NO930663L - HOMOCONJUGED IMMUNGLOBULINES - Google Patents

HOMOCONJUGED IMMUNGLOBULINES

Info

Publication number
NO930663L
NO930663L NO93930663A NO930663A NO930663L NO 930663 L NO930663 L NO 930663L NO 93930663 A NO93930663 A NO 93930663A NO 930663 A NO930663 A NO 930663A NO 930663 L NO930663 L NO 930663L
Authority
NO
Norway
Prior art keywords
homoconjugates
igg
immunglobulines
homoconjuged
antigen
Prior art date
Application number
NO93930663A
Other languages
Norwegian (no)
Other versions
NO930663D0 (en
Inventor
Edith Ann Wolff
Howard V Raff
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1991/006195 external-priority patent/WO1992004053A1/en
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO930663D0 publication Critical patent/NO930663D0/en
Publication of NO930663L publication Critical patent/NO930663L/en

Links

Landscapes

  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Homokonjugerte antistoffer med høy aviditet for antigen har økte terapeutiske virkninger og anvendes i farmasøytiske og diagnostiske preparater. Homokonjugatene, som typisk fremstilles av monoklonale antistoffer -av klasse IgG, som bindes til den samme antigeniske determi- nant, bindes kovalent ved hjelp av syntetisk tverrbinding. Homokonjugatene består av minst to immunglobulinmonomerer slik at det dannes et IgG-lignende molekyl som er tetra- valent, heksavalent eller mer for det valgte antigen. Homokonjugatene er i stand til å krysse placenta. Behand- lingsmåter under anvendelse av disse homokonjugater er også omtalt.Homoconjugated antibodies with high avidity for antigen have increased therapeutic effects and are used in pharmaceutical and diagnostic preparations. The homoconjugates, which are typically made of monoclonal antibodies of class IgG, which bind to the same antigenic determinant, are covalently bound by synthetic crosslinking. The homoconjugates consist of at least two immunoglobulin monomers to form an IgG-like molecule that is tetravalent, hexavalent, or more for the selected antigen. The homoconjugates are able to cross the placenta. Methods of treatment using these homoconjugates are also discussed.

NO93930663A 1990-08-31 1993-02-25 HOMOCONJUGED IMMUNGLOBULINES NO930663L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57572590A 1990-08-31 1990-08-31
US74866291A 1991-08-26 1991-08-26
PCT/US1991/006195 WO1992004053A1 (en) 1990-08-31 1991-08-29 Homoconjugated immunoglobulins

Publications (2)

Publication Number Publication Date
NO930663D0 NO930663D0 (en) 1993-02-25
NO930663L true NO930663L (en) 1993-04-28

Family

ID=27376802

Family Applications (1)

Application Number Title Priority Date Filing Date
NO93930663A NO930663L (en) 1990-08-31 1993-02-25 HOMOCONJUGED IMMUNGLOBULINES

Country Status (1)

Country Link
NO (1) NO930663L (en)

Also Published As

Publication number Publication date
NO930663D0 (en) 1993-02-25

Similar Documents

Publication Publication Date Title
Fahey et al. THE IMMUNOGLOBULINS OF MICE: II. TWO SUBCLASSES OF MOUSE 7S γ2-GLOBULINS: γ2a-ANDγ2b-GLOBULINS
Kohler et al. Elevation of cord over maternal IgG immunoglobulin: evidence for an active placental IgG transport
Ishizaka et al. Antigenic Structure of γE-Gobulin and Reaginic Antibody
HUP9802401A2 (en) Monoclonal antibodies specific for different epitopes of the human gp39 protein and methods for the diagnostic and therapeutic use of such antibodies
KR920701465A (en) CD4-specific recombinant antibody
KR930702029A (en) Homozygous Immunoglobulins
Vitetta et al. Characterization of the Spontaneous Murine B Cell Leukemia (BCL1) III. Evidence for Monoclonality by Using an anti-Idiotype Antibody
ATE214734T1 (en) HUMANIZED ANTIBODIES DIRECTED AGAINST THE A33 ANTIGEN
Kim et al. Characterization of early 19 S and late 7 S immunoglobulins in the mouse
KR940006602A (en) Reconstituted Monoclonal Antibodies to Immunoglobulin Isotypes
Pure et al. The murine B cell response to TNP-polyacrylamide beads: the relationship between the epitope density of the antigen and the requirements for T cell help and surface IgD.
Allard et al. Antigen binding properties of highly purified bispecific antibodies
Mellbye et al. Experimentally produced antibodies to the pepsin site of IgG due to untreated autologous IgG in immune complexes
NO930663L (en) HOMOCONJUGED IMMUNGLOBULINES
Taylor et al. Immunoregulatory effects of a covalent antigen–antibody complex
Riberi et al. Evidence for the presence of lambda chain dimers in cerebrospinal fluid of patients suffering from subacute sclerosing panencephalitis
Skvaril et al. IgG subclass composition and immunochemical characteristics of plasmin-treated human γ-globulin
Beckers et al. Allotypes of rat immunoglobulins—III: An allotype of the γ2b-chain locus
Ricardo Jr et al. Effect of pH on the binding between guinea pig IgG isotypes and protein A: evidence for intra-isotypic binding heterogeneity.
Carrel et al. Human tetanus antibodies: Isolation and characterization with special reference to the IgG subclasses
Thrasher et al. The effect of fluorescein conjugation on Fc-dependent properties of rabbit antibody
McDowell et al. Reaction of staphylococcal protein A with rabbit immunoglobulins
Frommel et al. Studies on human immunoglobulin G Fc sub-fragments. Structural requirements for biological expression
Sussdorf Dynamics of the 19S and 7S hemolysin responses in rabbits
Rowe et al. Antibody Activity in γ1 A-Globulin of Normal Human Serum