NO902318L - Fremgangsmaate for fremstilling av aminosubstituerte heterocykliske forbindelser. - Google Patents

Fremgangsmaate for fremstilling av aminosubstituerte heterocykliske forbindelser.

Info

Publication number: NO902318L
Authority: NO; Norway
Prior art keywords: amino; procedure; preparation; renin; substituted heterocyclic
Prior art date: 1989-05-26

Application number

NO90902318A

Other languages

English (en)

Norwegian (no)

Other versions

NO902318D0 (no

Inventor

Cleo Connolly

Annette Marian Doherty

Harriet Wall Hamilton

William Chester Patt

Ila Sircar

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-26

Filing date

1990-05-25

Publication date

1990-11-27

1990-05-25 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

1990-05-25 Publication of NO902318D0 publication Critical patent/NO902318D0/no

1990-11-27 Publication of NO902318L publication Critical patent/NO902318L/no

Links

206010020571 Hyperaldosteronism Diseases 0.000 abstract 2
206010020772 Hypertension Diseases 0.000 abstract 2
102100028255 Renin Human genes 0.000 abstract 2
108090000783 Renin Proteins 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
201000009395 primary hyperaldosteronism Diseases 0.000 abstract 2
206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
208000010412 Glaucoma Diseases 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
206010020460 Human T-cell lymphotropic virus type I infection Diseases 0.000 abstract 1
241000714260 Human T-lymphotropic virus 1 Species 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
241001430294 unidentified retrovirus Species 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/14—Angiotensins: Related peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Crystallography & Structural Chemistry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Ophthalmology & Optometry (AREA)
Virology (AREA)
Vascular Medicine (AREA)
Endocrinology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Thiazole And Isothizaole Compounds (AREA)
Pyridine Compounds (AREA)

NO90902318A 1989-05-26 1990-05-25 Fremgangsmaate for fremstilling av aminosubstituerte heterocykliske forbindelser. NO902318L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US35756189A	1989-05-26	1989-05-26
US07/511,271 US5238923A (en)	1989-05-26	1990-04-25	Amino-substituted heterocycles as renin inhibitors

Publications (2)

Publication Number	Publication Date
NO902318D0 NO902318D0 (no)	1990-05-25
NO902318L true NO902318L (no)	1990-11-27

Family

ID=26999702

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO90902318A NO902318L (no)	1989-05-26	1990-05-25	Fremgangsmaate for fremstilling av aminosubstituerte heterocykliske forbindelser.

Country Status (15)

Country	Link
US (3)	US5238923A (fr)
EP (1)	EP0399556B1 (fr)
JP (1)	JP2980129B2 (fr)
KR (1)	KR900018140A (fr)
AT (1)	ATE116331T1 (fr)
AU (1)	AU625354B2 (fr)
CA (1)	CA2017552A1 (fr)
DE (1)	DE69015437T2 (fr)
DK (1)	DK0399556T3 (fr)
ES (1)	ES2066905T3 (fr)
FI (1)	FI902557A7 (fr)
GR (1)	GR3015497T3 (fr)
NO (1)	NO902318L (fr)
NZ (1)	NZ233811A (fr)
PT (1)	PT94159A (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE68045B1 (en) *	1990-05-11	1996-05-15	Abbott Lab	Renin inhibitors
US5178877A (en) *	1991-01-04	1993-01-12	Abbott Laboratories	Encapsulated renin inhibitor composition
US5089616A (en) *	1991-04-23	1992-02-18	Warner-Lambert Company	Process for the preparation of [1S-(1R,2S,3R*)]-N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl-N-[(1-cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-alaninamide
US5220031A (en) *	1991-04-23	1993-06-15	Warner-Lambert Company	Process for the preparation of [1S-(1R,2S3R*)]-N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl-N-[(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-alaninamide
US5516784A (en) *	1991-08-13	1996-05-14	Schering Corporation	Anti-HIV (AIDS) agents
WO1993006127A1 (fr) *	1991-09-17	1993-04-01	Warner-Lambert Company	Nouveaux inhibiteurs de renine a base de promedicaments a acides amines
US6677360B2 (en) *	1998-12-16	2004-01-13	Bayer Aktiengesellschaft	Biphenyl and biphenyl-analogous compounds as integrin antagonists
US6420396B1 (en)	1998-12-16	2002-07-16	Beiersdorf Ag	Biphenyl and biphenyl-analogous compounds as integrin antagonists
AR039156A1 (es) *	2002-03-28	2005-02-09	Novartis Ag	Amidas del acido piperidinilamino sulfamico o piperazinil sulfamico y su uso para la manufactura de un medicamento en enfermedades mediadas por la accion de la sulfatasa esteroide

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4845079A (en) *	1985-01-23	1989-07-04	Luly Jay R	Peptidylaminodiols
CA1286846C (fr) *	1985-02-12	1991-07-23	Catherine Cazaubon	Derives peptidiques inhibant la renine et les proteases acides
HU200473B (en) *	1985-11-01	1990-06-28	Pfizer	Process for producing polypeptides containing difluorocyclostatine and pharmaceutical compositions comprising same
US4839357A (en) *	1987-10-02	1989-06-13	Merck & Co., Inc.	Renin inhibitors containing phenylalanyl-histidine replacements
US5063207A (en) *	1987-10-26	1991-11-05	Warner-Lambert Company	Renin inhibitors, method for using them, and compositions containing them
US5036053A (en) *	1988-05-27	1991-07-30	Warner-Lambert Company	Diol-containing renin inhibitors
US5178877A (en) *	1991-01-04	1993-01-12	Abbott Laboratories	Encapsulated renin inhibitor composition
US5219851A (en) *	1991-03-05	1993-06-15	Warner-Lambert Company	Tetrahydroisoquinoline-type renin inhibiting peptides
US5178887A (en) *	1991-04-10	1993-01-12	Ameron, Inc.	Compound fluted mold for casting prestressed concrete lamp poles

