NO933784L - Pyrazolo(4,3-c)pyridiner, en fremgangsmåte for fremstilling av dem og deres anvendelse som hemmere av reopptak av serotonin - Google Patents

Pyrazolo(4,3-c)pyridiner, en fremgangsmåte for fremstilling av dem og deres anvendelse som hemmere av reopptak av serotonin

Info

Publication number: NO933784L
Authority: NO; Norway
Prior art keywords: loweralkyl; serotonin reuptake; chem; hydrogen; inhibitors
Prior art date: 1992-10-22

Application number

NO933784A

Other languages

English (en)

Other versions

NO300374B1 (no

NO933784D0 (no

Inventor

Gregory M Shutske

Kevin J Kapples

Iv John D Tomer

Original Assignee

Hoechst Roussel Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-10-22

Filing date

1993-10-21

Publication date

1994-04-25

1993-10-21 Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma

1993-10-21 Publication of NO933784D0 publication Critical patent/NO933784D0/no

1994-04-25 Publication of NO933784L publication Critical patent/NO933784L/no

1997-05-20 Publication of NO300374B1 publication Critical patent/NO300374B1/no

Links

WCXFPLXZZSWROM-UHFFFAOYSA-N 1h-pyrazolo[4,3-c]pyridine Chemical class C1=NC=C2C=NNC2=C1 WCXFPLXZZSWROM-UHFFFAOYSA-N 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
230000000697 serotonin reuptake Effects 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000003772 serotonin uptake inhibitor Substances 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Neurology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Silver Salt Photography Or Processing Solution Therefor (AREA)

NO933784A 1992-10-22 1993-10-21 Pyrazolo£4,3-c|pyridiner, farmasöytiske sammensetninger inneholdende disse og deres anvendelse til fremstilling av hemmere av reopptak av serotonin NO300374B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/964,690 US5264576A (en)	1992-10-22	1992-10-22	Pyrazolo[4,3-c]pyridines which are intermediates

Publications (3)

Publication Number	Publication Date
NO933784D0 NO933784D0 (no)	1993-10-21
NO933784L true NO933784L (no)	1994-04-25
NO300374B1 NO300374B1 (no)	1997-05-20

Family

ID=25508857

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO933784A NO300374B1 (no)	1992-10-22	1993-10-21	Pyrazolo£4,3-c\|pyridiner, farmasöytiske sammensetninger inneholdende disse og deres anvendelse til fremstilling av hemmere av reopptak av serotonin

Country Status (18)

Country	Link
US (4)	US5264576A (no)
EP (1)	EP0594001B1 (no)
JP (1)	JP2656211B2 (no)
KR (1)	KR100295026B1 (no)
CN (1)	CN1049658C (no)
AT (1)	ATE195522T1 (no)
AU (1)	AU671305B2 (no)
CA (1)	CA2108941A1 (no)
DE (1)	DE69329231T2 (no)
DK (1)	DK0594001T3 (no)
ES (1)	ES2152237T3 (no)
FI (1)	FI103890B1 (no)
GR (1)	GR3034819T3 (no)
MX (1)	MX9306552A (no)
NO (1)	NO300374B1 (no)
NZ (1)	NZ250003A (no)
PT (1)	PT594001E (no)
TW (1)	TW252114B (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5300498A (en) *	1993-06-04	1994-04-05	Hoechst-Roussel Pharmaceuticals Incorporated	6-piperazinyl-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acids, esters, amides and related compounds
US5618824A (en) *	1994-03-09	1997-04-08	Merrell Pharmaceuticals Inc.	Treatment of obsessive-compulsive disorders with 5-HT2 antagonists
US5565413A (en) *	1994-12-06	1996-10-15	Zeneca Limited	Substituted pyridyl phenyl ketone herbicides
US20050101587A9 (en) *	2000-08-14	2005-05-12	Butler Christopher R.	Method for treating allergies using substituted pyrazoles
RU2317988C2 (ru)	2000-08-14	2008-02-27	Орто-Макнейл Фармасьютикал, Инк.	Замещенные пиразолы, фармацевтическая композиция на их основе, применение фармацевтической композиции и способ ингибирования активности катепсина s
AU2001281255B2 (en)	2000-08-14	2006-07-20	Ortho-Mcneil Pharmaceutical, Inc.	Substituted pyrazoles
US7332494B2 (en)	2000-08-14	2008-02-19	Janssen Pharmaceutica, N.V.	Method for treating allergies using substituted pyrazoles
US20070117785A1 (en) *	2000-08-14	2007-05-24	Butler Christopher R	Substituted pyrazoles and methods of treatment with substituted pyrazoles
PT1309592E (pt) *	2000-08-14	2006-07-31	Ortho Mcneil Pharm Inc	Pirazoles substituidos
CN1642973A (zh)	2000-09-06	2005-07-20	奥索-麦克尼尔药品公司	治疗变态反应的方法
KR20050004214A (ko) *	2002-05-31	2005-01-12	에자이 가부시키가이샤	피라졸 화합물 및 이것을 포함하여 이루어지는 의약 조성물
EP2328895B1 (en) *	2008-09-16	2013-03-27	Proximagen Limited	Pyrazolo[4,3-c]pyridine compounds and their use as inhibitors of SSAO
CN102558174B (zh) *	2011-08-23	2014-03-19	天津市斯芬克司药物研发有限公司	一种全新吡唑并[4,3-c]吡啶化合物的发明及其合成方法
CA2871388A1 (en)	2012-06-27	2014-01-03	F. Hoffmann-La Roche Ag	5-azaindazole compounds and methods of use

