NO873762L - Fremgangsmaate for fremstilling av benzo-kondenserte cykloalkan-(og oxa- og thiacykloalkan)trans-1,2-diaminderivater. - Google Patents
Fremgangsmaate for fremstilling av benzo-kondenserte cykloalkan-(og oxa- og thiacykloalkan)trans-1,2-diaminderivater.Info
- Publication number
- NO873762L NO873762L NO873762A NO873762A NO873762L NO 873762 L NO873762 L NO 873762L NO 873762 A NO873762 A NO 873762A NO 873762 A NO873762 A NO 873762A NO 873762 L NO873762 L NO 873762L
- Authority
- NO
- Norway
- Prior art keywords
- trans
- oxa
- benzo
- thiacycloalkan
- cycloalkan
- Prior art date
Links
- 150000004985 diamines Chemical class 0.000 title 1
- SYOPRZWROBOKGX-ZJSXRUAMSA-N 2-(3,4-dichlorophenyl)-n-[(1r,2r)-5-methoxy-2-pyrrolidin-1-yl-1,2,3,4-tetrahydronaphthalen-1-yl]-n-methylacetamide Chemical compound N1([C@H]2[C@@H](C=3C=CC=C(C=3CC2)OC)N(C)C(=O)CC=2C=C(Cl)C(Cl)=CC=2)CCCC1 SYOPRZWROBOKGX-ZJSXRUAMSA-N 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 150000001924 cycloalkanes Chemical class 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 229940030606 diuretics Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/41—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/41—Y being a hydrogen or an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polyesters Or Polycarbonates (AREA)
- Luminescent Compositions (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyrane Compounds (AREA)
- Pyrrole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Lubricants (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90554386A | 1986-09-10 | 1986-09-10 | |
| US07/071,028 US4876269A (en) | 1986-09-10 | 1987-07-16 | Benoz-fused cycloalkane trans-1,2-diamine derivatives |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO873762D0 NO873762D0 (no) | 1987-09-09 |
| NO873762L true NO873762L (no) | 1988-03-11 |
| NO172934B NO172934B (no) | 1993-06-21 |
| NO172934C NO172934C (no) | 1993-09-29 |
Family
ID=26751758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO87873762A NO172934C (no) | 1986-09-10 | 1987-09-09 | Analogifremgangsmaate for fremstilling av benzo-kondenserte cyklo-alkan-(og oxacykloalkan)trans-1,2-diaminderivater |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4876269A (no) |
| EP (1) | EP0260555B1 (no) |
| JP (1) | JPH0819065B2 (no) |
| KR (1) | KR960009421B1 (no) |
| AT (1) | ATE75223T1 (no) |
| AU (1) | AU607935B2 (no) |
| CA (1) | CA1341024C (no) |
| DE (1) | DE3778463D1 (no) |
| DK (1) | DK169071B1 (no) |
| ES (1) | ES2040721T3 (no) |
| FI (1) | FI88298C (no) |
| GR (1) | GR3004962T3 (no) |
| HU (1) | HU198016B (no) |
| IE (1) | IE60423B1 (no) |
| IL (1) | IL83842A (no) |
| MX (1) | MX170515B (no) |
| NO (1) | NO172934C (no) |
| NZ (1) | NZ221726A (no) |
| PT (1) | PT85668B (no) |
| SU (1) | SU1582984A3 (no) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5234944A (en) * | 1986-08-21 | 1993-08-10 | Roussel Uclaf | Novel indanes |
| US6271395B1 (en) * | 1978-08-19 | 2001-08-07 | Hoechst Marion Roussol | Substituted with an N-methyl benzene-acetamide and 1-pyrrolidinyl |
| ES2052593T3 (es) * | 1986-08-21 | 1994-07-16 | Roussel Uclaf | Procedimiento para preparar derivados del indano. |
| FR2640625B2 (fr) * | 1986-08-21 | 1993-05-21 | Roussel Uclaf | Nouveaux composes optiquement actifs derives de l'indane, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
| FR2608598B1 (fr) * | 1986-12-23 | 1989-04-14 | Roussel Uclaf | Nouveaux derives de l'indane, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions les renfermant |
| FR2627491B1 (fr) * | 1988-02-18 | 1992-01-24 | Roussel Uclaf | Nouveaux derives du benzocyclohexane et du benzocycloheptane ainsi que leurs sels, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions les renfermant |
