NO922853L - Aminosubstituerte piperazinderivater - Google Patents

Aminosubstituerte piperazinderivater

Info

Publication number
NO922853L
NO922853L NO92922853A NO922853A NO922853L NO 922853 L NO922853 L NO 922853L NO 92922853 A NO92922853 A NO 92922853A NO 922853 A NO922853 A NO 922853A NO 922853 L NO922853 L NO 922853L
Authority
NO
Norway
Prior art keywords
alkyl
alkoxy
lower alkyl
carboxy
stands
Prior art date
Application number
NO92922853A
Other languages
English (en)
Other versions
NO922853D0 (no
Inventor
Pier Giorgio Ferrini
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of NO922853D0 publication Critical patent/NO922853D0/no
Publication of NO922853L publication Critical patent/NO922853L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Det er beskrevet aminosubstituerte piperazinderivater med formel I X-C-N N¿Y hvor RI står for hydrogen, laverealkyl, laverealkoksy- laverealkyl, laverealkoksy-laverealkoksy-laverealkyl, aryloksy-laverealkyl, aryllaverealkoksy-laverealkyl, N- laverealkylamino-laverealkyl eller N,N-dllaverealkylam- ino-laverealkyl, 83 står for laverealkenoyl, (karboksy eller laverealkoksykarbonyl)-laverealkenoyl, elektrone- gatlvt substituert laverealkanoyl, karbamoyl, N- laverealkylkarbamoyl, N.N-dilaverealkylkarbamoyl, karboksy-karbonyl, laverealkoksykarbonyl-karbonyl, (karbamoyl, N-laverealkylkarbamoyl eller N,N-dilavere- alkylkarbamoyl)-karbonyl, eller 83 kan, såfremt R^ står for laverealkoksy-laverealkyl, laverealkoksy-lavereal- koksy-laverealkyl, aryloksy-laverealkyl, aryllavereal- koksy-laverealkyl , N-laverealkylamino-laverealkyl eller N.N-dilaverealkylamino-laverealkyl, også bety hydrogen, laverealkanoyl, karboksy, laverealkoksy- karbonyl eller aryllaverealkoksykarbonyl, RS og R4 betyr uavhengig av hverandre for hydrogen, laverealkyl, halogen, laverealkoksy eller laverealkyltio, RS og Rf, betyr uavhengig av hverandre hydrogen, laverealkyl, halogen-laverealkyl, laverealkoksy, laverealkyltio, halogen, amino, laverealkylamino, dilaverealkylamino eller laverealkanoylamlno, og X og Y betyr uavhengig av hverandre for en direkte binding, laverealkylen eller laverealkenylen og salter derav. Disse derivat- ene oppviser egenskaper som hemmer biosyntesen av interleukln-1 (IL-1) samt analgetiske egenskaper, de kan følgelig anvendes som legemiddelvlrkestoffer. De fremstilles på i og for seg kjent måte.
NO92922853A 1991-07-19 1992-07-17 Aminosubstituerte piperazinderivater NO922853L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH216091 1991-07-19
CH134092 1992-04-27

Publications (2)

Publication Number Publication Date
NO922853D0 NO922853D0 (no) 1992-07-17
NO922853L true NO922853L (no) 1993-01-20

Family

ID=25687395

Family Applications (1)

Application Number Title Priority Date Filing Date
NO92922853A NO922853L (no) 1991-07-19 1992-07-17 Aminosubstituerte piperazinderivater

Country Status (14)

