NO872875L - Modifisert vevsplasminaktivator, samt fremgangsmŸte for fremstilling av en slik. - Google Patents

Modifisert vevsplasminaktivator, samt fremgangsmŸte for fremstilling av en slik.

Info

Publication number
NO872875L
NO872875L NO872875A NO872875A NO872875L NO 872875 L NO872875 L NO 872875L NO 872875 A NO872875 A NO 872875A NO 872875 A NO872875 A NO 872875A NO 872875 L NO872875 L NO 872875L
Authority
NO
Norway
Prior art keywords
procedure
manufacture
well
modified tissue
plasmin activator
Prior art date
Application number
NO872875A
Other languages
English (en)
Other versions
NO872875D0 (no
Inventor
Per Bruno Wallen
Bo Anders Norrman
Bjn Andersen Nex
Original Assignee
Novo Industri As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Industri As filed Critical Novo Industri As
Publication of NO872875D0 publication Critical patent/NO872875D0/no
Publication of NO872875L publication Critical patent/NO872875L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
NO872875A 1986-07-11 1987-07-10 Modifisert vevsplasminaktivator, samt fremgangsmŸte for fremstilling av en slik. NO872875L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US88435786A 1986-07-11 1986-07-11

Publications (2)

Publication Number Publication Date
NO872875D0 NO872875D0 (no) 1987-07-10
NO872875L true NO872875L (no) 1988-01-12

Family

ID=25384445

Family Applications (1)

Application Number Title Priority Date Filing Date
NO872875A NO872875L (no) 1986-07-11 1987-07-10 Modifisert vevsplasminaktivator, samt fremgangsmŸte for fremstilling av en slik.

Country Status (5)

Country Link
EP (1) EP0253582A1 (no)
JP (1) JPS63119675A (no)
DK (1) DK345087A (no)
FI (1) FI873060L (no)
NO (1) NO872875L (no)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614190A (en) * 1988-09-02 1997-03-25 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5108909A (en) * 1985-03-22 1992-04-28 Chiron Corporation Expression of TPA in mammalian cells
DE3684680D1 (de) * 1985-12-23 1992-05-07 Chiron Corp Peptidplasminogenaktivatoren.
SE8702562L (sv) * 1987-06-18 1988-12-19 Kabigen Ab Nya fibrinolytiska enzymer
DK395288D0 (da) * 1988-07-15 1988-07-15 Novo Industri As Proteiner
US5108901A (en) * 1988-09-02 1992-04-28 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
JP3559559B2 (ja) * 1992-06-03 2004-09-02 ジェネンテク，インコーポレイテッド 向上した治療特性を有する組織プラスミノーゲン活性化因子グリコシル化変異体

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL68561A (en) * 1982-05-05 1991-01-31 Genentech Inc Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof
US4753879A (en) * 1984-08-27 1988-06-28 Biogen N.V. Modified tissue plasminogen activators

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614190A (en) * 1988-09-02 1997-03-25 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5616486A (en) * 1988-09-02 1997-04-01 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5770426A (en) * 1988-09-02 1998-06-23 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties

Also Published As

Publication number Publication date
DK345087A (da) 1988-01-12
FI873060A7 (fi) 1988-01-12
FI873060A0 (fi) 1987-07-10
DK345087D0 (da) 1987-07-06
JPS63119675A (ja) 1988-05-24
AU608232B2 (en) 1991-03-28
EP0253582A1 (en) 1988-01-20
AU7554687A (en) 1988-01-14
FI873060L (fi) 1988-01-12
NO872875D0 (no) 1987-07-10

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