| AU626949B2 (en) * | 1988-12-06 | 1992-08-13 | Warner-Lambert Company | 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics |
| US5348971A (en) * | 1988-12-16 | 1994-09-20 | Roussel Uclaf | Indanes useful as analgesics |
| DK626889A (da) * | 1988-12-16 | 1990-06-17 | Roussel Uclaf | Indanderivater, deres fremstilling samt laegemidler med indhold deraf |
| GB8902118D0 (en) * | 1989-02-01 | 1989-03-22 | Beecham Group Plc | Chemical process |
| US5239090A (en) * | 1989-02-01 | 1993-08-24 | Beecham Group P.L.C. | Certain optically active 3,4-dihydrobenzopyran-4-ols which are intermediates |
| JP2931986B2 (ja) * | 1989-02-17 | 1999-08-09 | 武田薬品工業株式会社 | アラルキルアミン誘導体 |
| US5063242A (en) * | 1989-04-21 | 1991-11-05 | Warner-Lambert Company | 7-((substituted)amino)-8-((substituted)carbonyl)-methylamino-1-oxaspiro[4,5]decanes as diuretics antiinflammatory, and cerebrovascular agents |
| US4965278A (en) | 1989-04-21 | 1990-10-23 | Warner-Lambert Company | 7-(substituted)amino)-8-((substituted)carbonyl)-methylamino)-1-oxaspiro[4,5]decanes as diuretics antiiflammatory, and cerebrovascular agents |
| US5545755A (en) * | 1989-05-31 | 1996-08-13 | The Upjohn Company | Therapeutically useful 2-aminotetralin derivatives |
| CA2051399C (en) | 1989-05-31 | 2003-12-30 | Chiu-Hong Lin | Therapeutically useful 2-aminotetralin derivatives |
| US5130330A (en) * | 1990-01-31 | 1992-07-14 | G. D. Searle & Co. | Nitrogen-containing cyclohetero cycloalkylaminoaryl derivatives for cns disorders |
| JPH06502165A (ja) * | 1990-10-12 | 1994-03-10 | ファルマシア・アンド・アップジョン・カンパニー | 治療上有用な２−アミノテトラリン誘導体 |
| ATE141278T1 (de) * | 1991-03-15 | 1996-08-15 | Hoffmann La Roche | Diphosphonsaurederivate als zwischenprodukte zur herstellung von diphosphinliganden |
| US5317028A (en) * | 1992-09-08 | 1994-05-31 | Warner-Lambert Co. | 7-((substituted)amino)-8((substituted)carbonyl)-methylamino-1-oxaspiro(4,5)decanes useful in Parkinson's disease, dystonia, and other movement disorders |
| US5646151A (en) * | 1996-03-08 | 1997-07-08 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| US6239154B1 (en) | 1996-03-08 | 2001-05-29 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| US5763445A (en) | 1996-03-08 | 1998-06-09 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| CA2288828A1 (en) * | 1997-07-14 | 1999-01-28 | Adolor Corporation | Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith |
| US5760023A (en) * | 1997-07-14 | 1998-06-02 | Adolor Corporation | Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith |
| FR2791671B1 (fr) * | 1999-04-01 | 2001-05-11 | Oreal | Nouveaux composes derives d'esters d'acide benzoique, composition les comprenant et utilisation |
| CZ290178B6 (cs) * | 1999-07-22 | 2002-06-12 | Sankyo Company Limited | Deriváty cyklobutenu |
| WO2024040266A2 (en) * | 2022-08-19 | 2024-02-22 | Mitokinin, Inc. | Disubstituted benzoimidazole and indole analogs as modulators of pink1 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4145435A (en) * | 1976-11-12 | 1979-03-20 | The Upjohn Company | 2-aminocycloaliphatic amide compounds |
| US4098904A (en) * | 1976-11-12 | 1978-07-04 | The Upjohn Company | Analgesic n-(2-aminocycloaliphatic)benzamides |
| US4212878A (en) * | 1978-01-26 | 1980-07-15 | The Upjohn Company | Phenylacetamide derivative analgesics |
| CA1109080A (en) * | 1978-05-30 | 1981-09-15 | Hideo Kato | Indanamine derivatives |
| US4466977A (en) * | 1981-04-09 | 1984-08-21 | The Upjohn Company | N-[2-Amino(oxy- or thia- group-substituted-cycloaliphatic)]benzeneacetamides and -benzamide analgesics |
| GB2096607B (en) * | 1981-04-09 | 1985-02-27 | Upjohn Co | Aminocycloalkyl amides |
