NO915122L - N-substituerte cykloalkyl- og polycykloalkyl- alfa-substituerte trp-phe- og fenetylamin-derivater - Google Patents

N-substituerte cykloalkyl- og polycykloalkyl- alfa-substituerte trp-phe- og fenetylamin-derivater

Info

Publication number: NO915122L
Authority: NO; Norway
Prior art keywords: substituted; agents; treatment; phe; polycycloalcyl
Prior art date: 1989-06-29

Application number

NO91915122A

Other languages

English (en)

Other versions

NO301831B1 (no

NO915122D0 (no

Inventor

David Christopher Horwell

Martyn Clive Pritchard

Reginald Stewart Richardson

Edward Roberts

Julian Aranda

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-06-29

Filing date

1991-12-27

Publication date

1992-02-27

1991-12-27 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

1991-12-27 Publication of NO915122D0 publication Critical patent/NO915122D0/no

1992-02-27 Publication of NO915122L publication Critical patent/NO915122L/no

1997-12-15 Publication of NO301831B1 publication Critical patent/NO301831B1/no

Links

IMMPMHKLUUZKAZ-WMZOPIPTSA-N Trp-Phe Chemical class C([C@H](NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)N)C(O)=O)C1=CC=CC=C1 IMMPMHKLUUZKAZ-WMZOPIPTSA-N 0.000 title abstract 2
IMPPGHMHELILKG-UHFFFAOYSA-N 4-ethoxyaniline Chemical class CCOC1=CC=C(N)C=C1 IMPPGHMHELILKG-UHFFFAOYSA-N 0.000 title 1
239000003795 chemical substances by application Substances 0.000 abstract 2
230000001684 chronic effect Effects 0.000 abstract 2
ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 abstract 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
102100021022 Gastrin Human genes 0.000 abstract 1
108010052343 Gastrins Proteins 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
208000008589 Obesity Diseases 0.000 abstract 1
239000000164 antipsychotic agent Substances 0.000 abstract 1
229940005529 antipsychotics Drugs 0.000 abstract 1
239000003699 antiulcer agent Substances 0.000 abstract 1
239000002249 anxiolytic agent Substances 0.000 abstract 1
AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 abstract 1
229960003920 cocaine Drugs 0.000 abstract 1
230000001419 dependent effect Effects 0.000 abstract 1
AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 abstract 1
229960003529 diazepam Drugs 0.000 abstract 1
210000004211 gastric acid Anatomy 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
229960002715 nicotine Drugs 0.000 abstract 1
SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 abstract 1
235000020824 obesity Nutrition 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Biophysics (AREA)
Hematology (AREA)
Obesity (AREA)
Diabetes (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Child & Adolescent Psychology (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Indole Compounds (AREA)
Peptides Or Proteins (AREA)
Plural Heterocyclic Compounds (AREA)

NO915122A 1989-06-29 1991-12-27 N-substituerte cykloalkyl- og polycykloalkyl-<alfa>-substituerte Trp-Phe- og fenetylamin-derivater NO301831B1 (no)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US37432789A	1989-06-29	1989-06-29
US42248689A	1989-10-16	1989-10-16
US53081190A	1990-06-05	1990-06-05
PCT/US1990/003553 WO1991000274A1 (en)	1989-06-29	1990-06-28	N-substituted cycloalkyl and polycycloalkyl alpha-substituted trp-phe- and phenethylamine derivatives

Publications (3)

Publication Number	Publication Date
NO915122D0 NO915122D0 (no)	1991-12-27
NO915122L true NO915122L (no)	1992-02-27
NO301831B1 NO301831B1 (no)	1997-12-15

Family

ID=27409174

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO915122A NO301831B1 (no)	1989-06-29	1991-12-27	N-substituerte cykloalkyl- og polycykloalkyl-<alfa>-substituerte Trp-Phe- og fenetylamin-derivater

Country Status (17)

Country	Link
EP (2)	EP0479910A1 (no)
JP (1)	JP2972331B2 (no)
KR (2)	KR0167315B1 (no)
CN (1)	CN1049165A (no)
AT (1)	ATE275546T1 (no)
AU (1)	AU644088B2 (no)
CA (2)	CA2344707C (no)
DE (1)	DE69034162T2 (no)
DK (1)	DK0405537T3 (no)
ES (1)	ES2229202T3 (no)
FI (1)	FI106197B (no)
IE (1)	IE902347A1 (no)
IL (1)	IL94903A0 (no)
NO (1)	NO301831B1 (no)
NZ (1)	NZ234264A (no)
PT (1)	PT94543B (no)
WO (1)	WO1991000274A1 (no)

