NO930498L - Fremgangsmaate for fremstilling av benzimidazolderivater - Google Patents

Fremgangsmaate for fremstilling av benzimidazolderivater

Info

Publication number: NO930498L
Authority: NO; Norway
Prior art keywords: preparing; procedure; paf; nitrogen atom; benzimidazold
Prior art date: 1990-08-15

Application number

NO93930498A

Other languages

English (en)

Other versions

NO301228B1 (no

NO930498D0 (no

Inventor

Mark Whittaker

Andrew Miller

Stephen Arthur Bowles

Original Assignee

British Bio Technology

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-08-15

Filing date

1993-02-12

Publication date

1993-04-14

1990-08-15 Priority claimed from GB909017878A external-priority patent/GB9017878D0/en

1990-08-16 Priority claimed from GB909018040A external-priority patent/GB9018040D0/en

1991-06-06 Priority claimed from GB919112214A external-priority patent/GB9112214D0/en

1993-02-12 Application filed by British Bio Technology filed Critical British Bio Technology

1993-02-12 Publication of NO930498D0 publication Critical patent/NO930498D0/no

1993-04-14 Publication of NO930498L publication Critical patent/NO930498L/no

1997-09-29 Publication of NO301228B1 publication Critical patent/NO301228B1/no

Links

HVAUUPRFYPCOCA-AREMUKBSSA-N 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCOC[C@@H](OC(C)=O)COP([O-])(=O)OCC[N+](C)(C)C HVAUUPRFYPCOCA-AREMUKBSSA-N 0.000 abstract 3
108010003541 Platelet Activating Factor Proteins 0.000 abstract 3
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

NO930498A 1990-08-15 1993-02-12 Analogifremgangsmåte for fremstilling av terapeutisk aktive benzimidazolderivater, samt mellomproduktforbindelser NO301228B1 (no)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB909017878A GB9017878D0 (en)	1990-08-15	1990-08-15	Compounds
GB909018040A GB9018040D0 (en)	1990-08-16	1990-08-16	Compounds
GB919112214A GB9112214D0 (en)	1991-06-06	1991-06-06	Compounds
PCT/GB1991/001392 WO1992003423A1 (en)	1990-08-15	1991-08-15	Benzimidazole derivatives, process for their preparation and application

Publications (3)

Publication Number	Publication Date
NO930498D0 NO930498D0 (no)	1993-02-12
NO930498L true NO930498L (no)	1993-04-14
NO301228B1 NO301228B1 (no)	1997-09-29

Family

ID=27265233

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO930498A NO301228B1 (no)	1990-08-15	1993-02-12	Analogifremgangsmåte for fremstilling av terapeutisk aktive benzimidazolderivater, samt mellomproduktforbindelser
NO972615A NO972615D0 (no)	1990-08-15	1997-06-06	Benzimidazolderivater

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
NO972615A NO972615D0 (no)	1990-08-15	1997-06-06	Benzimidazolderivater

Country Status (17)

