NO904067L - Fremgangsmaate for kjemisk opploesning av 5-alkoksy-substituert (+)-1,3-dimethyloxindolylethylaminer. - Google Patents

Fremgangsmaate for kjemisk opploesning av 5-alkoksy-substituert (+)-1,3-dimethyloxindolylethylaminer.

Info

Publication number: NO904067L
Authority: NO; Norway
Prior art keywords: tartaric acid; enantiomers; dimethyloxindolylethylamines; alcoxy; substituted
Prior art date: 1989-09-19

Application number

NO90904067A

Other languages

English (en)

Other versions

NO174252C (no

NO904067D0 (no

NO174252B (no

Inventor

Thomas Bing Kin Lee

George S K Wong

Original Assignee

Hoechst Roussel Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-09-19

Filing date

1990-09-18

Publication date

1991-03-20

1990-09-18 Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma

1990-09-18 Publication of NO904067D0 publication Critical patent/NO904067D0/no

1991-03-20 Publication of NO904067L publication Critical patent/NO904067L/no

1993-12-27 Publication of NO174252B publication Critical patent/NO174252B/no

1994-04-06 Publication of NO174252C publication Critical patent/NO174252C/no

Links

238000000034 method Methods 0.000 title abstract 3
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 4
239000002253 acid Substances 0.000 abstract 3
239000002244 precipitate Substances 0.000 abstract 3
YONLFQNRGZXBBF-ZIAGYGMSSA-N (2r,3r)-2,3-dibenzoyloxybutanedioic acid Chemical compound O([C@@H](C(=O)O)[C@@H](OC(=O)C=1C=CC=CC=1)C(O)=O)C(=O)C1=CC=CC=C1 YONLFQNRGZXBBF-ZIAGYGMSSA-N 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
WMJNKBXKYHXOHC-PMACEKPBSA-N (2S,3S)-2,3-dihydroxy-2,3-bis(2-methylbenzoyl)butanedioic acid Chemical compound C=1(C(=CC=CC1)C(=O)[C@]([C@](C(=O)O)(O)C(=O)C=1C(=CC=CC1)C)(O)C(=O)O)C WMJNKBXKYHXOHC-PMACEKPBSA-N 0.000 abstract 1
XEEBADQXIMNBQG-UHFFFAOYSA-N 3-(2-aminoethyl)-5-methoxy-1,3-dimethyl-2-indolone Chemical compound COC1=CC=C2N(C)C(=O)C(C)(CCN)C2=C1 XEEBADQXIMNBQG-UHFFFAOYSA-N 0.000 abstract 1
PIJVFDBKTWXHHD-UHFFFAOYSA-N Physostigmine Natural products C12=CC(OC(=O)NC)=CC=C2N(C)C2C1(C)CCN2C PIJVFDBKTWXHHD-UHFFFAOYSA-N 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
229960001270 d- tartaric acid Drugs 0.000 abstract 1
PIJVFDBKTWXHHD-HIFRSBDPSA-N physostigmine Chemical compound C12=CC(OC(=O)NC)=CC=C2N(C)[C@@H]2[C@@]1(C)CCN2C PIJVFDBKTWXHHD-HIFRSBDPSA-N 0.000 abstract 1
229960001697 physostigmine Drugs 0.000 abstract 1
150000003141 primary amines Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000000707 stereoselective effect Effects 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
150000003892 tartrate salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)

NO904067A 1989-09-19 1990-09-18 Fremgangsmåte for kjemisk opplösning av 5-alkoksy-substituert (+)-1,3-dimethyloxindolylethylaminer NO174252C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US40921389A	1989-09-19	1989-09-19

Publications (4)

Publication Number	Publication Date
NO904067D0 NO904067D0 (no)	1990-09-18
NO904067L true NO904067L (no)	1991-03-20
NO174252B NO174252B (no)	1993-12-27
NO174252C NO174252C (no)	1994-04-06

Family

ID=23619520

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO904067A NO174252C (no)	1989-09-19	1990-09-18	Fremgangsmåte for kjemisk opplösning av 5-alkoksy-substituert (+)-1,3-dimethyloxindolylethylaminer

Country Status (17)