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US5162336A (en) *	1990-06-21	1992-11-10	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Tetrahydro-pyrido-indoles as cholecystokinin and gastrin antagonists
US5244915A (en) *	1990-08-31	1993-09-14	Warner-Lambert Company	Amico acid derivatives cyclized at the c-terminal
US5593967A (en) *	1990-08-31	1997-01-14	Warner-Lambert Company	Cholecystokinin antagonists, their preparation and therapeutic use
NZ239591A (en) *	1990-08-31	1994-07-26	Warner Lambert Co	Tryptophan derivatives and pharmaceutical compositions
US5340825A (en) *	1990-08-31	1994-08-23	Warner-Lambert Company	Pro drugs for CCK antagonists
CA2088195A1 (en) *	1990-08-31	1992-03-01	David C. Horwell	Cholecystokinin antagonists, their preparation and therapeutic use
US5264420A (en) *	1990-09-27	1993-11-23	Merck & Co., Inc.	Fibrinogen receptor antagonists
AU1907292A (en) *	1991-04-24	1992-12-21	Warner-Lambert Company	Alpha-substituted polypeptides having therapeutic activity
FI934894A0 (fi) *	1991-05-07	1993-11-05	Merck & Co Inc	Fibrinogenreceptorantagonister
JPH06509095A (ja) *	1991-07-12	1994-10-13	ワーナー−ランバート・コンパニー	パニック発作の治療に有用なコレシストキニン拮抗薬
US5153191A (en) *	1991-08-20	1992-10-06	Warner-Lambert Company	Cholecystokinin antagonists useful for treating depression
US5217957A (en) *	1991-08-20	1993-06-08	Warner-Lambert Company	Cholecystokinin antagonists useful for treating depression
US5389631A (en) *	1991-10-29	1995-02-14	Merck & Co., Inc.	Fibrinogen receptor antagonists
US5272158A (en) *	1991-10-29	1993-12-21	Merck & Co., Inc.	Fibrinogen receptor antagonists
DE4137490A1 (de) *	1991-11-14	1993-05-19	Goedecke Ag	Synthese von tricyclo(3.3.1.13,7)dec-2.yl(r-(r,r))-3- (1h-indol-3-yl-methyl)-3-methyl-4,9-dioxo- 7,11-diphenyl-10-oxa-2,5,8-triaza-undecanat
US6492531B1 (en)	1992-02-18	2002-12-10	Warner-Lambert Company	Method of treating cognitive disorders
US5514683A (en) *	1992-02-20	1996-05-07	James Black Foundation Limited	Bicyclo 2,2,2!octane derivatives
DE69310152D1 (en) *	1992-02-20	1997-05-28	Black James Foundation	Bicyclo[2.2.2.]oktan derivate als cholestocystokinin harnstoffe
GB9316722D0 (en) *	1993-08-12	1993-09-29	Black James Foundation	Bicyclo (2.2.2)octane derivatives
US5227490A (en) *	1992-02-21	1993-07-13	Merck & Co., Inc.	Fibrinogen receptor antagonists
EP0655053B1 (en) *	1992-06-19	1997-09-03	James Black Foundation Limited	Bicyclooctane and bicycloheptane derivatives
US5380872A (en) *	1992-07-14	1995-01-10	Glaxo Inc.	Modulators of cholecystokinin
US5922681A (en) *	1992-09-14	1999-07-13	Warner-Lambert Company	Endothelin antagonists
US5340798A (en) *	1992-10-14	1994-08-23	Merck & Co., Inc.	Fibrinogen receptor antagonists
JP3322878B2 (ja) *	1992-10-14	2002-09-09	メルクエンドカンパニーインコーポレーテッド	フィブリノーゲンレセプターアンタゴニスト
WO1994008962A1 (en) *	1992-10-14	1994-04-28	Merck & Co., Inc.	Fibrinogen receptor antagonists
US5358956A (en) *	1992-10-14	1994-10-25	Merck & Co., Inc.	Fibrinogen receptor antagonists
WO1994012181A1 (en) *	1992-12-01	1994-06-09	Merck & Co., Inc.	Fibrinogen receptor antagonists
FR2700540B1 (fr) *	1993-01-15	1995-02-17	Irj	alpha-méthyl-(R)-tryptophyl-arylcycloalkylalkylamides ligands aux récepteurs des gastrines, leur préparation et leur utilisation en thérapeutique.
US5441952A (en) *	1993-04-05	1995-08-15	Merck & Co., Inc.	Fibrinogen receptor antagonists
US5334596A (en) *	1993-05-11	1994-08-02	Merck & Co., Inc.	Fibrinogen receptor antagonists
US5397791A (en) *	1993-08-09	1995-03-14	Merck & Co., Inc.	Fibrinogen receptor antagonists
US5821241A (en) *	1994-02-22	1998-10-13	Merck & Co., Inc.	Fibrinogen receptor antagonists
WO1995032949A1 (en) *	1994-05-27	1995-12-07	James Black Foundation Limited	Gastrin and cck antagonists
US5719144A (en) *	1995-02-22	1998-02-17	Merck & Co., Inc.	Fibrinogen receptor antagonists
US5852045A (en) *	1995-10-19	1998-12-22	Merck & Co., Inc.	Fibrinogen receptor antagonists
US5789421A (en) *	1995-10-26	1998-08-04	Merck & Co., Inc.	Fibrinogen receptor antagonist
US5780480A (en) *	1996-02-28	1998-07-14	Merck & Co., Inc.	Fibrinogen receptor antagonists
US5889023A (en) *	1996-05-10	1999-03-30	Merck & Co., Inc.	Fibrinogen receptor antagonist
US5981584A (en) *	1997-02-06	1999-11-09	Merck & Co., Inc.	Fibrinogen receptor antagonist prodrugs
RU2227144C2 (ru) *	2001-11-15	2004-04-20	Научно-исследовательский институт фармакологии РАМН	Замещенные триптофансодержащие дипептиды с холецистокининонегативной или холецистокининопозитивной активностью
US7375093B2 (en)	2002-07-05	2008-05-20	Intrexon Corporation	Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US20100222316A1 (en)	2004-04-29	2010-09-02	Abbott Laboratories	Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US8415354B2 (en)	2004-04-29	2013-04-09	Abbott Laboratories	Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US7880001B2 (en)	2004-04-29	2011-02-01	Abbott Laboratories	Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
KR101302627B1 (ko)	2005-01-05	2013-09-10	아비에 인코포레이티드	11-베타-하이드록시스테로이드 데하이드로게나제 타입 1 효소의 억제제
US8198331B2 (en)	2005-01-05	2012-06-12	Abbott Laboratories	Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US20090192198A1 (en)	2005-01-05	2009-07-30	Abbott Laboratories	Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
KR101496190B1 (ko)	2005-01-05	2015-02-26	애브비 인코포레이티드	11-베타-하이드록시스테로이드 데하이드로게나제 타입 1 효소의 억제제로서의 아다만틸 유도체
JP5736098B2 (ja)	2007-08-21	2015-06-17	アッヴィ・インコーポレイテッド	中枢神経系障害を治療するための医薬組成物
US10500194B2 (en) *	2017-04-10	2019-12-10	The Regents Of The University Of Michigan	Covalent small molecule DCN1 inhibitors and therapeutic methods using the same

