NO934366L - Kovalent modifiserte mikropartikulaere kontrastmidler - Google Patents

Kovalent modifiserte mikropartikulaere kontrastmidler

Info

Publication number
NO934366L
NO934366L NO934366A NO934366A NO934366L NO 934366 L NO934366 L NO 934366L NO 934366 A NO934366 A NO 934366A NO 934366 A NO934366 A NO 934366A NO 934366 L NO934366 L NO 934366L
Authority
NO
Norway
Prior art keywords
contrast agents
covalently modified
gas
microparticulate contrast
matrix
Prior art date
Application number
NO934366A
Other languages
English (en)
Other versions
NO934366D0 (no
Inventor
Jo Klaveness
Paal Rongved
Per Strande
Original Assignee
Nycomed Imaging As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27265687&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO934366(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB919111890A external-priority patent/GB9111890D0/en
Priority claimed from GB919114570A external-priority patent/GB9114570D0/en
Priority claimed from GB929200409A external-priority patent/GB9200409D0/en
Application filed by Nycomed Imaging As filed Critical Nycomed Imaging As
Publication of NO934366L publication Critical patent/NO934366L/no
Publication of NO934366D0 publication Critical patent/NO934366D0/no

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/22Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Acoustics & Sound (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Detergent Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Treating Waste Gases (AREA)

Abstract

Ultralydkontrastmidler i form av mikropartikler bestående av en biotolererbar matrix (f.eks. et karbohydrat eller et røntgenkontrastmiddel) i assosiasjon med en gass eller gassforløper er stabilisert for å øke in vivo stabilitet og/eller ekkogenisitet ved covalente modifi- kasjoner av matrix-strukturen, f.eks. ved å introdu- sere kryssbindende grupper eller lipofile grupper og/ eller molekyler. De covalent bundne enhetene kan inneholde biologisk nedbrytbare bindinger for å lette den påfølgende elimineringen fra systemet.
NO934366A 1991-06-03 1993-12-01 Konvalent modifiserte mikropartikul{re kontrastmidler NO934366D0 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB919111890A GB9111890D0 (en) 1991-06-03 1991-06-03 Improvements in or relating to contrast agents
GB919114570A GB9114570D0 (en) 1991-07-05 1991-07-05 Improvements in or relating to contrast agents
GB929200409A GB9200409D0 (en) 1992-01-09 1992-01-09 Improvements in or relating to contrast agents
PCT/EP1992/001327 WO1992021382A1 (en) 1991-06-03 1992-06-03 Improvements in or relating to contrast agents

Publications (2)

Publication Number Publication Date
NO934366L true NO934366L (no) 1993-12-01
NO934366D0 NO934366D0 (no) 1993-12-01

Family

ID=27265687

Family Applications (1)

Application Number Title Priority Date Filing Date
NO934366A NO934366D0 (no) 1991-06-03 1993-12-01 Konvalent modifiserte mikropartikul{re kontrastmidler

Country Status (12)

Country Link
US (2) US5558857A (no)
EP (1) EP0586524B2 (no)
JP (1) JP3319754B2 (no)
AT (1) ATE151992T1 (no)
CA (1) CA2110590A1 (no)
DE (1) DE69219331T3 (no)
DK (1) DK0586524T3 (no)
ES (1) ES2103947T5 (no)
FI (1) FI935394A0 (no)
IE (1) IE921797A1 (no)
NO (1) NO934366D0 (no)
WO (1) WO1992021382A1 (no)

