NO885568L - Nye polynukleotidanaloger, fremgangsmaater for inhibering av nukleinsyrepolymeraser og fremgangsmaater til aa induseresyntese av interferon. - Google Patents

Nye polynukleotidanaloger, fremgangsmaater for inhibering av nukleinsyrepolymeraser og fremgangsmaater til aa induseresyntese av interferon.

Info

Publication number: NO885568L
Authority: NO; Norway
Prior art keywords: poly; acid; mercapto; substituted; fluoro
Prior art date: 1987-12-16

Application number

NO88885568A

Other languages

English (en)

Norwegian (no)

Other versions

NO885568D0 (no

Inventor

Thomas Joseph Bardos

Yau-Kwan Ho

Steven John Kasper

Robert Godber Hughes Jr

Original Assignee

Univ New York State Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-12-16

Filing date

1988-12-15

Publication date

1989-06-19

1988-12-15 Application filed by Univ New York State Res Found filed Critical Univ New York State Res Found

1988-12-15 Publication of NO885568D0 publication Critical patent/NO885568D0/no

1989-06-19 Publication of NO885568L publication Critical patent/NO885568L/no

Links

238000000034 method Methods 0.000 title claims 14
102000040430 polynucleotide Human genes 0.000 title claims 11
108091033319 polynucleotide Proteins 0.000 title claims 11
239000002157 polynucleotide Substances 0.000 title claims 6
230000015572 biosynthetic process Effects 0.000 title claims 3
238000003786 synthesis reaction Methods 0.000 title claims 3
102000014150 Interferons Human genes 0.000 title 1
108010050904 Interferons Proteins 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1
229940079322 interferon Drugs 0.000 title 1
102000039446 nucleic acids Human genes 0.000 title 1
108020004707 nucleic acids Proteins 0.000 title 1
150000007523 nucleic acids Chemical class 0.000 title 1
125000004435 hydrogen atom Chemical group [H]* 0.000 claims 9
-1 poly(cytidylic acid) Polymers 0.000 claims 7
239000005547 deoxyribonucleotide Substances 0.000 claims 6
125000003396 thiol group Chemical group [H]S* 0.000 claims 6
DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 claims 5
125000001153 fluoro group Chemical group F* 0.000 claims 5
UHDGCWIWMRVCDJ-ZAKLUEHWSA-N cytidine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-ZAKLUEHWSA-N 0.000 claims 4
238000004519 manufacturing process Methods 0.000 claims 4
239000007858 starting material Substances 0.000 claims 4
UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 claims 3
UHDGCWIWMRVCDJ-PSQAKQOGSA-N Cytidine Natural products O=C1N=C(N)C=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-PSQAKQOGSA-N 0.000 claims 3
230000000536 complexating effect Effects 0.000 claims 3
UDMBCSSLTHHNCD-UHFFFAOYSA-N Coenzym Q(11) Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(O)=O)C(O)C1O UDMBCSSLTHHNCD-UHFFFAOYSA-N 0.000 claims 2
ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims 2
229950006790 adenosine phosphate Drugs 0.000 claims 2
OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical group NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 2
229910052731 fluorine Inorganic materials 0.000 claims 2
239000011737 fluorine Substances 0.000 claims 2
125000000714 pyrimidinyl group Chemical group 0.000 claims 2
150000003839 salts Chemical class 0.000 claims 2
230000002194 synthesizing effect Effects 0.000 claims 2
GRSZFWQUAKGDAV-UHFFFAOYSA-N Inosinic acid Natural products OC1C(O)C(COP(O)(O)=O)OC1N1C(NC=NC2=O)=C2N=C1 GRSZFWQUAKGDAV-UHFFFAOYSA-N 0.000 claims 1
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
DRTQHJPVMGBUCF-PSQAKQOGSA-N beta-L-uridine Natural products O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-PSQAKQOGSA-N 0.000 claims 1
IERHLVCPSMICTF-XVFCMESISA-N cytidine 5'-monophosphate Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(O)=O)O1 IERHLVCPSMICTF-XVFCMESISA-N 0.000 claims 1
IERHLVCPSMICTF-UHFFFAOYSA-N cytidine monophosphate Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(COP(O)(O)=O)O1 IERHLVCPSMICTF-UHFFFAOYSA-N 0.000 claims 1
229940104302 cytosine Drugs 0.000 claims 1
125000002637 deoxyribonucleotide group Chemical group 0.000 claims 1
229920000140 heteropolymer Polymers 0.000 claims 1
229910052739 hydrogen Inorganic materials 0.000 claims 1
239000001257 hydrogen Substances 0.000 claims 1
229940028843 inosinic acid Drugs 0.000 claims 1
235000013902 inosinic acid Nutrition 0.000 claims 1
239000004245 inosinic acid Substances 0.000 claims 1
229920000642 polymer Polymers 0.000 claims 1
238000002360 preparation method Methods 0.000 claims 1
150000003230 pyrimidines Chemical class 0.000 claims 1
229940035893 uracil Drugs 0.000 claims 1
DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 claims 1
229940045145 uridine Drugs 0.000 claims 1
DJJCXFVJDGTHFX-XVFCMESISA-N uridine 5'-monophosphate Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N1C(=O)NC(=O)C=C1 DJJCXFVJDGTHFX-XVFCMESISA-N 0.000 claims 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

