NO894547L - Fremgangsmaate for fremstilling av hydroksy-1,2,3,4-tetrahydroaminoakridiner, og deres anvendelse som medikamenter. - Google Patents

Fremgangsmaate for fremstilling av hydroksy-1,2,3,4-tetrahydroaminoakridiner, og deres anvendelse som medikamenter.

Info

Publication number: NO894547L
Authority: NO; Norway
Prior art keywords: hydroxy; loweralkyl; preparation; hydrogen; tetrahydroaminoacridines
Prior art date: 1988-11-16

Application number

NO89894547A

Other languages

English (en)

Norwegian (no)

Other versions

NO894547D0 (no

Inventor

Gregory Michael Shutske

John Dick Tomer Iv

Original Assignee

Hoechst Roussel Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-11-16

Filing date

1989-11-15

Publication date

1990-05-18

1989-11-15 Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma

1989-11-15 Publication of NO894547D0 publication Critical patent/NO894547D0/no

1990-05-18 Publication of NO894547L publication Critical patent/NO894547L/no

Links

238000000034 method Methods 0.000 title abstract 2
239000003814 drug Substances 0.000 title 1
150000002431 hydrogen Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
208000024827 Alzheimer disease Diseases 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
230000006949 cholinergic function Effects 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
230000003247 decreasing effect Effects 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000007074 memory dysfunction Effects 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
- C07D219/10—Nitrogen atoms attached in position 9
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
- C07D219/10—Nitrogen atoms attached in position 9
- C07D219/12—Amino-alkylamino radicals attached in position 9

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)
Saccharide Compounds (AREA)

NO89894547A 1988-11-16 1989-11-15 Fremgangsmaate for fremstilling av hydroksy-1,2,3,4-tetrahydroaminoakridiner, og deres anvendelse som medikamenter. NO894547L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US27178888A	1988-11-16	1988-11-16

Publications (2)

Publication Number	Publication Date
NO894547D0 NO894547D0 (no)	1989-11-15
NO894547L true NO894547L (no)	1990-05-18

Family

ID=23037088

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO89894547A NO894547L (no)	1988-11-16	1989-11-15	Fremgangsmaate for fremstilling av hydroksy-1,2,3,4-tetrahydroaminoakridiner, og deres anvendelse som medikamenter.

Country Status (15)

Country	Link
EP (1)	EP0369388B1 (de)
KR (1)	KR0156241B1 (de)
AT (1)	ATE89553T1 (de)
CA (1)	CA2003023C (de)
DE (1)	DE68906647T2 (de)
DK (1)	DK168290B1 (de)
ES (1)	ES2054987T3 (de)
FI (1)	FI90417C (de)
HU (2)	HU208674B (de)
IE (1)	IE63038B1 (de)
IL (1)	IL92307A0 (de)
NO (1)	NO894547L (de)
NZ (1)	NZ231376A (de)
PT (1)	PT92319B (de)
ZA (1)	ZA898720B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW200462B (de) *	1990-09-27	1993-02-21	Hoechst Roussel Pharma
GB2264707A (en) *	1991-06-18	1993-09-08	Roger Michael Marchbanks	Acridine derivatives for treating alzheimer's disease
US5466696A (en) *	1992-09-10	1995-11-14	Warner Lambert Company	Tacrine and cytochrome P450 oxidase inhibitors and methods of use
US5422350A (en) *	1992-09-10	1995-06-06	Warner-Lambert Company	Nitrogen substituted acridine and cytochrome P450 inhibitors and methods of use
WO2019207604A1 (en) *	2018-04-25	2019-10-31	Rajiv Gandhi Centre For Biotechnology	Tacrine derivatives targeting nmda receptor, acetylcholine esterase, butyryl choline and beta secretase activity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3582995D1 (de) *	1984-10-25	1991-07-04	Hoechst Roussel Pharma	9-amino-1,2,3,4-tetrahydroacridin-1-ol und verwandte verbindungen, verfahren zu ihrer herstellung und verwendung als arzneimittel.
IL85741A (en) *	1987-03-17	1996-05-14	Hoechst Roussel Pharma	Substituted tetrahydroacridines a process for their preparation and pharmaceutical compositions containing substituted alpha-amino-tetrahydroacridines

