NO854941L - Fremgangsmaate for fremstilling av terapeutisk aktive, sure indol-derivater. - Google Patents

Fremgangsmaate for fremstilling av terapeutisk aktive, sure indol-derivater.

Info

Publication number: NO854941L
Authority: NO; Norway
Prior art keywords: carbon atoms; radical; substituted; compounds; amino group
Prior art date: 1984-12-10

Application number

NO854941A

Other languages

English (en)

Other versions

NO159653B (no

NO159653C (no

Inventor

David T Connor

Paul C Unangst

S Russell Stabler

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-12-10

Filing date

1985-12-09

Publication date

1986-06-11

1985-12-09 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

1986-06-11 Publication of NO854941L publication Critical patent/NO854941L/no

1988-10-17 Publication of NO159653B publication Critical patent/NO159653B/no

1989-01-25 Publication of NO159653C publication Critical patent/NO159653C/no

Links

SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 12
125000003277 amino group Chemical group 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 3
BNJMRELGMDUDDB-UHFFFAOYSA-N $l^{1}-sulfanylbenzene Chemical compound [S]C1=CC=CC=C1 BNJMRELGMDUDDB-UHFFFAOYSA-N 0.000 abstract 2
CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 2
125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 2
125000004414 alkyl thio group Chemical group 0.000 abstract 2
-1 phenylsulphinyl radical Chemical class 0.000 abstract 2
150000003254 radicals Chemical class 0.000 abstract 2
125000003396 thiol group Chemical class [H]S* 0.000 abstract 2
SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical class [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
BQIKRTGTPBOIMK-UHFFFAOYSA-N [O]C[O] Chemical compound [O]C[O] BQIKRTGTPBOIMK-UHFFFAOYSA-N 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Immunology (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Lubricants (AREA)
Cosmetics (AREA)

NO854941A 1984-12-10 1985-12-09 Analogifremgangsm te for fremstilling av terapeutisk aktive, sure indol-derivater. NO159653C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US68011684A	1984-12-10	1984-12-10
US06/788,111 US4675332A (en)	1984-12-10	1985-10-21	Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents

Publications (3)

Publication Number	Publication Date
NO854941L true NO854941L (no)	1986-06-11
NO159653B NO159653B (no)	1988-10-17
NO159653C NO159653C (no)	1989-01-25

Family

ID=27102395

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO854941A NO159653C (no)	1984-12-10	1985-12-09	Analogifremgangsm te for fremstilling av terapeutisk aktive, sure indol-derivater.

Country Status (18)

Country	Link
US (1)	US4675332A (no)
EP (1)	EP0186367B1 (no)
JP (1)	JPH0653736B2 (no)
KR (1)	KR890000292B1 (no)
CN (1)	CN1005974B (no)
AT (1)	ATE86252T1 (no)
AU (1)	AU576131B2 (no)
CA (1)	CA1259317A (no)
DE (1)	DE3587148T2 (no)
DK (1)	DK174104B1 (no)
ES (1)	ES8700252A1 (no)
FI (1)	FI84719C (no)
GR (1)	GR852948B (no)
IE (1)	IE58554B1 (no)
NO (1)	NO159653C (no)
NZ (1)	NZ214480A (no)
PH (1)	PH24075A (no)
PT (1)	PT81637B (no)

Families Citing this family (44)