Country	Link
US (1)	US5180723A (no)
EP (1)	EP0543858B1 (no)
JP (2)	JP2976004B2 (no)
KR (1)	KR0185959B1 (no)
AT (1)	ATE198197T1 (no)
AU (2)	AU655595B2 (no)
CA (1)	CA2088761C (no)
DE (1)	DE69132497T2 (no)
ES (1)	ES2153820T3 (no)
FI (1)	FI103409B1 (no)
GR (1)	GR3035511T3 (no)
HU (1)	HUT67289A (no)
IE (1)	IE70217B1 (no)
NO (2)	NO301228B1 (no)
NZ (1)	NZ239409A (no)
PT (1)	PT98673B (no)
WO (1)	WO1992003423A1 (no)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT98674B (pt) *	1990-08-15	1999-01-29	British Bio Technology	Processo para a preparacao de compostos que sao antagonistas do factor de activacao de plaquetas por exemplo derivados de imidazole e de seus intermedriarios
US5274094A (en) *	1990-08-15	1993-12-28	British Bio-Technology Limited	Production of heterobicyclic containing benzene sulfonamides
GB9116056D0 (en) *	1991-07-24	1991-09-11	British Bio Technology	Compounds
GB9122308D0 (en) *	1991-10-21	1991-12-04	British Bio Technology	Compounds
GB9200209D0 (en) *	1992-01-07	1992-02-26	British Bio Technology	Compounds
GB9200245D0 (en) *	1992-01-07	1992-02-26	British Bio Technology	Compounds
GB9201755D0 (en) *	1992-01-28	1992-03-11	British Bio Technology	Compounds
GB9202791D0 (en) *	1992-02-11	1992-03-25	British Bio Technology	Compounds
DE4206042A1 (de) *	1992-02-27	1993-09-02	Bayer Ag	Sulfonylbenzyl-substituierte imidazopyridine
DE4327256A1 (de) *	1993-08-13	1995-02-16	Bayer Ag	Sulfonylbenzyl-substituierte Benzimidazole, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln
GB2298138B (en) *	1993-11-10	1997-07-09	British Biotech Pharm	4-(1h-2-methylimidazo 4,5-c pyridinylmethyl)phenyl sulphonamide carboxylic acid derivatives as antagonists
GB9323162D0 (en) *	1993-11-10	1994-01-05	British Bio Technology	4-(1h-2-methylimidazo(4,5-c)pyridinylmethyl)phenylsulphonamid e derivatives as antagonists of paf
AU704972B2 (en)	1994-08-04	1999-05-13	H. Lundbeck A/S	Novel benzimidazole derivatives
US5567711A (en) *	1995-04-19	1996-10-22	Abbott Laboratories	Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists
GB9508748D0 (en) *	1995-04-28	1995-06-14	British Biotech Pharm	Benzimidazole derivatives
DK0790998T3 (da) *	1995-09-08	2001-02-05	Uriach & Cia Sa J	Azo-derivater af 5-aminosalicylsyre til behandling af inflammatorisk tarmsygdom
ES2104513B1 (es) *	1995-10-11	1998-07-01	Uriach & Cia Sa J	Nuevos derivados del acido 5-aminosalicilico.
ES2106682B1 (es) *	1995-09-08	1998-07-01	Uriach & Cia Sa J	Nuevos derivados azo del acido 5-aminosalicilico.
US6495583B1 (en)	1997-03-25	2002-12-17	Synaptic Pharmaceutical Corporation	Benzimidazole derivatives
US6858630B2 (en)	1999-12-06	2005-02-22	Smithkline Beecham Corporation	Naphthimidazole derivatives and their use as thrombopoietin mimetics
WO2001039773A1 (en) *	1999-12-06	2001-06-07	Smithkline Beecham Corporation	Thrombopoietin mimetics
ES2165803B1 (es)	2000-04-10	2003-09-16	Uriach & Cia Sa J	Nueva sal de un derivado azo del acido 5-aminosalicilico
WO2003032919A2 (en) *	2001-10-17	2003-04-24	Croda, Inc.	Esters of aromatic alkoxylated alcohols and fatty carboxylic acids
TW200303742A (en)	2001-11-21	2003-09-16	Novartis Ag	Organic compounds
EP1893569A4 (en) *	2005-06-10	2009-08-05	Elixir Pharmaceuticals Inc	SULPHONAMIDE COMPOUNDS AND ITS USES
US7829589B2 (en) *	2005-06-10	2010-11-09	Elixir Pharmaceuticals, Inc.	Sulfonamide compounds and uses thereof
RU2453312C1 (ru) *	2010-11-10	2012-06-20	Федеральное государственное автономное образовательное учреждение высшего профессионального образования "ЮЖНЫЙ ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ"	Средство, проявляющее антиагрегантную и антитромбогенную активности
SG2014011209A (en) *	2011-11-23	2014-05-29	Cell Therapy Ltd	Platelet lysate gel
GB201321735D0 (en) *	2013-12-09	2014-01-22	Ucb Pharma Sa	Therapeutic Agents