Families Citing this family (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6146657A (en) 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US6551576B1 (en) 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5656211A (en) 1989-12-22 1997-08-12 Imarx Pharmaceutical Corp. Apparatus and method for making gas-filled vesicles of optimal size
US5776429A (en) 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US20020150539A1 (en) 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US6001335A (en) 1989-12-22 1999-12-14 Imarx Pharmaceutical Corp. Contrasting agents for ultrasonic imaging and methods for preparing the same
US5922304A (en) 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US5469854A (en) 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
USRE39146E1 (en) 1990-04-02 2006-06-27 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
IN172208B (no) * 1990-04-02 1993-05-01 Sint Sa
US7083778B2 (en) 1991-05-03 2006-08-01 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US6613306B1 (en) 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US6989141B2 (en) 1990-05-18 2006-01-24 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US5874062A (en) 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
US5205290A (en) * 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
SG54121A1 (en) * 1991-09-17 1998-11-16 Sonus Pharma Inc Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media
US6875420B1 (en) 1991-09-17 2005-04-05 Amersham Health As Method of ultrasound imaging
US5409688A (en) * 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
US6723303B1 (en) 1991-09-17 2004-04-20 Amersham Health, As Ultrasound contrast agents including protein stabilized microspheres of perfluoropropane, perfluorobutane or perfluoropentane
MX9205298A (es) 1991-09-17 1993-05-01 Steven Carl Quay Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
JP3650393B2 (ja) * 1992-03-06 2005-05-18 アメルシャム ヘルス アクスイェ セルスカプ 造影剤におけるまたは造影剤に関する改良
US5674468A (en) * 1992-03-06 1997-10-07 Nycomed Imaging As Contrast agents comprising gas-containing or gas-generating polymer microparticles or microballoons
US5558855A (en) * 1993-01-25 1996-09-24 Sonus Pharmaceuticals Phase shift colloids as ultrasound contrast agents
IL108416A (en) 1993-01-25 1998-10-30 Sonus Pharma Inc Colloids with phase difference as contrast ultrasound agents
SK281535B6 (sk) * 1993-01-25 2001-04-09 Sonus Pharmaceuticals, Inc. Kontrastné médium na ultrazvukové zobrazovanie a spôsob jeho prípravy
EP1550464A1 (en) 1993-07-30 2005-07-06 IMCOR Pharmaceutical Co. Stabilized microbubble composition for ultrasound
US5798091A (en) 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
US7083572B2 (en) 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
CZ208995A3 (en) 1993-12-15 1996-01-17 Bracco Research Sa Injectable ultrasound medium, process of its preparation and use
DE4406474A1 (de) 1994-02-23 1995-08-24 Schering Ag Gas enthaltende Mikropartikel, diese enthaltende Mittel, deren Verwendung in der Ultraschalldiagnostik, sowie Verfahren zur Herstellung der Partikel und Mittel
US5540909A (en) * 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US5830430A (en) 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
US5558092A (en) 1995-06-06 1996-09-24 Imarx Pharmaceutical Corp. Methods and apparatus for performing diagnostic and therapeutic ultrasound simultaneously
US5997898A (en) 1995-06-06 1999-12-07 Imarx Pharmaceutical Corp. Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery
US6139819A (en) 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US6033645A (en) 1996-06-19 2000-03-07 Unger; Evan C. Methods for diagnostic imaging by regulating the administration rate of a contrast agent
US5804162A (en) 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
US6231834B1 (en) 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
DE19602930A1 (de) * 1996-01-18 1997-07-24 Schering Ag Poröse Matrices aus niedermolekularen Substanzen zur Genierung stabiler Gasblasensuspensionen, deren Verwendung als Ultraschallkontrastmittel sowie Verfahren zu deren Herstellung
