NO924775L - SUBSTITUTED BENZIMIDAZOLES, PROCEDURES FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE - Google Patents
SUBSTITUTED BENZIMIDAZOLES, PROCEDURES FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USEInfo
- Publication number
- NO924775L NO924775L NO92924775A NO924775A NO924775L NO 924775 L NO924775 L NO 924775L NO 92924775 A NO92924775 A NO 92924775A NO 924775 A NO924775 A NO 924775A NO 924775 L NO924775 L NO 924775L
- Authority
- NO
- Norway
- Prior art keywords
- carbon atoms
- procedures
- preparation
- pharmaceutical use
- substituted benzimidazoles
- Prior art date
Links
- 150000001556 benzimidazoles Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Nye forblndelfler med formelen: (I) i hvor R1 og R2, som er forskjellige, hver er H, alkyl Inneholdende 1-4 karbonatomer eller -CfOj-R6; en av R1 og R2 er alltid valgt fra gruppen -C(0)-R6, hvor R6 er alkyl Inneholdende 1-4 karbonatomer eller alkoksy Inneholdende 1-4 karbonatomer, ¿ R3 er gruppen -CHgOCOQR7, hvor R7 er alkyl Inneholdende 1-6 karbonatomer eller benzyl; R4 og R5 er Ilke eller forskjellige og er valgt fra , eller /~~° -CH3, -C^, -CH2-<] ' "^ZA ) °8 - R* og Rs danner sammen med de tilstøtende oksygenatomene ; som er festet til pyridinringen og karbonatomene i pyridinringen en ring, hvor den delen som utgjøres av R* og R5 er -CH2CH2- eller -CH2-, i samt farmasøytiske preparater inneholdende slike forbindelser som i aktiv bestanddel, og anvendelsen av forbindelsene i medisinen.Novel blending cells of the formula: (I) wherein R 1 and R 2, which are different, are each H, alkyl Containing 1-4 carbon atoms or -CfO 2 -R 6; one of R1 and R2 is always selected from the group -C (O) -R6, where R6 is alkyl containing 1-4 carbon atoms or alkoxy containing 1-4 carbon atoms, ¿R3 is the group -CHgOCOQR7, wherein R7 is alkyl containing 1-6 carbon atoms or benzyl; R4 and R5 are the same or different and are selected from, or are -CH3, -C2, -CH2- <] - ZA) ° 8 - R * and R5 form together with the adjacent oxygen atoms; attached to the pyridine ring and the carbon atoms of the pyridine ring is a ring, wherein the portion constituted by R * and R 5 is -CH
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9002206A SE9002206D0 (en) | 1990-06-20 | 1990-06-20 | NEW COMPOUNDS |
| PCT/SE1991/000415 WO1991019711A1 (en) | 1990-06-20 | 1991-06-11 | Substituted benzimidazoles, process for their preparation and their pharmaceutical use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO924775L true NO924775L (en) | 1992-12-10 |
| NO924775D0 NO924775D0 (en) | 1992-12-10 |
Family
ID=20379831
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO924775A NO924775D0 (en) | 1990-06-20 | 1992-12-10 | SUBSTITUTED BENZIMIDAZOLES, PROCEDURES FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE |
Country Status (27)
| Country | Link |
|---|---|
| EP (1) | EP0535081A1 (en) |
| JP (1) | JPH05507713A (en) |
| CN (1) | CN1058212A (en) |
| AP (1) | AP215A (en) |
| AU (1) | AU649453B2 (en) |
| BG (1) | BG97200A (en) |
| CA (1) | CA2083714A1 (en) |
| CZ (1) | CZ279772B6 (en) |
| FI (1) | FI925766A0 (en) |
| HU (1) | HUT62881A (en) |
| IE (1) | IE912025A1 (en) |
| IL (1) | IL98470A0 (en) |
| IS (1) | IS3721A7 (en) |