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL6715600A (no) *	1966-12-02	1968-06-04
US4612323A (en) *	1983-06-27	1986-09-16	Sumitomo Chemical Company, Limited	Insecticidal and acaricidal derivatives of 1-benzylbenzimidazole
US4804658A (en) *	1986-09-15	1989-02-14	G. D. Searle & Co.	Imidazopyridine derivatives and pharmaceutical compositions
US4914108A (en) *	1988-03-14	1990-04-03	G. D. Searle & Co.	5-substituted(4,5-c)imidazopyridine compounds which have useful platelet activating factor antagonistic activity
DE68920998T2 (de) *	1988-03-15	1995-06-22	Searle & Co	1H/3H-[4-(N,N-CYCLOALKYL UND/ODER VERZWEIGTES ALKYLCARBOXAMIDO)-BENZYL]IMDAZO[4,5-c]PYRIDINE ALS PAF-ANTAGONISTEN.
GB8904174D0 (en) *	1989-02-23	1989-04-05	British Bio Technology	Compounds
US5157026A (en) *	1989-05-30	1992-10-20	Merck & Co., Inc.	Oxo-purines as angiotensin II antagonists
IL94390A (en) *	1989-05-30	1996-03-31	Merck & Co Inc	The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them
US5274094A (en) *	1990-08-15	1993-12-28	British Bio-Technology Limited	Production of heterobicyclic containing benzene sulfonamides
PT98674B (pt) *	1990-08-15	1999-01-29	British Bio Technology	Processo para a preparacao de compostos que sao antagonistas do factor de activacao de plaquetas por exemplo derivados de imidazole e de seus intermedriarios

1991
- 1991-08-14 PT PT98673A patent/PT98673B/pt not_active IP Right Cessation
- 1991-08-14 IE IE287591A patent/IE70217B1/en not_active IP Right Cessation
- 1991-08-15 AT AT91914348T patent/ATE198197T1/de not_active IP Right Cessation
- 1991-08-15 EP EP91914348A patent/EP0543858B1/en not_active Expired - Lifetime
- 1991-08-15 WO PCT/GB1991/001392 patent/WO1992003423A1/en not_active Ceased
- 1991-08-15 NZ NZ239409A patent/NZ239409A/en not_active IP Right Cessation
- 1991-08-15 CA CA002088761A patent/CA2088761C/en not_active Expired - Fee Related
- 1991-08-15 HU HU9300389A patent/HUT67289A/hu unknown
- 1991-08-15 ES ES91914348T patent/ES2153820T3/es not_active Expired - Lifetime
- 1991-08-15 JP JP3513676A patent/JP2976004B2/ja not_active Expired - Fee Related
- 1991-08-15 DE DE69132497T patent/DE69132497T2/de not_active Expired - Fee Related
- 1991-08-15 AU AU84268/91A patent/AU655595B2/en not_active Ceased
- 1991-08-15 US US07/746,246 patent/US5180723A/en not_active Expired - Fee Related
1993
- 1993-02-12 NO NO930498A patent/NO301228B1/no unknown
- 1993-02-12 FI FI930634A patent/FI103409B1/fi not_active IP Right Cessation
- 1993-02-15 KR KR1019930700437A patent/KR0185959B1/ko not_active Expired - Fee Related
1994
- 1994-01-07 AU AU53090/94A patent/AU658337B2/en not_active Ceased
1997
- 1997-06-06 NO NO972615A patent/NO972615D0/no unknown
1999
- 1999-04-01 JP JP11094507A patent/JP3120075B2/ja not_active Expired - Fee Related
2001
- 2001-03-05 GR GR20010400351T patent/GR3035511T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU658337B2 (en)	1995-04-06
NZ239409A (en)	1994-05-26
FI930634A0 (fi)	1993-02-12
IE912875A1 (en)	1992-02-26
JPH11315070A (ja)	1999-11-16
EP0543858B1 (en)	2000-12-20
EP0543858A1 (en)	1993-06-02
ES2153820T3 (es)	2001-03-16
DE69132497T2 (de)	2001-06-13
DE69132497D1 (de)	2001-01-25
HK1012336A1 (en)	1999-07-30
ATE198197T1 (de)	2001-01-15
KR0185959B1 (en)	1999-05-01
US5180723A (en)	1993-01-19
FI103409B (fi)	1999-06-30
HUT67289A (en)	1995-03-28
PT98673A (pt)	1992-07-31
JP2976004B2 (ja)	1999-11-10
FI930634L (fi)	1993-04-05
AU655595B2 (en)	1995-01-05
NO301228B1 (no)	1997-09-29
FI103409B1 (fi)	1999-06-30
JPH06500316A (ja)	1994-01-13
HU9300389D0 (en)	1993-04-28
JP3120075B2 (ja)	2000-12-25
IE70217B1 (en)	1996-10-30
NO972615L (no)	1997-06-06
NO972615D0 (no)	1997-06-06
WO1992003423A1 (en)	1992-03-05
AU8426891A (en)	1992-03-17
AU5309094A (en)	1994-03-17
KR930701413A (ko)	1993-06-11
PT98673B (pt)	1999-01-29
GR3035511T3 (en)	2001-06-29
NO930498D0 (no)	1993-02-12
CA2088761C (en)	1999-11-16
CA2088761A1 (en)	1992-02-16

