NO844907L - Tannpasta, nye sakkarinsalter og deres fremstilling - Google Patents

Tannpasta, nye sakkarinsalter og deres fremstilling

Info

Publication number: NO844907L
Authority: NO; Norway
Prior art keywords: carbon atoms; silica; alkyl; toothpaste; compound
Prior art date: 1983-12-09

Application number

NO844907A

Other languages

English (en)

Norwegian (no)

Inventor

Charles Edmund Alford

William George Gorman

Kenneth Michael Mavica

Karl Frederick Popp

Original Assignee

Sterling Drug Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-12-09

Filing date

1984-12-07

Publication date

1985-06-10

1983-12-09 Priority claimed from US06/560,059 external-priority patent/US4614649A/en

1984-12-07 Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc

1985-06-10 Publication of NO844907L publication Critical patent/NO844907L/no

Links

238000002360 preparation method Methods 0.000 title description 6
239000000606 toothpaste Substances 0.000 claims description 41
229940034610 toothpaste Drugs 0.000 claims description 40
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 27
150000001875 compounds Chemical class 0.000 claims description 27
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical class C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims description 27
125000004432 carbon atom Chemical group C* 0.000 claims description 25
125000000217 alkyl group Chemical group 0.000 claims description 24
-1 p-(2,2-dichloro-cyclopropyl)phenyl Chemical group 0.000 claims description 18
238000005498 polishing Methods 0.000 claims description 16
239000000499 gel Substances 0.000 claims description 13
150000003839 salts Chemical class 0.000 claims description 12
229960001866 silicon dioxide Drugs 0.000 claims description 12
239000003795 chemical substances by application Substances 0.000 claims description 11
239000004599 antimicrobial Substances 0.000 claims description 10
229910052739 hydrogen Inorganic materials 0.000 claims description 10
239000001257 hydrogen Substances 0.000 claims description 10
239000000377 silicon dioxide Substances 0.000 claims description 10
LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 claims description 9
230000002401 inhibitory effect Effects 0.000 claims description 9
229960004029 silicic acid Drugs 0.000 claims description 9
208000002064 Dental Plaque Diseases 0.000 claims description 8
239000004088 foaming agent Substances 0.000 claims description 8
235000012239 silicon dioxide Nutrition 0.000 claims description 8
230000002882 anti-plaque Effects 0.000 claims description 7
229910002027 silica gel Inorganic materials 0.000 claims description 7
239000000741 silica gel Substances 0.000 claims description 7
125000003118 aryl group Chemical group 0.000 claims description 6
239000002562 thickening agent Substances 0.000 claims description 6
125000003545 alkoxy group Chemical group 0.000 claims description 5
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 5
125000000753 cycloalkyl group Chemical group 0.000 claims description 5
229910052736 halogen Inorganic materials 0.000 claims description 5
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 5
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 5
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
229910052783 alkali metal Inorganic materials 0.000 claims description 4
125000003710 aryl alkyl group Chemical group 0.000 claims description 4
150000002367 halogens Chemical group 0.000 claims description 4
108700004121 sarkosyl Proteins 0.000 claims description 4
KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical group [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 claims description 4
125000002947 alkylene group Chemical group 0.000 claims description 3
125000004093 cyano group Chemical group *C#N 0.000 claims description 3
238000000034 method Methods 0.000 claims description 3
125000001453 quaternary ammonium group Chemical group 0.000 claims description 3
RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 claims description 3
125000001424 substituent group Chemical group 0.000 claims description 3
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 3
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 2
150000001340 alkali metals Chemical class 0.000 claims description 2
210000000214 mouth Anatomy 0.000 claims description 2
125000006574 non-aromatic ring group Chemical group 0.000 claims description 2
125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims description 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 2
125000005119 alkyl cycloalkyl group Chemical group 0.000 claims 1
239000003638 chemical reducing agent Substances 0.000 claims 1
239000003112 inhibitor Substances 0.000 claims 1
229940045885 sodium lauroyl sarcosinate Drugs 0.000 claims 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical group OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 10
239000002253 acid Substances 0.000 description 8
229940081974 saccharin Drugs 0.000 description 8
235000019204 saccharin Nutrition 0.000 description 8
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 8
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
230000000845 anti-microbial effect Effects 0.000 description 6