| LT (2) | LT3977B (en) |
| LV (1) | LV10953A (en) |
| MA (1) | MA22199A1 (en) |
| NO (1) | NO924775D0 (en) |
| NZ (1) | NZ238546A (en) |
| OA (1) | OA09682A (en) |
| PT (1) | PT98035A (en) |
| RO (1) | RO110493B1 (en) |
| SE (1) | SE9002206D0 (en) |
| TN (1) | TNSN91049A1 (en) |
| TW (1) | TW216418B (en) |
| WO (1) | WO1991019711A1 (en) |
| YU (1) | YU104191A (en) |
| ZA (2) | ZA914297B (en) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9002043D0 (en) * | 1990-06-07 | 1990-06-07 | Astra Ab | IMPROVED METHOD FOR SYNTHESIS |
| SE9103776D0 (en) * | 1991-12-19 | 1991-12-19 | Astra Ab | NEW COMPOUNDS |
| IS4232A (en) * | 1993-12-06 | 1995-06-07 | Astra Aktiebolag | Substituted benzimidazole, its methods of manufacture and pharmacological use |
| SE504459C2 (en) * | 1994-07-15 | 1997-02-17 | Astra Ab | Process for the preparation of substituted sulfoxides |
| SE9500422D0 (en) * | 1995-02-06 | 1995-02-06 | Astra Ab | New oral pharmaceutical dosage forms |
| SE9500478D0 (en) * | 1995-02-09 | 1995-02-09 | Astra Ab | New pharmaceutical formulation and process |
| SE9600070D0 (en) | 1996-01-08 | 1996-01-08 | Astra Ab | New oral pharmaceutical dosage forms |
| JP2003523386A (en) | 2000-02-24 | 2003-08-05 | コプラン・リサーチ・ラボラトリーズ・リミテッド | Orally administrable acid-stable antiulcer benzimidazole derivative |
| SE0101379D0 (en) | 2001-04-18 | 2001-04-18 | Diabact Ab | Composition that inhibits gastric acid secretion |
| US8206741B2 (en) | 2001-06-01 | 2012-06-26 | Pozen Inc. | Pharmaceutical compositions for the coordinated delivery of NSAIDs |
| JP4732696B2 (en) | 2002-04-09 | 2011-07-27 | フラメル・テクノロジー | Oral pharmaceutical formulation in the form of an aqueous suspension of microcapsules for modified release of the active ingredient |
| SE0203065D0 (en) | 2002-10-16 | 2002-10-16 | Diabact Ab | Gastric acid secretion inhibiting composition |
| KR20060092255A (en) | 2003-09-26 | 2006-08-22 | 알자 코포레이션 | Drug coating agent providing a high drug load and a method of manufacturing the same |
| TW200606163A (en) | 2004-04-22 | 2006-02-16 | Eisai Co Ltd | Imidazopyridine compound |
| US8541026B2 (en) | 2004-09-24 | 2013-09-24 | Abbvie Inc. | Sustained release formulations of opioid and nonopioid analgesics |
| US20070015782A1 (en) * | 2005-04-15 | 2007-01-18 | Eisai Co., Ltd. | Benzimidazole compound |
| US9040564B2 (en) | 2005-04-28 | 2015-05-26 | Eisai R&D Management Co., Ltd. | Stabilized composition |
| US7981908B2 (en) | 2005-05-11 | 2011-07-19 | Vecta, Ltd. | Compositions and methods for inhibiting gastric acid secretion |
| US7803817B2 (en) | 2005-05-11 | 2010-09-28 | Vecta, Ltd. | Composition and methods for inhibiting gastric acid secretion |
| WO2007122686A1 (en) * | 2006-04-14 | 2007-11-01 | Eisai R & D Management Co., Ltd. | Benzimidazole compounds |
| EP2046334B1 (en) | 2006-07-25 | 2014-05-21 | Vecta Ltd. | Compositions and meth0ds for inhibiting gastric acide secretion using derivatives of small dicarboxylic acids in combination with ppi |
| EP2065379A4 (en) * | 2006-10-13 | 2011-01-19 | Eisai R&D Man Co Ltd | Benzimidazole compound having gastric acid secretion inhibitory activity |
| KR20110079641A (en) | 2008-09-09 | 2011-07-07 | 아스트라제네카 아베 | How to deliver a pharmaceutical composition to a patient in need |
