NO884833L - Maalrettede former av metyltritio-anti-tumormidler. - Google Patents

Maalrettede former av metyltritio-anti-tumormidler.

Info

Publication number: NO884833L
Authority: NO; Norway
Prior art keywords: tritio; methyl; tumor agents; targeted forms; targeted
Prior art date: 1987-10-30

Application number

NO88884833A

Other languages

English (en)

Other versions

NO176480C (no

NO884833D0 (no

NO176480B (no

Inventor

William James Mcgahren

Martin Leon Sassiver

George A Ellestad

Phillip R Hamann

Lois M Hinman

Janis Upeslacis

Original Assignee

American Cyanamid Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-10-30

Filing date

1988-10-28

Publication date

1989-05-02

1988-10-28 Application filed by American Cyanamid Co filed Critical American Cyanamid Co

1988-10-28 Publication of NO884833D0 publication Critical patent/NO884833D0/no

1989-05-02 Publication of NO884833L publication Critical patent/NO884833L/no

1995-01-02 Publication of NO176480B publication Critical patent/NO176480B/no

1995-04-12 Publication of NO176480C publication Critical patent/NO176480C/no

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
- A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biochemistry (AREA)
Epidemiology (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicinal Preparation (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

NO884833A 1987-10-30 1988-10-28 Analogifremgangsmåte ved fremstilling av målrettede former av metyltritio-anti-tumormidler NO176480C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US11494087A	1987-10-30	1987-10-30

Publications (4)

Publication Number	Publication Date
NO884833D0 NO884833D0 (no)	1988-10-28
NO884833L true NO884833L (no)	1989-05-02
NO176480B NO176480B (no)	1995-01-02
NO176480C NO176480C (no)	1995-04-12

Family

ID=22358378

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO884834A NO173506C (no)	1987-10-30	1988-10-28	Fremgangsmaate ved fremtilling av disvovelanaloger av ll-E33288-antitumormidler
NO884833A NO176480C (no)	1987-10-30	1988-10-28	Analogifremgangsmåte ved fremstilling av målrettede former av metyltritio-anti-tumormidler

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
NO884834A NO173506C (no)	1987-10-30	1988-10-28	Fremgangsmaate ved fremtilling av disvovelanaloger av ll-E33288-antitumormidler

Country Status (20)

Country	Link
EP (2)	EP0313874B1 (no)
JP (2)	JP2820256B2 (no)
KR (2)	KR0133130B1 (no)
AR (1)	AR246083A1 (no)
AT (2)	ATE112172T1 (no)
AU (2)	AU612714B2 (no)
BR (1)	BR1100939A (no)
CA (1)	CA1321582C (no)
DE (2)	DE3851682T2 (no)
DK (2)	DK602488A (no)
ES (2)	ES2061586T3 (no)
FI (2)	FI95204C (no)
HK (2)	HK131997A (no)
IE (2)	IE65989B1 (no)
IL (2)	IL87946A (no)
NO (2)	NO173506C (no)
NZ (2)	NZ226727A (no)
PT (2)	PT88882B (no)
PY (1)	PY0101654A (no)
ZA (2)	ZA888123B (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5079233A (en) *	1987-01-30	1992-01-07	American Cyanamid Company	N-acyl derivatives of the LL-E33288 antitumor antibiotics, composition and methods for using the same
US5606040A (en) *	1987-10-30	1997-02-25	American Cyanamid Company	Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group
IL93733A (en) *	1989-04-14	1996-01-19	American Cyanamid Co	Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group and targeted forms thereof
GB9007384D0 (en) *	1990-04-02	1990-05-30	Duncan Ruth	Coupling between polymers and other organic molecular entities utilising thiol-specific reactive groups
US5712374A (en) *	1995-06-07	1998-01-27	American Cyanamid Company	Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
US5714586A (en) *	1995-06-07	1998-02-03	American Cyanamid Company	Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
ES2639020T3 (es)	1998-11-27	2017-10-25	Ucb Pharma S.A.	Composiciones y métodos para incrementar la mineralización de la substancia ósea
US20040009535A1 (en)	1998-11-27	2004-01-15	Celltech R&D, Inc.	Compositions and methods for increasing bone mineralization
NZ511705A (en) *	2001-05-14	2004-03-26	Horticulture & Food Res Inst	Methods and rapid immunoassay device for detecting progesterone and other steroids
CN1835974A (zh)	2003-06-16	2006-09-20	细胞技术研究与发展公司	对硬化素特异的抗体和用于增加骨矿化的方法
WO2008028050A2 (en) *	2006-08-30	2008-03-06	Wisconsin Alumni Research Foundation	Reversible natural product glycosyltransferase-catalyzed reactions, compounds and related methods
KR100979928B1 (ko) *	2008-07-16	2010-09-03	한주학	수직축형 부력풍차
SI3066074T1 (sl) *	2013-11-04	2020-03-31	Pfizer Inc.	Intermediati in postopki za sintetizacijo derivatov kaliheamicina
EP3573995A1 (en) *	2017-01-24	2019-12-04	Pfizer Inc.	Calicheamicin derivatives and antibody drug conjugates thereof
SG11202108655TA (en)	2019-02-15	2021-09-29	Univ Southern California	Lym-1 and lym-2 antibody compositions and improved car constructs
EP4234537A4 (en) *	2020-10-22	2024-05-29	FUJIFILM Corporation	Reagent for measuring skin sensitization, compound, and method for measuring skin sensitization

