NO932256L - Nye metylenbisfosfonsyrederivater - Google Patents

Nye metylenbisfosfonsyrederivater

Info

Publication number: NO932256L
Authority: NO; Norway
Prior art keywords: pct; groups; group; independently; formula
Prior art date: 1990-12-20

Application number

NO93932256A

Other languages

English (en)

Other versions

NO303121B1 (no

NO932256D0 (no

Inventor

Heikki Nupponen

Jouko Vepsaelaeinen

Esko Pohjala

Hannu Hanhijaervi

Original Assignee

Leiras Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-12-20

Filing date

1993-06-18

Publication date

1993-08-20

1993-06-18 Application filed by Leiras Oy filed Critical Leiras Oy

1993-06-18 Publication of NO932256D0 publication Critical patent/NO932256D0/no

1993-08-20 Publication of NO932256L publication Critical patent/NO932256L/no

1998-06-02 Publication of NO303121B1 publication Critical patent/NO303121B1/no

Links

MBKDYNNUVRNNRF-UHFFFAOYSA-N medronic acid Chemical class OP(O)(=O)CP(O)(O)=O MBKDYNNUVRNNRF-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
229920006395 saturated elastomer Polymers 0.000 abstract 2
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Substances 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 1
-1 methylenebisphosphonic acid ester amide Chemical class 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/6533—Six-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
- C07F9/4403—Amides thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4423—Amides of poly (thio)phosphonic acids

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Paints Or Removers (AREA)
Detergent Compositions (AREA)
Medicinal Preparation (AREA)
Luminescent Compositions (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO932256A 1990-12-20 1993-06-18 AnalogifremgangsmÕte ved fremstilling av terapeutisk aktive metylenbisfosfonsyreamid- og esteramidderivater NO303121B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FI906296A FI89365C (fi)	1990-12-20	1990-12-20	Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat
PCT/FI1991/000396 WO1992011268A1 (en)	1990-12-20	1991-12-18	Novel methylenebisphosphonic acid derivatives

Publications (3)

Publication Number	Publication Date
NO932256D0 NO932256D0 (no)	1993-06-18
NO932256L true NO932256L (no)	1993-08-20
NO303121B1 NO303121B1 (no)	1998-06-02

Family

ID=8531621

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO932256A NO303121B1 (no)	1990-12-20	1993-06-18	AnalogifremgangsmÕte ved fremstilling av terapeutisk aktive metylenbisfosfonsyreamid- og esteramidderivater

Country Status (25)

Country	Link
US (1)	US5442101A (no)
EP (1)	EP0570380B1 (no)
JP (1)	JPH06504770A (no)
KR (1)	KR930703336A (no)
CN (1)	CN1028866C (no)
AT (1)	ATE171182T1 (no)
AU (1)	AU663268B2 (no)
CA (1)	CA2098734A1 (no)
CZ (1)	CZ119593A3 (no)
DE (1)	DE69130231T2 (no)
DK (1)	DK0570380T3 (no)
EE (1)	EE02950B1 (no)
ES (1)	ES2121003T3 (no)
FI (1)	FI89365C (no)
HU (1)	HUT64547A (no)
IE (1)	IE914390A1 (no)
IL (1)	IL100336A (no)
NO (1)	NO303121B1 (no)
NZ (1)	NZ241039A (no)
PL (1)	PL169728B1 (no)
RU (1)	RU2100364C1 (no)
SK (1)	SK63093A3 (no)
TW (1)	TW203053B (no)
WO (1)	WO1992011268A1 (no)
ZA (1)	ZA9110007B (no)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BR9712285A (pt)	1996-10-09	2001-11-20	Pharmasset Ltd	Tetrafosfonato bicìclico de trianidridas
EP1469003A3 (en) *	1996-10-09	2004-11-24	Pharmasset, Ltd.	Tetraphosphonate bicyclic trisanhydrides
US20040181078A1 (en) *	1997-10-10	2004-09-16	Pharmasset, Ltd.	Tetraphosphonate bicyclic trisanhydrides
FI104901B (fi) *	1997-10-20	2000-04-28	Leiras Oy	Uudet metyleenibisfosfonihappojohdannaiset
US5998390A (en) *	1998-09-28	1999-12-07	The Research Foundation Of State University Of New York	Combination of bisphosphonate and tetracycline
RU2213959C2 (ru) *	2001-01-15	2003-10-10	Войсковая часть 61469 МО РФ	Способ количественного определения о-алкиловых эфиров метилфосфоновой кислоты в водных матрицах методом реакционной газовой хроматографии с атомно-эмиссионным детектированием
WO2005090370A1 (en) *	2004-02-05	2005-09-29	The Regents Of The University Of California	Pharmacologically active agents containing esterified phosphonates and methods for use thereof
US8642577B2 (en)	2005-04-08	2014-02-04	Chimerix, Inc.	Compounds, compositions and methods for the treatment of poxvirus infections
EP2842559A3 (en) *	2005-04-08	2015-03-18	Chimerix, Inc.	Compounds, compositions and methods for the treatment of viral infections and other medical disorders
US7862552B2 (en)	2005-05-09	2011-01-04	Boston Scientific Scimed, Inc.	Medical devices for treating urological and uterine conditions
ES2572631T3 (es) *	2008-01-25	2016-06-01	Chimerix, Inc.	Métodos de tratamiento de infecciones virales
WO2011011519A1 (en)	2009-07-21	2011-01-27	Chimerix, Inc.	Compounds, compositions and methods for treating ocular conditions
CA2770282A1 (en)	2009-08-03	2011-02-10	Chimerix, Inc.	Composition and methods of treating viral infections and viral induced tumors
US9006218B2 (en)	2010-02-12	2015-04-14	Chimerix Inc.	Nucleoside phosphonate salts
CN102190684A (zh) *	2010-03-15	2011-09-21	南通波锐生物医药有限公司	一种具有药物应用的含磷化合物及其制备和用途
CA2797601A1 (en)	2010-04-26	2011-11-10	Chimerix, Inc.	Methods of treating retroviral infections and related dosage regimes
CN102453050B (zh) *	2010-11-03	2015-01-07	成都云克药业有限责任公司	一种二膦酸化合物及其制备方法
US11457631B2 (en) *	2016-06-28	2022-10-04	Aequor, Inc.	Antimicrobial compounds and methods of use
RU2630226C1 (ru) *	2016-12-20	2017-09-06	Федеральное государственное бюджетное образовательное учреждение высшего образования "Тверской государственный университет"	Новая ионная жидкость производная бис-(N,N-диметиламида) метилфосфоновой кислоты с высокими термическими свойствами

