NO863138L - Rektal doseringsform. - Google Patents

Rektal doseringsform. Download PDF

Info

Publication number: NO863138L
Authority: NO; Norway
Prior art keywords: carrier; lactam antibiotic; rectal; ratio; enhancer
Prior art date: 1985-08-05

Application number

NO863138A

Other languages

English (en)

Norwegian (no)

Other versions

NO863138D0 (no

Inventor

Charanjit Behl

Joel Unowsky

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-08-05

Filing date

1986-08-04

Publication date

1987-02-06

1986-08-04 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1986-08-04 Publication of NO863138D0 publication Critical patent/NO863138D0/no

1987-02-06 Publication of NO863138L publication Critical patent/NO863138L/no

Links

239000002552 dosage form Substances 0.000 title claims description 18
230000003115 biocidal effect Effects 0.000 claims description 26
238000000034 method Methods 0.000 claims description 22
239000003623 enhancer Substances 0.000 claims description 13
239000000194 fatty acid Substances 0.000 claims description 12
235000014113 dietary fatty acids Nutrition 0.000 claims description 11
229930195729 fatty acid Natural products 0.000 claims description 11
239000000203 mixture Substances 0.000 claims description 11
238000002360 preparation method Methods 0.000 claims description 11
239000000829 suppository Substances 0.000 claims description 11
VAAUVRVFOQPIGI-SPQHTLEESA-N ceftriaxone Chemical compound S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1CSC1=NC(=O)C(=O)NN1C VAAUVRVFOQPIGI-SPQHTLEESA-N 0.000 claims description 9
RUDATBOHQWOJDD-UHFFFAOYSA-N (3beta,5beta,7alpha)-3,7-Dihydroxycholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 RUDATBOHQWOJDD-UHFFFAOYSA-N 0.000 claims description 8
229960004755 ceftriaxone Drugs 0.000 claims description 8
RUDATBOHQWOJDD-BSWAIDMHSA-N chenodeoxycholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-BSWAIDMHSA-N 0.000 claims description 8
229960001091 chenodeoxycholic acid Drugs 0.000 claims description 8
159000000000 sodium salts Chemical class 0.000 claims description 8
239000003782 beta lactam antibiotic agent Substances 0.000 claims description 6
238000010521 absorption reaction Methods 0.000 claims description 5
UIMOJFJSJSIGLV-JNHMLNOCSA-N carumonam Chemical compound O=C1N(S(O)(=O)=O)[C@H](COC(=O)N)[C@@H]1NC(=O)C(=N/OCC(O)=O)\C1=CSC(N)=N1 UIMOJFJSJSIGLV-JNHMLNOCSA-N 0.000 claims description 5
229960000662 carumonam Drugs 0.000 claims description 5
YPBATNHYBCGSSN-VWPFQQQWSA-N mezlocillin Chemical compound N([C@@H](C(=O)N[C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C=1C=CC=CC=1)C(=O)N1CCN(S(C)(=O)=O)C1=O YPBATNHYBCGSSN-VWPFQQQWSA-N 0.000 claims description 5
229960000198 mezlocillin Drugs 0.000 claims description 5
229960002292 piperacillin Drugs 0.000 claims description 5
WCMIIGXFCMNQDS-IDYPWDAWSA-M piperacillin sodium Chemical compound [Na+].O=C1C(=O)N(CC)CCN1C(=O)N[C@H](C=1C=CC=CC=1)C(=O)N[C@@H]1C(=O)N2[C@@H](C([O-])=O)C(C)(C)S[C@@H]21 WCMIIGXFCMNQDS-IDYPWDAWSA-M 0.000 claims description 5
239000002775 capsule Substances 0.000 claims description 4
OLVCFLKTBJRLHI-AXAPSJFSSA-N cefamandole Chemical compound CN1N=NN=C1SCC1=C(C(O)=O)N2C(=O)[C@@H](NC(=O)[C@H](O)C=3C=CC=CC=3)[C@H]2SC1 OLVCFLKTBJRLHI-AXAPSJFSSA-N 0.000 claims description 4
229960003012 cefamandole Drugs 0.000 claims description 4
MLYYVTUWGNIJIB-BXKDBHETSA-N cefazolin Chemical compound S1C(C)=NN=C1SCC1=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CN3N=NN=C3)[C@H]2SC1 MLYYVTUWGNIJIB-BXKDBHETSA-N 0.000 claims description 4
229960001139 cefazolin Drugs 0.000 claims description 4
125000005456 glyceride group Chemical group 0.000 claims description 4
150000003951 lactams Chemical class 0.000 claims description 4
239000007788 liquid Substances 0.000 claims description 4
239000000546 pharmaceutical excipient Substances 0.000 claims description 4
239000006185 dispersion Substances 0.000 claims description 3
239000004480 active ingredient Substances 0.000 claims description 2
238000010438 heat treatment Methods 0.000 claims description 2
238000002844 melting Methods 0.000 claims description 2
230000008018 melting Effects 0.000 claims description 2
-1 carbamoyloxy Chemical group 0.000 description 13
239000013543 active substance Substances 0.000 description 7
239000008280 blood Substances 0.000 description 6
210000004369 blood Anatomy 0.000 description 6
150000004665 fatty acids Chemical class 0.000 description 4
229910052739 hydrogen Inorganic materials 0.000 description 4
239000001257 hydrogen Substances 0.000 description 4
239000000126 substance Substances 0.000 description 4
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
229920003171 Poly (ethylene oxide) Polymers 0.000 description 3
150000001875 compounds Chemical class 0.000 description 3
238000001990 intravenous administration Methods 0.000 description 3
230000036470 plasma concentration Effects 0.000 description 3
210000000664 rectum Anatomy 0.000 description 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
