NO862750L - Fremgangsmaate for fremstilling av farmakologisk aktive oksindol-derivater. - Google Patents

Fremgangsmaate for fremstilling av farmakologisk aktive oksindol-derivater.

Info

Publication number
NO862750L
NO862750L NO862750A NO862750A NO862750L NO 862750 L NO862750 L NO 862750L NO 862750 A NO862750 A NO 862750A NO 862750 A NO862750 A NO 862750A NO 862750 L NO862750 L NO 862750L
Authority
NO
Norway
Prior art keywords
carbon atoms
mol
added
formula
reaction mixture
Prior art date
Application number
NO862750A
Other languages
English (en)
Norwegian (no)
Other versions
NO862750D0 (no
Inventor
Saul Bernard Kadin
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/825,017 external-priority patent/US4678802A/en
Application filed by Pfizer filed Critical Pfizer
Publication of NO862750D0 publication Critical patent/NO862750D0/no
Publication of NO862750L publication Critical patent/NO862750L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
NO862750A 1985-07-09 1986-07-08 Fremgangsmaate for fremstilling av farmakologisk aktive oksindol-derivater. NO862750L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75320085A 1985-07-09 1985-07-09
US82129686A 1986-01-22 1986-01-22
US06/825,017 US4678802A (en) 1985-07-09 1986-01-31 1-acylcarbamoyloxindole-3-carboxamides as antiinflammatory agents

Publications (2)

Publication Number Publication Date
NO862750D0 NO862750D0 (no) 1986-07-08
NO862750L true NO862750L (no) 1987-01-12

Family

ID=27419443

Family Applications (1)

Application Number Title Priority Date Filing Date
NO862750A NO862750L (no) 1985-07-09 1986-07-08 Fremgangsmaate for fremstilling av farmakologisk aktive oksindol-derivater.

Country Status (19)

Country Link
EP (1) EP0208510B1 (da)
JP (1) JPH0610193B2 (da)
CN (1) CN86105309A (da)
AT (1) ATE67185T1 (da)
AU (1) AU566065B2 (da)
CA (1) CA1286663C (da)
DE (1) DE3681358D1 (da)
DK (1) DK324286A (da)
ES (2) ES2001855A6 (da)
FI (1) FI862882A7 (da)
GR (1) GR861760B (da)
HU (2) HUT41386A (da)
IE (1) IE58566B1 (da)
IL (1) IL79356A (da)
NO (1) NO862750L (da)
NZ (1) NZ216788A (da)
PH (1) PH22641A (da)
PT (1) PT82931B (da)
YU (2) YU45346B (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE68593B1 (en) * 1989-12-06 1996-06-26 Sanofi Sa Heterocyclic substituted acylaminothiazoles their preparation and pharmaceutical compositions containing them
FR2655344B1 (fr) * 1989-12-06 1992-04-03 Sanofi Sa Derives heterocycliques d'acylaminothiazoles, leur preparation et compositions pharmaceutiques en contenant.
WO1991009598A1 (en) * 1990-01-05 1991-07-11 Pfizer Inc. Azaoxindole derivatives
FR2677356B1 (fr) * 1991-06-05 1995-03-17 Sanofi Sa Derives heterocycliques d'acylamino-2 thiazoles-5 substitues, leur preparation et compositions pharmaceutiques en contenant.
JPH08288983A (ja) * 1995-04-17 1996-11-01 Tokyo Tsuuki:Kk リンガ回路
US6423699B1 (en) 1999-05-04 2002-07-23 American Home Products Corporation Combination therapies using benzimidazolones
US6417214B1 (en) 1999-05-04 2002-07-09 Wyeth 3,3-substituted indoline derivatives
US6329416B1 (en) 1999-05-04 2001-12-11 American Home Products Corporation Combination regimens using 3,3-substituted indoline derivatives
US6369056B1 (en) 1999-05-04 2002-04-09 American Home Products Corporation Cyclic urea and cyclic amide derivatives
US6444668B1 (en) 1999-05-04 2002-09-03 Wyeth Combination regimens using progesterone receptor modulators
US6355648B1 (en) 1999-05-04 2002-03-12 American Home Products Corporation Thio-oxindole derivatives
US6358948B1 (en) 1999-05-04 2002-03-19 American Home Products Corporation Quinazolinone and benzoxazine derivatives as progesterone receptor modulators
US6380178B1 (en) 1999-05-04 2002-04-30 American Home Products Corporation Cyclic regimens using cyclocarbamate and cyclic amide derivatives
US6498154B1 (en) 1999-05-04 2002-12-24 Wyeth Cyclic regimens using quinazolinone and benzoxazine derivatives
US6380235B1 (en) 1999-05-04 2002-04-30 American Home Products Corporation Benzimidazolones and analogues
US6462032B1 (en) 1999-05-04 2002-10-08 Wyeth Cyclic regimens utilizing indoline derivatives
US6306851B1 (en) 1999-05-04 2001-10-23 American Home Products Corporation Cyclocarbamate and cyclic amide derivatives
US6509334B1 (en) 1999-05-04 2003-01-21 American Home Products Corporation Cyclocarbamate derivatives as progesterone receptor modulators
US6407101B1 (en) 1999-05-04 2002-06-18 American Home Products Corporation Cyanopyrroles
US6391907B1 (en) 1999-05-04 2002-05-21 American Home Products Corporation Indoline derivatives
US6339098B1 (en) 1999-05-04 2002-01-15 American Home Products Corporation 2,1-benzisothiazoline 2,2-dioxides
US6319912B1 (en) 1999-05-04 2001-11-20 American Home Products Corporation Cyclic regimens using 2,1-benzisothiazoline 2,2-dioxides
US6358947B1 (en) 1999-05-04 2002-03-19 American Home Products Corporation Tetracyclic progesterone receptor modulator compounds and methods
US6399593B1 (en) 1999-05-04 2002-06-04 Wyeth Cyclic regimens using cyclic urea and cyclic amide derivatives
UA73119C2 (en) 2000-04-19 2005-06-15 American Home Products Corpoir Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors
US6900335B2 (en) 2000-07-19 2005-05-31 Ube Industries, Ltd. Process for producing 5-fluorooxindole and for producing intermediates therefor
WO2002070478A1 (en) 2001-03-06 2002-09-12 Astrazeneca Ab Indolone derivatives having vascular-damaging activity
JP4770826B2 (ja) * 2007-11-22 2011-09-14 大日本印刷株式会社 ２−オキシインドール誘導体の製造法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3749731A (en) 1971-07-08 1973-07-31 Warner Lambert Co 2-oxo-n-(2-thiazolyl)-3-indoline-carboxamide
US3882236A (en) 1973-12-26 1975-05-06 Lilly Co Eli Pharmaceutical compositions containing substituted 2-oxo-indolines and the use thereof to treat anxiety and tension
US4556672A (en) * 1984-03-19 1985-12-03 Pfizer Inc. 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
US4690943A (en) * 1984-09-19 1987-09-01 Pfizer Inc. Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds

Also Published As

Publication number Publication date
IL79356A (en) 1990-03-19
IE58566B1 (en) 1993-10-06
EP0208510A3 (en) 1988-03-02
AU566065B2 (en) 1987-10-08
PT82931A (en) 1986-08-01
PH22641A (en) 1988-10-28
FI862882L (fi) 1987-01-10
DK324286D0 (da) 1986-07-08
IL79356A0 (en) 1986-10-31
YU120386A (en) 1988-02-29
EP0208510A2 (en) 1987-01-14
NZ216788A (en) 1988-10-28
PT82931B (pt) 1989-01-30
AU5984786A (en) 1987-04-09
IE861833L (en) 1987-01-09
CA1286663C (en) 1991-07-23
CN86105309A (zh) 1987-01-14
DK324286A (da) 1987-01-10
GR861760B (en) 1986-11-10
YU114487A (en) 1988-02-29
HUT41386A (en) 1987-04-28
DE3681358D1 (de) 1991-10-17
FI862882A7 (fi) 1987-01-10
JPS6226269A (ja) 1987-02-04
FI862882A0 (fi) 1986-07-08
NO862750D0 (no) 1986-07-08
EP0208510B1 (en) 1991-09-11
ES2001855A6 (es) 1988-07-01
ES2009227A6 (es) 1989-09-16
YU45346B (en) 1992-05-28
JPH0610193B2 (ja) 1994-02-09
ATE67185T1 (de) 1991-09-15
HU198015A (en) 1989-07-28

Similar Documents

Publication Publication Date Title
EP0208510B1 (en) 1-substituted oxindole-3-carboxamines as antiinflammatory and analgesic agents
EP0164860B1 (en) N,3-disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents
EP0156603B1 (en) 3-substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
EP0175551B1 (en) Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds
CA2146961C (en) Heterobicyclic sulfonamide and sulfonic ester derivatives
US4721712A (en) 1,3-disubstituted 2-oxindoles as analgesic and anti-inflammatory agents
US4658037A (en) Intermediates for 1,3-disubstituted 2-oxindoles as analgesic and antiinflammatory agents
US4678802A (en) 1-acylcarbamoyloxindole-3-carboxamides as antiinflammatory agents
NO340511B1 (no) Aminoarylsulfonamidderivater som funksjonelle 5-ht6 ligander
US4791129A (en) 1,3-dicarboxamidooxindoles as analgesic and antiinflammatory agents
EP2121602B1 (en) 4-(heterocyclyl)alkyl-n-(arylsulfonyl) indole compounds and their use as 5-ht6 ligands
EP0153818B1 (en) 1,3-disubstituted 2-oxindoles as analgesic and anti-inflammatory agents
EP0155828B1 (en) Process for making 2-oxindole-1-carboxamides and intermediates therefor
US4808601A (en) Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds
NO742929L (da)
US4730004A (en) Analgesic and anti-inflammatory 1-acyl-2-oxindole-3-carboxamides
US4791131A (en) Analgesic and antiinflammatory 1-acyl-2-oxindole-3-carboxamides
KR880002272B1 (ko) 1-치환된 옥신돌-3-카복사마이드의 제조방법
NO148490B (no) Analogifremgangsmaate for fremstilling av medisinsk virksomme 1,2-tiazino(5,6-b)indoler
NO163132B (no) Analogifremgangsmaate for fremstilling av en terapeutisk aktiv 2-oksindol-1-karboksamid-forbindelse og mellomproduktfor fremstilling derav.
HU194165B (en) Process for preparing 1,3-oxyacyl-2-oxindole derivatives
CA1289556C (en) 1- or 3-monosubstituted 2-oxindole compound intermediates useful for the production of analgesic and anti-inflammatory agents
IE850288L (en) Analgesic oxindoles.
NO165798B (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 1,3-disubstituerte 2-oksindol-derivater.
CZ418791A3 (en) 2-oxo-indole-1-carboxamides substituted in position 3 as analgesic and antiphlogistic agents