Publication	Publication Date	Title
NO930498D0 (no)	1993-02-12	Fremgangsmaate for fremstilling av benzimidazolderivater
NO930499D0 (no)	1993-02-12	Fremgangsmaate for fremstilling av benzimidazolderivater
NO890074D0 (no)	1989-01-06	Fremgangsmaate for fremstilling av substituerte pyrrol-, pyrazol- og triazolderivater.
HUT54279A (en)	1991-02-28	Herbicidal and bioregulating compositions comprising salicyl-aldehyde and salicylic acid derivatives and their sulfur analogs, as well as process for producing the active ingredients
HUT57763A (en)	1991-12-30	Process for producing 2,9-disubstituted-4h-pyrido(1,2-a)pyrimidine-4-one derivatives and pharmaceutical compositions comprising such compounds as active ingredient
NO163568C (no)	1990-06-20	Analogifremgangsmaate for fremstilling av terapeutisk aktive kinolonkarboksylsyrederivater.
DK132188D0 (da)	1988-03-11	Anvendelse af tetrahydrobenz(c,d)indol-6-carboxamider som anxiolytika
NO178968C (no)	1996-07-10	Analogifremgangsmåte for fremstilling av terapeutisk aktive aminopyrimidin-karboksamidderivater
ES8506652A1 (es)	1985-08-01	Un metodo de preparar dihidrobenzopirrolbenzodiazepinas
DE3462894D1 (de)	1987-05-07	3-indolecarboxamide compounds
AU534470B2 (en)	1984-02-02	Paromomycin derivatives
DE3785393D1 (de)	1993-05-19	4-(aroylamino)piperidinbutanamide derivate.
HUT58070A (en)	1992-01-28	Process for producing brackets open (1-arylpyrrolidin-2-yl)-methyl brackets closed-piperazine derivatives and pharmaceutical compositions comprising these derivatives as active ingredient
ZA885358B (en)	1989-03-29	Uricosuric composition
DE3782229D1 (de)	1992-11-19	Verwendung von 2-oxo-imidazolidin-derivaten zur behandlung von nierenkrankheiten.
SE8900725D0 (sv)	1989-03-02	Indolfoereningar och framstaellning daerav