Country	Link
US (1)	US5387695A (no)
EP (1)	EP0418770B1 (no)
JP (1)	JPH0757746B2 (no)
KR (1)	KR0165670B1 (no)
AT (1)	ATE125254T1 (no)
AU (1)	AU626458B2 (no)
CA (1)	CA2025593A1 (no)
DE (1)	DE69020989T2 (no)
DK (1)	DK0418770T3 (no)
ES (1)	ES2075102T3 (no)
FI (1)	FI95030C (no)
IE (1)	IE67640B1 (no)
IL (1)	IL95717A (no)
NO (1)	NO174252C (no)
NZ (1)	NZ235333A (no)
PT (1)	PT95340B (no)
ZA (1)	ZA907424B (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4914102A (en) *	1989-09-28	1990-04-03	Hoechst Roussel Pharmaceuticals, Inc.	N-aminocarbamates related to physostigmine, pharmacentical compositions and use
DK0438796T3 (da) *	1990-01-22	1999-05-25	Hoechst Marion Roussel Inc	Fremgangsmåde til enantioselektiv syntese af alkylerede oxindoler, som anvendes som mellemprodukter ved fremstilling af phy
US5840915A (en) *	1990-01-22	1998-11-24	Hoechst Marion Roussel, Inc.	Process for the enatioselective synthesis of intermediates used
US5521320A (en) *	1990-01-22	1996-05-28	Hoechst-Roussel Pharmaceuticals Incorporated	Process for the enantioselective synthesis of intermediates used in the preparation of physostigmine
US5665880A (en) *	1996-10-31	1997-09-09	Hoechst Marion Roussel, Inc.	Method of preparation of physostigmine carbamate derivatives from eseretholes
US5677457A (en) *	1996-12-19	1997-10-14	Hoechst Marion Roussel, Inc.	Method of preparation of physostigmine carbamate derivatives from eseroline ethers
JP6687596B2 (ja)	2015-02-17	2020-04-22	アモーレパシフィックコーポレーションＡｍｏｒｅｐａｃｉｆｉｃＣｏｒｐｏｒａｔｉｏｎ	Ｎ−［４−（１−アミノエチル）−フェニル］−スルホンアミド誘導体のキラル分割方法
CN116903633B (zh) *	2022-10-10	2025-11-18	福建医科大学	基于手性有机酸分离的高纯钩吻素子及其药学可接受盐的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4072698A (en) *	1976-12-02	1978-02-07	The Upjohn Company	Resolution of aminonitriles
US4914102A (en) *	1989-09-28	1990-04-03	Hoechst Roussel Pharmaceuticals, Inc.	N-aminocarbamates related to physostigmine, pharmacentical compositions and use
DK0438796T3 (da) *	1990-01-22	1999-05-25	Hoechst Marion Roussel Inc	Fremgangsmåde til enantioselektiv syntese af alkylerede oxindoler, som anvendes som mellemprodukter ved fremstilling af phy
US5274117A (en) *	1990-01-22	1993-12-28	Hoechst-Roussel Pharmaceuticals, Inc.	Process for the enantioselective synthesis of intermediates used in the preparation of physostigmine

1990
- 1990-09-15 ES ES90117821T patent/ES2075102T3/es not_active Expired - Lifetime
- 1990-09-15 EP EP90117821A patent/EP0418770B1/en not_active Expired - Lifetime
- 1990-09-15 AT AT90117821T patent/ATE125254T1/de not_active IP Right Cessation
- 1990-09-15 DE DE69020989T patent/DE69020989T2/de not_active Expired - Fee Related
- 1990-09-15 DK DK90117821.0T patent/DK0418770T3/da active
- 1990-09-17 NZ NZ235333A patent/NZ235333A/en unknown
- 1990-09-17 FI FI904562A patent/FI95030C/fi not_active IP Right Cessation
- 1990-09-17 IL IL9571790A patent/IL95717A/en not_active IP Right Cessation
- 1990-09-18 PT PT95340A patent/PT95340B/pt not_active IP Right Cessation
- 1990-09-18 ZA ZA907424A patent/ZA907424B/xx unknown
- 1990-09-18 AU AU62629/90A patent/AU626458B2/en not_active Ceased
- 1990-09-18 NO NO904067A patent/NO174252C/no not_active IP Right Cessation
- 1990-09-18 JP JP2246409A patent/JPH0757746B2/ja not_active Expired - Lifetime
- 1990-09-18 CA CA002025593A patent/CA2025593A1/en not_active Abandoned
- 1990-09-18 KR KR1019900014730A patent/KR0165670B1/ko not_active Expired - Fee Related
- 1990-09-18 IE IE337490A patent/IE67640B1/en not_active IP Right Cessation
1993
- 1993-02-17 US US08/022,605 patent/US5387695A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69020989D1 (de)	1995-08-24
NO174252C (no)	1994-04-06
DE69020989T2 (de)	1996-02-08
NZ235333A (en)	1992-03-26
US5387695A (en)	1995-02-07
IL95717A0 (en)	1991-06-30
CA2025593A1 (en)	1991-03-20
NO904067D0 (no)	1990-09-18
EP0418770A3 (en)	1991-11-27
FI95030B (fi)	1995-08-31
FI95030C (fi)	1995-12-11
JPH0757746B2 (ja)	1995-06-21
PT95340B (pt)	1997-06-30
ES2075102T3 (es)	1995-10-01
IE67640B1 (en)	1996-04-17
IL95717A (en)	1994-10-21
AU6262990A (en)	1991-03-28
ATE125254T1 (de)	1995-08-15
EP0418770A2 (en)	1991-03-27
IE903374A1 (en)	1991-04-10
FI904562A0 (fi)	1990-09-17
KR910006229A (ko)	1991-04-27
EP0418770B1 (en)	1995-07-19
AU626458B2 (en)	1992-07-30
DK0418770T3 (da)	1995-10-30
JPH03167172A (ja)	1991-07-19
KR0165670B1 (ko)	1999-01-15
NO174252B (no)	1993-12-27
ZA907424B (en)	1991-06-26
PT95340A (pt)	1991-05-22

