NO893367L - Alfa-underenheten av mac-1 leukocytadhesjons-reseptoren. - Google Patents

Alfa-underenheten av mac-1 leukocytadhesjons-reseptoren.

Info

Publication number
NO893367L
NO893367L NO89893367A NO893367A NO893367L NO 893367 L NO893367 L NO 893367L NO 89893367 A NO89893367 A NO 89893367A NO 893367 A NO893367 A NO 893367A NO 893367 L NO893367 L NO 893367L
Authority
NO
Norway
Prior art keywords
mac
molecules
leukocyte adhesion
adhesion receptor
subunit
Prior art date
Application number
NO89893367A
Other languages
English (en)
Other versions
NO893367D0 (no
Inventor
Timothy Springer
Angel Corbi
Original Assignee
Dana Farber Cancer Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Inst Inc filed Critical Dana Farber Cancer Inst Inc
Publication of NO893367D0 publication Critical patent/NO893367D0/no
Publication of NO893367L publication Critical patent/NO893367L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2845—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546—Integrin superfamily
    • C07K14/70553—Integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Foreliggende oppfinnelse vedrører Mac-1 alfa-underenheten som inngår i den prosess, gjennom hvilken cellene gjenkjenner og vandrer til steder hvor det er en inflammasjon, og der fester seg til cellulære overflater under inflammasjonen. Oppfinnelsen vedrører slike molekyler, funksjonelle derivater av slike molekyler, forskjellige prøver for identifikasjon av slike molekyler og terapeutisk og diagnostisk anvendelse for slike molekyler.
NO89893367A 1988-08-23 1989-08-22 Alfa-underenheten av mac-1 leukocytadhesjons-reseptoren. NO893367L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23535388A 1988-08-23 1988-08-23
US32123989A 1989-03-09 1989-03-09

Publications (2)

Publication Number Publication Date
NO893367D0 NO893367D0 (no) 1989-08-22
NO893367L true NO893367L (no) 1990-02-26

Family

ID=26928829

Family Applications (1)

Application Number Title Priority Date Filing Date
NO89893367A NO893367L (no) 1988-08-23 1989-08-22 Alfa-underenheten av mac-1 leukocytadhesjons-reseptoren.

Country Status (13)