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2430943A1 (fr) *	1978-07-13	1980-02-08	Toyo Jozo Kk	Nouveaux derives disulfures
EP0040506B1 (en) *	1980-05-21	1986-08-20	Teijin Limited	Reactive polymer and process for the preparation thereof
US4530835A (en) *	1983-07-08	1985-07-23	Warner-Lambert Company	CL-1577 Antibiotic compounds and their production
CA1314245C (en) *	1984-05-23	1993-03-09	Franz Jansen	Process for the preparation of conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule, which are useful as immunotoxin potentiators
ATE180513T1 (de) *	1984-11-16	1999-06-15	American Cyanamid Co	Antitumorale antibiotika (komplex ll-e-33288)
EP0330874A3 (en) *	1988-02-29	1989-10-18	American Cyanamid Company	Antibacterial and antitumor agents LL-E33288 epsilon-I and LL-E33288-epsilonBr, with processes and intermediates for producing said agents
EP0342341A3 (en) *	1988-05-17	1991-07-24	American Cyanamid Company	Process for producing antitumor antibiotic ll-e33288gamma2

1988
- 1988-10-03 EP EP88116339A patent/EP0313874B1/en not_active Expired - Lifetime
- 1988-10-03 DE DE3851682T patent/DE3851682T2/de not_active Expired - Lifetime
- 1988-10-03 AT AT88116338T patent/ATE112172T1/de not_active IP Right Cessation
- 1988-10-03 DE DE3889063T patent/DE3889063T2/de not_active Expired - Lifetime
- 1988-10-03 ES ES88116339T patent/ES2061586T3/es not_active Expired - Lifetime
- 1988-10-03 AT AT88116339T patent/ATE104309T1/de not_active IP Right Cessation
- 1988-10-03 ES ES88116338T patent/ES2059464T3/es not_active Expired - Lifetime
- 1988-10-03 EP EP88116338A patent/EP0313873B1/en not_active Expired - Lifetime
- 1988-10-06 IL IL8794688A patent/IL87946A/en active Protection Beyond IP Right Term
- 1988-10-06 IL IL8794788A patent/IL87947A/en active Protection Beyond IP Right Term
- 1988-10-26 NZ NZ226727A patent/NZ226727A/en unknown
- 1988-10-26 NZ NZ226726A patent/NZ226726A/xx unknown
- 1988-10-27 AR AR88312321A patent/AR246083A1/es active
- 1988-10-28 CA CA000581590A patent/CA1321582C/en not_active Expired - Lifetime
- 1988-10-28 IE IE326288A patent/IE65989B1/en not_active IP Right Cessation
- 1988-10-28 PT PT88882A patent/PT88882B/pt not_active IP Right Cessation
- 1988-10-28 NO NO884834A patent/NO173506C/no not_active IP Right Cessation
- 1988-10-28 DK DK602488A patent/DK602488A/da not_active Application Discontinuation
- 1988-10-28 NO NO884833A patent/NO176480C/no not_active IP Right Cessation
- 1988-10-28 ZA ZA888123A patent/ZA888123B/xx unknown
- 1988-10-28 IE IE326188A patent/IE65053B1/en not_active IP Right Cessation
- 1988-10-28 DK DK198806025A patent/DK174739B1/da not_active IP Right Cessation
- 1988-10-28 AU AU24494/88A patent/AU612714B2/en not_active Expired
- 1988-10-28 AU AU24489/88A patent/AU618763B2/en not_active Expired
