NO924775L - Substituerte benzimidazoler, fremgangsmaate for deres fremstilling og deres farmasoeytiske anvendelse - Google Patents

Substituerte benzimidazoler, fremgangsmaate for deres fremstilling og deres farmasoeytiske anvendelse

Info

Publication number
NO924775L
NO924775L NO92924775A NO924775A NO924775L NO 924775 L NO924775 L NO 924775L NO 92924775 A NO92924775 A NO 92924775A NO 924775 A NO924775 A NO 924775A NO 924775 L NO924775 L NO 924775L
Authority
NO
Norway
Prior art keywords
carbon atoms
procedures
preparation
pharmaceutical use
substituted benzimidazoles
Prior art date
Application number
NO92924775A
Other languages
English (en)
Other versions
NO924775D0 (no
Inventor
Arne Elof Braendstroem
Per Lennart Lindberg
Gunnel Elisabeth Sunden
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of NO924775L publication Critical patent/NO924775L/no
Publication of NO924775D0 publication Critical patent/NO924775D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Nye forblndelfler med formelen: (I) i hvor R1 og R2, som er forskjellige, hver er H, alkyl Inneholdende 1-4 karbonatomer eller -CfOj-R6; en av R1 og R2 er alltid valgt fra gruppen -C(0)-R6, hvor R6 er alkyl Inneholdende 1-4 karbonatomer eller alkoksy Inneholdende 1-4 karbonatomer, ¿ R3 er gruppen -CHgOCOQR7, hvor R7 er alkyl Inneholdende 1-6 karbonatomer eller benzyl; R4 og R5 er Ilke eller forskjellige og er valgt fra , eller /~~° -CH3, -C^, -CH2-<] ' "^ZA ) °8 - R* og Rs danner sammen med de tilstøtende oksygenatomene ; som er festet til pyridinringen og karbonatomene i pyridinringen en ring, hvor den delen som utgjøres av R* og R5 er -CH2CH2- eller -CH2-, i samt farmasøytiske preparater inneholdende slike forbindelser som i aktiv bestanddel, og anvendelsen av forbindelsene i medisinen.
NO924775A 1990-06-20 1992-12-10 Substituerte benzimidazoler, fremgangsmaate for deres fremstilling og deres farmasoeytiske anvendelse NO924775D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9002206A SE9002206D0 (sv) 1990-06-20 1990-06-20 New compounds
PCT/SE1991/000415 WO1991019711A1 (en) 1990-06-20 1991-06-11 Substituted benzimidazoles, process for their preparation and their pharmaceutical use

Publications (2)

Publication Number Publication Date
NO924775L true NO924775L (no) 1992-12-10
NO924775D0 NO924775D0 (no) 1992-12-10

Family

ID=20379831

Family Applications (1)

Application Number Title Priority Date Filing Date
NO924775A NO924775D0 (no) 1990-06-20 1992-12-10 Substituerte benzimidazoler, fremgangsmaate for deres fremstilling og deres farmasoeytiske anvendelse

Country Status (27)

Country Link
EP (1) EP0535081A1 (no)
JP (1) JPH05507713A (no)
CN (1) CN1058212A (no)
AP (1) AP215A (no)
AU (1) AU649453B2 (no)
BG (1) BG97200A (no)
CA (1) CA2083714A1 (no)
CZ (1) CZ279772B6 (no)
FI (1) FI925766A7 (no)
HU (1) HUT62881A (no)
IE (1) IE912025A1 (no)
IL (1) IL98470A0 (no)
IS (1) IS3721A7 (no)
LT (2) LT3977B (no)
LV (1) LV10953A (no)
MA (1) MA22199A1 (no)
NO (1) NO924775D0 (no)
NZ (1) NZ238546A (no)
OA (1) OA09682A (no)
PT (1) PT98035A (no)
RO (1) RO110493B1 (no)
SE (1) SE9002206D0 (no)
TN (1) TNSN91049A1 (no)
TW (1) TW216418B (no)
WO (1) WO1991019711A1 (no)
YU (1) YU104191A (no)
ZA (2) ZA914296B (no)