239000002609 medium Substances 0.000 description 6
SMGTYJPMKXNQFY-UHFFFAOYSA-N octenidine dihydrochloride Chemical compound Cl.Cl.C1=CC(=NCCCCCCCC)C=CN1CCCCCCCCCCN1C=CC(=NCCCCCCCC)C=C1 SMGTYJPMKXNQFY-UHFFFAOYSA-N 0.000 description 6
230000001680 brushing effect Effects 0.000 description 5
230000000694 effects Effects 0.000 description 5
238000004519 manufacturing process Methods 0.000 description 5
244000005700 microbiome Species 0.000 description 5
239000000243 solution Substances 0.000 description 5
239000008367 deionised water Substances 0.000 description 4
229910021641 deionized water Inorganic materials 0.000 description 4
239000000203 mixture Substances 0.000 description 4
229960001774 octenidine Drugs 0.000 description 4
FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical class OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 3
241000894006 Bacteria Species 0.000 description 3
GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 3
239000002202 Polyethylene glycol Substances 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
239000003125 aqueous solvent Substances 0.000 description 3
235000019658 bitter taste Nutrition 0.000 description 3
229960003260 chlorhexidine Drugs 0.000 description 3
239000006260 foam Substances 0.000 description 3
238000005187 foaming Methods 0.000 description 3
239000001963 growth medium Substances 0.000 description 3
238000000338 in vitro Methods 0.000 description 3
239000004615 ingredient Substances 0.000 description 3
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 3
229920001223 polyethylene glycol Polymers 0.000 description 3
239000000126 substance Substances 0.000 description 3
235000019640 taste Nutrition 0.000 description 3
241000228245 Aspergillus niger Species 0.000 description 2
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
241000222122 Candida albicans Species 0.000 description 2
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
241000233866 Fungi Species 0.000 description 2
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
241000194019 Streptococcus mutans Species 0.000 description 2
241000193996 Streptococcus pyogenes Species 0.000 description 2
241001045770 Trichophyton mentagrophytes Species 0.000 description 2
150000007513 acids Chemical class 0.000 description 2
239000002585 base Substances 0.000 description 2
125000001589 carboacyl group Chemical group 0.000 description 2
238000004140 cleaning Methods 0.000 description 2
208000002925 dental caries Diseases 0.000 description 2
238000010790 dilution Methods 0.000 description 2
239000012895 dilution Substances 0.000 description 2
239000012153 distilled water Substances 0.000 description 2
229940105546 durapatite Drugs 0.000 description 2
239000000796 flavoring agent Substances 0.000 description 2
150000004673 fluoride salts Chemical class 0.000 description 2
235000003599 food sweetener Nutrition 0.000 description 2
238000011534 incubation Methods 0.000 description 2
230000002503 metabolic effect Effects 0.000 description 2
IOQPZZOEVPZRBK-UHFFFAOYSA-N octan-1-amine Chemical class CCCCCCCCN IOQPZZOEVPZRBK-UHFFFAOYSA-N 0.000 description 2
210000003296 saliva Anatomy 0.000 description 2
229910002028 silica xerogel Inorganic materials 0.000 description 2
229910052708 sodium Inorganic materials 0.000 description 2
239000011734 sodium Substances 0.000 description 2
PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
239000002904 solvent Substances 0.000 description 2
239000000600 sorbitol Substances 0.000 description 2
238000004659 sterilization and disinfection Methods 0.000 description 2
238000003756 stirring Methods 0.000 description 2
239000003765 sweetening agent Substances 0.000 description 2
230000008719 thickening Effects 0.000 description 2
239000000080 wetting agent Substances 0.000 description 2
OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 1
XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 1
241000186044 Actinomyces viscosus Species 0.000 description 1
108010011485 Aspartame Proteins 0.000 description 1
UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
206010013911 Dysgeusia Diseases 0.000 description 1
241000588724 Escherichia coli Species 0.000 description 1
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical group C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
241000192125 Firmicutes Species 0.000 description 1
241000588747 Klebsiella pneumoniae Species 0.000 description 1
WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
239000001888 Peptone Substances 0.000 description 1
108010080698 Peptones Proteins 0.000 description 1
241000588770 Proteus mirabilis Species 0.000 description 1
241000588767 Proteus vulgaris Species 0.000 description 1
241000589517 Pseudomonas aeruginosa Species 0.000 description 1
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
241000191967 Staphylococcus aureus Species 0.000 description 1
241000194017 Streptococcus Species 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical class OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
125000002252 acyl group Chemical group 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
LFVVNPBBFUSSHL-UHFFFAOYSA-N alexidine Chemical compound CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC LFVVNPBBFUSSHL-UHFFFAOYSA-N 0.000 description 1
