NO841168L - Fremgangsmaate for fremstilling av pyrimidinderivater - Google Patents

Fremgangsmaate for fremstilling av pyrimidinderivater

Info

Publication number
NO841168L
NO841168L NO841168A NO841168A NO841168L NO 841168 L NO841168 L NO 841168L NO 841168 A NO841168 A NO 841168A NO 841168 A NO841168 A NO 841168A NO 841168 L NO841168 L NO 841168L
Authority
NO
Norway
Prior art keywords
compound
lower alkyl
general formula
dimethoxyphenyl
dihydro
Prior art date
Application number
NO841168A
Other languages
English (en)
Norwegian (no)
Inventor
Takao Takaya
Masayoshi Murata
Kiyotaka Ito
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838308290A external-priority patent/GB8308290D0/en
Priority claimed from GB838315542A external-priority patent/GB8315542D0/en
Priority claimed from GB838327859A external-priority patent/GB8327859D0/en
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of NO841168L publication Critical patent/NO841168L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO841168A 1983-03-25 1984-03-23 Fremgangsmaate for fremstilling av pyrimidinderivater NO841168L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB838308290A GB8308290D0 (en) 1983-03-25 1983-03-25 Pyrimidinone derivatives
GB838315542A GB8315542D0 (en) 1983-06-07 1983-06-07 Pyrimidinone derivatives
GB838327859A GB8327859D0 (en) 1983-10-18 1983-10-18 Pyrimidine derivatives

Publications (1)

Publication Number Publication Date
NO841168L true NO841168L (no) 1984-09-26

Family

ID=27262023

Family Applications (1)

Application Number Title Priority Date Filing Date
NO841168A NO841168L (no) 1983-03-25 1984-03-23 Fremgangsmaate for fremstilling av pyrimidinderivater

Country Status (13)