- 1988-10-28 PT PT88881A patent/PT88881B/pt not_active IP Right Cessation
- 1988-10-28 ZA ZA888127A patent/ZA888127B/xx unknown
- 1988-10-28 FI FI884984A patent/FI95204C/fi not_active IP Right Cessation
- 1988-10-28 FI FI884983A patent/FI91262C/fi not_active IP Right Cessation
- 1988-10-29 JP JP63272007A patent/JP2820256B2/ja not_active Expired - Lifetime
- 1988-10-29 JP JP63272006A patent/JP2720933B2/ja not_active Expired - Lifetime
- 1988-10-30 KR KR1019880014246A patent/KR0133130B1/ko not_active Expired - Fee Related
- 1988-10-30 KR KR1019880014245A patent/KR970011385B1/ko not_active Expired - Fee Related
1997
- 1997-05-14 BR BR1100939-0A patent/BR1100939A/pt active IP Right Grant
- 1997-06-26 HK HK131997A patent/HK131997A/en not_active IP Right Cessation
- 1997-06-26 HK HK131897A patent/HK131897A/en not_active IP Right Cessation
2001
- 2001-01-26 PY PY200100101654A patent/PY0101654A/es unknown

Also Published As

Publication number	Publication date
HK131997A (en)	1997-10-03
NO884834L (no)	1989-05-02
ES2059464T3 (es)	1994-11-16
JP2820256B2 (ja)	1998-11-05
PT88881B (pt)	1993-01-29
DE3851682D1 (de)	1994-11-03
DK602588D0 (da)	1988-10-28
DK174739B1 (da)	2003-10-13
DE3889063T2 (de)	1994-12-01
FI95204C (fi)	1996-01-10
DK602488A (da)	1989-05-01
ZA888123B (en)	1989-07-26
EP0313873A1 (en)	1989-05-03
DE3851682T2 (de)	1995-05-04
AU2449488A (en)	1989-05-04
AU618763B2 (en)	1992-01-09
IL87946A (en)	1995-06-29
CA1321582C (en)	1993-08-24
EP0313874B1 (en)	1994-04-13
FI884984A0 (fi)	1988-10-28
FI91262B (fi)	1994-02-28
NO884834D0 (no)	1988-10-28
AU612714B2 (en)	1991-07-18
NO176480C (no)	1995-04-12
NO884833D0 (no)	1988-10-28
DK602588A (da)	1989-05-01
ZA888127B (en)	1989-07-26
AU2448988A (en)	1989-05-04
FI884983A0 (fi)	1988-10-28
DK602488D0 (da)	1988-10-28
IE65989B1 (en)	1995-11-29
NO176480B (no)	1995-01-02
BR1100939A (pt)	1999-08-31
KR0133130B1 (ko)	1998-04-17
NZ226727A (en)	1991-12-23
EP0313874A3 (en)	1990-05-09
PY0101654A (es)	2002-08-01
EP0313874A2 (en)	1989-05-03
PT88882B (pt)	1993-01-29
NO173506C (no)	1993-12-22
KR890006245A (ko)	1989-06-12
IE883261L (en)	1989-04-30
IL87947A0 (en)	1989-03-31
JPH01193282A (ja)	1989-08-03
IL87946A0 (en)	1989-03-31
KR970011385B1 (ko)	1997-07-10
FI95204B (fi)	1995-09-29
ATE112172T1 (de)	1994-10-15
FI91262C (fi)	1994-06-10
IE883262L (en)	1989-04-30
HK131897A (en)	1997-10-03
FI884983L (fi)	1989-05-01
AR246083A1 (es)	1994-03-30
DE3889063D1 (de)	1994-05-19
KR890006244A (ko)	1989-06-12
FI884984A7 (fi)	1989-05-01
ES2061586T3 (es)	1994-12-16
JPH0296599A (ja)	1990-04-09
JP2720933B2 (ja)	1998-03-04
NO173506B (no)	1993-09-13
ATE104309T1 (de)	1994-04-15
IL87947A (en)	1995-05-26
IE65053B1 (en)	1995-10-04
NZ226726A (en)	1991-08-27
EP0313873B1 (en)	1994-09-28