229950010221 alexidine Drugs 0.000 description 1
125000003342 alkenyl group Chemical group 0.000 description 1
150000001408 amides Chemical class 0.000 description 1
230000000844 anti-bacterial effect Effects 0.000 description 1
230000000843 anti-fungal effect Effects 0.000 description 1
229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 description 1
239000000605 aspartame Substances 0.000 description 1
IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
235000010357 aspartame Nutrition 0.000 description 1
229960003438 aspartame Drugs 0.000 description 1
239000012298 atmosphere Substances 0.000 description 1
229960000686 benzalkonium chloride Drugs 0.000 description 1
229960001950 benzethonium chloride Drugs 0.000 description 1
UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 1
CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
229940095731 candida albicans Drugs 0.000 description 1
150000001735 carboxylic acids Chemical class 0.000 description 1
239000000919 ceramic Substances 0.000 description 1
229960001927 cetylpyridinium chloride Drugs 0.000 description 1
YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
229960003333 chlorhexidine gluconate Drugs 0.000 description 1
239000012459 cleaning agent Substances 0.000 description 1
239000003086 colorant Substances 0.000 description 1
239000007799 cork Substances 0.000 description 1
229940109275 cyclamate Drugs 0.000 description 1
229960001378 dequalinium chloride Drugs 0.000 description 1
LTNZEXKYNRNOGT-UHFFFAOYSA-N dequalinium chloride Chemical compound [Cl-].[Cl-].C1=CC=C2[N+](CCCCCCCCCC[N+]3=C4C=CC=CC4=C(N)C=C3C)=C(C)C=C(N)C2=C1 LTNZEXKYNRNOGT-UHFFFAOYSA-N 0.000 description 1
239000000645 desinfectant Substances 0.000 description 1
ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
239000003814 drug Substances 0.000 description 1
IINNWAYUJNWZRM-UHFFFAOYSA-L erythrosin B Chemical compound [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1=C2C=C(I)C(=O)C(I)=C2OC2=C(I)C([O-])=C(I)C=C21 IINNWAYUJNWZRM-UHFFFAOYSA-L 0.000 description 1
XJRPTMORGOIMMI-UHFFFAOYSA-N ethyl 2-amino-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate Chemical compound CCOC(=O)C=1SC(N)=NC=1C(F)(F)F XJRPTMORGOIMMI-UHFFFAOYSA-N 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
239000012458 free base Substances 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
125000005843 halogen group Chemical group 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
230000036571 hydration Effects 0.000 description 1
238000006703 hydration reaction Methods 0.000 description 1
229910052588 hydroxylapatite Inorganic materials 0.000 description 1
238000011065 in-situ storage Methods 0.000 description 1
238000001802 infusion Methods 0.000 description 1
150000002576 ketones Chemical class 0.000 description 1
125000000400 lauroyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
239000007788 liquid Substances 0.000 description 1
229910052744 lithium Inorganic materials 0.000 description 1
235000013372 meat Nutrition 0.000 description 1
238000009629 microbiological culture Methods 0.000 description 1
150000002825 nitriles Chemical class 0.000 description 1
RMKWPXUWGHPLHL-UHFFFAOYSA-N octan-1-amine;dihydrochloride Chemical compound Cl.Cl.CCCCCCCCN RMKWPXUWGHPLHL-UHFFFAOYSA-N 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
239000006072 paste Substances 0.000 description 1
235000019319 peptone Nutrition 0.000 description 1
230000002085 persistent effect Effects 0.000 description 1
239000007793 ph indicator Substances 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
229940068196 placebo Drugs 0.000 description 1
239000000902 placebo Substances 0.000 description 1
230000007505 plaque formation Effects 0.000 description 1
159000000001 potassium salts Chemical class 0.000 description 1
238000004321 preservation Methods 0.000 description 1
230000002265 prevention Effects 0.000 description 1
229940007042 proteus vulgaris Drugs 0.000 description 1
150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
229940071089 sarcosinate Drugs 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
239000011775 sodium fluoride Substances 0.000 description 1
235000013024 sodium fluoride Nutrition 0.000 description 1
229960000414 sodium fluoride Drugs 0.000 description 1
229960004711 sodium monofluorophosphate Drugs 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
ZUFONQSOSYEWCN-UHFFFAOYSA-M sodium;2-(methylamino)acetate Chemical compound [Na+].CNCC([O-])=O ZUFONQSOSYEWCN-UHFFFAOYSA-M 0.000 description 1
239000007787 solid Substances 0.000 description 1
238000010186 staining Methods 0.000 description 1
ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
229960002799 stannous fluoride Drugs 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
239000000758 substrate Substances 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
150000003462 sulfoxides Chemical class 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000007143 thioglycolate medium Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Birds (AREA)
Epidemiology (AREA)
Oral & Maxillofacial Surgery (AREA)
Cosmetics (AREA)
Dental Preparations (AREA)

