NO902099L - Analogifremgangsmaate for fremstilling av terapeutisk aktive arylsulfonamider. - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive arylsulfonamider.

Info

Publication number: NO902099L
Authority: NO; Norway
Prior art keywords: arylsulphonamides; thromboxane; preparation; therapeutic active; addition salts
Prior art date: 1989-05-12

Application number

NO90902099A

Other languages

English (en)

Other versions

NO176176B (no

NO902099D0 (no

NO176176C (no

Inventor

Armin Heckel

Josef Nickl

Rainer Soyka

Wolfgang Eisert

Thomas Mueller

Johannes Weisenberger

Christopher Meade

Gojko Muacevic

Original Assignee

Thomae Gmbh Dr K

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-12

Filing date

1990-05-11

Publication date

1990-11-13

1989-05-12 Priority claimed from DE3915506A external-priority patent/DE3915506A1/de

1990-05-11 Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K

1990-05-11 Publication of NO902099D0 publication Critical patent/NO902099D0/no

1990-11-13 Publication of NO902099L publication Critical patent/NO902099L/no

1994-11-07 Publication of NO176176B publication Critical patent/NO176176B/no

1995-02-15 Publication of NO176176C publication Critical patent/NO176176C/no

Links

230000001225 therapeutic effect Effects 0.000 title 1
RZWIIPASKMUIAC-VQTJNVASSA-N thromboxane Chemical compound CCCCCCCC[C@H]1OCCC[C@@H]1CCCCCCC RZWIIPASKMUIAC-VQTJNVASSA-N 0.000 abstract 3
230000000694 effects Effects 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
230000002785 anti-thrombosis Effects 0.000 abstract 1
125000004421 aryl sulphonamide group Chemical group 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
239000011203 carbon fibre reinforced carbon Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 abstract 1
229960002986 dinoprostone Drugs 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
150000007529 inorganic bases Chemical class 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
150000007530 organic bases Chemical class 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Pulmonology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Immunology (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)

NO902099A 1989-05-12 1990-05-11 Analogifremgangsmåte for fremstilling av terapeutisk aktive arylsulfonamider NO176176C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3915506A DE3915506A1 (de)	1989-05-12	1989-05-12	Neue arylsulfonamide, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3932403A DE3932403A1 (de)	1989-05-12	1989-09-28	Neue arylsulfonamide, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Publications (4)

Publication Number	Publication Date
NO902099D0 NO902099D0 (no)	1990-05-11
NO902099L true NO902099L (no)	1990-11-13
NO176176B NO176176B (no)	1994-11-07
NO176176C NO176176C (no)	1995-02-15

Family

ID=25880794

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO902099A NO176176C (no)	1989-05-12	1990-05-11	Analogifremgangsmåte for fremstilling av terapeutisk aktive arylsulfonamider

Country Status (21)

Country	Link
US (3)	US5294626A (no)
EP (1)	EP0397044B1 (no)
JP (1)	JP2868283B2 (no)
KR (1)	KR0153527B1 (no)
AT (1)	ATE132138T1 (no)
AU (1)	AU627024B2 (no)
CA (1)	CA2016646C (no)
DE (2)	DE3932403A1 (no)
DK (1)	DK0397044T3 (no)
ES (1)	ES2083394T3 (no)
FI (1)	FI95372C (no)
GR (1)	GR3019044T3 (no)
HU (1)	HU214586B (no)
IE (1)	IE74207B1 (no)
IL (1)	IL94347A0 (no)
MX (1)	MX9202816A (no)
NO (1)	NO176176C (no)
NZ (1)	NZ233638A (no)
PT (1)	PT93994B (no)
RU (1)	RU2096405C1 (no)
UA (1)	UA26136C2 (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5153214A (en) *	1989-06-28	1992-10-06	Ciba-Geigy Corporation	Certain (arylsulfonamido- and imidazolyl-)-substituted carboxylic acids and derivatives thereof and use for suppressing thromboxane activity
DE4025818A1 (de) *	1990-08-16	1992-02-20	Bayer Ag	Phenylsulfonamid substituierte pyridinalken- und -aminooxyalkancarbonsaeure-derivate
US5286736A (en) *	1990-11-22	1994-02-15	Dr. Karl Thomae Gmbh	Pyridyl compounds and pharmaceutical compositions containing these compounds
DE4037112A1 (de) *	1990-11-22	1992-05-27	Thomae Gmbh Dr K	Neue pyridylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5374641A (en) *	1991-02-25	1994-12-20	Terumo Kabushiki Kaisha	N-(3-pyridylalkyl)sulfonamide compounds which have useful pharmaceutical activity
GB9107043D0 (en) *	1991-04-04	1991-05-22	Pfizer Ltd	Therapeutic agents
DE4216364A1 (de) *	1991-12-14	1993-11-25	Thomae Gmbh Dr K	Neue Pyridylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
FR2686339B1 (fr) *	1992-01-22	1994-03-11	Adir Cie	Nouveaux amides et sulfonamides naphtaleniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
DE4213919A1 (de) *	1992-04-28	1993-11-04	Thomae Gmbh Dr K	Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
CA2347939C (en)	1998-10-23	2006-10-10	Akira Matsumori	Composition for the treatment of rheumatism, hepatitis or pancreatitis
YU78601A (sh) *	1999-05-05	2005-07-19	Aventis Pharma Deutschland Gmbh.	1-(p-tienilbenzil)-imidazoli kao agonisti angiotenzin-(1-7)- receptora, postupak za njihovu proizvodnju, njihova primena i farmaceutski preparati koji ih sadrže
EP2417101B1 (en) *	2009-04-09	2013-10-23	Merck Sharp & Dohme B.V.	Indane derivatives
KR101701943B1 (ko)	2009-11-13	2017-02-02	도레이 카부시키가이샤	당뇨병의 치료 또는 예방약
US9955802B2 (en)	2015-04-08	2018-05-01	Fasteners For Retail, Inc.	Divider with selectively securable track assembly