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IE64995B1 (en) *	1987-07-14	1995-09-20	Warner Lambert Co	Novel benzothiophenes having antiallergic activity and both novel and other selected benzothiophenes having activity for treating acute respiratory distress syndrome
IT1228893B (it) *	1989-02-24	1991-07-09	Valeas Spa	Derivati tetrazol ammidici di acidi alchenil eterociclici e loroimpiego come sostanze antiallergiche
LU87611A1 (fr) *	1989-10-20	1991-05-07	Oreal	Composition tinctoriale pour fibres keratiniques contenant des precurseurs de colorants par oxydation et des coupleurs amino indoliques,procedes de teinture mettant en oeuvre ces compositions et composes nouveaux
US5051442A (en) *	1990-04-25	1991-09-24	Merrell Dow Pharmaceuticals Inc.	3-indolyl thioacetate derivatives and NMDA receptor antagonistic use thereof
US5095031A (en) *	1990-08-20	1992-03-10	Abbott Laboratories	Indole derivatives which inhibit leukotriene biosynthesis
AU641052B2 (en) *	1990-11-02	1993-09-09	Aventisub Ii Inc.	3-amidoindolyl derivatives
US5189054A (en) *	1990-11-02	1993-02-23	Merrell Dow Pharmaceuticals Inc.	3-amidoindolyl derivatives and pharmaceutical compositions thereof
US5599774A (en) *	1992-01-22	1997-02-04	Imperial Chemical Industries Plc	N-arylindoles and their use as herbicides
US5395817A (en) *	1992-01-22	1995-03-07	Imperial Chemical Industries Plc	N-arylindoles and their use as herbicides
US5424329A (en) *	1993-08-18	1995-06-13	Warner-Lambert Company	Indole-2-carboxamides as inhibitors of cell adhesion
GB9716657D0 (en)	1997-08-07	1997-10-15	Zeneca Ltd	Chemical compounds
GB9803226D0 (en)	1998-02-17	1998-04-08	Zeneca Ltd	Chemical compounds
GB9902453D0 (en)	1999-02-05	1999-03-24	Zeneca Ltd	Chemical compounds
GB9902459D0 (en) *	1999-02-05	1999-03-24	Zeneca Ltd	Chemical compounds
GB9902461D0 (en) *	1999-02-05	1999-03-24	Zeneca Ltd	Chemical compounds
GB9902455D0 (en) *	1999-02-05	1999-03-24	Zeneca Ltd	Chemical compounds
GB9902452D0 (en)	1999-02-05	1999-03-24	Zeneca Ltd	Chemical compounds
GB0000625D0 (en)	2000-01-13	2000-03-01	Zeneca Ltd	Chemical compounds
US6436965B1 (en)	2000-03-02	2002-08-20	Merck Frosst Canada & Co.	PDE IV inhibiting amides, compositions and methods of treatment
EP1314733A1 (en)	2001-11-22	2003-05-28	Aventis Pharma Deutschland GmbH	Indole-2-carboxamides as factor Xa inhibitors
GB0217920D0 (en) *	2002-04-23	2002-09-11	Aventis Pharm Prod Inc	Interleukin-4 Gene Expression inhibitors
AU2003225131A1 (en) *	2002-04-23	2003-11-10	Aventis Pharmaceuticals Inc.	3-substituted amino-1h-indole-2-carboxylic acid and 3-substituted amino-benzo' b! thiophene-2-carboxylic acid derivatives as interieukin-4 gene expression inhibitors
EP1545510A4 (en) *	2002-08-07	2006-11-15	Idenix Cayman Ltd	SUBSTITUTED PHENYLINDOLE FOR THE TREATMENT OF HIV
EP1479677A1 (en) *	2003-05-19	2004-11-24	Aventis Pharma Deutschland GmbH	New indole derivatives as factor xa inhibitors
CA2527779A1 (en) *	2003-06-05	2004-12-16	Warner-Lambert Company Llc	3-substituted indoles and derivatives thereof as therapeutic agents
CN100439367C (zh) *	2003-12-11	2008-12-03	安万特药物公司	作为酪蛋白激酶Iε抑制剂的取代的1H-吡咯并[3,2-b、3,2-c和2,3-c]吡啶-2-甲酰胺以及相关类似物
BRPI0512252A (pt)	2004-06-18	2008-02-19	Biolipox Ab	composto ou um sal farmaceuticamente aceitável do mesmo, formulação farmacêutica, uso de um composto, método de tratamento de uma doença, produto combinado, e, processo para a preparação de um composto
WO2006077366A1 (en)	2005-01-19	2006-07-27	Biolipox Ab	Indoles useful in the treatment of inflammation
AU2006249866B2 (en)	2005-05-26	2011-10-13	Aldeyra Therapeutics, Inc.	Compositions and methods of treating retinal disease
CA2782015C (en)	2009-12-11	2020-08-25	Neuron Systems, Inc.	Topical ophthalmic compositions and methods for the treatment of macular degeneration
WO2012081893A2 (ko) *	2010-12-13	2012-06-21	한국화학연구원	신규한 3-인돌리논 유도체 및 이를 포함하는 조성물
KR20150118106A (ko)	2012-12-20	2015-10-21	알데이라 테라퓨틱스, 아이엔씨.	페리-카르비놀
CN111135171B (zh)	2013-01-23	2023-09-08	奥尔德拉医疗公司	与毒性醛相关的疾病和治疗
AU2014209585A1 (en)	2013-01-25	2015-07-23	Aldeyra Therapeutics, Inc.	Novel traps in the treatment of macular degeneration
CN118724806A (zh)	2015-08-21	2024-10-01	奥尔德拉医疗公司	氘化化合物和其用途
CN109152774A (zh)	2016-05-09	2019-01-04	奥尔德拉医疗公司	眼部炎性病症和疾病的组合治疗
WO2018170476A1 (en)	2017-03-16	2018-09-20	Aldeyra Therapeutics, Inc.	Polymorphic compounds and uses thereof
CN111356451A (zh)	2017-10-10	2020-06-30	奥尔德拉医疗公司	炎性病症的治疗
WO2019199979A1 (en)	2018-04-10	2019-10-17	The General Hospital Corporation	Antibacterial compounds
CN112714762A (zh)	2018-08-06	2021-04-27	奥尔德拉医疗公司	多晶型化合物及其用途
US12098132B2 (en)	2019-05-02	2024-09-24	Aldeyra Therapeutics, Inc.	Process for preparation of aldehyde scavenger and intermediates
CN113784954A (zh)	2019-05-02	2021-12-10	奥尔德拉医疗公司	多晶型化合物和其用途
CN112028815A (zh) *	2019-06-03	2020-12-04	中国药科大学	吲哚类衍生物及其医药用途
WO2021231792A1 (en)	2020-05-13	2021-11-18	Aldeyra Therapeutics, Inc.	Pharmaceutical formulations and uses thereof

