NO890632L - Fremgangsmaate for fremstilling av terapeutisk aktive pyrimidin-derivater. - Google Patents

Fremgangsmaate for fremstilling av terapeutisk aktive pyrimidin-derivater.

Info

Publication number: NO890632L
Authority: NO; Norway
Prior art keywords: carbon atoms; alkyl; alkoxy; hydrogen; procedure
Prior art date: 1988-02-16

Application number

NO89890632A

Other languages

English (en)

Other versions

NO171850B (no

NO171850C (no

NO890632D0 (no

Inventor

Conrad Santini

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-02-16

Filing date

1989-02-15

Publication date

1989-08-17

1989-02-15 Application filed by Pfizer filed Critical Pfizer

1989-02-15 Publication of NO890632D0 publication Critical patent/NO890632D0/no

1989-08-17 Publication of NO890632L publication Critical patent/NO890632L/no

1993-02-01 Publication of NO171850B publication Critical patent/NO171850B/no

1993-05-12 Publication of NO171850C publication Critical patent/NO171850C/no

Links

CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 15
125000000217 alkyl group Chemical group 0.000 abstract 8
125000003545 alkoxy group Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
-1 chloro, nitro, amino Chemical group 0.000 abstract 3
125000004663 dialkyl amino group Chemical group 0.000 abstract 2
125000001153 fluoro group Chemical group F* 0.000 abstract 2
BUBXHLKSFNUIJJ-UHFFFAOYSA-N 8-pyrimidin-2-ylsulfinylquinoline Chemical class C=1C=CC2=CC=CN=C2C=1S(=O)C1=NC=CC=N1 BUBXHLKSFNUIJJ-UHFFFAOYSA-N 0.000 abstract 1
108091006112 ATPases Proteins 0.000 abstract 1
102000057290 Adenosine Triphosphatases Human genes 0.000 abstract 1
208000025865 Ulcer Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000005236 alkanoylamino group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
125000000440 benzylamino group Chemical group [H]N(*)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
125000001246 bromo group Chemical group Br* 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
231100000397 ulcer Toxicity 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Compositions Of Macromolecular Compounds (AREA)

NO890632A 1988-02-16 1989-02-15 Analogifremgangsmaate for fremstilling av terapeutisk aktive 8-(2-pyrimidinylsulfinyl) kinolin-derivater NO171850C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/156,371 US4808591A (en)	1988-02-16	1988-02-16	Antiulcer 8-(2-pyrimidylsulfinyl)quinolines

Publications (4)

Publication Number	Publication Date
NO890632D0 NO890632D0 (no)	1989-02-15
NO890632L true NO890632L (no)	1989-08-17
NO171850B NO171850B (no)	1993-02-01
NO171850C NO171850C (no)	1993-05-12

Family

ID=22559294

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO890632A NO171850C (no)	1988-02-16	1989-02-15	Analogifremgangsmaate for fremstilling av terapeutisk aktive 8-(2-pyrimidinylsulfinyl) kinolin-derivater

Country Status (20)

Country	Link
US (1)	US4808591A (no)
EP (1)	EP0330329B1 (no)
JP (1)	JPH0699424B2 (no)
KR (1)	KR910002582B1 (no)
AT (1)	ATE78477T1 (no)
AU (1)	AU604398B2 (no)
CA (1)	CA1317946C (no)
DE (1)	DE68902152T2 (no)
DK (1)	DK70389A (no)
ES (1)	ES2042994T3 (no)
FI (1)	FI90774C (no)
GR (1)	GR3005745T3 (no)
HU (1)	HU200455B (no)
IE (1)	IE61945B1 (no)
IL (1)	IL89257A (no)
MY (1)	MY103822A (no)
NO (1)	NO171850C (no)
NZ (1)	NZ227996A (no)
PT (1)	PT89712B (no)
ZA (1)	ZA891133B (no)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4859679A (en) *	1988-07-19	1989-08-22	Pfizer Inc.	Antiulcer (alkyldithio) quinoline derivatives
DE4037003A1 (de) *	1990-05-30	1991-12-05	Bayer Ag	Substituierte azine
CA2060282C (en) *	1991-01-31	1997-11-25	Katsutoshi Ishikawa	Pyrimidinyloxy(thio) quinoline derivative, preparation process of the derivative, and agri-horticultural fungicide comprising the derivative as active ingredient
US5202329A (en) *	1991-01-31	1993-04-13	Mitsui Toatsu Chemicals Inc.	Pyrimidinyloxy(thio)quinoline derivative, and agri-horticultural fungicide comprising the derivative as active ingredient

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE16799T1 (de) *	1980-01-10	1985-12-15	Nyegaard & Co As	Pyrimidin-2-sulfide und ihre s-oxide zur verwendung in der medizin, die verbindungen enthaltende pharmazeutische zusammensetzungen, verfahren zu ihrer herstellung und die verbindungen an sich, sofern sie neu sind.
EP0239129B1 (en) *	1986-03-28	1991-09-25	Otsuka Pharmaceutical Co., Ltd.	Hydroquinoline compounds, compositions containing same and processes for preparing same
AU2817989A (en) *	1987-12-11	1989-07-05	Byk Gulden Lomberg Chemische Fabrik Gmbh	Novel benzimidazole derivatives
JPH0615273A (ja) *	1992-07-01	1994-01-25	Funai Electric Co Ltd	イオン水生成器の電源装置