1989
- 1989-11-14 FI FI895416A patent/FI90417C/fi not_active IP Right Cessation
- 1989-11-14 DE DE89121037T patent/DE68906647T2/de not_active Expired - Fee Related
- 1989-11-14 ES ES89121037T patent/ES2054987T3/es not_active Expired - Lifetime
- 1989-11-14 IL IL92307A patent/IL92307A0/xx unknown
- 1989-11-14 NZ NZ231376A patent/NZ231376A/en unknown
- 1989-11-14 EP EP89121037A patent/EP0369388B1/de not_active Expired - Lifetime
- 1989-11-14 AT AT89121037T patent/ATE89553T1/de not_active IP Right Cessation
- 1989-11-14 KR KR1019890016456A patent/KR0156241B1/ko not_active Expired - Fee Related
- 1989-11-15 PT PT92319A patent/PT92319B/pt active IP Right Grant
- 1989-11-15 NO NO89894547A patent/NO894547L/no unknown
- 1989-11-15 CA CA002003023A patent/CA2003023C/en not_active Expired - Fee Related
- 1989-11-15 IE IE365989A patent/IE63038B1/en not_active IP Right Cessation
- 1989-11-15 ZA ZA898720A patent/ZA898720B/xx unknown
- 1989-11-15 DK DK571989A patent/DK168290B1/da not_active IP Right Cessation
- 1989-11-16 HU HU593189A patent/HU208674B/hu unknown
1995
- 1995-06-22 HU HU95P/P00336P patent/HU211701A9/hu unknown

Also Published As

Publication number	Publication date
HUT53087A (en)	1990-09-28
HU895931D0 (en)	1990-02-28
EP0369388A1 (de)	1990-05-23
DE68906647D1 (de)	1993-06-24
DK168290B1 (da)	1994-03-07
KR0156241B1 (ko)	1998-11-16
ZA898720B (en)	1990-08-29
DK571989D0 (da)	1989-11-15
KR900007809A (ko)	1990-06-02
IL92307A0 (en)	1990-07-26
NO894547D0 (no)	1989-11-15
FI90417B (fi)	1993-10-29
HU208674B (en)	1993-12-28
DK571989A (da)	1990-05-17
PT92319A (pt)	1990-05-31
ATE89553T1 (de)	1993-06-15
FI90417C (fi)	1994-02-10
PT92319B (pt)	1995-08-09
IE63038B1 (en)	1995-03-22
NZ231376A (en)	1992-05-26
FI895416A0 (fi)	1989-11-14
ES2054987T3 (es)	1994-08-16
CA2003023A1 (en)	1990-05-16
DE68906647T2 (de)	1993-10-07
HU211701A9 (en)	1995-12-28
CA2003023C (en)	2001-05-29
EP0369388B1 (de)	1993-05-19
IE893659L (en)	1990-05-16

Publication	Publication Date	Title
PH25571A (en)	1991-08-08	Alpha'-alkyl-4-amino-3-quinolinemethanols, 1-(4-aralkylamino-3-quinolinyl) alaknones, their use as medicaments
NO904209L (no)	1991-04-02	Fremgangsmaate for fremstilling av n-aminokarbamater relatert til fysostigmin, og deres anvendelse som medikamenter.
NO894445L (no)	1990-05-10	Fremgangsmaate for fremstilling av 1,2,3,4-tetrahydro-1,9-acridindiaminer, og deres anvendelse som medikamenter.
NO894547L (no)	1990-05-18	Fremgangsmaate for fremstilling av hydroksy-1,2,3,4-tetrahydroaminoakridiner, og deres anvendelse som medikamenter.
NO902813L (no)	1990-12-27	(1,2,3,4-tetrahydro-9-acridinimino)cykloheksankarboksylsyre og relaterte forbindelser, fremgangsmaate for fremstilling og anvendelse som medikamenter.
DK0401779T3 (da)	1995-10-16	4,5,5a,6-Tetrahydro-3H-isoazolo(5,4,3-kl)acridinderivater, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler
ES2033859T3 (es)	1993-04-01	Acidos y esteres 2-amino-3-aroil-gamma-oxobencenbutanoicos.