PT89712A - Processo para a preparacao de derivados de pirimidina antiulcerosos - Google Patents

Processo para a preparacao de derivados de pirimidina antiulcerosos

Info

Publication number: PT89712A
Authority: PT; Portugal
Prior art keywords: carbon atoms; alkyl; alkoxy; hydrogen; cultivated
Prior art date: 1988-02-16

Application number

PT89712A

Other languages

English (en)

Other versions

PT89712B (pt

Inventor

Conrad Santini

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-02-16

Filing date

1989-02-14

Publication date

1989-10-04

1989-02-14 Application filed by Pfizer filed Critical Pfizer

1989-10-04 Publication of PT89712A publication Critical patent/PT89712A/pt

1994-04-29 Publication of PT89712B publication Critical patent/PT89712B/pt

Links

CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 15
125000000217 alkyl group Chemical group 0.000 abstract 8
125000003545 alkoxy group Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
-1 chloro, nitro, amino Chemical group 0.000 abstract 3
125000004663 dialkyl amino group Chemical group 0.000 abstract 2
125000001153 fluoro group Chemical group F* 0.000 abstract 2
BUBXHLKSFNUIJJ-UHFFFAOYSA-N 8-pyrimidin-2-ylsulfinylquinoline Chemical class C=1C=CC2=CC=CN=C2C=1S(=O)C1=NC=CC=N1 BUBXHLKSFNUIJJ-UHFFFAOYSA-N 0.000 abstract 1
108091006112 ATPases Proteins 0.000 abstract 1
102000057290 Adenosine Triphosphatases Human genes 0.000 abstract 1
208000025865 Ulcer Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000005236 alkanoylamino group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
125000000440 benzylamino group Chemical group [H]N(*)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
125000001246 bromo group Chemical group Br* 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
231100000397 ulcer Toxicity 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Compositions Of Macromolecular Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

PT89712A 1988-02-16 1989-02-14 Processo para a preparacao de derivados de pirimidina antiulcerosos PT89712B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/156,371 US4808591A (en)	1988-02-16	1988-02-16	Antiulcer 8-(2-pyrimidylsulfinyl)quinolines

Publications (2)

Publication Number	Publication Date
PT89712A true PT89712A (pt)	1989-10-04
PT89712B PT89712B (pt)	1994-04-29

Family

ID=22559294

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT89712A PT89712B (pt)	1988-02-16	1989-02-14	Processo para a preparacao de derivados de pirimidina antiulcerosos

Country Status (20)

Country	Link
US (1)	US4808591A (pt)
EP (1)	EP0330329B1 (pt)
JP (1)	JPH0699424B2 (pt)
KR (1)	KR910002582B1 (pt)
AT (1)	ATE78477T1 (pt)
AU (1)	AU604398B2 (pt)
CA (1)	CA1317946C (pt)
DE (1)	DE68902152T2 (pt)
DK (1)	DK70389A (pt)
ES (1)	ES2042994T3 (pt)
FI (1)	FI90774C (pt)
GR (1)	GR3005745T3 (pt)
HU (1)	HU200455B (pt)
IE (1)	IE61945B1 (pt)
IL (1)	IL89257A (pt)
MY (1)	MY103822A (pt)
NO (1)	NO171850C (pt)
NZ (1)	NZ227996A (pt)
PT (1)	PT89712B (pt)
ZA (1)	ZA891133B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4859679A (en) *	1988-07-19	1989-08-22	Pfizer Inc.	Antiulcer (alkyldithio) quinoline derivatives
DE4037003A1 (de) *	1990-05-30	1991-12-05	Bayer Ag	Substituierte azine
CA2060282C (en) *	1991-01-31	1997-11-25	Katsutoshi Ishikawa	Pyrimidinyloxy(thio) quinoline derivative, preparation process of the derivative, and agri-horticultural fungicide comprising the derivative as active ingredient
US5202329A (en) *	1991-01-31	1993-04-13	Mitsui Toatsu Chemicals Inc.	Pyrimidinyloxy(thio)quinoline derivative, and agri-horticultural fungicide comprising the derivative as active ingredient

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU549117B2 (en) *	1980-01-10	1986-01-16	Nyegaard & Co. A/S	Pyrimidine-2-sulphides and their 5-oxides
KR870008853A (ko) *	1986-03-28	1987-10-21	오쯔까 아끼히꼬	하이드로퀴놀린 화합물의 제조방법
JPH03501609A (ja) *	1987-12-11	1991-04-11	ビイク　グルデン　ロンベルク　ヒエーミツシエ　フアブリーク　ゲゼルシヤフト　ミツト　ベシユレンクテル　ハフツング	新規ベンゾイミダゾール誘導体
JPH0615273A (ja) *	1992-07-01	1994-01-25	Funai Electric Co Ltd	イオン水生成器の電源装置