241000282520 Papio Species 0.000 description 2
239000003242 anti bacterial agent Substances 0.000 description 2
229940088710 antibiotic agent Drugs 0.000 description 2
125000004432 carbon atom Chemical group C* 0.000 description 2
239000000969 carrier Substances 0.000 description 2
150000001768 cations Chemical class 0.000 description 2
238000001647 drug administration Methods 0.000 description 2
150000002431 hydrogen Chemical class 0.000 description 2
239000004615 ingredient Substances 0.000 description 2
150000003626 triacylglycerols Chemical class 0.000 description 2
239000000080 wetting agent Substances 0.000 description 2
UPXRTVAIJMUAQR-UHFFFAOYSA-N 4-(9h-fluoren-9-ylmethoxycarbonylamino)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid Chemical compound C1C(C(O)=O)N(C(=O)OC(C)(C)C)CC1NC(=O)OCC1C2=CC=CC=C2C2=CC=CC=C21 UPXRTVAIJMUAQR-UHFFFAOYSA-N 0.000 description 1
125000002373 5 membered heterocyclic group Chemical group 0.000 description 1
125000004070 6 membered heterocyclic group Chemical group 0.000 description 1
229920001817 Agar Polymers 0.000 description 1
229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
229930186147 Cephalosporin Natural products 0.000 description 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
241000792859 Enema Species 0.000 description 1
241000588724 Escherichia coli Species 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
241001504519 Papio ursinus Species 0.000 description 1
229930182555 Penicillin Natural products 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
229920001214 Polysorbate 60 Polymers 0.000 description 1
125000004423 acyloxy group Chemical group 0.000 description 1
239000008272 agar Substances 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
125000003545 alkoxy group Chemical group 0.000 description 1
125000000217 alkyl group Chemical group 0.000 description 1
125000000129 anionic group Chemical group 0.000 description 1
MNFORVFSTILPAW-UHFFFAOYSA-N azetidin-2-one Chemical group O=C1CCN1 MNFORVFSTILPAW-UHFFFAOYSA-N 0.000 description 1
125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 description 1
235000021028 berry Nutrition 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
150000001721 carbon Chemical group 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
239000003093 cationic surfactant Substances 0.000 description 1
229940124587 cephalosporin Drugs 0.000 description 1
150000001780 cephalosporins Chemical class 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
239000006071 cream Substances 0.000 description 1
125000004122 cyclic group Chemical group 0.000 description 1
239000002270 dispersing agent Substances 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000003814 drug Substances 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
239000007920 enema Substances 0.000 description 1
229940095399 enema Drugs 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
238000009472 formulation Methods 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
239000011521 glass Substances 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
229910052736 halogen Inorganic materials 0.000 description 1
150000002367 halogens Chemical class 0.000 description 1
239000003906 humectant Substances 0.000 description 1
150000004677 hydrates Chemical class 0.000 description 1
125000002768 hydroxyalkyl group Chemical group 0.000 description 1
235000015110 jellies Nutrition 0.000 description 1
239000008274 jelly Substances 0.000 description 1
229960004184 ketamine hydrochloride Drugs 0.000 description 1
210000002414 leg Anatomy 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
235000010981 methylcellulose Nutrition 0.000 description 1
230000002906 microbiologic effect Effects 0.000 description 1
244000005700 microbiome Species 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
125000004433 nitrogen atom Chemical group N* 0.000 description 1
239000002674 ointment Substances 0.000 description 1
150000002960 penicillins Chemical class 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920001451 polypropylene glycol Polymers 0.000 description 1
DBABZHXKTCFAPX-UHFFFAOYSA-N probenecid Chemical compound CCCN(CCC)S(=O)(=O)C1=CC=C(C(O)=O)C=C1 DBABZHXKTCFAPX-UHFFFAOYSA-N 0.000 description 1
229960003081 probenecid Drugs 0.000 description 1
PFZCOWLKXHIVII-UHFFFAOYSA-N pyridin-1-ium-1-amine Chemical group N[N+]1=CC=CC=C1 PFZCOWLKXHIVII-UHFFFAOYSA-N 0.000 description 1
JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 description 1
239000006215 rectal suppository Substances 0.000 description 1
210000003752 saphenous vein Anatomy 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
210000000689 upper leg Anatomy 0.000 description 1
210000003462 vein Anatomy 0.000 description 1
239000002132 β-lactam antibiotic Substances 0.000 description 1
229940124586 β-lactam antibiotics Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/15—Suppositories

