NO893196L - Hybrid-protein-c-sammensetninger og fremgangsmaater for deres fremstilling. - Google Patents

Hybrid-protein-c-sammensetninger og fremgangsmaater for deres fremstilling.

Info

Publication number
NO893196L
NO893196L NO89893196A NO893196A NO893196L NO 893196 L NO893196 L NO 893196L NO 89893196 A NO89893196 A NO 89893196A NO 893196 A NO893196 A NO 893196A NO 893196 L NO893196 L NO 893196L
Authority
NO
Norway
Prior art keywords
protein
dna
hybrid
bovine
sequence
Prior art date
Application number
NO89893196A
Other languages
English (en)
Norwegian (no)
Other versions
NO893196D0 (no
Inventor
Tamotsu Hashimoto
Mikiko Takahashi
Original Assignee
Hoechst Japan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Japan filed Critical Hoechst Japan
Publication of NO893196D0 publication Critical patent/NO893196D0/no
Publication of NO893196L publication Critical patent/NO893196L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
NO89893196A 1988-08-09 1989-08-08 Hybrid-protein-c-sammensetninger og fremgangsmaater for deres fremstilling. NO893196L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP63197144A JPH0246296A (ja) 1988-08-09 1988-08-09 雑種プロテインｃ及びその製造方法

Publications (2)

Publication Number Publication Date
NO893196D0 NO893196D0 (no) 1989-08-08
NO893196L true NO893196L (no) 1990-02-12

Family

ID=16369490

Family Applications (1)

Application Number Title Priority Date Filing Date
NO89893196A NO893196L (no) 1988-08-09 1989-08-08 Hybrid-protein-c-sammensetninger og fremgangsmaater for deres fremstilling.

Country Status (9)

Country Link
EP (1) EP0354504A2 (fr)
JP (1) JPH0246296A (fr)
KR (1) KR900002795A (fr)
AU (1) AU3937289A (fr)
DK (1) DK388789A (fr)
FI (1) FI893724A7 (fr)
IL (1) IL91234A0 (fr)
NO (1) NO893196L (fr)
PT (1) PT91391A (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7168591A (en) * 1989-12-29 1991-07-24 Zymogenetics Inc. Hybrid protein c
US5358932A (en) * 1989-12-29 1994-10-25 Zymogenetics, Inc. Hybrid protein C
JPH04127174U (ja) * 1991-05-09 1992-11-19 株式会社シマノ 釣り用リール
US5618714A (en) * 1993-12-15 1997-04-08 Eli Lilly And Company Methods for producing protein C
ATE321846T1 (de) * 1996-11-08 2006-04-15 Oklahoma Med Res Found Verwendung eines modifizierten protein-c
US6747003B1 (en) 1997-10-23 2004-06-08 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US7247708B2 (en) 1997-10-23 2007-07-24 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US6693075B1 (en) 1997-10-23 2004-02-17 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US6017882A (en) * 1997-10-23 2000-01-25 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US6998122B1 (en) 1999-04-30 2006-02-14 Eli Lilly And Company Protein C derivatives
AU2001232736A1 (en) 2000-02-02 2001-08-14 Eli Lilly And Company Protein c derivatives
WO2001058935A2 (fr) 2000-02-11 2001-08-16 Maxygen Aps MOLECULES DE TYPE FACTEUR VII OU VIIa
WO2001059084A1 (fr) 2000-02-11 2001-08-16 Eli Lilly And Company Derives de la proteine c
US7220837B1 (en) 2000-04-28 2007-05-22 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US7812132B2 (en) 2000-04-28 2010-10-12 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US20030211094A1 (en) 2001-06-26 2003-11-13 Nelsestuen Gary L. High molecular weight derivatives of vitamin k-dependent polypeptides
AU2002235073B2 (en) * 2001-03-02 2007-02-01 T.A.C. Thrombosis And Coagulation Ab Protein C variants
DE60334983D1 (de) 2002-04-30 2010-12-30 Bayer Healthcare Llc Faktor vii oder faktor viia polypeptidvarianten
EP2085470B1 (fr) 2003-03-20 2012-05-16 Bayer HealthCare LLC Variants de FVII ou FVIIa
JP4915918B2 (ja) 2003-06-19 2012-04-11 バイエル ヘルスケア エルエルシー 第ＶＩＩ因子または第ＶＩＩａ因子のＧｌａドメイン変種

Also Published As

Publication number Publication date
NO893196D0 (no) 1989-08-08
IL91234A0 (en) 1990-03-19
KR900002795A (ko) 1990-03-23
FI893724L (fi) 1990-02-10
FI893724A0 (fi) 1989-08-07
FI893724A7 (fi) 1990-02-10
DK388789D0 (da) 1989-08-08
PT91391A (pt) 1990-03-08
EP0354504A2 (fr) 1990-02-14
DK388789A (da) 1990-02-10
AU3937289A (en) 1990-04-12
JPH0246296A (ja) 1990-02-15

Similar Documents

Publication Publication Date Title
JP4317976B2 (ja) 修飾されたプロテアーゼ切断部位を有するｘ因子類似体
EP0370036B1 (fr) FACTEUR VII/VIIa MODIFIE
KR100188302B1 (ko) 활성화피브린용해성과항-혈전성단백질
JP2799316B2 (ja) 雑種ヒトプロテインｃおよびその遺伝子工学的製法
EP0354504A2 (fr) Constructions des hybrides de la protéine C et procédé pour leur préparation
Paborsky et al. Purification of recombinant human tissue factor
DE3885419T2 (de) Für die direkte Expression von aktiviertem menschlichen Protein-C verwendbare Vektoren und Zusammensetzungen.
JP3404038B2 (ja) トロンビンの製造方法
AU732953B2 (en) Factor X deletion mutants and analogues thereof
NO176799B (no) DNA som koder for et polypeptid, rekombinant plasmid som koder for og kan uttrykke et polypeptid og fremgangsmåte for fremstilling av dette polypeptid
US5268275A (en) Vitamin K-dependent carboxylase
JP3121611B2 (ja) 神経成長因子を真核生物細胞において発現させるための遺伝子ベクター
NO307305B1 (no) Fremgangsmåter og materialer for ekspresjon av en variant av humant plasminogen
EP0437427A1 (fr) Dimeres clives de polypeptides semblables a substance d'inhibition mullerienne
WO2001010896A2 (fr) Analogue de facteur x a activation amelioree
JPH02167096A (ja) ヒトプロテインｃ変異体及びその製造方法
AU741798B2 (en) Recombinant protein C and protein S variants
JP2004527239A (ja) プロテインｃ変異体
AU674180B2 (en) Thrombin activatable plasminogen derivatives
WO1991012320A1 (fr) Proteine c activee a chaine legere tronquee
EP2633058B1 (fr) Procédé de production à grande échelle du facteur vii/viia
Norman et al. Stable expression, secretion, and characterization of active human renin in mammalian cells.
AU3064989A (en) Modified gene sequences encoding modified tpa and products therefrom
CA2078667A1 (fr) Vecteur d'expression de la proteine c humaine
KR20010022127A (ko) 상동 재조합에 의해 사람 세포에서 사람 변이 단백질을생성시키는 방법