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3994890A (en) *	1974-01-31	1976-11-30	Chugai Seiyaku Kabushiki Kaisha	1-Aminoalkyl, 3-phenyl indazoles
JPS5944314B2 (ja) *	1975-01-15	1984-10-29	中外製薬株式会社	インダゾ−ル誘導体の製法
JPS5936627B2 (ja) *	1975-07-25	1984-09-05	中外製薬株式会社	インダゾ−ル誘導体の製法
DK27383A (da) *	1982-02-17	1983-08-18	Lepetit Spa	Fremgangsmaade til fremstilling af pyrazol(4,3-c)pyridiner
JPH0615542B2 (ja) *	1986-07-22	1994-03-02	吉富製薬株式会社	ピラゾロピリジン化合物
EP0338087A4 (en) *	1987-10-13	1991-07-24	Yoshitomi Pharmaceutical Industries, Ltd.	Fused pyrazole compounds, process for their preparation, and their medicinal use
DK181190D0 (da) *	1990-07-30	1990-07-30	Lundbeck & Co As H	3-aryl-indol- eller 3-aryl-indazolderivater
EP0494774A1 (en) *	1991-01-11	1992-07-15	MERCK SHARP & DOHME LTD.	Indazole-substituted fivemembered heteroaromatic compounds
GB9216783D0 (en) *	1992-08-07	1992-09-23	Ici Plc	Heterocyclic derivatives
US5300478A (en) *	1993-01-28	1994-04-05	Zeneca Limited	Substituted fused pyrazolo compounds