| MX2011013467A (en) | 2009-06-25 | 2012-02-13 | Astrazeneca Ab | Method for treating a patient at risk for developing an nsaid-associated ulcer. |
| WO2011080500A2 (en) | 2009-12-29 | 2011-07-07 | Orexo Ab | New pharmaceutical dosage form for the treatment of gastric acid-related disorders |
| US20120294937A1 (en) | 2009-12-29 | 2012-11-22 | Novartis Ag | New pharmaceutical dosage form for the treatment of gastric acid-related disorders |
| WO2011080502A2 (en) | 2009-12-29 | 2011-07-07 | Orexo Ab | New pharmaceutical dosage form for the treatment of gastric acid-related disorders |
| EP2601947A1 (en) | 2011-12-05 | 2013-06-12 | Abo Bakr Mohammed Ali Al-Mehdar | Fixed-dose combination for treatment of helicobacter pylori associated diseases |
| US9539214B2 (en) | 2011-12-28 | 2017-01-10 | Pozen Inc. | Compositions and methods for delivery of omeprazole plus acetylsalicylic acid |
| EP4289425A3 (en) * | 2016-09-14 | 2024-08-07 | Yufeng Jane Tseng | Novel substituted benzimidazole derivatives as d-amino acid oxidase (daao) inhibitors |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE418966B (en) | 1974-02-18 | 1981-07-06 | Haessle Ab | ANALOGY PROCEDURE FOR THE PREPARATION OF COMPOUNDS WITH Gastric Acid Secretion Inhibitory Effects |
| SE416649B (en) | 1974-05-16 | 1981-01-26 | Haessle Ab | PROCEDURE FOR THE PREPARATION OF SUBSTANCES WHICH PREVENT Gastric acid secretion |
| IN148930B (en) | 1977-09-19 | 1981-07-25 | Hoffmann La Roche | |
| SE7804231L (en) | 1978-04-14 | 1979-10-15 | Haessle Ab | Gastric acid secretion |
| US4359465A (en) | 1980-07-28 | 1982-11-16 | The Upjohn Company | Methods for treating gastrointestinal inflammation |
| CH644116A5 (en) | 1980-08-21 | 1984-07-13 | Hoffmann La Roche | IMIDAZOLE DERIVATIVES. |
| SE8300736D0 (en) | 1983-02-11 | 1983-02-11 | Haessle Ab | NOVEL PHARMACOLOGICALLY ACTIVE COMPOUNDS |
| SE8301182D0 (en) | 1983-03-04 | 1983-03-04 | Haessle Ab | NOVEL COMPOUNDS |
| IL75400A (en) * | 1984-06-16 | 1988-10-31 | Byk Gulden Lomberg Chem Fab | Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same |
| AU568441B2 (en) * | 1984-09-24 | 1987-12-24 | Upjohn Company, The | 2-(pyridylalkenesulfinyl) benzimidazole derivatives |
| IL76839A (en) * | 1984-10-31 | 1988-08-31 | Byk Gulden Lomberg Chem Fab | Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
| US4738975A (en) | 1985-07-02 | 1988-04-19 | Takeda Chemical Industries, Ltd. | Pyridine derivatives, and use as anti-ulcer agents |
| SE8505112D0 (en) * | 1985-10-29 | 1985-10-29 | Haessle Ab | NOVEL PHARMACOLOGICAL COMPOUNDS |
| NZ234564A (en) | 1986-11-21 | 1991-04-26 | Haessle Ab | 1-substituted benzimidazoles and pharmaceutical compositions |
| DE3722810A1 (en) * | 1987-07-10 | 1989-01-19 | Hoechst Ag | SUBSTITUTED BENZIMIDAZOLES, METHOD FOR THE PRODUCTION THEREOF, THE PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND THE USE THEREOF |
| KR890701580A (en) * | 1987-10-30 | 1989-12-21 | 앤더스 베딘 | 2-pyridinylmethyl (sulfinyl or thio) benzimidazole for the treatment of diseases related to bone loss |
| JPH03501609A (en) * | 1987-12-11 | 1991-04-11 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | New benzimidazole derivatives |