Country Link
US (3) US5849896A (no)
EP (1) EP0364690A3 (no)
JP (1) JPH0347077A (no)
KR (1) KR0185964B1 (no)
AU (1) AU638937B2 (no)
CA (1) CA1341293C (no)
DK (1) DK412489A (no)
FI (1) FI893917L (no)
HU (1) HU213014B (no)
IL (1) IL91370A (no)
NO (1) NO893367L (no)
NZ (1) NZ230397A (no)
PT (1) PT91502B (no)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0303692A4 (en) * 1987-02-26 1990-12-05 Dana Farber Cancer Institute Cloning of lfa-1
US5395929A (en) * 1987-12-15 1995-03-07 Dana Farber Cancer Institute Isolated nucleic acid encoding the alpha subunit of the human leukocyte adhesion receptor
US5877275A (en) * 1988-06-28 1999-03-02 The General Hospital Corporation Controlling cellular immune/inflammatory responses with β2 integrins
EP0364690A3 (en) 1988-08-23 1990-07-18 Dana Farber Cancer Institute The alpha-subunit of the mac-1 leukocyte adhesion receptor
US6051231A (en) * 1988-09-01 2000-04-18 Bayer Corporation Antiviral methods and prepations
US6143298A (en) * 1988-09-01 2000-11-07 Bayer Corporation Soluble truncated forms of ICAM-1
ZA896668B (en) * 1988-09-01 1990-06-27 Molecular Therapeutics Inc A human rhinovirus receptor protein that inhibits virus infectivity
US6514936B1 (en) 1988-09-01 2003-02-04 Bayer Corporation Antiviral methods using human rhinovirus receptor (ICAM-1)
JPH04505009A (ja) * 1989-03-09 1992-09-03 ダナ・ファーバー・キャンサー・インスティチュート クローニングｌｆａ―１
ZA901842B (en) * 1989-03-09 1990-12-28 Boehringer Ingelheim Pharma Use of intercellular adhesion molecules,and their binding ligans in the treatment of asthma
US5871733A (en) * 1990-07-20 1999-02-16 Bayer Corporation Multimeric forms of human rhinovirus receptor protein
US6107461A (en) * 1990-07-20 2000-08-22 Bayer Corporation Multimeric forms of human rhinovirus receptor and fragments thereof, and method of use
US5686581A (en) * 1990-07-20 1997-11-11 Bayer Corporation Multimeric form of human rhinovirus receptor protein
ES2134762T3 (es) * 1990-07-20 1999-10-16 Bayer Ag Formas multimericas de proteinas receptoras de rinovirus humanos.
CA2144738A1 (en) * 1992-10-09 1994-04-28 Michael Diamond A subpopulation of mac-1 (cd11b/cd18) molecules which mediate neutrophil adhesion to icam-1 and fibrinogen
JPH09512426A (ja) * 1994-04-26 1997-12-16 ファルマシア・アンド・アップジョン・カンパニー 好中球の接着および移動の遮断に有用なＭａｃ−１ Ｉ−ドメイン蛋白質
WO1996001644A1 (en) * 1994-07-11 1996-01-25 Athena Neurosciences, Inc. Inhibitors of leukocyte adhesion
US5696229A (en) * 1995-03-16 1997-12-09 The University Of Virginia Patent Foundation Polypeptide with laminin cell adhesion and morphogenesis activity
US6037454A (en) 1996-11-27 2000-03-14 Genentech, Inc. Humanized anti-CD11a antibodies
US7400477B2 (en) 1998-08-24 2008-07-15 Leviton Manufacturing Co., Inc. Method of distribution of a circuit interrupting device with reset lockout and reverse wiring protection
US6210897B1 (en) 1999-05-26 2001-04-03 Leif Andersson Identification of canine leukocyte adhesion deficiency in dogs
WO2001070266A2 (en) 2000-03-17 2001-09-27 Millennium Pharmaceuticals, Inc. Method of inhibiting stenosis and restenosis with a mixture of antibodies anti cd18 and anti ccr2
CA2417432C (en) 2000-09-01 2010-11-02 The Center For Blood Research, Inc. Modified polypeptides stabilized in a desired conformation and methods for producing same
US7372678B2 (en) * 2005-08-24 2008-05-13 Leviton Manufacturing Co., Inc. Circuit interrupting device with automatic test
US7852606B2 (en) * 2005-08-24 2010-12-14 Leviton Manufacturing Company, Inc. Self-testing circuit interrupting device
US7911746B2 (en) * 2006-06-01 2011-03-22 Leviton Manufacturing Co., Inc. GFCI with self-test and remote annunciation capabilities
US8603628B2 (en) * 2007-04-30 2013-12-10 Saint-Gobain Performance Plastics Corporation Turbine blade protective barrier
WO2009097469A1 (en) 2008-01-29 2009-08-06 Leviton Manufacturing Co., Inc. Self testing fault circuit interrupter apparatus and method
US9759758B2 (en) 2014-04-25 2017-09-12 Leviton Manufacturing Co., Inc. Ground fault detector

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4761371A (en) * 1985-02-12 1988-08-02 Genentech, Inc. Insulin receptor
US5424399A (en) * 1988-06-28 1995-06-13 The Children's Medical Center Corporation Human CR3α/β heterodimers
EP0364690A3 (en) 1988-08-23 1990-07-18 Dana Farber Cancer Institute The alpha-subunit of the mac-1 leukocyte adhesion receptor

Also Published As

Publication number Publication date
CA1341293C (en) 2001-09-18
FI893917A0 (fi) 1989-08-21
US20030013850A1 (en) 2003-01-16
US6683158B2 (en) 2004-01-27
FI893917A7 (fi) 1990-02-24
KR900002797A (ko) 1990-03-23
EP0364690A3 (en) 1990-07-18
DK412489D0 (da) 1989-08-22
PT91502A (pt) 1990-03-08
HUT54207A (en) 1991-01-28
AU4014489A (en) 1990-03-01
NO893367D0 (no) 1989-08-22
KR0185964B1 (ko) 1999-05-01
JPH0347077A (ja) 1991-02-28
AU638937B2 (en) 1993-07-15
HU213014B (en) 1997-01-28
NZ230397A (en) 1997-07-27
EP0364690A2 (en) 1990-04-25
US20020022595A1 (en) 2002-02-21
IL91370A0 (en) 1990-04-29
PT91502B (pt) 1995-05-04
FI893917L (fi) 1990-02-24
US5849896A (en) 1998-12-15
IL91370A (en) 1995-07-31
DK412489A (da) 1990-02-24

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