US5611344A (en) * 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
DK0904113T3 (da) * 1996-03-05 2004-08-30 Acusphere Inc Mikroindkapslede fluorerede gasser til anvendelse som billeddannende midler
EP0935415B1 (en) 1996-05-01 2006-11-22 Imarx Pharmaceutical Corp. In vitro methods for delivering nucleic acids into a cell
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US20020052310A1 (en) 1997-09-15 2002-05-02 Massachusetts Institute Of Technology The Penn State Research Foundation Particles for inhalation having sustained release properties
US5985309A (en) * 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
US6652837B1 (en) 1996-05-24 2003-11-25 Massachusetts Institute Of Technology Preparation of novel particles for inhalation
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
DE69737915T2 (de) 1996-09-11 2008-03-13 Bristol-Myers Squibb Medical Imaging, Inc. Verfahren zur diagnostischen Bilderzeugung der Nierenregion unter Verwendung eines Kontrastmittels und eines Vasodilators
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6143276A (en) 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US7452551B1 (en) 2000-10-30 2008-11-18 Imarx Therapeutics, Inc. Targeted compositions for diagnostic and therapeutic use
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US6045777A (en) * 1997-06-30 2000-04-04 Acusphere, Inc. Method for enhancing the echogenicity and decreasing the attenuation of microencapsulated gases
US7052678B2 (en) 1997-09-15 2006-05-30 Massachusetts Institute Of Technology Particles for inhalation having sustained release properties
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US6123923A (en) 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
US6048736A (en) * 1998-04-29 2000-04-11 Kosak; Kenneth M. Cyclodextrin polymers for carrying and releasing drugs
FR2780901B1 (fr) * 1998-07-09 2000-09-29 Coletica Particules, en particulier micro- ou nanoparticules de monosaccharides et oligosaccharides reticules, leurs procedes de preparation et compositions cosmetiques, pharmaceutiques ou alimentaires en contenant
US6956021B1 (en) 1998-08-25 2005-10-18 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
US6426145B1 (en) 1999-05-20 2002-07-30 Scimed Life Systems, Inc. Radiopaque compositions for visualization of medical devices
US6572840B1 (en) 1999-07-28 2003-06-03 Bristol-Myers Squibb Pharma Company Stable microbubbles comprised of a perfluoropropane encapsulated lipid moiety for use as an ultrasound contrast agent
EP2279757A3 (en) 2000-06-02 2011-08-03 Bracco Suisse SA Compounds for targeting endothelial cells
AU2002230993B2 (en) 2000-12-29 2006-02-02 Alkermes, Inc. Particles for inhalation having sustained release properties
JP3819845B2 (ja) * 2001-04-06 2006-09-13 ブラッコ・リサーチ・ソシエテ・アノニム 流体で充填された空洞内の局所物理パラメータの改善された測定方法
WO2003043585A2 (en) 2001-11-20 2003-05-30 Advanced Inhalation Research, Inc. Improved particulate compositions for pulmonary delivery
WO2003074005A2 (en) 2002-03-01 2003-09-12 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7794693B2 (en) * 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
WO2004065621A1 (en) 2002-03-01 2004-08-05 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US7094369B2 (en) 2002-03-29 2006-08-22 Scimed Life Systems, Inc. Processes for manufacturing polymeric microspheres
US7131997B2 (en) 2002-03-29 2006-11-07 Scimed Life Systems, Inc. Tissue treatment
US7462366B2 (en) 2002-03-29 2008-12-09 Boston Scientific Scimed, Inc. Drug delivery particle
US7053134B2 (en) 2002-04-04 2006-05-30 Scimed Life Systems, Inc. Forming a chemically cross-linked particle of a desired shape and diameter
EP1511522B1 (en) 2002-06-12 2011-08-10 Boston Scientific Limited Bulking agents
