NO931745L - Stabiliserte, sterkt virkende grf-analoger - Google Patents

Stabiliserte, sterkt virkende grf-analoger

Info

Publication number
NO931745L
NO931745L NO93931745A NO931745A NO931745L NO 931745 L NO931745 L NO 931745L NO 93931745 A NO93931745 A NO 93931745A NO 931745 A NO931745 A NO 931745A NO 931745 L NO931745 L NO 931745L
Authority
NO
Norway
Prior art keywords
stabilized
val
amino acid
grf analogs
strong effective
Prior art date
Application number
NO93931745A
Other languages
English (en)
Other versions
NO931745D0 (no
Inventor
Alan R Friedman
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of NO931745D0 publication Critical patent/NO931745D0/no
Publication of NO931745L publication Critical patent/NO931745L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Oscillators With Electromechanical Resonators (AREA)
  • Amplifiers (AREA)
  • Tires In General (AREA)
  • Detergent Compositions (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

GRF-peptid med Val eller Ile i stedet for aminosyreresten som normalt finnes i 19-stilling, med Gly, Thr, Val eller Ile i stedet for amino- syreresten som normalt finnes i 2-stilling, og med en aminosyre valgt fra gruppen bestående av Ala, Val, Leu, Ile eller Gly i 15-stilling. Peptidene har forøkt stabilitet i plasma og vandige miljøer ved nøytral pH.
NO93931745A 1990-11-14 1993-05-13 Stabiliserte, sterkt virkende grf-analoger NO931745L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61417090A 1990-11-14 1990-11-14
PCT/US1991/008248 WO1992008481A1 (en) 1990-11-14 1991-11-13 Stabilized, potent grf analogs

Publications (2)

Publication Number Publication Date
NO931745D0 NO931745D0 (no) 1993-05-13
NO931745L true NO931745L (no) 1993-05-13

Family

ID=24460133

Family Applications (1)

Application Number Title Priority Date Filing Date
NO93931745A NO931745L (no) 1990-11-14 1993-05-13 Stabiliserte, sterkt virkende grf-analoger

Country Status (11)

Country Link
EP (1) EP0565536A1 (no)
JP (1) JPH06502650A (no)
AU (1) AU655791B2 (no)
CA (1) CA2092906A1 (no)
CZ (1) CZ85393A3 (no)
FI (1) FI932185A7 (no)
HU (1) HUT63857A (no)
NO (1) NO931745L (no)
RU (1) RU2119800C1 (no)
SK (1) SK49093A3 (no)
WO (1) WO1992008481A1 (no)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6057422A (en) * 1998-11-25 2000-05-02 The Administrators Of The Tulane Educational Fund Antagonistic analogs of GH-RH inhibiting IGF-I and -II
GB9906715D0 (en) * 1999-03-23 1999-05-19 Ferring Bv Compositions for promoting growth

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4689318A (en) * 1985-08-29 1987-08-25 The Salk Institute For Biological Studies GRF analogs
US5043322A (en) * 1988-07-22 1991-08-27 The Salk Institute For Biological Studies Cyclic GRF analogs
ATE113965T1 (de) * 1989-06-16 1994-11-15 Upjohn Co Stabilisierte, starke grf-analoga.

Also Published As

Publication number Publication date
WO1992008481A1 (en) 1992-05-29
HUT63857A (en) 1993-10-28
CZ85393A3 (en) 1994-03-16
NO931745D0 (no) 1993-05-13
CA2092906A1 (en) 1992-05-15
SK49093A3 (en) 1993-10-06
FI932185A0 (fi) 1993-05-13
FI932185L (fi) 1993-05-13
JPH06502650A (ja) 1994-03-24
AU655791B2 (en) 1995-01-12
RU2119800C1 (ru) 1998-10-10
AU9055191A (en) 1992-06-11
FI932185A7 (fi) 1993-05-13
EP0565536A1 (en) 1993-10-20
HU9301385D0 (en) 1993-09-28

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