NO844907A 1983-12-09 1984-12-07 Tannpasta, nye sakkarinsalter og deres fremstilling NO844907L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US55999783A	1983-12-09	1983-12-09
US06/560,059 US4614649A (en)	1983-12-09	1983-12-09	Antiplaque saccharin salt dentrifices and method of use thereof

Publications (1)

Publication Number	Publication Date
NO844907L true NO844907L (no)	1985-06-10

Family

ID=27072225

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO844907A NO844907L (no)	1983-12-09	1984-12-07	Tannpasta, nye sakkarinsalter og deres fremstilling

Country Status (8)

Country	Link
EP (1)	EP0144960A3 (de)
KR (1)	KR890000904B1 (de)
AU (1)	AU570288B2 (de)
DK (1)	DK586184A (de)
GR (1)	GR81184B (de)
IL (1)	IL73739A (de)
NO (1)	NO844907L (de)
NZ (1)	NZ210386A (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2092956B1 (es) *	1994-11-16	1997-07-16	Medilent S L	Solucion acuosa para lentes de contacto.
DE19940740A1 (de) *	1999-08-31	2001-03-01	Gruenenthal Gmbh	Pharmazeutische Salze
DE102004052308B4 (de) *	2004-10-12	2013-04-04	Divapharma-Knufinke Arzneimittelwerk Gmbh	Octenidinhaltige Lutschtabletten gegen entzündliche Erkrankungen des Mund- und Rachenraums

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3223704A (en) *	1961-10-27	1965-12-14	Hollichem Corp	Quaternary ammonium sulfamates
GB1066795A (en) *	1963-10-15	1967-04-26	Hollichem Corp	Compositions comprising biocidal quaternary ammonium benzosulfimides
US3984537A (en) *	1973-05-08	1976-10-05	Colgate-Palmolive Company	Oral preparations
DE2409755A1 (de) *	1974-03-01	1975-09-11	Blendax Werke Schneider Co	Zahnpflegemittel
US4206215A (en) *	1976-02-25	1980-06-03	Sterling Drug Inc.	Antimicrobial bis-[4-(substituted-amino)-1-pyridinium]alkanes
US4053636A (en) *	1976-05-24	1977-10-11	Sterling Drug Inc.	Dichlorocyclopropylphenyl bisbiguanide compounds, processes and compositions