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JP5614660B2 (ja)	2012-07-19	2014-10-29	株式会社デンソー	燃料性状センサ

1990
- 1990-06-27 NZ NZ234264A patent/NZ234264A/xx unknown
- 1990-06-28 KR KR1019910702001A patent/KR0167315B1/ko not_active Expired - Fee Related
- 1990-06-28 JP JP2510126A patent/JP2972331B2/ja not_active Expired - Fee Related
- 1990-06-28 IL IL94903A patent/IL94903A0/xx unknown
- 1990-06-28 EP EP90911185A patent/EP0479910A1/en active Pending
- 1990-06-28 AT AT90112333T patent/ATE275546T1/de not_active IP Right Cessation
- 1990-06-28 CA CA002344707A patent/CA2344707C/en not_active Expired - Fee Related
- 1990-06-28 AU AU59628/90A patent/AU644088B2/en not_active Ceased
- 1990-06-28 DE DE69034162T patent/DE69034162T2/de not_active Expired - Fee Related
- 1990-06-28 CA CA002060652A patent/CA2060652C/en not_active Expired - Fee Related
- 1990-06-28 IE IE234790A patent/IE902347A1/en unknown
- 1990-06-28 DK DK90112333T patent/DK0405537T3/da active
- 1990-06-28 EP EP90112333A patent/EP0405537B1/en not_active Expired - Lifetime
- 1990-06-28 WO PCT/US1990/003553 patent/WO1991000274A1/en not_active Ceased
- 1990-06-28 ES ES90112333T patent/ES2229202T3/es not_active Expired - Lifetime
- 1990-06-29 CN CN90106804A patent/CN1049165A/zh active Pending
- 1990-06-29 PT PT94543A patent/PT94543B/pt not_active IP Right Cessation
1991
- 1991-12-20 FI FI916060A patent/FI106197B/fi not_active IP Right Cessation
- 1991-12-27 NO NO915122A patent/NO301831B1/no not_active IP Right Cessation
1998
- 1998-06-26 KR KR1019980704957A patent/KR0180539B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0405537A1 (en)	1991-01-02
IE902347A1 (en)	1991-01-16
NZ234264A (en)	1993-05-26
ATE275546T1 (de)	2004-09-15
IL94903A0 (en)	1991-04-15
PT94543A (pt)	1991-03-20
CN1049165A (zh)	1991-02-13
CA2344707A1 (en)	1991-01-10
CA2060652C (en)	2001-08-21
KR920702678A (ko)	1992-10-06
DE69034162D1 (de)	2004-10-14
KR0167315B1 (ko)	1999-01-15
CA2344707C (en)	2002-07-30
EP0405537B1 (en)	2004-09-08
AU5962890A (en)	1991-01-17
PT94543B (pt)	1997-04-30
EP0479910A1 (en)	1992-04-15
NO301831B1 (no)	1997-12-15
FI916060A0 (fi)	1991-12-20
JPH04506079A (ja)	1992-10-22
WO1991000274A1 (en)	1991-01-10
JP2972331B2 (ja)	1999-11-08
FI106197B (fi)	2000-12-15
AU644088B2 (en)	1993-12-02
NO915122D0 (no)	1991-12-27
IE902347L (en)	1990-12-29
ES2229202T3 (es)	2005-04-16
DE69034162T2 (de)	2005-09-22
DK0405537T3 (da)	2005-01-10
KR0180539B1 (en)	1999-05-01
CA2060652A1 (en)	1990-12-30