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO863138A 1985-08-05 1986-08-04 Rektal doseringsform. NO863138L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/762,248 US4760059A (en)	1985-08-05	1985-08-05	Rectal dosage form

Publications (2)

Publication Number	Publication Date
NO863138D0 NO863138D0 (no)	1986-08-04
NO863138L true NO863138L (no)	1987-02-06

Family

ID=25064508

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO863138A NO863138L (no)	1985-08-05	1986-08-04	Rektal doseringsform.

Country Status (17)

Country	Link
US (1)	US4760059A (da)
EP (1)	EP0211434A3 (da)
JP (1)	JPS6233129A (da)
KR (1)	KR870001826A (da)
CN (1)	CN86105639A (da)
AU (1)	AU6082886A (da)
DK (1)	DK371786A (da)
ES (1)	ES2001061A6 (da)
FI (1)	FI863170L (da)
GR (1)	GR862050B (da)
HU (1)	HU195732B (da)
IL (1)	IL79607A0 (da)
MC (1)	MC1765A1 (da)
NO (1)	NO863138L (da)
PT (1)	PT83135A (da)
ZA (1)	ZA865182B (da)
ZW (1)	ZW15686A1 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA876930B (en) *	1986-10-07	1988-05-25	Hoffmann La Roche	Pharmaceutical compositions
US5190748A (en) *	1988-11-22	1993-03-02	Hoffmann-La Roche Inc.	Absorption enhancement of antibiotics
GB9212511D0 (en) *	1992-06-12	1992-07-22	Cortecs Ltd	Pharmaceutical compositions
GB0308734D0 (en) *	2003-04-15	2003-05-21	Axcess Ltd	Uptake of macromolecules
CN104906336A (zh) *	2015-06-09	2015-09-16	杨秦	止咳桃花散用于制备直肠给药制剂的用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1563311A (en) *	1975-09-26	1980-03-26	Yamanouchi Pharma Co Ltd	Pharmaceutical composition of insulin for rectal use
JPS53107408A (en) *	1977-02-28	1978-09-19	Yamanouchi Pharmaceut Co Ltd	Micellar preparation for rectal infusion
JPS5517342A (en) *	1978-07-25	1980-02-06	Toyama Chem Co Ltd	Cephalosporin composition for rectal administaration
JPS5562007A (en) *	1978-11-02	1980-05-10	Fujisawa Pharmaceut Co Ltd	Preparation for rectal administration
US4406896A (en) *	1979-12-20	1983-09-27	Merck & Co., Inc.	Adjuvants for rectal delivery of drug substances
JPS5764610A (en) *	1980-10-08	1982-04-19	Fujisawa Pharmaceut Co Ltd	Pharmaceutical for rectal administration
JPS57158719A (en) *	1981-03-24	1982-09-30	Fujisawa Pharmaceut Co Ltd	Rectal administration pharmaceutical
US4525339A (en) *	1982-10-15	1985-06-25	Hoffmann-La Roche Inc.	Enteric coated oral dosage form
IL68769A (en) *	1983-05-23	1986-02-28	Hadassah Med Org	Pharmaceutical compositions containing insulin for oral administration