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1134828A (en) *	1978-12-28	1982-11-02	Tadao Tanouchi	Pyridine derivatives
EP0098690B1 (en) *	1982-06-14	1987-09-09	Takeda Chemical Industries, Ltd.	Vinyl carboxylic acid derivatives, their production and use
US4518602A (en) *	1982-10-07	1985-05-21	Takeda Chemical Industries, Ltd.	Vinyl carboxylic acid derivatives, their production and use as inhibitors of thromboxane synthetase
US4563446A (en) *	1983-07-27	1986-01-07	Takeda Chemical Industries, Ltd.	Thromboxane synthetase inhibiting 3-(1-alkenyl) pyridines
EP0219756B1 (de) *	1985-10-09	1994-01-05	Shell Internationale Researchmaatschappij B.V.	Neue Acrylsäureamide
DE3623944A1 (de) *	1986-07-16	1988-02-11	Thomae Gmbh Dr K	Neue benzolsulfonamido-indanylverbindungen, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
GB8708233D0 (en) *	1987-04-07	1987-05-13	Smith Kline French Lab	Pharmaceutically active compounds
KR890701095A (ko) *	1987-08-20	1989-12-19	원본미기재	생물학적 활성 화합물

1989
- 1989-09-28 DE DE3932403A patent/DE3932403A1/de not_active Withdrawn
1990
- 1990-05-04 AT AT90108433T patent/ATE132138T1/de not_active IP Right Cessation
- 1990-05-04 DK DK90108433.5T patent/DK0397044T3/da active
- 1990-05-04 ES ES90108433T patent/ES2083394T3/es not_active Expired - Lifetime
- 1990-05-04 EP EP90108433A patent/EP0397044B1/de not_active Expired - Lifetime
- 1990-05-04 DE DE59009994T patent/DE59009994D1/de not_active Expired - Fee Related
- 1990-05-10 IL IL94347A patent/IL94347A0/xx not_active IP Right Cessation
- 1990-05-10 NZ NZ233638A patent/NZ233638A/en unknown
- 1990-05-10 KR KR1019900006587A patent/KR0153527B1/ko not_active Expired - Fee Related
- 1990-05-10 PT PT93994A patent/PT93994B/pt not_active IP Right Cessation
- 1990-05-11 HU HU903013A patent/HU214586B/hu not_active IP Right Cessation
- 1990-05-11 IE IE170890A patent/IE74207B1/en not_active IP Right Cessation
- 1990-05-11 AU AU54924/90A patent/AU627024B2/en not_active Ceased
- 1990-05-11 JP JP2122825A patent/JP2868283B2/ja not_active Expired - Lifetime
- 1990-05-11 NO NO902099A patent/NO176176C/no not_active IP Right Cessation
- 1990-05-11 FI FI902358A patent/FI95372C/fi not_active IP Right Cessation
- 1990-05-11 CA CA002016646A patent/CA2016646C/en not_active Expired - Fee Related
- 1990-05-14 US US07/523,167 patent/US5294626A/en not_active Expired - Fee Related
1992
- 1992-01-08 RU SU925010477A patent/RU2096405C1/ru active
- 1992-06-12 MX MX9202816A patent/MX9202816A/es unknown
1993
- 1993-05-12 UA UA93002789A patent/UA26136C2/uk unknown
- 1993-11-18 US US08/154,647 patent/US5426119A/en not_active Expired - Fee Related
1995
- 1995-03-21 US US08/407,180 patent/US5681961A/en not_active Expired - Fee Related
1996
- 1996-02-21 GR GR960400447T patent/GR3019044T3/el unknown