1984
- 1984-11-29 NZ NZ210386A patent/NZ210386A/en unknown
- 1984-12-03 EP EP84114701A patent/EP0144960A3/de not_active Withdrawn
- 1984-12-05 GR GR81184A patent/GR81184B/el unknown
- 1984-12-05 AU AU36303/84A patent/AU570288B2/en not_active Ceased
- 1984-12-05 IL IL73739A patent/IL73739A/xx unknown
- 1984-12-07 NO NO844907A patent/NO844907L/no unknown
- 1984-12-07 DK DK586184A patent/DK586184A/da not_active Application Discontinuation
- 1984-12-08 KR KR1019840007776A patent/KR890000904B1/ko not_active Expired

Also Published As

Publication number	Publication date
DK586184A (da)	1985-06-10
NZ210386A (en)	1987-11-27
GR81184B (en)	1985-04-09
IL73739A (en)	1988-11-15
KR890000904B1 (ko)	1989-04-13
DK586184D0 (da)	1984-12-07
AU3630384A (en)	1985-06-13
AU570288B2 (en)	1988-03-10
EP0144960A3 (de)	1987-03-25
EP0144960A2 (de)	1985-06-19
KR850004383A (ko)	1985-07-15
IL73739A0 (en)	1985-03-31

Publication	Publication Date	Title
US4614649A (en)	1986-09-30	Antiplaque saccharin salt dentrifices and method of use thereof
US8748617B2 (en)	2014-06-10	Amide compound or salt thereof, and biofilm inhibitor, biofilm remover and disinfectant containing the same
DK167336B1 (da)	1993-10-18	Midler mod daarlig aande
US5158763A (en)	1992-10-27	Non-staining anti-bacterial oral composition
WO1999029289A1 (en)	1999-06-17	Stabilized oral compositions containing (n alpha-acyl-l-arginine) alkyl ester salts
Gjermo et al.	1973	Effect on dental plaque formation and some in vitro properties of 12 bis‐biguanides
US6770268B1 (en)	2004-08-03	Non-foaming anti-infective periodontic compositions
DK151883B (da)	1988-01-11	2- eller 3-alkylsubstituerede n-hydroxyalkylmorfoliner og praeparater indeholdende dem
US4820507A (en)	1989-04-11	Oral and dental hygiene preparations
Baker et al.	1978	The in vitro inhibition of microbial growth and plaque formation by surfactant drugs
NO169754B (no)	1992-04-27	Munnpleiemiddel som virker mot plaque og har forbedret smak
EP2077260B1 (de)	2015-02-18	Amidverbindung oder salz davon und inhibitor der bildung von biologischen filmen, substanz zum entfernen biologischer filme und bakterizid, bei denen jeweils die amidverbindung oder ein salz davon verwendet wird
NO844907L (no)	1985-06-10	Tannpasta, nye sakkarinsalter og deres fremstilling
NO145789B (no)	1982-02-22	Nye piperidinforbindelser med plaquehemmende virkning og for anvendelse i preparater for behandling av munnhule og tannflater
US3932655A (en)	1976-01-13	Surgical skin scrub
US20080241081A1 (en)	2008-10-02	Amide compound or salt thereof, and biofilm remover containing the same
DK152729B (da)	1988-05-02	Piperidinderivater og praeparat til anvendelse i mund- og tandplejemidler
CA1260941A (en)	1989-09-26	Bis¬4-(substituted-amino)-1-pyridinium\|alkane saccharin salts and process of preparation thereof
EP0174632B1 (de)	1990-02-07	Gegen Mikroben wirkende N-(1-(Alkyl oder arylmethyl)-4(1H)-pyridinyliden)-alkanamine, ihre Säureadditionssalze und Verfahren zur Herstellung, Verfahren zur Verwendung und Zusammensetzungen daraus
US4046873A (en)	1977-09-06	Alicyclic amido-quaternary ammonium anti-bacterial agents
US4133772A (en)	1979-01-09	Aqueous detergent compositions containing amphoteric surfactants having anti-microbial and preservative properties
NO146484B (no)	1982-07-05	Munn- og tannpleiemiddel
JPH07543B2 (ja)	1995-01-11	歯磨組成物
NO165477B (no)	1990-11-12	Tannpleiemiddel og fremgangsmaate for fremstilling av dette
US3961075A (en)	1976-06-01	Ether-linked quaternary ammonium compositions