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4293505A (en) *	1967-04-06	1981-10-06	Randall David I	Preparation of β-haloethylphosphonic acids and half esters thereof
US3524846A (en) *	1967-06-02	1970-08-18	Syntex Corp	Process for the didealkylation of phosphonate esters
US3808265A (en) *	1971-03-26	1974-04-30	Gaf Corp	Preparation of 2-haloethylphosphonic acid
IT1187828B (it) *	1985-05-24	1987-12-23	Gentili Ist Spa	Composizione farmaceutica a base di difosfonati per il trattamento dell aretrosi
EP0356866A3 (en) *	1988-08-29	1991-03-27	E.R. SQUIBB & SONS, INC.	Phosphorus-containing squalene synthetase inhibitors and method
US5273969A (en) *	1988-08-29	1993-12-28	E. R. Squibb & Sons, Inc.	Phosphorus-containing squalene synthetase inhibitors and method
US5212164A (en) *	1988-08-29	1993-05-18	E. R. Squibb & Sons, Inc.	Phosphorus-containing squalene synthetase inhibitors
FI89366C (fi) *	1990-12-20	1993-09-27	Leiras Oy	Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat

1990
- 1990-12-20 FI FI906296A patent/FI89365C/fi not_active IP Right Cessation
1991
- 1991-12-11 IL IL10033691A patent/IL100336A/en not_active IP Right Cessation
- 1991-12-17 IE IE439091A patent/IE914390A1/en not_active Application Discontinuation
- 1991-12-18 NZ NZ241039A patent/NZ241039A/en unknown
- 1991-12-18 CA CA002098734A patent/CA2098734A1/en not_active Abandoned
- 1991-12-18 DK DK92901217T patent/DK0570380T3/da active
- 1991-12-18 JP JP4502098A patent/JPH06504770A/ja active Pending
- 1991-12-18 RU RU9393050805A patent/RU2100364C1/ru active
- 1991-12-18 EP EP92901217A patent/EP0570380B1/en not_active Expired - Lifetime
- 1991-12-18 KR KR1019930701879A patent/KR930703336A/ko not_active Abandoned
- 1991-12-18 DE DE69130231T patent/DE69130231T2/de not_active Expired - Fee Related
- 1991-12-18 AU AU90800/91A patent/AU663268B2/en not_active Ceased
- 1991-12-18 PL PL91299980A patent/PL169728B1/pl unknown
- 1991-12-18 CZ CS931195A patent/CZ119593A3/cs unknown
- 1991-12-18 HU HU9301780A patent/HUT64547A/hu unknown
- 1991-12-18 WO PCT/FI1991/000396 patent/WO1992011268A1/en not_active Ceased
- 1991-12-18 ES ES92901217T patent/ES2121003T3/es not_active Expired - Lifetime
- 1991-12-18 US US08/078,155 patent/US5442101A/en not_active Expired - Fee Related
- 1991-12-18 AT AT92901217T patent/ATE171182T1/de not_active IP Right Cessation
- 1991-12-18 SK SK630-93A patent/SK63093A3/sk unknown
- 1991-12-19 ZA ZA9110007A patent/ZA9110007B/xx unknown
- 1991-12-20 CN CN91111881A patent/CN1028866C/zh not_active Expired - Fee Related
- 1991-12-31 TW TW081100320A patent/TW203053B/zh active
1993
- 1993-06-18 NO NO932256A patent/NO303121B1/no unknown
1994
- 1994-11-14 EE EE9400299A patent/EE02950B1/xx unknown