Country Link
US (1) US5286728A (no)
EP (1) EP0524146A1 (no)
JP (1) JPH05202014A (no)
KR (1) KR930002330A (no)
AU (1) AU650989B2 (no)
CA (1) CA2074154A1 (no)
CZ (1) CZ222392A3 (no)
FI (1) FI923280A7 (no)
HU (1) HUT67047A (no)
IE (1) IE922336A1 (no)
IL (1) IL102533A0 (no)
MX (1) MX9204171A (no)
NO (1) NO922853L (no)
NZ (1) NZ243607A (no)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0489690A1 (de) * 1990-12-05 1992-06-10 Ciba-Geigy Ag Substituierte N-Benzoyl-N'-(2-phenylethyl)-piperazine
US5384319A (en) * 1993-01-06 1995-01-24 Ciba-Geigy Corporation Aminoalkylphenyl compounds
US5380726A (en) * 1993-01-15 1995-01-10 Ciba-Geigy Corporation Substituted dialkylthio ethers
US5561212A (en) * 1993-03-05 1996-10-01 Baylor University Poly(methylene oxalate), a new composition of matter
US5371171A (en) * 1993-03-05 1994-12-06 Baylor University Poly(methylene oxalate) and precursors thereto
AU5321796A (en) * 1995-03-23 1996-10-08 Affymax Technologies N.V. Novel piperazine derivatives as type il-1 receptor antagonists
FR2740134B1 (fr) * 1995-10-18 1998-01-09 Pf Medicament Derives d'amines cycliques d'aryl-piperazines, leur preparation et les compositions pharmaceutiques les contenant
FR2744450A1 (fr) * 1996-02-02 1997-08-08 Pf Medicament Nouvelles naphtylpiperazines derivees de cycloazanes substitues, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments
FR2744449B1 (fr) * 1996-02-02 1998-04-24 Pf Medicament Nouvelles piperazines aromatiques derivees de cycloazanes substitues, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments
US6124299A (en) * 1997-02-24 2000-09-26 Zymogenetics, Inc. Calcitonin mimetics
US6455528B1 (en) * 1997-10-14 2002-09-24 Mitsubishi Pharma Corporation Piperazine compounds and medicinal use thereof
WO2000042852A1 (en) * 1999-01-25 2000-07-27 Smithkline Beecham Corporation Compounds and methods
UY27003A1 (es) 2000-11-06 2002-07-31 Schering Ag Productos radiofarmacéuticos para el diagnóstico de la enfermedad de alzheimer
US20050119251A1 (en) * 2001-12-21 2005-06-02 Jian-Min Fu Nicotinamide derivatives and their use as therapeutic agents
DE60326436D1 (en) * 2002-03-13 2009-04-16 Janssen Pharmaceutica Nv Aminoderivate als histone-deacetylase-inhibitoren
US7829712B2 (en) 2004-09-20 2010-11-09 Xenon Pharmaceuticals Inc. Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase
EP1807085B1 (en) 2004-09-20 2013-08-21 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
AR051091A1 (es) 2004-09-20 2006-12-20 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa
EP2289510A1 (en) 2004-09-20 2011-03-02 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
JP5080256B2 (ja) * 2004-09-20 2012-11-21 ゼノン・ファーマシューティカルズ・インコーポレイテッド 二環式複素環誘導体およびステアロイル−ＣｏＡデサチュラーゼ（ＳＣＤ）のインヒビターとしてのそれらの使用
CA2580762A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as therapeutic agents
CA2580857A1 (en) 2004-09-20 2006-09-28 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
AU2005286648A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
AU2006343359A1 (en) 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
CN101597278B (zh) * 2008-06-04 2013-04-17 中国中化股份有限公司 酰胺类化合物及其制备与应用
EP4092013A1 (en) 2017-06-20 2022-11-23 Imbria Pharmaceuticals, Inc. Compositions and methods for increasing efficiency of cardiac metabolism
WO2020081361A1 (en) 2018-10-17 2020-04-23 Imbria Pharmaceuticals, Inc. Methods of treating rheumatic diseases using trimetazidine-based compounds
WO2020243120A1 (en) 2019-05-31 2020-12-03 Imbria Pharmaceuticals, Inc. Methods of treating fibrosis using compounds that promote glucose oxidation
US11780811B2 (en) 2020-06-30 2023-10-10 Imbria Pharmaceuticals, Inc. Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11530184B2 (en) 2020-06-30 2022-12-20 Imbria Pharmaceuticals, Inc. Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11883396B2 (en) 2021-05-03 2024-01-30 Imbria Pharmaceuticals, Inc. Methods of treating kidney conditions using modified forms of trimetazidine

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL105768C (no) * 1959-02-25
CH590259A5 (no) * 1973-07-10 1977-07-29 Ciba Geigy Ag
DE2365988B2 (de) * 1973-07-12 1978-09-07 Ludwig Heumann & Co Gmbh, 8500 Nuernberg Verfahren zur Herstellung von N-Dialkylaminoäthyl-2-alkoxy-4-amino-5-chlor-benzoesäureamiden
CY1344A (en) * 1978-08-10 1987-01-16 Ciba Geigy Ag Substituted anthranilic acid amides,process for their preparation,and pharmaceutical compositions containing them
MY102447A (en) * 1986-06-16 1992-06-30 Ciba Geigy Ag Disubtituted piperazines
AU606808B2 (en) * 1988-06-29 1991-02-14 Otsuka Pharmaceutical Factory, Inc. Arylcarboxamide substituted by alkylphosphonates, process for preparing the same and a pharmaceutical composition containing the same
US5051423A (en) * 1988-07-13 1991-09-24 Schering Ag Derivatized alkanolamines as cardiovascular agents
EP0385043A1 (en) * 1989-02-28 1990-09-05 Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. (Faes) New derivatives of 4-substituted piperazines
EP0489690A1 (de) * 1990-12-05 1992-06-10 Ciba-Geigy Ag Substituierte N-Benzoyl-N'-(2-phenylethyl)-piperazine

Also Published As

Publication number Publication date
IL102533A0 (en) 1993-01-14
EP0524146A1 (de) 1993-01-20
IE922336A1 (en) 1993-01-27
AU650989B2 (en) 1994-07-07
NZ243607A (en) 1995-02-24
NO922853D0 (no) 1992-07-17
CA2074154A1 (en) 1993-01-20
FI923280A7 (fi) 1993-01-20
AU2031792A (en) 1993-01-21
HU9202359D0 (en) 1992-10-28
JPH05202014A (ja) 1993-08-10
MX9204171A (es) 1993-01-01
HUT67047A (en) 1995-01-30
KR930002330A (ko) 1993-02-23
FI923280A0 (fi) 1992-07-17
CZ222392A3 (en) 1993-02-17
US5286728A (en) 1994-02-15

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