20
NO159166B (no)	1988-08-29
DE3265206D1 (en)	1985-09-12
FI821724A0 (fi)	1982-05-17
CS251760B2 (en)	1987-08-13
ES8306726A1 (es)	1983-06-01
FI77856C (fi)	1989-05-10
EP0065229B1 (de)	1985-08-07
IE53016B1 (en)	1988-05-11
CS410291A3 (en)	1992-08-12
PL136914B1 (en)	1986-04-30
HU186584B (en)	1985-08-28
ES8308310A1 (es)	1983-08-16
SU1160935A3 (ru)	1985-06-07
PT74919A (de)	1982-06-01
IL65814A0 (en)	1982-08-31
ES512285A0 (es)	1983-06-01
ES8308311A1 (es)	1983-08-16
JPH0136829B2 (no)	1989-08-02
FI77856B (fi)	1989-01-31
HK43388A (en)	1988-06-17
ES517756A0 (es)	1983-08-16
DK222382A (da)	1982-11-20
DE3119874A1 (de)	1982-12-09
NZ200659A (en)	1985-05-31
GB2099425B (en)	1985-02-06
KR830010077A (ko)	1983-12-26
ZA823413B (en)	1984-01-25
AU8379482A (en)	1982-11-25
YU105182A (en)	1986-12-31
ES517757A0 (es)	1983-08-16
IL65814A (en)	1986-02-28

Legal Events

Date	Code	Title	Description
2002-07-08	MK1K	Patent expired	Free format text: EXPIRED IN MAY 2002

Publication	Publication Date	Title
NO821645L (no)	1982-11-22	Analogifremgangsmaate for fremstilling av farmakologisk aktive benzoazepinderivater
NO159016C (no)	1988-11-23	Analogifremgangsmaate for fremstilling av terapeutisk aktive fenetanolaminderivater.
NO164025C (no)	1990-08-22	Analogifremgangsmaate for fremstilling av terapeutisk aktive 3-imidazolylmetyl-tetrahydrokarbazolon-derivater.
NO156785C (no)	1987-11-25	Analogifremgangsmaate for fremstilling av terapeutisk aktive cyklobutan-derivater.
NO872946D0 (no)	1987-07-15	Analogifremgangsmaate for fremstilling av terapeutisk aktive benzensulfonamidoindanylforbindelser.
NO161497C (no)	1989-08-23	Analogifremgangsmaate for fremstilling av terapeutisk aktive 9a-aza-9a-homoerytromycin-derivater.
NO874153D0 (no)	1987-10-02	Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazo-benzoksazinon-derivater.
NO854965L (no)	1986-06-13	Analogifremgangsmaate for fremstilling av terapeutisk aktive pteridin-derivater.
NO165397C (no)	1991-02-06	Analogifremgangsmaate for fremstilling av terapeutisk aktive tiazolforbindelser.
NO903941D0 (no)	1990-09-10	Analogifremgangsmaate for fremstilling av terapeutisk aktive diazepinon-derivater.
NO157296C (no)	1988-02-24	Analogifremgangsmaate for fremstilling av terapeutisk aktive n-(4-indolyl-piperidino-alkyl)-benzimidazolon-derivater.
NO157503C (no)	1988-03-30	Analogifremgangsmaate for fremstilling av farmakologisk aktive azepinderivater.
NO158876C (no)	1988-11-09	Analogifremgangsmaate for fremstilling av terapeutisk aktive adenosin-derivater.
NO871028D0 (no)	1987-03-12	Analogifremgangsmaate for fremstilling av terapeutisk aktive tiazol- og oksazol-derivater.
NO164541C (no)	1990-10-17	Analogifremgangsmaate for fremstilling av terapeutisk aktive benzimidazolderivater.
NO155771C (no)	1987-05-27	Analogifremgangsmaate for fremstilling av terapeutisk aktive aminopropanolderivater.
NO834729L (no)	1984-06-25	Fremgangsmaate for fremstilling av farmakologisk aktive tio-cefalosporiner
NO159090C (no)	1988-11-30	Analogifremgangsmaate for fremstilling av terapeutisk aktive pyridoindol-derivater.
NO821882L (no)	1982-12-07	Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrazolo-pyrido-diazepin-derivater
NO159273C (no)	1988-12-14	Analogifremgangsmaate for fremstilling av farmakologisk aktive benzotriazol-derivater.
NO162188C (no)	1989-11-29	Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazokinoliner.
NO168530C (no)	1992-03-04	Analogifremgangsmaate for fremstilling av terapeutisk aktive benzoksazoninforbindelser.
NO163617C (no)	1990-06-27	Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolidinon-derivater.
NO874780D0 (no)	1987-11-17	Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolo-benzimidazol-derivater.
NO156408C (no)	1987-09-16	Analogifremgangsmte for fremstilling av terapeutisk aktive l-prolinderivater.