| US4359476A (en) * | 1981-04-09 | 1982-11-16 | The Upjohn Company | Adjacently substituted cycloalkane-amide analgesics |
| US4460600A (en) * | 1981-04-09 | 1984-07-17 | The Upjohn Company | Adjacently substituted ketal derivatives of cycloalkane-amide analgesics |
| US4360531A (en) * | 1981-04-09 | 1982-11-23 | The Upjohn Company | Substituted cycloalkanes |
| US4438130A (en) * | 1981-11-12 | 1984-03-20 | The Upjohn Company | Analgesic 1-oxa-, aza- and thia-spirocyclic compounds |
| US4560767A (en) * | 1983-06-17 | 1985-12-24 | The Upjohn Company | N-(2-amino-cycloalkenyl)benzeneacetamide and -benzamide analgesics and tritiated kappa agonists therefrom |
| US4656182A (en) * | 1983-12-06 | 1987-04-07 | Warner-Lambert Company | Substituted trans-1,2-diaminocyclohexyl amide compounds |
| US4632935A (en) * | 1984-05-30 | 1986-12-30 | The Upjohn Company | Omega-(hydroxy-, ether and ester)-alkyl-2-amino-cycloalkyl- and cycloalkenyl amides as analgesics |
| ES2052593T3 (es) * | 1986-08-21 | 1994-07-16 | Roussel Uclaf | Procedimiento para preparar derivados del indano. |
-
1987
- 1987-07-16 US US07/071,028 patent/US4876269A/en not_active Expired - Lifetime
- 1987-09-05 EP EP87113010A patent/EP0260555B1/en not_active Expired - Lifetime
- 1987-09-05 AT AT87113010T patent/ATE75223T1/de not_active IP Right Cessation
- 1987-09-05 ES ES87113010T patent/ES2040721T3/es not_active Expired - Lifetime
- 1987-09-05 DE DE8787113010T patent/DE3778463D1/de not_active Expired - Lifetime
- 1987-09-08 NZ NZ221726A patent/NZ221726A/en unknown
- 1987-09-08 CA CA000546354A patent/CA1341024C/en not_active Expired - Fee Related
- 1987-09-09 HU HU874018A patent/HU198016B/hu not_active IP Right Cessation
- 1987-09-09 SU SU874203411A patent/SU1582984A3/ru active
- 1987-09-09 IL IL83842A patent/IL83842A/xx unknown
- 1987-09-09 DK DK470087A patent/DK169071B1/da not_active IP Right Cessation
- 1987-09-09 IE IE240687A patent/IE60423B1/en not_active IP Right Cessation
- 1987-09-09 PT PT85668A patent/PT85668B/pt not_active IP Right Cessation
- 1987-09-09 FI FI873896A patent/FI88298C/fi not_active IP Right Cessation
- 1987-09-09 NO NO87873762A patent/NO172934C/no unknown
- 1987-09-09 JP JP62224204A patent/JPH0819065B2/ja not_active Expired - Lifetime
- 1987-09-10 MX MX008173A patent/MX170515B/es unknown
- 1987-09-10 KR KR87010028A patent/KR960009421B1/ko not_active Expired - Fee Related
- 1987-09-10 AU AU78224/87A patent/AU607935B2/en not_active Ceased
-
1992
- 1992-06-18 GR GR920401296T patent/GR3004962T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK470087A (da) | 1988-03-11 |
| FI873896A0 (fi) | 1987-09-09 |
| NZ221726A (en) | 1990-04-26 |
| SU1582984A3 (ru) | 1990-07-30 |
| AU607935B2 (en) | 1991-03-21 |
| JPS63146852A (ja) | 1988-06-18 |
| GR3004962T3 (no) | 1993-04-28 |
| NO172934B (no) | 1993-06-21 |
| IE60423B1 (en) | 1994-07-13 |
| DE3778463D1 (de) | 1992-05-27 |
| ES2040721T3 (es) | 1993-11-01 |
| KR960009421B1 (en) | 1996-07-19 |
| DK470087D0 (da) | 1987-09-09 |
| IE872406L (en) | 1988-03-10 |
| JPH0819065B2 (ja) | 1996-02-28 |
| FI88298B (fi) | 1993-01-15 |
| HUT47076A (en) | 1989-01-30 |
| IL83842A0 (en) | 1988-02-29 |
| DK169071B1 (da) | 1994-08-08 |
| NO873762D0 (no) | 1987-09-09 |
| AU7822487A (en) | 1988-03-17 |
| FI88298C (fi) | 1993-04-26 |
| ATE75223T1 (de) | 1992-05-15 |
| KR880003906A (ko) | 1988-05-31 |
| MX170515B (es) | 1993-08-27 |
| HU198016B (en) | 1989-07-28 |
| EP0260555B1 (en) | 1992-04-22 |
| CA1341024C (en) | 2000-06-13 |
| US4876269A (en) | 1989-10-24 |
| IL83842A (en) | 1991-06-30 |
| PT85668B (pt) | 1990-05-31 |
| PT85668A (en) | 1987-10-01 |
| EP0260555A1 (en) | 1988-03-23 |
| NO172934C (no) | 1993-09-29 |
| FI873896A7 (fi) | 1988-03-11 |
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