1992
- 1992-10-22 US US07/964,690 patent/US5264576A/en not_active Expired - Fee Related
1993
- 1993-08-17 US US08/106,953 patent/US5296491A/en not_active Expired - Fee Related
- 1993-10-08 AT AT93116317T patent/ATE195522T1/de not_active IP Right Cessation
- 1993-10-08 EP EP93116317A patent/EP0594001B1/en not_active Expired - Lifetime
- 1993-10-08 DE DE69329231T patent/DE69329231T2/de not_active Expired - Fee Related
- 1993-10-08 PT PT93116317T patent/PT594001E/pt unknown
- 1993-10-08 ES ES93116317T patent/ES2152237T3/es not_active Expired - Lifetime
- 1993-10-08 DK DK93116317T patent/DK0594001T3/da active
- 1993-10-20 FI FI934621A patent/FI103890B1/fi active
- 1993-10-20 NZ NZ250003A patent/NZ250003A/en unknown
- 1993-10-21 AU AU49128/93A patent/AU671305B2/en not_active Ceased
- 1993-10-21 NO NO933784A patent/NO300374B1/no not_active IP Right Cessation
- 1993-10-21 CA CA002108941A patent/CA2108941A1/en not_active Abandoned
- 1993-10-21 MX MX9306552A patent/MX9306552A/es not_active IP Right Cessation
- 1993-10-22 KR KR1019930022006A patent/KR100295026B1/ko not_active Expired - Fee Related
- 1993-10-22 JP JP5265158A patent/JP2656211B2/ja not_active Expired - Fee Related
- 1993-10-22 CN CN93120396A patent/CN1049658C/zh not_active Expired - Fee Related
- 1993-10-22 TW TW082108790A patent/TW252114B/zh active
1994
- 1994-01-12 US US08/181,147 patent/US5380847A/en not_active Expired - Fee Related
- 1994-09-15 US US08/306,294 patent/US5428169A/en not_active Expired - Fee Related
2000
- 2000-11-10 GR GR20000402506T patent/GR3034819T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0594001B1 (en)	2000-08-16
ES2152237T3 (es)	2001-02-01
MX9306552A (es)	1994-06-30
DE69329231T2 (de)	2001-03-29
FI103890B (fi)	1999-10-15
AU4912893A (en)	1994-05-05
US5428169A (en)	1995-06-27
CN1049658C (zh)	2000-02-23
ATE195522T1 (de)	2000-09-15
EP0594001A1 (en)	1994-04-27
KR100295026B1 (ko)	2001-09-17
US5264576A (en)	1993-11-23
NO300374B1 (no)	1997-05-20
TW252114B (no)	1995-07-21
DK0594001T3 (da)	2000-10-30
FI934621A0 (fi)	1993-10-20
GR3034819T3 (en)	2001-02-28
DE69329231D1 (de)	2000-09-21
FI934621L (fi)	1994-04-23
KR940009185A (ko)	1994-05-20
NZ250003A (en)	1996-03-26
CA2108941A1 (en)	1994-04-23
FI103890B1 (fi)	1999-10-15
US5296491A (en)	1994-03-22
US5380847A (en)	1995-01-10
CN1099033A (zh)	1995-02-22
PT594001E (pt)	2001-01-31
AU671305B2 (en)	1996-08-22
NO933784D0 (no)	1993-10-21
JPH06192257A (ja)	1994-07-12
JP2656211B2 (ja)	1997-09-24

Legal Events

Date	Code	Title	Description
2001-05-28	MM1K	Lapsed by not paying the annual fees	Free format text: LAPSED IN APRIL 2001

Publication	Publication Date	Title
NO903851D0 (no)	1990-09-04	Fremgangsmaate for fremstilling av n-substituerte-4-pyrimidinaminer og -pyrimidindiaminer, og deres anvendelse som medikamenter.
NO933784D0 (no)	1993-10-21	Pyrazolo(4,3-c)pyridiner, en fremgangsmaate for fremstilling av dem og deres anvendelse som hemmere av reopptak av serotonin
HUT57773A (en)	1991-12-30	Process for produicng n-(aminocarbonyl)-carbamates related to physostigmine, as well as pharmaceutical compositions comprising such compounds
CA2135783A1 (en)	1994-10-13	Substituted (arylalkoxybenzyl) amino-propanamide derivatives and process for their preparation
AU7581394A (en)	1995-05-04	Galanthamine derivatives, a process for their preparation and their use as medicaments
HU9203977D0 (en)	1993-04-28	Method for producing heteroaryl-8-aza-bicyclo-/3.2.1/octanes and pharmaceutical preparatives containing them
DK164057C (da)	1992-09-28	Oe5,6aa-cis-1,3-oxathianderivater og fremgangsmaade til deres fremstilling og farmaceutisk middel indeholdende et saadant derivat
IL99434A0 (en)	1992-08-18	3-(1h-indazol-3-yl)-4-pyridinamines,a process and intermediates for their preparation and pharmaceutical compositions containing them
DK0401779T3 (da)	1995-10-16	4,5,5a,6-Tetrahydro-3H-isoazolo(5,4,3-kl)acridinderivater, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler
HUT60744A (en)	1992-10-28	Process for producing pyrido/3,4-b/pyrrolo/1,2-e//1,4,5/oxadiazepine derivatives and pharmaceutical compositions comprising same