1985
- 1985-08-05 US US06/762,248 patent/US4760059A/en not_active Expired - Fee Related
1986
- 1986-07-10 ZA ZA865182A patent/ZA865182B/xx unknown
- 1986-08-04 FI FI863170A patent/FI863170L/fi not_active IP Right Cessation
- 1986-08-04 PT PT83135A patent/PT83135A/pt unknown
- 1986-08-04 JP JP61182071A patent/JPS6233129A/ja active Pending
- 1986-08-04 NO NO863138A patent/NO863138L/no unknown
- 1986-08-04 HU HU863359A patent/HU195732B/hu unknown
- 1986-08-04 GR GR862050A patent/GR862050B/el unknown
- 1986-08-04 EP EP86110785A patent/EP0211434A3/de not_active Withdrawn
- 1986-08-04 DK DK371786A patent/DK371786A/da not_active Application Discontinuation
- 1986-08-04 CN CN198686105639A patent/CN86105639A/zh active Pending
- 1986-08-04 AU AU60828/86A patent/AU6082886A/en not_active Abandoned
- 1986-08-04 IL IL79607A patent/IL79607A0/xx unknown
- 1986-08-04 MC MC861844A patent/MC1765A1/fr unknown
- 1986-08-04 KR KR1019860006431A patent/KR870001826A/ko not_active Withdrawn
- 1986-08-04 ES ES8600834A patent/ES2001061A6/es not_active Expired
- 1986-08-04 ZW ZW156/86A patent/ZW15686A1/xx unknown

Also Published As

Publication number	Publication date
FI863170A7 (fi)	1987-02-06
FI863170L (fi)	1987-02-06
NO863138D0 (no)	1986-08-04
US4760059A (en)	1988-07-26
JPS6233129A (ja)	1987-02-13
EP0211434A3 (de)	1987-10-07
CN86105639A (zh)	1987-02-25
ZA865182B (en)	1987-03-25
GR862050B (en)	1986-12-24
HUT41635A (en)	1987-05-28
DK371786A (da)	1987-02-06
EP0211434A2 (de)	1987-02-25
MC1765A1 (fr)	1987-07-17
AU6082886A (en)	1987-02-12
HU195732B (en)	1988-07-28
DK371786D0 (da)	1986-08-04
ZW15686A1 (en)	1988-03-30
FI863170A0 (fi)	1986-08-04
IL79607A0 (en)	1986-11-30
KR870001826A (ko)	1987-03-28
PT83135A (pt)	1986-09-01
ES2001061A6 (es)	1988-04-16

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US4855307A (en)	1989-08-08	Acetic acid ester of haloperidol
US4594357A (en)	1986-06-10	Depot antiinflammatory agents
JPH07196512A (ja)	1995-08-01	医薬組成物
NO863138L (no)	1987-02-06	Rektal doseringsform.
US4454140A (en)	1984-06-12	Nasal administration of dextromethorphan
EP1713466B1 (en)	2009-03-18	Antiparasitic composition containing an organic amine salt of closantel
EA200100871A1 (ru)	2002-04-25	Кристаллическая форма эплеренона, обладающая повышенной скоростью растворения
EP0263493A2 (de)	1988-04-13	Pharmazeutische Präparate zur verbesserten gastrointestinalen Resorption
AU707220B2 (en)	1999-07-08	Pharmaceutical composition for parenteral application containing an indole-carboxylic acid
EP0238753A1 (en)	1987-09-30	N-substituted condensed polymethylene imine derivatives
EA200100869A1 (ru)	2002-04-25	Кристаллическая форма эплеренона
JPS60172929A (ja)	1985-09-06	抗健忘症剤
KR100453803B1 (ko)	2004-10-20	알프로스타딜 함유 외용제 조성물
MC1153A1 (fr)	1978-04-17	N-(1'-allyl 2'-pyrrolidylmethyl)2,3-dimethoxy 5-sulfamoyl benzamide,ses derives
US20100279994A1 (en)	2010-11-04	Ansamycin Formulations and Methods of Use Thereof
SK5682000A3 (en)	2000-09-12	Compositions containing thiamphenicol and diclofenac
US4612310A (en)	1986-09-16	Antirheumatically active suppositories
EP0533938A1 (en)	1993-03-31	Composition for rectal administration of difficultly absorbable peptide
JP2628020B2 (ja)	1997-07-09	医薬製剤用水溶液
EA010293B1 (ru)	2008-08-29	Частицеобразующие композиции, содержащие конденсированные пирролокарбазолы
EP0339176A1 (en)	1989-11-02	Suppository containing a non-steroidal anti-inflammatory medicament