1988
- 1988-02-16 US US07/156,371 patent/US4808591A/en not_active Expired - Lifetime
1989
- 1989-02-06 AT AT89301119T patent/ATE78477T1/de not_active IP Right Cessation
- 1989-02-06 DE DE8989301119T patent/DE68902152T2/de not_active Expired - Lifetime
- 1989-02-06 EP EP89301119A patent/EP0330329B1/en not_active Expired - Lifetime
- 1989-02-06 ES ES89301119T patent/ES2042994T3/es not_active Expired - Lifetime
- 1989-02-10 IL IL89257A patent/IL89257A/xx not_active IP Right Cessation
- 1989-02-14 CA CA000590948A patent/CA1317946C/en not_active Expired - Fee Related
- 1989-02-14 MY MYPI89000183A patent/MY103822A/en unknown
- 1989-02-14 ZA ZA891133A patent/ZA891133B/xx unknown
- 1989-02-14 PT PT89712A patent/PT89712B/pt not_active IP Right Cessation
- 1989-02-15 NO NO890632A patent/NO171850C/no unknown
- 1989-02-15 KR KR1019890001722A patent/KR910002582B1/ko not_active Expired
- 1989-02-15 FI FI890720A patent/FI90774C/fi not_active IP Right Cessation
- 1989-02-15 DK DK070389A patent/DK70389A/da not_active Application Discontinuation
- 1989-02-15 JP JP1035991A patent/JPH0699424B2/ja not_active Expired - Lifetime
- 1989-02-15 IE IE48489A patent/IE61945B1/en not_active IP Right Cessation
- 1989-02-15 HU HU89768A patent/HU200455B/hu not_active IP Right Cessation
- 1989-02-15 NZ NZ227996A patent/NZ227996A/en unknown
- 1989-02-15 AU AU29946/89A patent/AU604398B2/en not_active Ceased
1992
- 1992-09-17 GR GR920402071T patent/GR3005745T3/el unknown

Also Published As

Publication number	Publication date
ATE78477T1 (de)	1992-08-15
NZ227996A (en)	1990-08-28
IL89257A0 (en)	1989-09-10
FI90774C (fi)	1994-03-25
ZA891133B (en)	1990-09-26
HUT49347A (en)	1989-09-28
JPH01250377A (ja)	1989-10-05
FI890720L (fi)	1989-08-17
ES2042994T3 (es)	1993-12-16
JPH0699424B2 (ja)	1994-12-07
FI90774B (fi)	1993-12-15
PT89712B (pt)	1994-04-29
HU200455B (en)	1990-06-28
NO171850B (no)	1993-02-01
NO171850C (no)	1993-05-12
AU2994689A (en)	1989-08-17
AU604398B2 (en)	1990-12-13
IE890484L (en)	1989-08-16
GR3005745T3 (no)	1993-06-07
DE68902152T2 (de)	1992-12-17
DK70389D0 (da)	1989-02-15
PT89712A (pt)	1989-10-04
EP0330329B1 (en)	1992-07-22
NO890632D0 (no)	1989-02-15
KR910002582B1 (ko)	1991-04-27
KR900012927A (ko)	1990-09-03
MY103822A (en)	1993-09-30
IL89257A (en)	1993-01-31
DE68902152D1 (de)	1992-08-27
DK70389A (da)	1989-10-17
CA1317946C (en)	1993-05-18
US4808591A (en)	1989-02-28
FI890720A0 (fi)	1989-02-15
IE61945B1 (en)	1994-11-30
EP0330329A1 (en)	1989-08-30

Publication	Publication Date	Title
NO170335C (no)	1992-10-07	Analogifremgangsmaate for fremstilling av terapeutisk aktive diazabicykloalkyl-kinolon-karboksylsyrer
NO942452D0 (no)	1994-06-29	Amid- og ureaderivater med antihyperkolesteremisk aktivitet, deres fremstilling og terapeutiske anvendelser
NO166126C (no)	1991-06-05	Analogifremgangsmaate ved fremstilling av terapeutisk aktive kinolonkarboksylsyrederivater.
NO163568C (no)	1990-06-20	Analogifremgangsmaate for fremstilling av terapeutisk aktive kinolonkarboksylsyrederivater.
ZA89389B (en)	1989-10-25	Use of 1,4-disubstituted-piperidinyl compounds in the manufacture of a medicament for the treatment of insomnia
NO890632D0 (no)	1989-02-15	Fremgangsmaate for fremstilling av terapeutisk aktive pyrimidin-derivater.
NO160360C (no)	1989-04-12	Analogifremgangsmaate for fremstilling av terapeutisk aktive naftalen-derivater.
ZA898498B (en)	1990-08-29	1,2,3,4-tetrahydro-1,9-acridinediamines,a process for their preparation and their use as medicaments
ATE46332T1 (de)	1989-09-15	Spiro-imidazolidine als aldose-reduktaseinhibitoren.
NO861868L (no)	1986-11-11	Fremgangsmaate for fremstilling av terapeutisk aktive 1,3-oksatian-derivater.
HU912567D0 (en)	1992-01-28	Preparation for decreasing uric acid contain in blood
DE3884878D1 (de)	1993-11-18	Uricosuretische Zusammensetzung.
NO169899C (no)	1992-08-19	Analogifremgangsmaate for fremstilling av terapeutisk aktive tiadiazolguanidiner
DK0560231T3 (da)	1999-03-22	Pyrazolo(3,4-a)acridinderivater som smertestillende midler
ATE101609T1 (de)	1994-03-15	Amino-substituierte verbrueckte azabicyclische chinoloncarbonsaeure und ester.
ATE74123T1 (de)	1992-04-15	2-amino-3-aroyl-gamma-oxobenzolbuttersaeure und ihre ester.
ATE111462T1 (de)	1994-09-15	1,4-dihydropyridin-derivate.