Legal Events

Date	Code	Title	Description
2001-04-30	MM1K	Lapsed by not paying the annual fees	Free format text: LAPSED IN MARCH 2001

Publication	Publication Date	Title
CA2066640A1 (en)	1991-04-15	Heterocyclic compounds
DE69327567D1 (de)	2000-02-17	Verfahren zur Herstellung von Alanylglutamin
DE69026851D1 (de)	1996-06-13	Verfahren zur Erhöhung von Chemilumineszenz
NO904067D0 (no)	1990-09-18	Fremgangsmaate for kjemisk opploesning av 5-alkoksy-substituert (+)-1,3-dimethyloxindolylethylaminer.
HU904810D0 (en)	1991-06-28	Process for producing new 8-substituted 2-amino-tetralines
ATE127809T1 (de)	1995-09-15	Verfahren zur herstellung von verbindungen zur behandlung der gutartigen prostatahypertrophie.
KR850002269A (ko)	1985-05-10	피리도인돌 유도체의 제조방법
ATE49193T1 (de)	1990-01-15	Verfahren zur herstellung von (+)s-2-hydroxy-2methyl-hexans\|ure.
ATE546429T1 (de)	2012-03-15	Verfahren zur trennung von piperidylacetamid- stereoisomeren
DE3862006D1 (de)	1991-04-18	Verfahren zur herstellung von n-alkylierten aminosaeuren und deren estern, verwendung zur synthese von carboxyalkyldipeptiden.
DE69715846D1 (de)	2002-10-31	Optische auflösung von narwedin-ähnlichen verbindungen
DE3866148D1 (de)	1991-12-19	Chinolincarbonsaeure-derivate, diese enthaltende zusammensetzung, verfahren zu ihrer herstellung und ihre verwendung zur herstellung von medikamenten.
ATE60783T1 (de)	1991-02-15	Verfahren zur herstellung von 14-hydroxy- 6-0methyl-erythromycin a.
ATE233267T1 (de)	2003-03-15	Verfahren zur herstellung von 3- vinylcephalosporinen
DE3786770D1 (de)	1993-09-02	Stereokonvergentverfahren zur herstellung von optisch aktiven carbonsaeuren.
ATE118755T1 (de)	1995-03-15	Verfahren zur trennung von r und s-2, 2-r1,r2-1,3-dioxolan-4-carbonsäure.
ATE92481T1 (de)	1993-08-15	Verfahren zur herstellung von n,n'-bis-(2hydroxyethyl)-piperazin.
ATE205497T1 (de)	2001-09-15	Verfahren zur herstellung von 3-norcephem- verbindungen
DK560887A (da)	1988-05-04	Piperidin forbindelser, deres fremstilling og anvendelse
ATE63545T1 (de)	1991-06-15	Verfahren zur herstellung von isochinolinen.
ES8206464A1 (es)	1981-12-01	Procedimiento de preparacion de nuevos derivados de pirrol