Legal Events

Date	Code	Title	Description
2008-11-10	MK1K	Patent expired

Publication	Publication Date	Title
DE3886433D1 (de)	1994-02-03	Desodoriervorrichtung.
ATA179188A (de)	1993-11-15	Spritzampulle
DE3869446D1 (de)	1992-04-30	Desodorierungsmittel.
FI875020A7 (fi)	1988-05-21	Terapeuttiset aineet.
MX9203069A (es)	1992-07-31	Vesticulacion espontanea de liposomas multilamelares.
FI882186L (fi)	1988-11-12	Brandmotstaondskraftig bjaelklagsbalk av staol i samverkan med betong.
NO884833D0 (no)	1988-10-28	Maalrettede former av metyltritio-anti-tumormidler.
FI885166L (fi)	1988-11-10	Foerfarande foer saenkning av maengden kvaeveoxider i avgaser med anvaendning av socker.
FI883867A7 (fi)	1989-02-22	2-pyrimidinyyli-1 -piperatsiinijohdannaisten käyttö.
FI885342A0 (fi)	1988-11-17	Gasturbin med laenkinfaestning av en taetningsring i en ledskovelkrans.
FI884006L (fi)	1989-03-03	Hoernfog av vaendraelsar.
FI880056A7 (fi)	1988-07-08	Framstaellning av plastledning med spaerreffekt.
FR2654822B1 (fr)	1993-04-23	Dispenseur de sous-projectiles.
BR8804951A (pt)	1989-10-03	Ferradura
FI885328L (fi)	1989-05-21	Foerfarande foer selektiv spaltning av fusionsproteiner.
FR2619009B1 (fr)	1994-09-23	Agent anti-hyperlipemique
ES2012433A4 (es)	1990-04-01	Descafeinizacion de estractos acuosos.
FI884007A7 (fi)	1989-03-03	Hoernfog av vaendraelsar.
NO884062D0 (no)	1988-09-13	Desinfeksjon av avforminger.
FI913285A0 (fi)	1991-07-05	Svavelsubstituerade mevinsyraderivat.
KR890700354A (ko)	1989-04-24	향지성제
FI870397A0 (fi)	1987-01-29	Anordning foer foerbaettring av styrbarhet i fordon med svaengbar larvmatta.
DK629387D0 (da)	1987-12-01	Fremgangsmaade
ES2010642B3 (es)	1991-12-01	Esteres alquilicos de l-aspartil-3-(bicicloalquil)-l-alanina.
FR2616660B1 (fr)	1990-06-22	Agent antiepileptique