ATE171182T1 - Neue methylenbisphosphonsaürederivate - Google Patents

Neue methylenbisphosphonsaürederivate

Info

Publication number: ATE171182T1
Authority: AT; Austria
Prior art keywords: pct; groups; group; independently; formula
Prior art date: 1990-12-20

Application number

AT92901217T

Other languages

English (en)

Inventor

Hannu Hanhijaervi

Heikki Nupponen

Jouko Vepsaelaeinen

Esko Pohjala

Original Assignee

Leiras Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-12-20

Filing date

1991-12-18

Publication date

1998-10-15

1991-12-18 Application filed by Leiras Oy filed Critical Leiras Oy

1998-10-15 Application granted granted Critical

1998-10-15 Publication of ATE171182T1 publication Critical patent/ATE171182T1/de

Links

MBKDYNNUVRNNRF-UHFFFAOYSA-N medronic acid Chemical class OP(O)(=O)CP(O)(O)=O MBKDYNNUVRNNRF-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
229920006395 saturated elastomer Polymers 0.000 abstract 2
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Substances 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 1
-1 methylenebisphosphonic acid ester amide Chemical class 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/6533—Six-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
- C07F9/4403—Amides thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4423—Amides of poly (thio)phosphonic acids

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Paints Or Removers (AREA)
Detergent Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)
Luminescent Compositions (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

AT92901217T 1990-12-20 1991-12-18 Neue methylenbisphosphonsaürederivate ATE171182T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FI906296A FI89365C (fi)	1990-12-20	1990-12-20	Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat

Publications (1)

Publication Number	Publication Date
ATE171182T1 true ATE171182T1 (de)	1998-10-15

Family

ID=8531621

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92901217T ATE171182T1 (de)	1990-12-20	1991-12-18	Neue methylenbisphosphonsaürederivate

Country Status (25)

Country	Link
US (1)	US5442101A (de)
EP (1)	EP0570380B1 (de)
JP (1)	JPH06504770A (de)
KR (1)	KR930703336A (de)
CN (1)	CN1028866C (de)
AT (1)	ATE171182T1 (de)
AU (1)	AU663268B2 (de)
CA (1)	CA2098734A1 (de)
CZ (1)	CZ119593A3 (de)
DE (1)	DE69130231T2 (de)
DK (1)	DK0570380T3 (de)
EE (1)	EE02950B1 (de)
ES (1)	ES2121003T3 (de)
FI (1)	FI89365C (de)
HU (1)	HUT64547A (de)
IE (1)	IE914390A1 (de)
IL (1)	IL100336A (de)
NO (1)	NO303121B1 (de)
NZ (1)	NZ241039A (de)
PL (1)	PL169728B1 (de)
RU (1)	RU2100364C1 (de)
SK (1)	SK63093A3 (de)
TW (1)	TW203053B (de)
WO (1)	WO1992011268A1 (de)
ZA (1)	ZA9110007B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4118958B2 (ja) *	1996-10-09	2008-07-16	ファーマセット，リミティド	テトラホスホネート二環式トリス無水物
EP1469003A3 (de) *	1996-10-09	2004-11-24	Pharmasset, Ltd.	Tetraphosphonat bizyklische Trisanhydride
US20040181078A1 (en) *	1997-10-10	2004-09-16	Pharmasset, Ltd.	Tetraphosphonate bicyclic trisanhydrides
FI104901B (fi) *	1997-10-20	2000-04-28	Leiras Oy	Uudet metyleenibisfosfonihappojohdannaiset
US5998390A (en) *	1998-09-28	1999-12-07	The Research Foundation Of State University Of New York	Combination of bisphosphonate and tetracycline
RU2213959C2 (ru) *	2001-01-15	2003-10-10	Войсковая часть 61469 МО РФ	Способ количественного определения о-алкиловых эфиров метилфосфоновой кислоты в водных матрицах методом реакционной газовой хроматографии с атомно-эмиссионным детектированием
WO2005090370A1 (en)	2004-02-05	2005-09-29	The Regents Of The University Of California	Pharmacologically active agents containing esterified phosphonates and methods for use thereof
US8642577B2 (en)	2005-04-08	2014-02-04	Chimerix, Inc.	Compounds, compositions and methods for the treatment of poxvirus infections
JP2008538354A (ja)	2005-04-08	2008-10-23	キメリクス，インコーポレイテッド	ウイルス感染症およびその他の内科疾患を治療するための化合物、組成物および方法
US7862552B2 (en)	2005-05-09	2011-01-04	Boston Scientific Scimed, Inc.	Medical devices for treating urological and uterine conditions
CN101977610B (zh) *	2008-01-25	2012-05-16	奇默里克斯公司	治疗病毒感染的方法
WO2011011519A1 (en)	2009-07-21	2011-01-27	Chimerix, Inc.	Compounds, compositions and methods for treating ocular conditions
US20120164104A1 (en)	2009-08-03	2012-06-28	Chimerix, Inc.	Composition and Methods of Treating Viral Infections and Viral Induced Tumors
PT2534150T (pt)	2010-02-12	2017-05-02	Chimerix Inc	Métodos para tratar uma infecção viral
CN102190684A (zh) *	2010-03-15	2011-09-21	南通波锐生物医药有限公司	一种具有药物应用的含磷化合物及其制备和用途
US9278135B2 (en)	2010-04-26	2016-03-08	Chimerix Inc.	Methods of treating retroviral infections and related dosage regimes
CN102453050B (zh)	2010-11-03	2015-01-07	成都云克药业有限责任公司	一种二膦酸化合物及其制备方法
CA3028739A1 (en) *	2016-06-28	2018-01-04	Aequor, Inc.	Antimicrobial compounds and methods of use
RU2630226C1 (ru) *	2016-12-20	2017-09-06	Федеральное государственное бюджетное образовательное учреждение высшего образования "Тверской государственный университет"	Новая ионная жидкость производная бис-(N,N-диметиламида) метилфосфоновой кислоты с высокими термическими свойствами

