NO920283L - Polyamintioler som radiobeskyttende midler - Google Patents

Polyamintioler som radiobeskyttende midler

Info

Publication number
NO920283L
NO920283L NO92920283A NO920283A NO920283L NO 920283 L NO920283 L NO 920283L NO 92920283 A NO92920283 A NO 92920283A NO 920283 A NO920283 A NO 920283A NO 920283 L NO920283 L NO 920283L
Authority
NO
Norway
Prior art keywords
spo3h2
polyamintiols
integer
protective agents
radio protective
Prior art date
Application number
NO92920283A
Other languages
English (en)
Other versions
NO179003B (no
NO179003C (no
NO920283D0 (no
Inventor
Michael Louis Edwards
Ronald Duayne Snyder
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of NO920283D0 publication Critical patent/NO920283D0/no
Publication of NO920283L publication Critical patent/NO920283L/no
Publication of NO179003B publication Critical patent/NO179003B/no
Publication of NO179003C publication Critical patent/NO179003C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/33—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring
    • C07C323/34—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring the thio group being a mercapto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
    • C07F9/165—Esters of thiophosphoric acids
    • C07F9/1651—Esters of thiophosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Polyethers (AREA)
  • Materials For Medical Uses (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Display Devices Of Pinball Game Machines (AREA)
  • Coating Of Shaped Articles Made Of Macromolecular Substances (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
NO920283A 1991-01-23 1992-01-22 Polyaminthioler som radiobeskyttende midler, og farmasöytisk preparat inneholdende disse NO179003C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/644,810 US5217964A (en) 1991-01-23 1991-01-23 Polyamine thiols as radioprotective agents

Publications (4)

Publication Number Publication Date
NO920283D0 NO920283D0 (no) 1992-01-22
NO920283L true NO920283L (no) 1992-07-24
NO179003B NO179003B (no) 1996-04-09
NO179003C NO179003C (no) 1996-07-17

Family

ID=24586432

Family Applications (1)

Application Number Title Priority Date Filing Date
NO920283A NO179003C (no) 1991-01-23 1992-01-22 Polyaminthioler som radiobeskyttende midler, og farmasöytisk preparat inneholdende disse

Country Status (16)

Country Link
US (1) US5217964A (no)
EP (1) EP0497202B1 (no)
JP (1) JP3203582B2 (no)
KR (1) KR100195420B1 (no)
AT (1) ATE127785T1 (no)
AU (1) AU647570B2 (no)
CA (1) CA2059817C (no)
DE (1) DE69204698T2 (no)
ES (1) ES2079695T3 (no)
FI (1) FI111251B (no)
IE (1) IE67961B1 (no)
IL (1) IL100698A (no)
NO (1) NO179003C (no)
NZ (1) NZ241347A (no)
PT (1) PT100045B (no)
ZA (1) ZA92360B (no)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5342945A (en) * 1986-12-02 1994-08-30 University Of Florida Research Foundation, Inc. Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
US5677351A (en) * 1986-12-02 1997-10-14 University Of Florida Research Foundation, Inc. Sterically hindered tetraamines and method for their production
US5393757A (en) * 1986-12-02 1995-02-28 University Of Florida Polyamines and anti-diarrheal and gastrointestinal anti-spasmodic pharmaceutical compositions and methods of treatment
US5354782A (en) * 1991-01-17 1994-10-11 Merrell Dow Pharmaceuticals Inc. Polyamine phenols as radioprotective agents
US5488042A (en) * 1992-03-13 1996-01-30 Arch Development Corporation Method for protection against genotoxic mutagenesis
EP0686142B1 (en) * 1993-02-23 1998-12-30 Merrell Pharmaceuticals Inc. Polyamine derivatives as radioprotective agents
DE69411271T2 (de) * 1993-05-26 1998-11-05 Merrell Pharma Inc N-alkylthiopolyaminderivate als radioprotektive mittel
US5994409A (en) * 1997-12-09 1999-11-30 U.S. Bioscience, Inc. Methods for treatment of neuro--and nephro--disorders and therapeutic toxicities using aminothiol compounds
IL146127A0 (en) 1999-04-30 2002-07-25 Slil Biomedical Corp Conformationally restricted polymine analogs as disease therapies
US7312244B2 (en) * 1999-04-30 2007-12-25 Cellgate, Inc. Polyamine analog-amino acid conjugates useful as anticancer agents
WO2000066175A2 (en) * 1999-04-30 2000-11-09 Slil Biomedical Corporation Conjugates as therapies for cancer and prostate diseases
US6482943B1 (en) 1999-04-30 2002-11-19 Slil Biomedical Corporation Quinones as disease therapies
US6649587B1 (en) 1999-04-30 2003-11-18 Slil Biomedical Corporation Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
US6489312B1 (en) 1999-06-15 2002-12-03 Medimmune Oncology, Inc. Pharmaceutical formulations comprising aminoalkyl phosphorothioates
JP2004515453A (ja) * 2000-05-05 2004-05-27 ウィスコンシン・アルムナイ・リサーチ・ファウンデーション 癌を化学療法および放射線療法に付する間に細胞を保護するための組成物および方法
US7053072B2 (en) 2001-05-11 2006-05-30 Medimmune Oncology, Inc. Methods for the administration of amifostine and related compounds
WO2003013245A1 (en) * 2001-08-07 2003-02-20 Wisconsin Alumni Research Foundation Polyamines and analogs for protecting cells during cancer chemotherapy and radiotherapy
US6982351B2 (en) * 2001-12-07 2006-01-03 Cellgate, Inc. Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor
WO2003066572A1 (en) * 2002-02-07 2003-08-14 Wisconsin Alumni Research Foundation Polyamine compounds and compositions for use in conjunction with cancer therapy
US7314959B2 (en) * 2003-08-07 2008-01-01 Wisconsin Alumni Research Foundation Amino thiol compounds and compositions for use in conjunction with cancer therapy
US7754463B2 (en) * 2006-06-20 2010-07-13 Dana-Farber Cancer Institute Inhibitors of USP1 Deubiquitinating Enzyme Complex
US9518032B2 (en) 2010-04-30 2016-12-13 Dana-Farber Cancer Institute, Inc. Small molecule inhibitors of USP1 deubiquitinating enzyme activity
US9725425B1 (en) 2014-02-25 2017-08-08 Dana-Farber Cancer Institute, Inc. Compounds and methods for treating cancer
TWM528362U (zh) * 2016-04-15 2016-09-11 Calendar Entpr Co Ltd 無繩式電動節能捲簾結構改良