| JPH03504497A (en) * | 1988-05-25 | 1991-10-03 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | New fluoroalkoxy compound |
-
1990
- 1990-06-20 SE SE9002206A patent/SE9002206D0/en unknown
-
1991
- 1991-06-05 ZA ZA914297A patent/ZA914297B/en unknown
- 1991-06-05 ZA ZA914296A patent/ZA914296B/en unknown
- 1991-06-11 RO RO92-01581A patent/RO110493B1/en unknown
- 1991-06-11 CA CA002083714A patent/CA2083714A1/en not_active Abandoned
- 1991-06-11 WO PCT/SE1991/000415 patent/WO1991019711A1/en not_active Ceased
- 1991-06-11 JP JP91511435A patent/JPH05507713A/en active Pending
- 1991-06-11 EP EP91911659A patent/EP0535081A1/en not_active Withdrawn
- 1991-06-11 HU HU924033A patent/HUT62881A/en unknown
- 1991-06-11 AU AU80097/91A patent/AU649453B2/en not_active Ceased
- 1991-06-12 YU YU104191A patent/YU104191A/en unknown
- 1991-06-12 IL IL98470A patent/IL98470A0/en unknown
- 1991-06-12 TW TW080104582A patent/TW216418B/zh active
- 1991-06-14 NZ NZ238546A patent/NZ238546A/en unknown
- 1991-06-14 IE IE202591A patent/IE912025A1/en unknown
- 1991-06-18 MA MA22462A patent/MA22199A1/en unknown
- 1991-06-19 TN TNTNSN91049A patent/TNSN91049A1/en unknown
- 1991-06-19 AP APAP/P/1991/000285A patent/AP215A/en active
- 1991-06-19 PT PT98035A patent/PT98035A/en not_active Application Discontinuation
- 1991-06-20 IS IS3721A patent/IS3721A7/en unknown
- 1991-06-20 CN CN91105024A patent/CN1058212A/en active Pending
- 1991-06-20 CZ CS911894A patent/CZ279772B6/en unknown
-
1992
- 1992-11-27 OA OA60306A patent/OA09682A/en unknown
- 1992-12-10 NO NO924775A patent/NO924775D0/en unknown
- 1992-12-18 BG BG097200A patent/BG97200A/en unknown
- 1992-12-18 FI FI925766A patent/FI925766A0/en not_active Application Discontinuation
-
1993
- 1993-08-27 LV LV931045A patent/LV10953A/en unknown
- 1993-12-30 LT LTIP1713A patent/LT3977B/en not_active IP Right Cessation
- 1993-12-30 LT LTIP1712A patent/LT3952B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AP215A (en) | 1992-09-02 |
| LV10953A (en) | 1995-12-20 |
| IL98470A0 (en) | 1992-07-15 |
| ZA914296B (en) | 1992-03-25 |
| EP0535081A1 (en) | 1993-04-07 |
| LT3977B (en) | 1996-06-25 |
| LTIP1713A (en) | 1995-08-25 |
| WO1991019711A1 (en) | 1991-12-26 |
| IS3721A7 (en) | 1991-12-21 |
| IE912025A1 (en) | 1992-01-01 |
| SE9002206D0 (en) | 1990-06-20 |
| MA22199A1 (en) | 1992-04-01 |
| AU649453B2 (en) | 1994-05-26 |
| PT98035A (en) | 1992-03-31 |
| JPH05507713A (en) | 1993-11-04 |
| CZ279772B6 (en) | 1995-06-14 |
| YU104191A (en) | 1994-01-20 |
| FI925766A7 (en) | 1992-12-18 |
| TW216418B (en) | 1993-11-21 |
| LT3952B (en) | 1996-05-27 |
| OA09682A (en) | 1993-05-15 |
| NO924775D0 (en) | 1992-12-10 |
| CS189491A3 (en) | 1992-04-15 |
| FI925766A0 (en) | 1992-12-18 |
| HU9204033D0 (en) | 1993-03-29 |
| HUT62881A (en) | 1993-06-28 |
| TNSN91049A1 (en) | 1992-10-25 |
| ZA914297B (en) | 1992-03-25 |
| NZ238546A (en) | 1994-03-25 |
| CN1058212A (en) | 1992-01-29 |
| AP9100285A0 (en) | 1991-07-31 |
| BG97200A (en) | 1993-12-24 |
| AU8009791A (en) | 1992-01-07 |
| RO110493B1 (en) | 1996-01-30 |
| LTIP1712A (en) | 1995-08-25 |
| CA2083714A1 (en) | 1991-12-21 |
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