1988
- 1988-02-16 US US07/156,371 patent/US4808591A/en not_active Expired - Lifetime
1989
- 1989-02-06 ES ES89301119T patent/ES2042994T3/es not_active Expired - Lifetime
- 1989-02-06 AT AT89301119T patent/ATE78477T1/de not_active IP Right Cessation
- 1989-02-06 EP EP89301119A patent/EP0330329B1/en not_active Expired - Lifetime
- 1989-02-06 DE DE8989301119T patent/DE68902152T2/de not_active Expired - Lifetime
- 1989-02-10 IL IL89257A patent/IL89257A/xx not_active IP Right Cessation
- 1989-02-14 ZA ZA891133A patent/ZA891133B/xx unknown
- 1989-02-14 MY MYPI89000183A patent/MY103822A/en unknown
- 1989-02-14 CA CA000590948A patent/CA1317946C/en not_active Expired - Fee Related
- 1989-02-14 PT PT89712A patent/PT89712B/pt not_active IP Right Cessation
- 1989-02-15 NZ NZ227996A patent/NZ227996A/en unknown
- 1989-02-15 DK DK070389A patent/DK70389A/da not_active Application Discontinuation
- 1989-02-15 KR KR1019890001722A patent/KR910002582B1/ko not_active Expired
- 1989-02-15 HU HU89768A patent/HU200455B/hu not_active IP Right Cessation
- 1989-02-15 IE IE48489A patent/IE61945B1/en not_active IP Right Cessation
- 1989-02-15 FI FI890720A patent/FI90774C/fi not_active IP Right Cessation
- 1989-02-15 AU AU29946/89A patent/AU604398B2/en not_active Ceased
- 1989-02-15 JP JP1035991A patent/JPH0699424B2/ja not_active Expired - Lifetime
- 1989-02-15 NO NO890632A patent/NO171850C/no unknown
1992
- 1992-09-17 GR GR920402071T patent/GR3005745T3/el unknown

Also Published As

Publication number	Publication date
GR3005745T3 (pt)	1993-06-07
NO171850B (no)	1993-02-01
KR900012927A (ko)	1990-09-03
AU2994689A (en)	1989-08-17
NO171850C (no)	1993-05-12
EP0330329B1 (en)	1992-07-22
CA1317946C (en)	1993-05-18
JPH0699424B2 (ja)	1994-12-07
DK70389A (da)	1989-10-17
DE68902152D1 (de)	1992-08-27
IL89257A0 (en)	1989-09-10
DK70389D0 (da)	1989-02-15
AU604398B2 (en)	1990-12-13
FI90774C (fi)	1994-03-25
NZ227996A (en)	1990-08-28
MY103822A (en)	1993-09-30
JPH01250377A (ja)	1989-10-05
EP0330329A1 (en)	1989-08-30
HU200455B (en)	1990-06-28
US4808591A (en)	1989-02-28
KR910002582B1 (ko)	1991-04-27
FI890720A0 (fi)	1989-02-15
ZA891133B (en)	1990-09-26
IL89257A (en)	1993-01-31
NO890632D0 (no)	1989-02-15
FI90774B (fi)	1993-12-15
NO890632L (no)	1989-08-17
PT89712B (pt)	1994-04-29
IE61945B1 (en)	1994-11-30
ATE78477T1 (de)	1992-08-15
ES2042994T3 (es)	1993-12-16
FI890720L (fi)	1989-08-17
DE68902152T2 (de)	1992-12-17
HUT49347A (en)	1989-09-28
IE890484L (en)	1989-08-16

Legal Events

Date

Code

Title

Description

1994-04-29

FG3A

Patent granted, date of granting

Effective date: 19931001

1995-09-12

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19950430

Publication	Publication Date	Title
ZA907033B (en)	1991-06-26	N-substituted-4-pyrimidinamines an pyrimidindiamines,a process for their preparation and their use as medicaments
FI102175B1 (fi)	1998-10-30	Menetelmä terapeuttisesti käyttökelpoisten piperatsiinijohdannaisten valmistamiseksi
DK0616807T3 (da)	1999-04-19	Benzimidazol anvendelig i behandlingen af forstyrrelser i centralnervesystemet
NO942452D0 (no)	1994-06-29	Amid- og ureaderivater med antihyperkolesteremisk aktivitet, deres fremstilling og terapeutiske anvendelser
PT82854B (pt)	1988-05-27	Processo para a preparacao de derivados do acido piridono-carboxilico
PT81476B (pt)	1987-11-11	Processo para a preparacao de derivados do acido quinolono-carboxilico
IE890177L (en)	1989-07-21	Piperidinyl derivatives
FI890720A0 (fi)	1989-02-15	Menetelmä uusien terapeuttisesti käyttökelpoisten pyrimidiinijohdannaisten valmistamiseksi
PT92234A (pt)	1990-05-31	Processo para a preparacao de 1,2,3,4-tetraidro-1,9-acridinodiaminas
HUT50354A (en)	1990-01-29	Process for producing new s-adenosylmethionine decarboxilase inhibitors
FI903624A0 (fi)	1990-07-18	Analogiamenetelmä terapeuttisesti käyttökelpoisten N,N'-bis(alkoksi- ja hydroksialkyyli)pyridiini-2,4-dikarboksyylihappodiamidien valmistamiseksi
PT98509A (pt)	1992-06-30	Metodo para o abaixamento dos niveis de acido urico no sangue com derivados de acido acetico oxoftalazinilo
FI943875A0 (fi)	1994-08-23	2,3,4,5-Tetrahydro-1H-3-bentsatsepiinejä ja niiden farmaseuttisesti hyväksyttäviä happoadditiosuoloja
PT91498A (pt)	1990-03-08	Processo para preparacao de acidos e esteres quinolonocarboxilicos azabiciclicos em ponte amino-substituidos
DE3483318D1 (de)	1990-10-31	Lorazepam-haltiges schlafmittel.