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SE9002043D0 (sv) * 1990-06-07 1990-06-07 Astra Ab Improved method for synthesis
SE9103776D0 (sv) * 1991-12-19 1991-12-19 Astra Ab New compounds
IS4232A (is) * 1993-12-06 1995-06-07 Astra Aktiebolag Súbstitúerað bensimidasól, aðferðir við framleiðslu þess og lyfjafræðileg notkun
SE504459C2 (sv) * 1994-07-15 1997-02-17 Astra Ab Förfarande för framställning av substituerade sulfoxider
SE9500422D0 (sv) * 1995-02-06 1995-02-06 Astra Ab New oral pharmaceutical dosage forms
SE9500478D0 (sv) * 1995-02-09 1995-02-09 Astra Ab New pharmaceutical formulation and process
SE9600070D0 (sv) 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
WO2001062248A1 (en) 2000-02-24 2001-08-30 Kopran Research Laboratories Limited Orally administrable acid stable anti-ulcer benzimidazole derivatives
SE0101379D0 (sv) 2001-04-18 2001-04-18 Diabact Ab Komposition som hämmar utsöndring av magsyra
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
EP1492511B3 (fr) 2002-04-09 2012-05-02 Flamel Technologies Formulation pharmaceutique orale sous forme de suspension aqueuse de microcapsules permettant la liberation modifiee de principe(s) actif(s)
SE0203065D0 (sv) 2002-10-16 2002-10-16 Diabact Ab Gastric acid secretion inhibiting composition
CA2540308C (en) 2003-09-26 2013-08-06 Alza Corporation Drug coating providing high drug loading and methods for providing the same
TW200606163A (en) 2004-04-22 2006-02-16 Eisai Co Ltd Imidazopyridine compound
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
US20070015782A1 (en) * 2005-04-15 2007-01-18 Eisai Co., Ltd. Benzimidazole compound
US9040564B2 (en) 2005-04-28 2015-05-26 Eisai R&D Management Co., Ltd. Stabilized composition
US7981908B2 (en) 2005-05-11 2011-07-19 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
US7803817B2 (en) 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
WO2007122686A1 (ja) * 2006-04-14 2007-11-01 Eisai R & D Management Co., Ltd. ベンズイミダゾール化合物
PL2046334T3 (pl) 2006-07-25 2015-02-27 Vecta Ltd Kompozycje i sposoby hamowania wydzielania kwasów żołądkowych z wykorzystaniem pochodnych małych kwasów dikarboksylowych w połączeniu z PPI
WO2008047681A1 (en) * 2006-10-13 2008-04-24 Eisai R & D Management Co., Ltd. Benzimidazole compound having gastric acid secretion inhibitory activity
US9220698B2 (en) 2008-09-09 2015-12-29 Pozen Inc. Method for delivering a pharmaceutical composition to patient in need thereof
KR20120030106A (ko) 2009-06-25 2012-03-27 아스트라제네카 아베 Ｎｓａｉｄ-연관된 궤양의 발생 위험이 있는 환자의 치료 방법
WO2011080502A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
WO2011080500A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
US20120294937A1 (en) 2009-12-29 2012-11-22 Novartis Ag New pharmaceutical dosage form for the treatment of gastric acid-related disorders
EP2601947A1 (en) 2011-12-05 2013-06-12 Abo Bakr Mohammed Ali Al-Mehdar Fixed-dose combination for treatment of helicobacter pylori associated diseases
EP2797600A4 (en) 2011-12-28 2015-09-16 Pozen Inc IMPROVED COMPOSITIONS AND METHODS OF DISTRIBUTING OMEPRAZOLE AND ACETYL SALICYLIC ACID
EP3512840B1 (en) 2016-09-14 2024-03-06 Yufeng Jane Tseng Novel substituted benzimidazole derivatives as d-amino acid oxidase (daao) inhibitors

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Publication number Priority date Publication date Assignee Title
SE418966B (sv) 1974-02-18 1981-07-06 Haessle Ab Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan
SE416649B (sv) 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
IN148930B (no) 1977-09-19 1981-07-25 Hoffmann La Roche
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4359465A (en) 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
CH644116A5 (de) 1980-08-21 1984-07-13 Hoffmann La Roche Imidazolderivate.
SE8300736D0 (sv) 1983-02-11 1983-02-11 Haessle Ab Novel pharmacologically active compounds
SE8301182D0 (sv) 1983-03-04 1983-03-04 Haessle Ab Novel compounds
IL75400A (en) * 1984-06-16 1988-10-31 Byk Gulden Lomberg Chem Fab Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same
AU568441B2 (en) * 1984-09-24 1987-12-24 Upjohn Company, The 2-(pyridylalkenesulfinyl) benzimidazole derivatives
IL76839A (en) * 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
US4738975A (en) 1985-07-02 1988-04-19 Takeda Chemical Industries, Ltd. Pyridine derivatives, and use as anti-ulcer agents
SE8505112D0 (sv) * 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds
NZ234564A (en) 1986-11-21 1991-04-26 Haessle Ab 1-substituted benzimidazoles and pharmaceutical compositions
DE3722810A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag Substituierte benzimidazole, verfahren zu deren herstellung, diese enthaltende pharmazeutische zubereitungen und deren verwendung
AU2621888A (en) * 1987-10-30 1989-05-23 Aktiebolaget Hassle Omeprazole for treatment of diseases related to bone loss
AU2817989A (en) * 1987-12-11 1989-07-05 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel benzimidazole derivatives
EP0415990A1 (de) * 1988-05-25 1991-03-13 Byk Gulden Lomberg Chemische Fabrik GmbH Neue fluoralkoxyverbindungen

Also Published As

Publication number Publication date
IS3721A7 (is) 1991-12-21
JPH05507713A (ja) 1993-11-04
CS189491A3 (en) 1992-04-15
CN1058212A (zh) 1992-01-29
FI925766A0 (fi) 1992-12-18
ZA914296B (en) 1992-03-25
IE912025A1 (en) 1992-01-01
LTIP1712A (en) 1995-08-25
AP9100285A0 (en) 1991-07-31
MA22199A1 (fr) 1992-04-01
RO110493B1 (ro) 1996-01-30
LT3952B (en) 1996-05-27
LTIP1713A (en) 1995-08-25
TNSN91049A1 (fr) 1992-10-25
TW216418B (no) 1993-11-21
AP215A (en) 1992-09-02
IL98470A0 (en) 1992-07-15
WO1991019711A1 (en) 1991-12-26
CA2083714A1 (en) 1991-12-21
CZ279772B6 (cs) 1995-06-14
AU8009791A (en) 1992-01-07
FI925766A7 (fi) 1992-12-18
BG97200A (bg) 1993-12-24
NZ238546A (en) 1994-03-25
NO924775D0 (no) 1992-12-10
YU104191A (sh) 1994-01-20
LV10953A (lv) 1995-12-20
LT3977B (en) 1996-06-25
PT98035A (pt) 1992-03-31
HU9204033D0 (en) 1993-03-29
AU649453B2 (en) 1994-05-26
EP0535081A1 (en) 1993-04-07
HUT62881A (en) 1993-06-28
SE9002206D0 (sv) 1990-06-20
OA09682A (en) 1993-05-15
ZA914297B (en) 1992-03-25

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