NO934726L - (S)(+)-2-etoksy-4-(N-(1-(2-piperidinofenyl)-3-metyl-1-butyl)aminokarbonylmetyl)-benzoesyre - Google Patents

(S)(+)-2-etoksy-4-(N-(1-(2-piperidinofenyl)-3-metyl-1-butyl)aminokarbonylmetyl)-benzoesyre

Info

Publication number
NO934726L
NO934726L NO934726A NO934726A NO934726L NO 934726 L NO934726 L NO 934726L NO 934726 A NO934726 A NO 934726A NO 934726 A NO934726 A NO 934726A NO 934726 L NO934726 L NO 934726L
Authority
NO
Norway
Prior art keywords
piperidinophenyl
aminocarbonylmethyl
benzoic
ethoxy
butyl
Prior art date
Application number
NO934726A
Other languages
English (en)
Other versions
NO934726D0 (no
NO303687B1 (no
Inventor
Wolfgang Grell
Andreas Greischel
Gabriele Zahn
Michael Mark
Hansjoerg Knorr
Eckhard Rupprecht
Uelrich Mueller
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36781542&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO934726(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of NO934726D0 publication Critical patent/NO934726D0/no
Publication of NO934726L publication Critical patent/NO934726L/no
Publication of NO303687B1 publication Critical patent/NO303687B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO934726A 1991-06-21 1993-12-20 Analogifremgangsmåte for fremstilling av den terapeutisk aktive forbindelse (S)(+)-2-etoksy-4-[N-[1-(2-piperidino-fenyl)-3-metyl-1-butyl]aminokarbonylmetyl]-benzosyre NO303687B1 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/EP1991/001147 WO1993000337A1 (de) 1991-06-21 1991-06-21 (s)(+)-2-äthoxy-4-[n-[1-(2-piperidino-phenyl)-3-methyl-1-butyl]aminocarbonylmethyl]-benzoesäure
SG1996002715A SG43036A1 (en) 1991-06-21 1991-06-21 (S) (+) -2-ethoxy-4-[N-[1-(2-piperidino-phenyl)-3-methyl- 1-buthyl]aminocarbony methyl] - benzoic a cid
CA002111851A CA2111851C (en) 1991-06-21 1991-06-21 (s)(+)-2-ethoxy-4-[n-{1-(2-piperidino-phenyl)-3-methyl-1-butyl]aminocarbonylmethyl]benzoic acid
CN91104984A CN1048722C (zh) 1991-06-21 1991-07-22 (s)(+)-2-乙氧基-4-[n-[1-(2-哌啶子基-苯基)-3-甲基-1-丁基]氨基羰基甲基]苯甲酸,含该化合物的药物组合物及其制备方法

Publications (3)

Publication Number Publication Date
NO934726D0 NO934726D0 (no) 1993-12-20
NO934726L true NO934726L (no) 1993-12-20
NO303687B1 NO303687B1 (no) 1998-08-17

Family

ID=36781542

Family Applications (2)

Application Number Title Priority Date Filing Date
NO934726A NO303687B1 (no) 1991-06-21 1993-12-20 Analogifremgangsmåte for fremstilling av den terapeutisk aktive forbindelse (S)(+)-2-etoksy-4-[N-[1-(2-piperidino-fenyl)-3-metyl-1-butyl]aminokarbonylmetyl]-benzosyre
NO1999017C NO1999017I1 (no) 1991-06-21 1999-07-20 Repaglinid

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO1999017C NO1999017I1 (no) 1991-06-21 1999-07-20 Repaglinid

Country Status (18)

Country Link
EP (1) EP0589874B1 (no)
JP (1) JP2921982B2 (no)
KR (1) KR100496720B1 (no)
CN (1) CN1048722C (no)
AU (1) AU660930B2 (no)
BG (1) BG61690B1 (no)
CA (1) CA2111851C (no)
DE (2) DE59109151D1 (no)
DK (2) DK0589874T3 (no)
FI (1) FI106027B (no)
GR (1) GR3031654T3 (no)
NO (2) NO303687B1 (no)
PL (1) PL170210B1 (no)
RO (1) RO113462B1 (no)
SG (1) SG43036A1 (no)
SK (1) SK281246B6 (no)
UY (1) UY25923A1 (no)
WO (1) WO1993000337A1 (no)