NO88885568A 1987-12-16 1988-12-15 Nye polynukleotidanaloger, fremgangsmaater for inhibering av nukleinsyrepolymeraser og fremgangsmaater til aa induseresyntese av interferon. NO885568L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/133,524 US4882147A (en)	1987-12-16	1987-12-16	Novel polynucleotide analogs, methods for inhibiting nucleic acid polymerases and methods for inducing synthesis of interferon

Publications (2)

Publication Number	Publication Date
NO885568D0 NO885568D0 (no)	1988-12-15
NO885568L true NO885568L (no)	1989-06-19

Family

ID=22459024

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO88885568A NO885568L (no)	1987-12-16	1988-12-15	Nye polynukleotidanaloger, fremgangsmaater for inhibering av nukleinsyrepolymeraser og fremgangsmaater til aa induseresyntese av interferon.

Country Status (10)

Country	Link
US (1)	US4882147A (de)
EP (1)	EP0320807A3 (de)
JP (1)	JPH02295A (de)
AU (1)	AU2687488A (de)
CA (1)	CA1295269C (de)
DK (1)	DK696888A (de)
IL (1)	IL88589A0 (de)
NO (1)	NO885568L (de)
NZ (1)	NZ227230A (de)
ZA (1)	ZA889207B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5276019A (en) *	1987-03-25	1994-01-04	The United States Of America As Represented By The Department Of Health And Human Services	Inhibitors for replication of retroviruses and for the expression of oncogene products
KR100283601B1 (ko) *	1993-02-19	2001-03-02	아만 히데아키	글리세롤 유도체, 디바이스 및 의약 조성물
US6383783B1 (en)	1999-09-21	2002-05-07	3M Innovative Properties Company	Nucleic acid isolation by adhering to hydrophobic solid phase and removing with nonionic surfactant

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3594278A (en) *	1968-12-31	1971-07-20	Pabst Brewing Co	Preparation of polynucleotides
IL37076A (en) *	1971-06-16	1974-05-16	Littauer U	A method for stepwise synthesis of oligoribonucleotides of defined sequence using 2'(3')-o-acyl-nucleoside diphosphates and polynucleotide phosphorylase
GB1364987A (en) *	1971-06-19	1974-08-29	Merck Patent Gmbh	Biologically active two component complexes

1987
- 1987-12-16 US US07/133,524 patent/US4882147A/en not_active Expired - Fee Related
1988
- 1988-12-05 IL IL88589A patent/IL88589A0/xx unknown
- 1988-12-07 NZ NZ227230A patent/NZ227230A/xx unknown
- 1988-12-08 ZA ZA889207A patent/ZA889207B/xx unknown
- 1988-12-09 EP EP19880120569 patent/EP0320807A3/de not_active Withdrawn
- 1988-12-13 CA CA000585731A patent/CA1295269C/en not_active Expired - Lifetime
- 1988-12-14 AU AU26874/88A patent/AU2687488A/en not_active Abandoned
- 1988-12-15 NO NO88885568A patent/NO885568L/no unknown
- 1988-12-15 DK DK696888A patent/DK696888A/da not_active Application Discontinuation
- 1988-12-15 JP JP63317562A patent/JPH02295A/ja active Pending

Also Published As

Publication number	Publication date
US4882147A (en)	1989-11-21
DK696888D0 (da)	1988-12-15
AU2687488A (en)	1989-06-22
NO885568D0 (no)	1988-12-15
ZA889207B (en)	1989-08-30
IL88589A0 (en)	1989-07-31
EP0320807A3 (de)	1991-05-08
EP0320807A2 (de)	1989-06-21
NZ227230A (en)	1990-07-26
DK696888A (da)	1989-06-17
CA1295269C (en)	1992-02-04
JPH02295A (ja)	1990-01-05

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