US7842377B2 (en) 2003-08-08 2010-11-30 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US7449236B2 (en) 2002-08-09 2008-11-11 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US8012454B2 (en) 2002-08-30 2011-09-06 Boston Scientific Scimed, Inc. Embolization
US7883490B2 (en) 2002-10-23 2011-02-08 Boston Scientific Scimed, Inc. Mixing and delivery of therapeutic compositions
US7588825B2 (en) 2002-10-23 2009-09-15 Boston Scientific Scimed, Inc. Embolic compositions
US20050214859A1 (en) 2003-03-03 2005-09-29 Dyax Corp. Peptides that specifically bind HGF receptor (cMet) and uses thereof
US7976823B2 (en) 2003-08-29 2011-07-12 Boston Scientific Scimed, Inc. Ferromagnetic particles and methods
JP2007509989A (ja) 2003-10-31 2007-04-19 ポイント バイオメディカル コーポレイション 超音波造影剤として有用な再構成可能なミクロスフィア組成物
US7736671B2 (en) 2004-03-02 2010-06-15 Boston Scientific Scimed, Inc. Embolization
US8173176B2 (en) 2004-03-30 2012-05-08 Boston Scientific Scimed, Inc. Embolization
US7311861B2 (en) 2004-06-01 2007-12-25 Boston Scientific Scimed, Inc. Embolization
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
US8425550B2 (en) 2004-12-01 2013-04-23 Boston Scientific Scimed, Inc. Embolic coils
US7858183B2 (en) 2005-03-02 2010-12-28 Boston Scientific Scimed, Inc. Particles
US7727555B2 (en) 2005-03-02 2010-06-01 Boston Scientific Scimed, Inc. Particles
US7963287B2 (en) 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
US8123693B2 (en) * 2005-06-20 2012-02-28 Conceptus, Inc. Methods and devices for determining lumen occlusion
US9463426B2 (en) 2005-06-24 2016-10-11 Boston Scientific Scimed, Inc. Methods and systems for coating particles
US8007509B2 (en) 2005-10-12 2011-08-30 Boston Scientific Scimed, Inc. Coil assemblies, components and methods
US8101197B2 (en) 2005-12-19 2012-01-24 Stryker Corporation Forming coils
US8152839B2 (en) 2005-12-19 2012-04-10 Boston Scientific Scimed, Inc. Embolic coils
US7501179B2 (en) 2005-12-21 2009-03-10 Boston Scientific Scimed, Inc. Block copolymer particles
US7947368B2 (en) 2005-12-21 2011-05-24 Boston Scientific Scimed, Inc. Block copolymer particles
US8414927B2 (en) 2006-11-03 2013-04-09 Boston Scientific Scimed, Inc. Cross-linked polymer particles
US8585616B2 (en) * 2009-10-09 2013-11-19 Conceptus, Inc. Methods and apparatus for determining fallopian tube occlusion
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
HK1220119A1 (zh) 2013-03-15 2017-04-28 Matthew R. Dreher 可成像栓塞微球
GB2519738A (en) 2013-09-06 2015-05-06 Biocompatibles Uk Ltd Radiopaque polymers
GB2521997A (en) 2013-09-06 2015-07-15 Biocompatibles Uk Ltd Radiopaque polymers
CN112716895A (zh) * 2020-12-18 2021-04-30 济南大学 基于苯丁酸修饰的普朗尼克f127的穿心莲内酯载药胶束及其制备
CN114808179B (zh) * 2022-03-30 2023-06-16 华南理工大学 一种可控弛豫时间的复合材料及其制备方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3173476D1 (en) * 1980-11-17 1986-02-20 Schering Ag Composition generating microbubbles
SE8204244L (sv) * 1982-07-09 1984-01-10 Ulf Schroder Kristalliserad kolhydratsmatris for biologiskt aktiva substanser
DE3313947A1 (de) 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen Mikropartikel und gasblaeschen enthaltende ultraschall-kontrastmittel
DE3313946A1 (de) 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen Mikropartikel und gasblaeschen enthaltende ultraschall-kontrastmittel
JPS60231609A (ja) * 1984-04-28 1985-11-18 Terumo Corp リポソ−ム製剤
DE3577185D1 (de) * 1984-11-01 1990-05-23 Nycomed As Paramagnetische kontrastmittel fuer die anwendung in "in vivo" nmr-diagnostischen methoden und die herstellung davon.
EP0586875A1 (de) * 1988-02-05 1994-03-16 Schering Aktiengesellschaft Ultraschallkontrastmittel, Verfahren zu deren Herstellung und deren Verwendung als Diagnostika und Therapeutika
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
PH31064A (en) * 1990-09-07 1998-02-05 Nycomed As Of Nycoveten Polymers containing diester units.
JP3247374B2 (ja) * 1990-10-05 2002-01-15 ブラッコ インターナショナル ベスローテン フェンノートシャップ 超音波エコグラフィーに適切な中空気体封入微小球の安定懸濁物の製造のための方法
US5370901A (en) * 1991-02-15 1994-12-06 Bracco International B.V. Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients

Also Published As

Publication number Publication date
EP0586524A1 (en) 1994-03-16
ATE151992T1 (de) 1997-05-15
AU1929192A (en) 1993-01-08
HK1006946A1 (en) 1999-03-26
FI935394L (fi) 1993-12-02
US5558857A (en) 1996-09-24
DE69219331T3 (de) 2001-06-07
FI935394A7 (fi) 1993-12-02
IE921797A1 (en) 1992-12-16
ES2103947T3 (es) 1997-10-01
ES2103947T5 (es) 2001-05-16
CA2110590A1 (en) 1992-12-10
EP0586524B2 (en) 2000-11-02
FI935394A0 (fi) 1993-12-02
AU665198B2 (en) 1995-12-21
WO1992021382A1 (en) 1992-12-10
NO934366D0 (no) 1993-12-01
US5569449A (en) 1996-10-29
DE69219331D1 (de) 1997-05-28
DK0586524T3 (no) 1997-05-20
DE69219331T2 (de) 1997-09-04
EP0586524B1 (en) 1997-04-23
JP3319754B2 (ja) 2002-09-03
JPH06509065A (ja) 1994-10-13

Similar Documents

Publication Publication Date Title
NO934366L (no) Kovalent modifiserte mikropartikulaere kontrastmidler
NO306198B1 (no) Kovalent modifiserte mikropartikulaere kontrastmidler
ATE204482T1 (de) In vivo mitteln enthaltend radioaktive metallionen - chelaten mit säure saccariden und glycosaminoglycanen gebende ein
UA19813A (uk) Спосіб одержаhhя комплексів включеhhя 7-ізопропоксіізофлавоhу
EP0249008B1 (de) Verwendung von spezifischen Monosacchariden zur Herstellung eines Arzneimittels zur Verhinderung von Metastasen maligner Tumore
RU93054941A (ru) Композиции, содержащие наночастицы, на поверхности которых адсорбирован тилоксапол, способ получения наночастиц, способ диагностики, применение наночастиц
GR3005457T3 (no)
NO923739L (no) Kontrastmidler
DE69637642D1 (de) Und kombinierte zusammensetzungen und deren verwendung
BR0016787A (pt) Ciclodextrinas ligadas de forma covalente a polissacarìdeos
NO954434D0 (no) Bioaktive og/eller målsökende dendrimer-konjugater
NO158627C (no) Polymerisasjonsdyktig eller "levende" acryl-, maleimid- eller acryl-maleimidpolymer, fremgangsmaate for fremstillingav polymeren og anvendelse av samme i form av opploesninger, filmer eller fibere.
BR1100808A (pt) Agentes de contraste usados em estudos de ultra-som empregado em diagnóstico que compreendem microesferas compostas de um gás ou um precursor de gás encapsulado num invólucro de proteìna, processo para a preparação de um agente de contraste, microesferas, e, dispersão aquosa de microesferas
ES2107044T3 (es) Panel de aglomerado y utilizacion de este ultimo.
RU2000107148A (ru) Способ получения нити, покрытой сверхабсорбентом
BG102657A (en) Method for radiation retention by means of fullerene molecules
DK0531421T3 (da) Kontrastmedier til ultralydsimagografi
FI972287A0 (fi) Uudenlaisia polysubstituoituja DTPA-johdoksia ja niiden metallikomplekseja, kyseisiä komplekseja sisältäviä farmaseuttisia aineita, niiden käyttö diagnosoinnissa ja terapiassa sekä menetelmiä kyseisten kompleksinmuodostajien ja kompleksien valmistamiseksi ja menetelmiä kyseisten.
NO178571C (no) Analogifremgangsmåte for fremstilling av et bifunksjonelt chelateringsmiddel
ATE254481T1 (de) Radioaktiven chitosankomplex und deren anwendung in strahlungstherapie
FI102462B1 (fi) Menetelmä nimesulidin syklodekstriinikompleksin valmistamiseksi
DE59010838D1 (de) Glycosyl-Etoposid-Prodrugs, Verfahren zu ihrer Herstellung und ihre Anwendung in Kombination mit funktionalisierten tumorspezifischen Enzym-Konjugaten
DE58905379D1 (de) Celluloseester/Polymerkombinationen, deren Herstellung und Verwendung.
ATE240108T1 (de) Doxorubicin enthaltende einspritzbare gebrauchsfertige lösungen gegen krebs
Sarosi et al. Hydrolytic degradation of dental composites