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AU7906898A (en) 1997-06-13 1998-12-30 Novo Nordisk A/S Novel niddm regimen
IN192862B (no) * 1999-11-16 2004-05-22 Ranbaxy Lab Ltd
AR033390A1 (es) 2000-08-22 2003-12-17 Novartis Ag Una composicion farmaceutica que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina, el uso de dicha composicion para la fabricacion de un medicamento y un kit de partes
EP2316468A1 (en) 2002-02-22 2011-05-04 Shire LLC Delivery system and methods for protecting and administering dextroamphetamine
WO2004018442A1 (en) * 2002-08-23 2004-03-04 Dr. Reddy's Laboratories Limited Crystalline and amorphous forms of (s) -repaglinide and the processes for preparation thereof
US7915421B2 (en) * 2003-05-14 2011-03-29 Cilag Ltd. Method for preparing phenyl acetic acid derivatives
AU2003237595A1 (en) * 2003-05-26 2004-12-13 Biocon Limited Process for the preparation of s(+)-2-ethoxy-4-(n-{1-(2-piperidinophelyl)-3-methyl-1- butyl} aminocarbonylmethyl)benzoic acid derivatives
EP1664008A1 (en) * 2003-08-28 2006-06-07 Ranbaxy Laboratories Limited Process for the preparation of amorphous form of repaglinide
CN1305863C (zh) * 2004-12-27 2007-03-21 浙江大学 (s)－异丙基－(2－哌啶)苯基－甲基胺的合成方法
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
FR2898894B1 (fr) * 2006-03-24 2008-06-06 Genfit Sa Composes derives de n-(phenethyl)benzamide substitues, preparation et utilisations
US7763607B2 (en) * 2006-04-27 2010-07-27 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators
PT2724722T (pt) * 2006-10-20 2017-03-14 Neurendo Pharma Llc Método de restaurar o efeito incretina
US8101769B2 (en) * 2007-02-15 2012-01-24 Actavis Group Ptc Ehf Process for preparing ethyl (S)-2-ethoxy-4-[N-[1-(2-piperidinophenyl)-3-methyl-1-butyl]aminocarbonyl methyl]benzoate and use thereof for the preparation of Repaglinide
CN101772491A (zh) * 2007-06-06 2010-07-07 阿克塔维什集团Ptc公司 基本不含有二聚体杂质的瑞格列奈
EP2019097A1 (en) 2007-07-25 2009-01-28 Aurobindo Pharma Limited Process for preparing (alphaS)-alpha-(2-methylpropyl)-2-(1-piperidinyl)benzenemethanamine
SI2200588T1 (sl) 2007-09-25 2019-08-30 Solubest Ltd. Sestavki, ki obsegajo lipofilne aktivne spojine, in postopek za njihovo pripravo
DE102008046995B4 (de) * 2008-09-12 2010-08-26 Stada Arzneimittel Ag 2-Ethoxy-benzoesäurederivat
EP2177221A1 (en) 2008-10-20 2010-04-21 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of substantially optically pure Repaglinide and precursors thereof
WO2010130773A2 (en) 2009-05-15 2010-11-18 Novartis Ag Benzoxazolone derivatives as aldosterone symthase inhibitors
HRP20140371T1 (hr) 2009-05-15 2014-05-23 Novartis Ag Arilpiridini kao inhibitori sinteze aldosterona
EP2435402B1 (en) 2009-05-28 2016-04-13 Novartis AG Substituted aminobutyric derivatives as neprilysin inhibitors
CN103896796B (zh) 2009-05-28 2016-04-27 诺华股份有限公司 作为脑啡肽酶抑制剂的取代的氨基丙酸衍生物
US8519134B2 (en) 2009-11-17 2013-08-27 Novartis Ag Aryl-pyridine derivatives as aldosterone synthase inhibitors
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