Also Published As

Publication number	Publication date
MX9202816A (es)	1992-06-30
AU5492490A (en)	1990-11-15
JPH035457A (ja)	1991-01-11
NO176176B (no)	1994-11-07
US5294626A (en)	1994-03-15
DK0397044T3 (da)	1996-05-13
US5681961A (en)	1997-10-28
PT93994B (pt)	1997-04-30
FI95372C (fi)	1996-01-25
CA2016646C (en)	1999-09-07
JP2868283B2 (ja)	1999-03-10
HUT54649A (en)	1991-03-28
AU627024B2 (en)	1992-08-13
NZ233638A (en)	1992-03-26
ATE132138T1 (de)	1996-01-15
UA26136C2 (uk)	1999-06-07
HU214586B (hu)	1998-04-28
DE3932403A1 (de)	1991-04-11
IE901708A1 (en)	1991-06-19
FI95372B (fi)	1995-10-13
EP0397044B1 (de)	1995-12-27
DE59009994D1 (de)	1996-02-08
IL94347A0 (en)	1991-03-10
IE901708L (en)	1990-11-12
FI902358A0 (fi)	1990-05-11
KR900018031A (ko)	1990-12-20
HU903013D0 (en)	1990-09-28
EP0397044A2 (de)	1990-11-14
RU2096405C1 (ru)	1997-11-20
EP0397044A3 (de)	1991-10-16
KR0153527B1 (ko)	1998-11-16
NO902099D0 (no)	1990-05-11
GR3019044T3 (en)	1996-05-31
NO176176C (no)	1995-02-15
ES2083394T3 (es)	1996-04-16
US5426119A (en)	1995-06-20
CA2016646A1 (en)	1990-11-12
IE74207B1 (en)	1997-07-16
PT93994A (pt)	1991-01-08

Legal Events

Date	Code	Title	Description
2001-01-02	MM1K	Lapsed by not paying the annual fees	Free format text: LAPSED IN NOVEMBER 2000

Publication	Publication Date	Title
NO902099D0 (no)	1990-05-11	Analogifremgangsmaate for fremstilling av terapeutisk aktive arylsulfonamider.
FI961239A0 (fi)	1996-03-15	3-amino-5-karboksisubstituoituja piperidiinejä ja 3-amino-5-karboksisubstituoituja pyrrolidiinejä takykiniiantagonisteina
ATE301117T1 (de)	2005-08-15	Neue cyclopropane als cgrp-antagonisten, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
ATE181553T1 (de)	1999-07-15	Kondensierte thiazolverbindungen, ihre darstellung und ihre anwendung
EA200000996A1 (ru)	2001-06-25	Конденсированные с арилом азаполициклические соединения
NO914567D0 (no)	1991-11-21	Fremgangsmaate for fremstilling av terapeutisk aktive pyridylderivate
RU95110110A (ru)	1996-12-27	Производные бензофурана, способ их получения, фармкомпозиция и способ лечения
ATE445589T1 (de)	2009-10-15	Neue retinoidderivate und eine pharmazeutische anti-krebs-zusammensetzung, die diese verbindungen enthält
RU94038063A (ru)	1996-05-27	3-фенилуреидо-азепин-2-оны и -бензазепин-2-оны, способы их получения, промежуточные соединения, фармацевтические композиции и способы лечения
ATE100102T1 (de)	1994-01-15	Substituierte derivate von 20,21dinoreburnamenin, verfahren zur herstellung und so hergestellte zwischenprodukte, ihre verwendung als arzneimittel und diese enthaltende pharmazeutische zusammenstellungen.
DK0815109T3 (da)	2001-11-05	Fremgangsmåde til fremstilling af estere af anhydroecgonin
RU93045455A (ru)	1996-07-20	Производные пиперидина, способ их получения и фармацевтическая композиция на их основе