Family Cites Families (13)

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US3417096A (en) *	1965-07-01	1968-12-17	Bristol Myers Co	Certain 5(1-benzoyl-3-indolylmethyl) tetrazoles
US4316904A (en) *	1978-06-05	1982-02-23	Brown Richard E	Indolopyrone tetrazoles and carboxamidotetrazoles having antiallergic activity
US4432986A (en) *	1979-06-18	1984-02-21	Riker Laboratories, Inc.	Tetrazoles bonded to certain polycyclic aromatic systems and anti-allergic use thereof
US4333943A (en) *	1980-04-24	1982-06-08	Miles Laboratories, Inc.	Ethyl 3-(3-indolyl)-3-(5-tetrazolyl) propionate compounds used as anti-hypertensive agents
DE3131527A1 (de) *	1981-08-08	1983-02-24	Kali-Chemie Pharma Gmbh, 3000 Hannover	1-phenyl-2-aminocarbonylindol-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
GB2111050B (en) *	1981-11-19	1985-09-11	Ciba Geigy Ag	N-substituted-2-pyridylindoles
US4567201A (en) *	1981-11-25	1986-01-28	Takeda Chemical Industries, Ltd.	Diphenoxypropane derivatives and compositions of antiasthmatic and antiinflammatory agents thereof
US4436746A (en) *	1982-09-30	1984-03-13	Ciba-Geigy Corporation	Thromboxane synthetase inhibitory N-substituted-2-(1-imidazolyl)indoles
US4511573A (en) *	1983-05-17	1985-04-16	Ciba-Geigy Corporation	3-Substituted-2-(heteroaryl) indoles
US4536505A (en) *	1983-05-17	1985-08-20	Ciba-Geigy Corporation	Certain N-(pyridyl) indoles
EP0146243A1 (en) *	1983-10-31	1985-06-26	Merck Frosst Canada Inc.	Lipoxygenase inhibitors
US4581354A (en) *	1984-08-06	1986-04-08	Sterling Drug Inc.	3-arylcarbonyl- and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles, compositions and use
IE58555B1 (en) *	1984-12-10	1993-10-06	Warner Almbert Company	Novel benzothiophenes and benzofurans having antiallergy activity