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4293505A (en) *	1967-04-06	1981-10-06	Randall David I	Preparation of β-haloethylphosphonic acids and half esters thereof
US3524846A (en) *	1967-06-02	1970-08-18	Syntex Corp	Process for the didealkylation of phosphonate esters
US3808265A (en) *	1971-03-26	1974-04-30	Gaf Corp	Preparation of 2-haloethylphosphonic acid
IT1187828B (it) *	1985-05-24	1987-12-23	Gentili Ist Spa	Composizione farmaceutica a base di difosfonati per il trattamento dell aretrosi
EP0356866A3 (de) *	1988-08-29	1991-03-27	E.R. SQUIBB & SONS, INC.	Phosphor enthaltende Squalen-Synthetase-Inhibitoren und Verfahren
US5212164A (en) *	1988-08-29	1993-05-18	E. R. Squibb & Sons, Inc.	Phosphorus-containing squalene synthetase inhibitors
US5273969A (en) *	1988-08-29	1993-12-28	E. R. Squibb & Sons, Inc.	Phosphorus-containing squalene synthetase inhibitors and method
FI89366C (fi) *	1990-12-20	1993-09-27	Leiras Oy	Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat

1990
- 1990-12-20 FI FI906296A patent/FI89365C/fi not_active IP Right Cessation
1991
- 1991-12-11 IL IL10033691A patent/IL100336A/en not_active IP Right Cessation
- 1991-12-17 IE IE439091A patent/IE914390A1/en not_active Application Discontinuation
- 1991-12-18 AT AT92901217T patent/ATE171182T1/de not_active IP Right Cessation
- 1991-12-18 AU AU90800/91A patent/AU663268B2/en not_active Ceased
- 1991-12-18 PL PL91299980A patent/PL169728B1/pl unknown
- 1991-12-18 DK DK92901217T patent/DK0570380T3/da active
- 1991-12-18 NZ NZ241039A patent/NZ241039A/en unknown
- 1991-12-18 DE DE69130231T patent/DE69130231T2/de not_active Expired - Fee Related
- 1991-12-18 SK SK630-93A patent/SK63093A3/sk unknown
- 1991-12-18 JP JP4502098A patent/JPH06504770A/ja active Pending
- 1991-12-18 KR KR1019930701879A patent/KR930703336A/ko not_active Abandoned
- 1991-12-18 RU RU9393050805A patent/RU2100364C1/ru active
- 1991-12-18 US US08/078,155 patent/US5442101A/en not_active Expired - Fee Related
- 1991-12-18 WO PCT/FI1991/000396 patent/WO1992011268A1/en not_active Ceased
- 1991-12-18 ES ES92901217T patent/ES2121003T3/es not_active Expired - Lifetime
- 1991-12-18 HU HU9301780A patent/HUT64547A/hu unknown
- 1991-12-18 CZ CS931195A patent/CZ119593A3/cs unknown
- 1991-12-18 CA CA002098734A patent/CA2098734A1/en not_active Abandoned
- 1991-12-18 EP EP92901217A patent/EP0570380B1/de not_active Expired - Lifetime
- 1991-12-19 ZA ZA9110007A patent/ZA9110007B/xx unknown
- 1991-12-20 CN CN91111881A patent/CN1028866C/zh not_active Expired - Fee Related
- 1991-12-31 TW TW081100320A patent/TW203053B/zh active
1993
- 1993-06-18 NO NO932256A patent/NO303121B1/no unknown
1994
- 1994-11-14 EE EE9400299A patent/EE02950B1/xx unknown