1990
- 1990-04-25 US US07/511,271 patent/US5238923A/en not_active Expired - Lifetime
- 1990-05-23 FI FI902557A patent/FI902557A7/fi not_active IP Right Cessation
- 1990-05-24 NZ NZ233811A patent/NZ233811A/en unknown
- 1990-05-24 AU AU55908/90A patent/AU625354B2/en not_active Ceased
- 1990-05-25 NO NO90902318A patent/NO902318L/no unknown
- 1990-05-25 AT AT90109990T patent/ATE116331T1/de not_active IP Right Cessation
- 1990-05-25 CA CA002017552A patent/CA2017552A1/fr not_active Abandoned
- 1990-05-25 DK DK90109990.3T patent/DK0399556T3/da active
- 1990-05-25 PT PT94159A patent/PT94159A/pt not_active Application Discontinuation
- 1990-05-25 KR KR1019900007732A patent/KR900018140A/ko not_active Withdrawn
- 1990-05-25 JP JP2134257A patent/JP2980129B2/ja not_active Expired - Fee Related
- 1990-05-25 ES ES90109990T patent/ES2066905T3/es not_active Expired - Lifetime
- 1990-05-25 DE DE69015437T patent/DE69015437T2/de not_active Expired - Fee Related
- 1990-05-25 EP EP90109990A patent/EP0399556B1/fr not_active Expired - Lifetime
1993
- 1993-03-26 US US08/038,728 patent/US5453488A/en not_active Expired - Fee Related
1995
- 1995-03-20 GR GR950400628T patent/GR3015497T3/el unknown
- 1995-05-15 US US08/440,585 patent/US5643879A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US5643879A (en)	1997-07-01
AU5590890A (en)	1990-11-29
KR900018140A (ko)	1990-12-20
DK0399556T3 (da)	1995-05-29
JP2980129B2 (ja)	1999-11-22
EP0399556A1 (fr)	1990-11-28
US5453488A (en)	1995-09-26
NO902318D0 (no)	1990-05-25
ATE116331T1 (de)	1995-01-15
US5238923A (en)	1993-08-24
NZ233811A (en)	1992-10-28
JPH0386870A (ja)	1991-04-11
FI902557A0 (fi)	1990-05-23
DE69015437D1 (de)	1995-02-09
DE69015437T2 (de)	1995-05-04
FI902557A7 (fi)	1990-11-27
CA2017552A1 (fr)	1990-11-26
PT94159A (pt)	1991-02-08
GR3015497T3 (en)	1995-06-30
ES2066905T3 (es)	1995-03-16
EP0399556B1 (fr)	1994-12-28
AU625354B2 (en)	1992-07-09

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AU577802B2 (en)	1988-10-06	Blood-pressure lowering piperazine derivatives
DE60226912D1 (de)	2008-07-10	Chinolin- und Chianzolinderivate zur Behandlung von Tumoren
DE69011318D1 (de)	1994-09-08	Diazinderivate als Angiotensin II Rezeptor Antagonisten.
SE8804586L (sv)	1988-12-20	1,4-dihydro-4-oxonaftyridinderivat och salter daerav foerfarande foer framstaellning av dessa jaemte antibakteriella medel innefattande dessa
AU625354B2 (en)	1992-07-09	Amino-substituted heterocycles as renin inhibitors
NO161564C (no)	1989-08-30	Analogifremgangsmaate ved fremstilling av terapeutisk aktive beta-carbolin-3-oxadiazolylderivater.
NO882239D0 (no)	1988-05-20	Fremgangsmaate for fremstilling av terapeutisk aktive cykliske peptider.
NO882238D0 (no)	1988-05-20	Fremgangsmaate for fremstilling av terapeutisk aktive cykliske peptider.
ES2033279T3 (es)	1993-03-16	Procedimiento para preparar un compuesto a base de quinolina.
DK147588D0 (da)	1988-03-17	Benzoxazinderivat samt fremgangsmaade til fremstilling deraf
NO891894L (no)	1989-11-13	Fremgangsmaate for fremstilling av antikoagulerende peptidalkoholer.
NO173991C (no)	1994-03-02	Analogifremgangsmaate til fremstilling av terapeutisk aktive 1,2,5-ditiazocin-derivater
ES2106439T3 (es)	1997-11-01	5-(piperazinilalquil)-1,5-benzotiazepinonas utiles como antagonistas de calcio.
NO164474C (no)	1990-10-10	Analogifremgangsmaate for fremstilling av terapeutisk aktive heksahydropyrrolo(2,1-a)isokinolin-derivater.
MX9703363A (es)	1998-02-28	Nuevos derivados de pirimidiniloxi- y pirimidinilamino etilfenil-dioxolano.
DE3880564D1 (de)	1993-06-03	Arzneimittel zur behandlung von herzinsuffizienz.
NO159927C (no)	1989-02-22	Analogifremgangsmaate for fremstilling av terapeutisk aktive aromatiske aminoacetylener.
DK0437645T3 (da)	1995-05-01	Imidazolylpropylguanidinderivat, fremgangsmåde til fremstilling deraf og lægemidler indeholdende denne forbindelse
DK46884D0 (da)	1984-02-02	5-aminomethyl-imidazol-1-yl-1,3-dialkyl-1h-pyrazol-4-yl-aroyl-methanoner,fremgangsmaade til deres fremstilling samt deres anvendelse
DK284080A (da)	1981-01-03	Fremgangsmaade til fremstilling af clavulansyrederivater