NO931675L - Nye n-aralkyl- og n-heteroaralkylaminoalkanfosfinsyrer - Google Patents

Nye n-aralkyl- og n-heteroaralkylaminoalkanfosfinsyrer

Info

Publication number
NO931675L
NO931675L NO93931675A NO931675A NO931675L NO 931675 L NO931675 L NO 931675L NO 93931675 A NO93931675 A NO 93931675A NO 931675 A NO931675 A NO 931675A NO 931675 L NO931675 L NO 931675L
Authority
NO
Norway
Prior art keywords
aralkyl
aliphatic
nootropic
heteroaryl
acids
Prior art date
Application number
NO93931675A
Other languages
English (en)
Other versions
NO931675D0 (no
Inventor
Stuart John Mickel
Wolfgang Froestl
Pascal Furet
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of NO931675D0 publication Critical patent/NO931675D0/no
Publication of NO931675L publication Critical patent/NO931675L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653—Five-membered rings
    • C07F9/65306—Five-membered rings containing two nitrogen atoms
    • C07F9/65318—Five-membered rings containing two nitrogen atoms having the two nitrogen atoms in positions 1 and 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • C07F9/6518—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Confectionery (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Alcoholic Beverages (AREA)

Abstract

Det er beskrevet N-aralkyl- og N-heteroaralkylamlno- alkanfosfinsyrer med formel I hvor R betyr en allfatisk, cykloallfatisk, cyklo- allfatlsk-allfatisk, arallfatlsk eller heteroaryl- allfatlsk rest med minst 2 C-atomer, R} betyr hydrogen eller hydroksy, R2 betyr en med direkte eller over en Spacer bundet, eventuelt funksjonelt avledet karboksy- substltuert arallfatlsk eller heteroarylallfatisk rest og R3 betyr hydrogen, laverealkyl eller en gruppe R2, og deres salter. Forbindelsene oppviser verdifulle nootrope og antiepileptiske egenskaper og kan anvendes for fremstilling av et nootropt eller antiepileptisk legemiddel.
NO93931675A 1992-05-08 1993-05-07 Nye n-aralkyl- og n-heteroaralkylaminoalkanfosfinsyrer NO931675L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH148092 1992-05-08

Publications (2)

Publication Number Publication Date
NO931675D0 NO931675D0 (no) 1993-05-07
NO931675L true NO931675L (no) 1993-11-09

Family

ID=4211459

Family Applications (1)

Application Number Title Priority Date Filing Date
NO93931675A NO931675L (no) 1992-05-08 1993-05-07 Nye n-aralkyl- og n-heteroaralkylaminoalkanfosfinsyrer

Country Status (18)