1985
- 1985-10-21 US US06/788,111 patent/US4675332A/en not_active Expired - Lifetime
- 1985-11-13 IE IE284185A patent/IE58554B1/en not_active IP Right Cessation
- 1985-11-29 AU AU50508/85A patent/AU576131B2/en not_active Ceased
- 1985-12-04 FI FI854821A patent/FI84719C/fi not_active IP Right Cessation
- 1985-12-06 PH PH33140A patent/PH24075A/en unknown
- 1985-12-09 DK DK198505688A patent/DK174104B1/da not_active IP Right Cessation
- 1985-12-09 NZ NZ214480A patent/NZ214480A/en unknown
- 1985-12-09 GR GR852948A patent/GR852948B/el unknown
- 1985-12-09 JP JP60275227A patent/JPH0653736B2/ja not_active Expired - Fee Related
- 1985-12-09 NO NO854941A patent/NO159653C/no unknown
- 1985-12-10 PT PT81637A patent/PT81637B/pt not_active IP Right Cessation
- 1985-12-10 AT AT85308948T patent/ATE86252T1/de not_active IP Right Cessation
- 1985-12-10 EP EP85308948A patent/EP0186367B1/en not_active Expired - Lifetime
- 1985-12-10 ES ES549768A patent/ES8700252A1/es not_active Expired
- 1985-12-10 KR KR1019850009255A patent/KR890000292B1/ko not_active Expired
- 1985-12-10 CN CN85109061.3A patent/CN1005974B/zh not_active Expired
- 1985-12-10 DE DE8585308948T patent/DE3587148T2/de not_active Expired - Fee Related
- 1985-12-10 CA CA000497268A patent/CA1259317A/en not_active Expired

Also Published As

Publication number	Publication date
CN85109061A (zh)	1987-01-21
AU576131B2 (en)	1988-08-11
NO159653B (no)	1988-10-17
JPS61191683A (ja)	1986-08-26
EP0186367B1 (en)	1993-03-03
KR890000292B1 (ko)	1989-03-13
EP0186367A2 (en)	1986-07-02
PT81637B (pt)	1988-02-17
ATE86252T1 (de)	1993-03-15
FI854821A7 (fi)	1986-06-11
FI84719B (fi)	1991-09-30
PH24075A (en)	1990-03-05
NZ214480A (en)	1988-05-30
ES8700252A1 (es)	1986-10-16
JPH0653736B2 (ja)	1994-07-20
DK174104B1 (da)	2002-06-17
FI854821A0 (fi)	1985-12-04
DE3587148D1 (de)	1993-04-08
ES549768A0 (es)	1986-04-16
IE58554B1 (en)	1993-10-06
DK568885D0 (da)	1985-12-09
KR860004882A (ko)	1986-07-14
DE3587148T2 (de)	1993-07-15
PT81637A (en)	1986-01-01
AU5050885A (en)	1986-06-19
GR852948B (no)	1986-04-11
DK568885A (da)	1986-06-11
EP0186367A3 (en)	1988-01-07
CA1259317A (en)	1989-09-12
NO159653C (no)	1989-01-25
CN1005974B (zh)	1989-12-06
FI84719C (fi)	1992-01-10
US4675332A (en)	1987-06-23
IE852841L (en)	1986-06-10

Publication	Publication Date	Title
AU576131B2 (en)	1988-08-11	N-1h-tetrazol-5-yl-1h-indole-2-carboxamide and 2-1h- tetrazol-5-yl-1h-indole derivatives
AU549927B2 (en)	1986-02-20	2-oxindole-1-carboxamide derivatives
ES539446A0 (es)	1986-06-01	Un procedimiento para preparar un derivado de dihidropiridazinona
DK599789A (da)	1990-05-30	3,5-di-tertiaer-butyl-4-hydroxyphenyl-1,3,4-thiadazoler og -oxadiazoler samt 3,5-di-tertiaer-butyl-4-hydroxyphenyl-1,2,4-thiadazoler, -oxadiazoler og -triazoler som anti-inflammatoriske midler
AU586187B2 (en)	1989-07-06	7-``2-(dialkylamino)ethyl``-4-hydroxy-1, 3-benzimidazol-2- ones
MX11866A (es)	1993-12-01	Nuevas cicloalquilamidas y procedimiento para su preparacion.
NO169442C (no)	1992-06-24	Analogifremgangsmaate ved fremstilling av terapeutisk aktive prolinderivater og lignende forbindelser
AU580677B2 (en)	1989-01-27	Bis (6-oxo-hydropyridazinyl)benzene derivatives
FR2598914B1 (fr)	1991-10-25	Composition prophylactique et curative pour l'arteriosclerose