Also Published As

Publication number	Publication date
CA2098734A1 (en)	1992-06-21
AU663268B2 (en)	1995-09-28
CN1062533A (zh)	1992-07-08
DE69130231D1 (de)	1998-10-22
DK0570380T3 (da)	1999-02-08
CN1028866C (zh)	1995-06-14
IL100336A0 (en)	1992-09-06
ES2121003T3 (es)	1998-11-16
EP0570380A1 (en)	1993-11-24
KR930703336A (ko)	1993-11-29
IL100336A (en)	1998-07-15
AU9080091A (en)	1992-07-22
ATE171182T1 (de)	1998-10-15
FI906296A7 (fi)	1992-06-21
DE69130231T2 (de)	1999-03-25
FI89365B (fi)	1993-06-15
TW203053B (no)	1993-04-01
FI89365C (fi)	1993-09-27
CZ119593A3 (en)	1994-02-16
HU9301780D0 (en)	1993-09-28
WO1992011268A1 (en)	1992-07-09
ZA9110007B (en)	1992-09-30
FI906296A0 (fi)	1990-12-20
EE02950B1 (et)	1996-12-16
IE914390A1 (en)	1992-07-01
PL169728B1 (pl)	1996-08-30
RU2100364C1 (ru)	1997-12-27
SK63093A3 (en)	1993-12-08
EP0570380B1 (en)	1998-09-16
HUT64547A (en)	1994-01-28
NO303121B1 (no)	1998-06-02
US5442101A (en)	1995-08-15
JPH06504770A (ja)	1994-06-02
NZ241039A (en)	1993-05-26
NO932256D0 (no)	1993-06-18

Publication	Publication Date	Title
DK0570380T3 (da)	1999-02-08	Nye methylenbisphosphonsyrederivater
EA200100970A1 (ru)	2002-04-25	Аминопроизводные как ингибиторы протеазы
ES2115058T3 (es)	1998-06-16	Derivados basicos de acido glutamico y acido aspartico como antagonistas de la gastrina o colecistoquinina.
ES2093399T3 (es)	1996-12-16	Nuevos derivados de acido fosfono-succinico, procedimiento para su preparacion y medicamentos que contienen estos compuestos.
RU93050805A (ru)	1996-06-20	Новые производные метиленбисфосфоновой кислоты
DE69320952D1 (de)	1998-10-15	Verwendung von terfenadin-derivaten als antihistaminika in leberkranken patienten
DE69410081D1 (de)	1998-06-10	Zwischenprodukte für die Herstellung von Endothelinrezeptor-Antagonist-Triterpen-Derivaten
FI954016A0 (fi)	1995-08-25	Uudet yhdisteet
DE69725585D1 (de)	2003-11-20	Phenylalkylcarbonsäure-derivate
NO915021D0 (no)	1991-12-19	Nye metylenbisfosfonsyrederivater
BR9707250A (pt)	1999-04-06	Dihidrobenzofurano e compostos correlatos úteis como agentes antiinflamatórios
ES8707550A1 (es)	1986-04-01	Un procedimiento para preparar compuestos peptidicos sustituidos.
DK216186D0 (da)	1986-05-09	Hexensyrer
SE8008189L (sv)	1981-05-24	Foreningar med antiallergisk och antiulceros verkan, nemligen 1-oxo-1h-tiazolo(3,2-a)pyrimidin-2-karboxamider och mellanprodukter for dessa
WO1993004059A1 (fr)	1993-03-04	Derive de 4-acylaminoimidazole
EP0802179A4 (en)	2000-04-05	DERIVATE SUBSTITUTED AMIDINONAPHTHYLESTER
DK0707587T3 (da)	1998-05-11	Farmakologisk aktive enantiomerer
KR970061847A (ko)	1997-09-12	(±)-2-[4-(2-옥소시클로펜틸메틸)페닐]프로피온산 및 그의 염들의 제조방법