Country Link
US (2) US5332729A (no)
EP (1) EP0569333B1 (no)
JP (1) JP3243056B2 (no)
KR (1) KR940005649A (no)
AT (1) ATE175415T1 (no)
AU (1) AU662404B2 (no)
CA (1) CA2095708C (no)
DE (1) DE59309265D1 (no)
ES (1) ES2128409T3 (no)
FI (1) FI932028A7 (no)
GR (1) GR3029899T3 (no)
HU (1) HUT64079A (no)
IL (1) IL105628A0 (no)
NO (1) NO931675L (no)
NZ (1) NZ247561A (no)
PH (1) PH30222A (no)
TW (1) TW224966B (no)
ZA (1) ZA933206B (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5457095A (en) * 1984-10-12 1995-10-10 Ciba-Geigy Corporation Substituted propane-phosponous acid compounds
IL114631A (en) * 1990-06-22 1998-12-06 Novartis Ag Anti-epileptic compositions containing gabab- antagonistic compounds
EP0543780A3 (en) * 1991-11-21 1993-09-01 Ciba-Geigy Ag Novel aminoalkanephosphinic acids and their salts
WO1997011953A1 (en) * 1995-09-28 1997-04-03 Novartis Ag Novel hydroxylated and alkoxylated n- and/or p-aralkylphosphinic acid derivatives
JP4131568B2 (ja) * 1996-05-30 2008-08-13 ノバルティス アクチエンゲゼルシャフト 代謝調節型ｇａｂａ［ｂ］レセプター、レセプター特異的リガンドおよびそれらの使用
US7119189B2 (en) 1997-03-19 2006-10-10 Novartis Ag Metabotropic GABA [B] receptors, receptor-specific ligands and their uses
GB9906882D0 (en) * 1999-03-25 1999-05-19 Novartis Ag Organic compounds
SE9904508D0 (sv) * 1999-12-09 1999-12-09 Astra Ab New compounds
US7319095B2 (en) * 1999-12-09 2008-01-15 Astrazeneca Ab Use of GABAB receptor agonists
ATE448193T1 (de) * 2002-01-18 2009-11-15 Merck & Co Inc ßN-(BENZYL)AMINOALKYL CARBOXYLATE, PHOSPHINATE, PHOSPHONATE UND TETRAZOLE ALS EDG REZEPTORAGONISTENß
AR045794A1 (es) * 2003-09-23 2005-11-16 Aventis Pharma Inc Procedimiento para preparar derivados de acido 3- amino-2- hidroxipropilfosfinico
GB0327186D0 (en) * 2003-11-21 2003-12-24 Novartis Ag Organic compounds
WO2005112946A1 (en) * 2004-05-14 2005-12-01 The Johns Hopkins University Method for improving cognitive function by co-administration of a gabab receptor antagonist and an acetylcholinesterase inhibitor
US7494985B2 (en) * 2004-11-03 2009-02-24 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis, and use
US7566738B2 (en) * 2004-11-03 2009-07-28 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use
US7585996B2 (en) * 2006-09-15 2009-09-08 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3493639A (en) * 1965-10-27 1970-02-03 Shell Oil Co Process for producing pentavalent phosphorus derivatives
JPS4714129Y1 (no) * 1969-06-11 1972-05-22
DE2032712C3 (de) * 1970-07-02 1978-10-19 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von w-Amino-alkanphosphonsäure bzw.- phosphinsäurederivaten
DE2440239A1 (de) * 1974-08-22 1976-03-04 Hoechst Ag Innere ammoniumsalze von phosphinsaeuren
JPS5463024A (en) * 1977-10-27 1979-05-21 Fujisawa Pharmaceut Co Ltd 3-(n-formyl-n-hydroxyamino)-2(r)-hydroxypropyl-phosphonic acid, its preparation, and its use
DE3362581D1 (en) * 1982-04-23 1986-04-24 Ciba Geigy Ag Herbicide and plant-growth regulator product
US4536355A (en) * 1982-10-08 1985-08-20 Zoecon Corporation Phenoxyphenylaminoalkylphosphinates useful in weed control
GB8425872D0 (en) * 1984-10-12 1984-11-21 Ciba Geigy Ag Chemical compounds
FR2572078B1 (fr) * 1984-10-24 1988-07-15 Inst Francais Du Petrole Phosphobetaines neutres, leur preparation et leur application a la recuperation assistee du petrole
USD302521S (en) 1986-03-13 1989-08-01 Grinde James E Dual compartment container with measurement indicator
US5190933A (en) * 1987-12-04 1993-03-02 Ciba-Geigy Corporation Substituted propane-phosphinic acid compounds
GB8728483D0 (en) * 1987-12-04 1988-01-13 Ciba Geigy Ag Chemical compounds
GB8820266D0 (en) * 1988-08-26 1988-09-28 Smith Kline French Lab Compounds
US5212164A (en) * 1988-08-29 1993-05-18 E. R. Squibb & Sons, Inc. Phosphorus-containing squalene synthetase inhibitors
US5190934A (en) * 1989-06-03 1993-03-02 Ciba-Geigy Corporation P-subsituted propane-phosphinic acid compounds
IL114631A (en) * 1990-06-22 1998-12-06 Novartis Ag Anti-epileptic compositions containing gabab- antagonistic compounds
EP0543780A3 (en) * 1991-11-21 1993-09-01 Ciba-Geigy Ag Novel aminoalkanephosphinic acids and their salts
GB9125615D0 (en) * 1991-12-02 1992-01-29 Wyeth John & Brother Ltd Amines

Also Published As

Publication number Publication date
CA2095708C (en) 2005-12-06
NO931675D0 (no) 1993-05-07
TW224966B (no) 1994-06-11
NZ247561A (en) 1995-07-26
FI932028L (fi) 1993-11-09
IL105628A0 (en) 1993-09-22
DE59309265D1 (de) 1999-02-18
PH30222A (en) 1997-02-05
AU662404B2 (en) 1995-08-31
US5332729A (en) 1994-07-26
ATE175415T1 (de) 1999-01-15
EP0569333A2 (de) 1993-11-10
EP0569333B1 (de) 1999-01-07
US5424441A (en) 1995-06-13
HU9301332D0 (en) 1993-09-28
FI932028A0 (fi) 1993-05-05
AU3711293A (en) 1993-11-11
JPH0632793A (ja) 1994-02-08
FI932028A7 (fi) 1993-11-09
ZA933206B (en) 1993-11-08
CA2095708A1 (en) 1993-11-09
HUT64079A (en) 1993-11-29
KR940005649A (ko) 1994-03-22
GR3029899T3 (en) 1999-07-30
EP0569333A3 (no) 1994-04-06
ES2128409T3 (es) 1999-05-16
JP3243056B2 (ja) 2002-01-07

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