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2901503A (en) * 1956-08-28 1959-08-25 Campbell Pharmaceuticals Inc Dialkylaminophenyl esters of thiophosphoric acids
US3368972A (en) * 1965-01-06 1968-02-13 Mobil Oil Corp High molecular weight mannich bases as engine oil additives
ZA88600B (en) * 1987-02-03 1988-07-28 Merrell Dow Pharmaceuticals Inc. Novel polyamine derivatives
ZA887410B (en) * 1987-10-08 1989-06-28 Merrell Dow Pharma Polyamine derivatives as antineoplastic agents

Also Published As

Publication number Publication date
KR920014772A (ko) 1992-08-25
PT100045A (pt) 1993-03-31
CA2059817C (en) 2003-07-15
FI920271L (fi) 1992-07-24
NO179003B (no) 1996-04-09
JP3203582B2 (ja) 2001-08-27
IE67961B1 (en) 1996-05-15
DE69204698D1 (de) 1995-10-19
IE920189A1 (en) 1992-07-29
CA2059817A1 (en) 1992-07-24
AU1030492A (en) 1992-07-30
DE69204698T2 (de) 1996-02-15
NZ241347A (en) 1994-04-27
KR100195420B1 (ko) 1999-06-15
EP0497202A1 (en) 1992-08-05
EP0497202B1 (en) 1995-09-13
ATE127785T1 (de) 1995-09-15
IL100698A (en) 1998-08-16
AU647570B2 (en) 1994-03-24
PT100045B (pt) 1999-10-29
FI920271A0 (fi) 1992-01-22
IL100698A0 (en) 1992-09-06
US5217964A (en) 1993-06-08
JPH04334362A (ja) 1992-11-20
NO179003C (no) 1996-07-17
ZA92360B (en) 1992-11-25
FI111251B (fi) 2003-06-30
NO920283D0 (no) 1992-01-22
ES2079695T3 (es) 1996-01-16

Similar Documents

Publication Publication Date Title
FI920271A0 (fi) Polyamintioler som straolningsskyddande aemnen.
EP1424330A4 (en) ACTIVATOR FOR THE PEROXISOME PROLIFERATOR RESPONSIVE RECEPTOR DELTA
DK1385514T3 (da) Spiroinden- og spiroindanforbindelser
ZA200309887B (en) Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents.
ATE343367T1 (de) Photostabile organische sonnenschutzmittel mit antioxidativen eigenschaften und zusammensetzungen damit
GR3036455T3 (en) Atherosclerosis treatment
CA2161869A1 (en) N-alkylthio polyamine derivatives as radioprotective agents
PT1975164E (pt) Compostos de octa-hidrobenzimidazolona utilizados como analgésicos
NO20004092D0 (no) Cyklisk amidforbindelse
NO902336D0 (no) Antispasmotiske midler.
DK0807627T3 (da) Anilidforbindelser som ACAT-inhibitorer
DE60101639D1 (de) Ein (1'R,2'S,5'R)-3-l-Menthoxypropan-1-ol, das eine kühlende Empfindung erzeugt
ATE154598T1 (de) Carbamate des indan-pyrrolidins
TW374693B (en) Fungicidal mixtures
DE69801554D1 (de) Di(meth)acrylate
NZ235577A (en) 4'-vinylhalo-inosine/guanosine derivatives and pharmaceutical compositions thereof