ES2472446T3 (es) 2009-11-30 2014-07-01 Novartis Ag Derivados de imidazol como inhibidores de aldosterona sintasa
EP2364977A1 (en) 2010-01-26 2011-09-14 Reuter Chemische Apparatebau KG Process for the enantiomeric enrichment of 3-methyl-1-(2-piperidinophenyl)-1-butylamine
US8673974B2 (en) 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
CN102267959B (zh) * 2011-07-06 2013-05-01 海南锦瑞制药股份有限公司 一种瑞格列奈晶体、其制备方法及含有该晶体的固体口服制剂
CN103012319B (zh) * 2011-09-20 2015-06-10 浙江九洲药业股份有限公司 瑞格列奈中间体的合成工艺改进
CN102584743A (zh) * 2011-12-28 2012-07-18 中国药科大学 对二甲氨基吡啶瑞格列奈共晶
UY35144A (es) 2012-11-20 2014-06-30 Novartis Ag Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
CU24330B1 (es) 2013-02-14 2018-03-13 Novartis Ag Derivados del ácido 4-((1,1) bifenil-4-il)-3-(3-fosfonopropanamido) butanoico, activos como inhibidores de nep (endopeptidasa neutral)
MX2016001020A (es) 2013-07-25 2016-08-03 Novartis Ag Polipeptidos ciclicos para el tratamiento de insuficiencia cardiaca.
CN105705167A (zh) 2013-07-25 2016-06-22 诺华股份有限公司 合成的apelin多肽的生物缀合物
EP3215154B1 (en) 2014-11-07 2020-01-29 Regents of the University of Minnesota Salts and compositions useful for treating disease
CR20170338A (es) 2015-01-23 2017-09-12 Novartis Ag Conjugados de ácidos grasos y apelina sintética con mayor vida media
WO2018034627A1 (en) 2016-08-18 2018-02-22 İlko Ilaç Sanayi Ve Ticaret Anonim Şirketi Pharmaceutical composition of antidiabetic tablet
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3347565A1 (de) * 1983-12-30 1985-07-11 Thomae Gmbh Dr K Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
EP0589874B1 (de) 1999-09-08
NO934726D0 (no) 1993-12-20
SG43036A1 (en) 1997-10-17
CA2111851A1 (en) 1993-01-07
FI935724L (fi) 1993-12-20
HK1011968A1 (en) 1999-07-23
UY25923A1 (es) 2001-08-27
FI935724A0 (fi) 1993-12-20
DK0965591T3 (da) 2002-11-18
GR3031654T3 (en) 2000-02-29
CN1068820A (zh) 1993-02-10
DE10075006I1 (de) 2000-04-20
NO303687B1 (no) 1998-08-17
SK281246B6 (sk) 2001-01-18
RO113462B1 (ro) 1998-07-30
WO1993000337A1 (de) 1993-01-07
DE10075006I2 (de) 2004-01-08
BG98300A (bg) 1994-09-30
KR100496720B1 (ko) 2006-01-27
PL170210B1 (pl) 1996-11-29
AU660930B2 (en) 1995-07-13
FI106027B (fi) 2000-11-15
DE59109151D1 (de) 1999-10-14
CN1048722C (zh) 2000-01-26
SK128093A3 (en) 1994-11-09
AU8078191A (en) 1993-01-25
BG61690B1 (bg) 1998-03-31
JPH06508816A (ja) 1994-10-06
DK0589874T3 (da) 2000-04-03
CA2111851C (en) 2002-02-26
NO1999017I1 (no) 1999-07-20
EP0589874A1 (de) 1994-04-06
JP2921982B2 (ja) 1999-07-19

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Legal Events

Date Code Title Description
SPCG Granted supplementary protection certificate

Free format text: PRODUCT NAME: REPAGLINID; NAT. REG. NO/DATE: NO , 97-2543 , NO , 97-2544 , NO , 97-2545 19990301; FIRST REG. NO/DATE: EP , 1/98/076/- 19980817

Spc suppl protection certif: 1999017

Filing date: 19990720

Extension date: 20130817

MK1K Patent expired
SPCX Expiry of an spc

Spc suppl protection certif: 1999017

Effective date: 20130817