Legal Events

Date	Code	Title	Description
2005-04-25	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO915122D0 (no)	1991-12-27	N-substituerte cykloalkyl- og polycykloalkyl- alfa-substituerte trp-phe- og fenetylamin-derivater
DK0975595T3 (da)	2009-10-19	Kokainanaloger
EP0285008A3 (en)	1990-06-06	The use of buspirone for preparing a pharmaceutical composition for the treatment of alcohol abuse
NO157145C (no)	1988-01-27	Analogifremgangsmaate til fremstilling av terapeutisk aktive n-glykosylerte karboksylsyreamidderivater.
DK0546108T3 (da)	2002-02-18	Pro-drugs for CCK-antagonister
EP0315591A3 (en)	1990-05-16	Physiologically active substances, a process for the preparation thereof and pharmaceutical compositions containing them
UA45942A (uk)	2002-05-15	1,3-оксатіолан, його похідні, спосіб (варіанти) його одержання та фармацевтична композиція
EP0270093A3 (en)	1989-12-27	Lactam derivatives, processes for the preparation thereof, pharmaceutical compositions comprising the same, and the use of such derivatives for the manufacture of a medicament having valuable therapeutic properties
FR2655043B1 (fr)	1992-02-07	Nouveaux derives du thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant.
KR890012942A (ko)	1989-09-20	5-치환된 오르니틴 유도체
NO891071L (no)	1989-09-15	Fremgangsmaate for fremstilling av 4,5,6,7-tetrahydro-isotiazolo(4,5-c)-pyridinderivater og isomere.
ES2126577T3 (es)	1999-04-01	Analogos alquilidenicos de 1'-aminoespiro(isoquinolino-4(1h),3'-pirrolidino)-1,2',3,5'(2h)-tetronas utiles como inhibidores de la aldosa reductasa in vivo.
OA09451A (fr)	1992-10-15	"Nouveaux dérivés de la pyrrolidone, leur procédé de préparation et les compositions pharmaceutiques les renfermant".
RU92016209A (ru)	1996-03-20	Бензофуранилимидазольные производные, способ их получения и терапевтические композиции, содержащие названные производные
KR940021524A (ko)	1994-10-19	1,2,5,6-테트라하이드로피리딘 유도체와 이의 제조 방법 및 치료시 이의 이용방법
EP0369776A3 (en)	1991-03-13	Use of a composition containing organic germanium for the manufacture of a medicament for treating AIDS
SE8201308D0 (sv)	1982-03-03	Alkylendiaminderivat och forfarande for framstellning derav
FR2381761A1 (fr)	1978-09-22	Nouveaux derives de 1-piperidine-butanol utiles comme medicaments et procedes pour leur preparation
EP0253166A3 (de)	1988-05-25	Neue 1,4-Piperazinderivate, Verfahren zu ihrer Herstellung, ihre Verwendung und diese enthaltendes Arzneimittel
DK0437645T3 (da)	1995-05-01	Imidazolylpropylguanidinderivat, fremgangsmåde til fremstilling deraf og lægemidler indeholdende denne forbindelse
KR890002016A (ko)	1989-04-07	피리딘 유도체