Country Link
US (3) US4612376A (de)
EP (1) EP0123402B1 (de)
KR (1) KR840008333A (de)
CA (1) CA1256107A (de)
DE (1) DE3473875D1 (de)
DK (1) DK160492C (de)
ES (2) ES530916A0 (de)
FI (1) FI841128A7 (de)
GR (1) GR81758B (de)
HU (1) HU195195B (de)
NO (1) NO841168L (de)
PH (1) PH22022A (de)
SU (2) SU1349698A3 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4612376A (en) * 1983-03-25 1986-09-16 Fujisawa Pharmaceutical Co., Ltd. Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent
US4598149A (en) * 1984-03-02 1986-07-01 Merck & Co., Inc. 3-amino-2-hydroxypropyl of pyrimidin-4-one useful as antihypertensive, cardioprotective, antiarrythmic, and antianginal agents
US4649142A (en) * 1984-06-25 1987-03-10 Fujisawa Pharmaceutical Co., Ltd. 3,4-dihydro-1,3-disubstituted-6-(substituted phenylimino)-2(1H)-pyrimidinone useful as cardiotonic agent and anti-allergic agent
US4708958A (en) * 1986-09-24 1987-11-24 G. D. Searle & Co. 6-(imidazolyphenyl)-4-iminopyrimidinones useful as hypotensive agents
US5521315A (en) * 1993-01-12 1996-05-28 Cell Therapeutics, Inc. Olefin substituted long chain compounds
IT1270122B (it) * 1994-10-04 1997-04-28 Ist Superiore Sanita 6-benzil-4-ossopirimidine sostituite, processo per la loro preparazione e composizioni farmaceutiche che le contengono
DE69630799T2 (de) * 1995-09-06 2004-08-12 Kowa Co., Ltd., Nagoya Pyrimidinderivate
US6244121B1 (en) * 1998-03-06 2001-06-12 Applied Materials, Inc. Sensor device for non-intrusive diagnosis of a semiconductor processing system
KR101078098B1 (ko) 2003-01-14 2011-10-28 아레나 파마슈티칼스, 인크. 대사 조절제로서의 １,２,３-삼치환된 아릴 및 헤테로아릴유도체, 및 당뇨병 및 고혈당증을 비롯한 이에 관련된장애의 예방 및 치료
AR045697A1 (es) 2003-07-14 2005-11-09 Arena Pharm Inc Aril y heteroaril derivados fusionados como moduladores del metabolismo y la prevencion y tratamiento de trastornos relacionados con el mismo
DOP2006000009A (es) 2005-01-13 2006-08-15 Arena Pharm Inc Procedimiento para preparar eteres de pirazolo [3,4-d] pirimidina
KR101577554B1 (ko) 2005-08-22 2015-12-14 멜리어 파마슈티칼스 아이, 인코포레이티드 Ｌｙｎ 키나제 활성의 조절 및 관련된 장애의 치료를 위한 방법 및 제제
CN101686686A (zh) * 2007-02-20 2010-03-31 梅里奥尔医药I公司 鉴别Lyn激酶激活剂的方法
JP2010534668A (ja) * 2007-07-23 2010-11-11 メリオール・ディスカヴァリー・インコーポレイテッド Ｉｒｓ−１及びａｋｔを活性化する方法
US8552184B2 (en) * 2008-07-03 2013-10-08 Melior Pharmaceuticals I, Inc. Compounds and methods for treating disorders related to glucose metabolism
EP2462123B1 (de) * 2009-08-04 2013-10-02 Merck Sharp & Dohme Corp. 4,5,6-trisubstituierte pyrimidin- derivate als factor ixa inhibitoren
CN108558740B (zh) 2010-01-27 2021-10-19 艾尼纳制药公司 S1p1受体调节剂及其盐的制备方法
WO2011150300A1 (en) 2010-05-28 2011-12-01 Melior Pharmaceuticals I, Inc. Prevention of pancreatic beta cell degeneration
SG188548A1 (en) 2010-09-22 2013-04-30 Arena Pharm Inc Modulators of the gpr119 receptor and the treatment of disorders related thereto
US10183949B2 (en) 2014-08-29 2019-01-22 The University Of Tokyo Pyrimidinone derivative having autotaxin-inhibitory activity
EP3187492A4 (de) * 2014-08-29 2018-05-09 The University of Tokyo Pyrimidinonderivat mit autotaxin-hemmender wirkung
PL3242666T3 (pl) 2015-01-06 2025-02-17 Arena Pharmaceuticals, Inc. Związek do zastosowania w leczeniu dolegliwości związanych z receptorem s1p1
HUE060476T2 (hu) 2015-06-22 2023-03-28 Arena Pharm Inc (R)-2-(7-(4-ciklopentil-3-(trifluormetil)benziloxi)-1,2,3,4- tetrahidrociklopenta[B]indol-3-il)ecetsav kristályos L-arginin-sója S1P1 receptorral kapcsolatos rendellenességek esetén való alkalmazásra
WO2018151873A1 (en) 2017-02-16 2018-08-23 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of primary biliary cholangitis
MX387305B (es) 2017-04-10 2025-03-18 Melior Pharmaceuticals I Inc Tratamiento de adipocitos
US12156866B2 (en) 2018-06-06 2024-12-03 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the S1P1 receptor
CN109053589A (zh) * 2018-09-30 2018-12-21 浙江师范大学 4-亚胺基四氢嘧啶-2-酮类化合物的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1296371A (de) * 1969-02-26 1972-11-15
AU1108070A (en) * 1969-03-06 1971-08-12 Imperial Chemical Industries Limited Pyrimidine derivatives
GB1336138A (en) * 1969-12-10 1973-11-07 Ici Ltd Process for the production of pyrimidine derivatives
US3923807A (en) * 1973-09-10 1975-12-02 Takeda Chemical Industries Ltd 6-Aminouracil derivatives
US4208366A (en) * 1978-10-31 1980-06-17 E. I. Du Pont De Nemours And Company Process for preparing a nonwoven web
DE2847693A1 (de) * 1978-11-03 1980-05-22 Hoechst Ag Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen
US4612376A (en) * 1983-03-25 1986-09-16 Fujisawa Pharmaceutical Co., Ltd. Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent

Also Published As

Publication number Publication date
ES8601922A1 (es) 1985-11-01
DK160492C (da) 1991-08-26
FI841128A7 (fi) 1984-09-26
ES8505972A1 (es) 1985-06-16
ES530916A0 (es) 1985-06-16
EP0123402A3 (en) 1985-09-18
FI841128A0 (fi) 1984-03-21
EP0123402A2 (de) 1984-10-31
SU1349698A3 (ru) 1987-10-30
DK160492B (da) 1991-03-18
KR840008333A (ko) 1984-12-14
CA1256107A (en) 1989-06-20
ES538190A0 (es) 1985-11-01
EP0123402B1 (de) 1988-09-07
DK166884D0 (da) 1984-03-23
US4824851A (en) 1989-04-25
DE3473875D1 (en) 1988-10-13
PH22022A (en) 1988-05-13
DK166884A (da) 1984-09-26
US4746664A (en) 1988-05-24
GR81758B (de) 1984-12-12
SU1436872A3 (ru) 1988-11-07
HU195195B (en) 1988-04-28
US4612376A (en) 1986-09-16

Similar Documents

Publication Publication Date Title
NO841168L (no) Fremgangsmaate for fremstilling av pyrimidinderivater
JP2896532B2 (ja) 新規なピリミジン誘導体およびその製造方法
US4725600A (en) Pyrimidine compounds having activity as a cardiotonic anti-hypertensive cerebrovascular vasodilator and anti-platelet aggregation agent
EP0163599B1 (de) Pyrimidopyrimidinderivate, Verfahren zu ihrer Herstellung, diese enthaltende pharmazeutische Zubereitungen und ihre Verwendung als anti-allergische Mittel
US4818756A (en) 2-pyrimidinyl-1-piperazine derivatives, processes for their preparation and medicaments containing them
US3037980A (en) Pyrrolopyrimidine vasodilators and method of making them
SE440079B (sv) Substituerade 5-(2-imidazolin-2-yl)-aminopyrimidiner och farmaceutisk komposition
CA2014760A1 (en) Chemical compounds
JPS6136831B2 (de)
NO177054B (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive aminopyrimidinderivater
EP0084250B1 (de) 6-(Substituierte Phenyl)-4,5-dihydro-3(2H)-Pyridazinonverbindungen und Verfahren zu deren Herstellung
HU228457B1 (en) Substituted aza- and diazacycloheptane and cyclooctane derivatives, use thereof, pharmaceutical compositions containing there of
JPWO1996007641A1 (ja) 複素環誘導体及び医薬
CZ9797A3 (en) Triazole derivative, process of its preparation and pharmaceutical composition containing thereof
EP0077983B1 (de) Triazinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
SU1232145A3 (ru) Способ получени производных пиримидона или их фармацевтически приемлемых солей
Winn et al. 2-(Alkylamino) nicotinic acid and analogs. Potent angiotensin II antagonists
DK165744B (da) Thienopyrimidinderivater, fremgangsmaader til fremstilling deraf og farmaceutiske praeparater
SE448876B (sv) Inre salter av sulfoxi-triazinium-, -pyrimidinium- och -pyridiniumhydroxid och sett att framstella dessa
DK156722B (da) Analogifremgangsmaade til fremstilling af 2-piperazinopyrimidinderivater
US4666915A (en) 2-anilino-1,6-dihydro-6-oxo-5-pyrimidine-carboxylic acid derivatives, process for the preparation thereof, and antiallergic agent containing the same
EP0230402A2 (de) Pharmakologisch aktive Alkylol-Derivate
EP0244352B1 (de) Pyrido[4,3-d]pyrimidin-Derivate
HU201059B (en) Process for producing 6-oxo-pyridazine derivatives and pharmaceutical compositions containing them
JPH0546340B2 (de)