Also Published As

Publication number	Publication date
DK0570380T3 (da)	1999-02-08
HU9301780D0 (en)	1993-09-28
DE69130231T2 (de)	1999-03-25
FI906296A7 (fi)	1992-06-21
CN1062533A (zh)	1992-07-08
RU2100364C1 (ru)	1997-12-27
EE02950B1 (et)	1996-12-16
NZ241039A (en)	1993-05-26
HUT64547A (en)	1994-01-28
IL100336A (en)	1998-07-15
US5442101A (en)	1995-08-15
IE914390A1 (en)	1992-07-01
FI89365B (fi)	1993-06-15
JPH06504770A (ja)	1994-06-02
ES2121003T3 (es)	1998-11-16
NO932256L (no)	1993-08-20
AU9080091A (en)	1992-07-22
AU663268B2 (en)	1995-09-28
TW203053B (de)	1993-04-01
SK63093A3 (en)	1993-12-08
DE69130231D1 (de)	1998-10-22
NO932256D0 (no)	1993-06-18
WO1992011268A1 (en)	1992-07-09
IL100336A0 (en)	1992-09-06
EP0570380B1 (de)	1998-09-16
CN1028866C (zh)	1995-06-14
FI89365C (fi)	1993-09-27
EP0570380A1 (de)	1993-11-24
CA2098734A1 (en)	1992-06-21
PL169728B1 (pl)	1996-08-30
ZA9110007B (en)	1992-09-30
FI906296A0 (fi)	1990-12-20
KR930703336A (ko)	1993-11-29
CZ119593A3 (en)	1994-02-16
NO303121B1 (no)	1998-06-02

Legal Events

Date	Code	Title	Description
1999-04-15	UEP	Publication of translation of european patent specification
2000-09-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69130231D1 (de)	1998-10-22	Neue methylenbisphosphonsaürederivate
EA200100970A1 (ru)	2002-04-25	Аминопроизводные как ингибиторы протеазы
ES2115058T3 (es)	1998-06-16	Derivados basicos de acido glutamico y acido aspartico como antagonistas de la gastrina o colecistoquinina.
ES2187025T3 (es)	2003-05-16	Nuevos agentes quelantes de hierro (iii) activos via oral.
ATE194913T1 (de)	2000-08-15	Verwendung von terfenadin-derivaten als antihistaminika in leberkranken patienten
RU93050805A (ru)	1996-06-20	Новые производные метиленбисфосфоновой кислоты
SE9300657D0 (sv)	1993-02-26	New compounds
DE69022593D1 (de)	1995-10-26	Neue methylenbisphosphonsäurederivate.
LV10235A (lv)	1994-10-20	Jauni esteri to iegusanas panemiens farmaceitiska kompozicija arstesanas metode
BR9707250A (pt)	1999-04-06	Dihidrobenzofurano e compostos correlatos úteis como agentes antiinflamatórios
DE69623610D1 (de)	2002-10-17	Neue heterozyklische chemie
MX9101270A (es)	1992-07-08	Compuesto,preparacion y uso
MX9806249A (es)	1998-11-30	Dihidrobenzofurano y compuestos relacionados utiles como agentes antiinflamatorios.
SE8008189L (sv)	1981-05-24	Foreningar med antiallergisk och antiulceros verkan, nemligen 1-oxo-1h-tiazolo(3,2-a)pyrimidin-2-karboxamider och mellanprodukter for dessa
EP0802179A4 (de)	2000-04-05	Derivate substituierter amidinonaphthylester