NO922636L - Fremgangsmaate for fremstilling av 2,4-dihydro-2-alkyl-3-okso-2h-(1)benzotieno-(3,2-e)-1,2-tiazin-1,1-dioksyder - Google Patents
Fremgangsmaate for fremstilling av 2,4-dihydro-2-alkyl-3-okso-2h-(1)benzotieno-(3,2-e)-1,2-tiazin-1,1-dioksyderInfo
- Publication number
- NO922636L NO922636L NO92922636A NO922636A NO922636L NO 922636 L NO922636 L NO 922636L NO 92922636 A NO92922636 A NO 92922636A NO 922636 A NO922636 A NO 922636A NO 922636 L NO922636 L NO 922636L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- benzotieno
- thiazine
- dihydro
- oxo
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- MJPPGVVIDGQOQT-UHFFFAOYSA-N 2-bromo-5-(2-bromo-2-nitroethenyl)furan Chemical compound [O-][N+](=O)C(Br)=CC1=CC=C(Br)O1 MJPPGVVIDGQOQT-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Hydrogenated Pyridines (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Fremgangsmåte for fremstilling av en forbindelse med formelen O VI hvor R1 er hydrogen, halogen eller GI til C4 alkyl, og R2 er hydrogen eller C til C. alkyl, ved cyklodehydratisering av en forbindelse med formelen ¿>" SO,NKR' hvor R1 og R2 er som angitt ovenfor. De fremstilte forbindelser er egnet som mellomprodukter ved fremstilling av terapeutisk aktive 3,4-dihydro-2-alkyl-3-okso-N-aryl-2H- [l]benzotieno[3,2-e]-l,2-tiazin-4-karboksamid-l,1-dioksyder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO922636A NO922636D0 (no) | 1987-06-10 | 1992-07-03 | Fremgangsmaate for fremstilling av 2,4-dihydro-2-alkyl-3-okso-2h-(1)benzotieno-(3,2-e)-1,2-tiazin-1,1-dioksyder |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1987/001357 WO1988009793A1 (en) | 1987-06-10 | 1987-06-10 | 3,4-DIHYDRO-2-ALKYL-3-OXO-N-ARYL-2H-[1]BENZOTHIENO[3,2-e]-1,2-THIAZINE-4-CARBOXAMIDE-1,1-DIOXIDES |
| NO890531A NO176277C (no) | 1987-06-10 | 1989-02-08 | Analogifremgangsmåte for fremstilling av terapeutisk aktive 3,4-dihydro-2-alkyl-3-okso-N-aryl-2H-[1Åbenzotieno[3,2-eÅ-1,2-tiazin-4-karboksamid-1,1-dioksyder |
| NO922636A NO922636D0 (no) | 1987-06-10 | 1992-07-03 | Fremgangsmaate for fremstilling av 2,4-dihydro-2-alkyl-3-okso-2h-(1)benzotieno-(3,2-e)-1,2-tiazin-1,1-dioksyder |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO922636L true NO922636L (no) | 1989-02-08 |
| NO922636D0 NO922636D0 (no) | 1992-07-03 |
Family
ID=55448100
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO890531A NO176277C (no) | 1987-06-10 | 1989-02-08 | Analogifremgangsmåte for fremstilling av terapeutisk aktive 3,4-dihydro-2-alkyl-3-okso-N-aryl-2H-[1Åbenzotieno[3,2-eÅ-1,2-tiazin-4-karboksamid-1,1-dioksyder |
| NO922636A NO922636D0 (no) | 1987-06-10 | 1992-07-03 | Fremgangsmaate for fremstilling av 2,4-dihydro-2-alkyl-3-okso-2h-(1)benzotieno-(3,2-e)-1,2-tiazin-1,1-dioksyder |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO890531A NO176277C (no) | 1987-06-10 | 1989-02-08 | Analogifremgangsmåte for fremstilling av terapeutisk aktive 3,4-dihydro-2-alkyl-3-okso-N-aryl-2H-[1Åbenzotieno[3,2-eÅ-1,2-tiazin-4-karboksamid-1,1-dioksyder |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US4914101A (no) |
| EP (1) | EP0294994B1 (no) |
| JP (1) | JPH078874B2 (no) |
| KR (1) | KR900006758B1 (no) |
| CN (1) | CN1019576B (no) |
| AT (1) | ATE105561T1 (no) |
| AU (1) | AU593743B2 (no) |
| CA (1) | CA1300625C (no) |
| CZ (1) | CZ281857B6 (no) |
| DD (1) | DD281602A5 (no) |
| DE (1) | DE3889497T2 (no) |
| DK (1) | DK313388A (no) |
| EG (1) | EG18525A (no) |
| ES (1) | ES2051846T3 (no) |
| FI (1) | FI89802C (no) |
| HU (1) | HU203762B (no) |
| IE (1) | IE63214B1 (no) |
| IL (1) | IL86602A (no) |
| MX (1) | MX174093B (no) |
| MY (1) | MY103572A (no) |
| NO (2) | NO176277C (no) |
| NZ (1) | NZ224956A (no) |
| PH (1) | PH25187A (no) |
| PL (1) | PL158994B1 (no) |
| PT (1) | PT87678B (no) |
| WO (1) | WO1988009793A1 (no) |
