NO872461L - Fremgangsmaate ved fremstilling av nye antihypertensive midler. - Google Patents

Fremgangsmaate ved fremstilling av nye antihypertensive midler.

Info

Publication number: NO872461L
Authority: NO; Norway
Prior art keywords: alkyl; preparation; substituted; independently hydrogen; aryl
Prior art date: 1986-06-13

Application number

NO872461A

Other languages

English (en)

Other versions

NO168584B (no

NO168584C (no

NO872461D0 (no

Inventor

Gary A Flynn

Douglas W Beight

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-06-13

Filing date

1987-06-12

Publication date

1987-12-14

1987-06-12 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1987-06-12 Publication of NO872461D0 publication Critical patent/NO872461D0/no

1987-12-14 Publication of NO872461L publication Critical patent/NO872461L/no

1991-12-02 Publication of NO168584B publication Critical patent/NO168584B/no

1992-03-11 Publication of NO168584C publication Critical patent/NO168584C/no

Links

229940030600 antihypertensive agent Drugs 0.000 title 1
239000002220 antihypertensive agent Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
150000002431 hydrogen Chemical group 0.000 abstract 2
125000000547 substituted alkyl group Chemical group 0.000 abstract 2
UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 abstract 1
OHIVDUHJQGWYAT-UHFFFAOYSA-N C1=CN2C(C(=O)O)=CSCC2=C2C=CC=CC2=C1 Chemical class C1=CN2C(C(=O)O)=CSCC2=C2C=CC=CC2=C1 OHIVDUHJQGWYAT-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
102000004270 Peptidyl-Dipeptidase A Human genes 0.000 abstract 1
108090000882 Peptidyl-Dipeptidase A Proteins 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000006193 alkinyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000539 amino acid group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000005553 heteroaryloxy group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000003107 substituted aryl group Chemical group 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Cardiology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Indole Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Hydrogenated Pyridines (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO872461A 1986-06-13 1987-06-12 Analogifremgangsmaate ved fremstilling av terapeutisk aktive 1,2,3,4,6,7,8,12b-octahydro-6-oxopyrido(2,1-a)-(2)benzazepin-4-carboxylsyrederivater NO168584C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US87375486A	1986-06-13	1986-06-13

Publications (4)

Publication Number	Publication Date
NO872461D0 NO872461D0 (no)	1987-06-12
NO872461L true NO872461L (no)	1987-12-14
NO168584B NO168584B (no)	1991-12-02
NO168584C NO168584C (no)	1992-03-11

Family

ID=25362243

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO872461A NO168584C (no)	1986-06-13	1987-06-12	Analogifremgangsmaate ved fremstilling av terapeutisk aktive 1,2,3,4,6,7,8,12b-octahydro-6-oxopyrido(2,1-a)-(2)benzazepin-4-carboxylsyrederivater

Country Status (9)

Country	Link
CN (1)	CN1020612C (no)
AT (1)	ATE81511T1 (no)
DE (1)	DE3782190T2 (no)
FI (1)	FI84481C (no)
HU (2)	HU201326B (no)
IL (1)	IL82850A (no)
NO (1)	NO168584C (no)
NZ (1)	NZ220649A (no)
PT (1)	PT85070B (no)

1987
- 1987-06-10 NZ NZ220649A patent/NZ220649A/xx unknown
- 1987-06-11 IL IL82850A patent/IL82850A/xx not_active IP Right Cessation
- 1987-06-11 FI FI872613A patent/FI84481C/fi not_active IP Right Cessation
- 1987-06-11 PT PT85070A patent/PT85070B/pt unknown
- 1987-06-11 DE DE8787108410T patent/DE3782190T2/de not_active Expired - Lifetime
- 1987-06-11 AT AT87108410T patent/ATE81511T1/de not_active IP Right Cessation
- 1987-06-12 HU HU8990A patent/HU201326B/hu not_active IP Right Cessation
- 1987-06-12 NO NO872461A patent/NO168584C/no not_active IP Right Cessation
- 1987-06-12 CN CN87104166A patent/CN1020612C/zh not_active Expired - Fee Related
- 1987-06-12 HU HU872684A patent/HU197328B/hu not_active IP Right Cessation

Also Published As

Publication number	Publication date
NZ220649A (en)	1990-09-26
DE3782190T2 (de)	1993-02-25
IL82850A (en)	1991-03-10
FI872613A7 (fi)	1987-12-14
NO168584B (no)	1991-12-02
DE3782190D1 (de)	1992-11-19
CN1020612C (zh)	1993-05-12
IL82850A0 (en)	1987-12-20
HU197328B (en)	1989-03-28
FI84481C (fi)	1991-12-10
FI872613A0 (fi)	1987-06-11
CN87104166A (zh)	1988-01-20
PT85070A (en)	1987-07-01
NO168584C (no)	1992-03-11
FI84481B (fi)	1991-08-30
PT85070B (pt)	1990-03-08
NO872461D0 (no)	1987-06-12
ATE81511T1 (de)	1992-10-15
HUT44518A (en)	1988-03-28
HU201326B (en)	1990-10-28

Legal Events

Date	Code	Title	Description
2001-01-29	MM1K	Lapsed by not paying the annual fees	Free format text: LAPSED IN DECEMBER 2000

Publication	Publication Date	Title
NO164983C (no)	1990-12-05	Analogifremgangsmaate ved fremstilling av terapeutisk aktive carboxyalkyldipeptider.
DK20987A (da)	1987-07-17	Peptidylaminodioler og fremgangsmaade til deres fremstilling
BG102792A (bg)	1999-08-31	Производни на заместени 4-хидроксифенилалканоилови киселини с агонистична активност към рраr-гама
ATE12042T1 (de)	1985-03-15	Aminosaeurederivate und ihre therapeutische verwendung.
ES8801245A1 (es)	1988-01-01	Un procedimiento para preparar derivados de piperidina
DK0383686T3 (da)	1993-12-20	Carboxyalkylethere af 2-amino-7-hydroxytetralin samt fremgangsmåde til fremstilling deraf
BR9707250A (pt)	1999-04-06	Dihidrobenzofurano e compostos correlatos úteis como agentes antiinflamatórios
ATE83234T1 (de)	1992-12-15	Oxadiazol-pyrimidinone, ihre herstellung und ihre kosmetische und dermopharmazeutische verwendung.
DK165247C (da)	1993-04-26	2,3,4,5-substituerede 1,6-naphthyridinderivater, deres fremstilling samt anvendelse af disse til fremstilling af laegemidler til bekaempelse af cardiale, cerebrale og perifere karlidelser, myocardial iskaemi, cerebral infarkt, lungethrombose, stenoser, arterioscleroser og hjerte-kredsloebslidelser og laegemiddel indeholdende disse derivater
ES508706A0 (es)	1982-11-01	"procedimiento de preparar acidos aroilaminicos y similares".
NO872461L (no)	1987-12-14	Fremgangsmaate ved fremstilling av nye antihypertensive midler.
ATE16010T1 (de)	1985-10-15	Neue hydrocortison-derivate, ihre herstellung und verwendung.
IE781382L (en)	1979-01-12	Indole derivatives
NO852471L (no)	1985-12-23	Fremgangsmaate for fremstilling av heterocyklylfenylformamidiner.