| YU (1) | YU46767B (no) |
| ZA (1) | ZA884115B (no) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR920700646A (ko) * | 1989-11-30 | 1992-08-10 | 미끼 도꾸따로오 | 티아진 옥시드 유도체 함유 약제 |
| US6340659B1 (en) | 1995-12-13 | 2002-01-22 | The Lubrizol Corporation | Metal salts of lactones as lubricant additives |
| JP4250344B2 (ja) | 2001-01-29 | 2009-04-08 | インターナショナル・ビジネス・マシーンズ・コーポレーション | ワークフローシステム、ワークフローサーバ、および記憶媒体 |
| US8741299B2 (en) | 2011-06-20 | 2014-06-03 | The Feinstein Institute For Medical Research | Method for treating pathologies associated with hypoxia using MIF inhibitors |
| US9666805B2 (en) * | 2014-11-25 | 2017-05-30 | Northwestern University | Bithiophene sulfonamide-based molecular and polymeric semiconductors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3591584A (en) * | 1968-08-27 | 1971-07-06 | Pfizer | Benzothiazine dioxides |
| CA1066711A (en) * | 1974-08-26 | 1979-11-20 | Hoffmann-La Roche Limited | Thiophene derivatives |
| LU78009A1 (de) * | 1977-08-22 | 1979-05-23 | Hoffmann La Roche | Verfahren zur herstellung von thiazinderivaten |
| AU518216B2 (en) * | 1977-09-06 | 1981-09-17 | Hafslund Nycomed Pharma Aktiengesellschaft | Thienothiazine derivatives |
| DE2838377A1 (de) * | 1978-09-02 | 1980-03-20 | Thomae Gmbh Dr K | Neue 4-hydroxy-2h eckige klammer auf 1 eckige klammer zu benzothieno eckige klammer auf 2,3-e eckige klammer zu -1,2- thiazin-3-carboxamid-1,1-dioxide sowie deren salze, deren verwendung und verfahren zu ihrer herstellung |
| AU5811280A (en) * | 1979-06-13 | 1980-12-18 | F. Hoffmann-La Roche Ag | Thiazine derivatives |
| ZA803401B (en) * | 1979-06-13 | 1981-05-27 | Hoffmann La Roche | Thiazine derivatives |
-
1987
- 1987-06-10 WO PCT/US1987/001357 patent/WO1988009793A1/en not_active Ceased
- 1987-06-10 HU HU873899A patent/HU203762B/hu not_active IP Right Cessation
- 1987-06-10 MX MX011827A patent/MX174093B/es unknown
- 1987-06-10 US US07/382,161 patent/US4914101A/en not_active Expired - Lifetime
-
1988
- 1988-06-01 AT AT8888304975T patent/ATE105561T1/de not_active IP Right Cessation
- 1988-06-01 EP EP88304975A patent/EP0294994B1/en not_active Expired - Lifetime
- 1988-06-01 DE DE3889497T patent/DE3889497T2/de not_active Expired - Fee Related
- 1988-06-01 ES ES88304975T patent/ES2051846T3/es not_active Expired - Lifetime
- 1988-06-02 IL IL86602A patent/IL86602A/xx not_active IP Right Cessation
- 1988-06-06 MY MYPI88000605A patent/MY103572A/en unknown
- 1988-06-06 JP JP13920488A patent/JPH078874B2/ja not_active Expired - Lifetime
- 1988-06-07 CZ CS883925A patent/CZ281857B6/cs not_active IP Right Cessation
- 1988-06-08 PH PH37029A patent/PH25187A/en unknown
- 1988-06-08 PL PL1988272928A patent/PL158994B1/pl unknown
- 1988-06-08 PT PT87678A patent/PT87678B/pt not_active IP Right Cessation
- 1988-06-08 CA CA000568893A patent/CA1300625C/en not_active Expired - Lifetime
- 1988-06-08 DD DD88316546A patent/DD281602A5/de not_active IP Right Cessation
- 1988-06-09 KR KR1019880006909A patent/KR900006758B1/ko not_active Expired
- 1988-06-09 ZA ZA884115A patent/ZA884115B/xx unknown
- 1988-06-09 IE IE173388A patent/IE63214B1/en not_active IP Right Cessation
- 1988-06-09 DK DK313388A patent/DK313388A/da not_active Application Discontinuation
- 1988-06-09 NZ NZ224956A patent/NZ224956A/xx unknown
- 1988-06-09 EG EG32188A patent/EG18525A/xx active
- 1988-06-09 AU AU17535/88A patent/AU593743B2/en not_active Ceased
- 1988-06-09 YU YU111988A patent/YU46767B/sh unknown
- 1988-06-09 CN CN88103539A patent/CN1019576B/zh not_active Expired
-
1989
- 1989-02-08 NO NO890531A patent/NO176277C/no unknown
- 1989-02-09 FI FI890620A patent/FI89802C/fi not_active IP Right Cessation
-
1992
- 1992-07-03 NO NO922636A patent/NO922636D0/no unknown
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