NO940261L - 5-membered heterocycles, process for the preparation thereof and drugs containing these compounds - Google Patents

5-membered heterocycles, process for the preparation thereof and drugs containing these compounds

Info

Publication number
NO940261L
NO940261L NO940261A NO940261A NO940261L NO 940261 L NO940261 L NO 940261L NO 940261 A NO940261 A NO 940261A NO 940261 A NO940261 A NO 940261A NO 940261 L NO940261 L NO 940261L
Authority
NO
Norway
Prior art keywords
compounds
preparation
membered heterocycles
drugs containing
salts
Prior art date
Application number
NO940261A
Other languages
Norwegian (no)
Other versions
NO940261D0 (en
Inventor
Gunter Linz
Frank Himmelsbach
Volkhard Austel
Helmut Pieper
Thomas Muller
Hans Weisenberger
Brian Guth
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of NO940261D0 publication Critical patent/NO940261D0/en
Publication of NO940261L publication Critical patent/NO940261L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Denne oppfinnelse vedrører 5-leddede heterocykler med den generelle formel. hvori. Xtil Xer definert som i krav 1, deres tautomerer, deres stereoisomerer innbefattet deres blandinger og deres salter, særlig deres fysiologisk aksepterbare salter med uorganiske eller organiske syrer eller baser, som har verdifulle farma-kologiske egenskaper, fortrinnsvis aggregeringshemmende virk-ninger, legemidler som inneholder forbindelsene og fremgangs-måter for deres fremstilling.This invention relates to 5-membered heterocycles of the general formula. where. Xtil Xer as defined in claim 1, their tautomers, their stereoisomers including their mixtures and their salts, in particular their physiologically acceptable salts with inorganic or organic acids or bases, which have valuable pharmacological properties, preferably anti-aggregation effects, drugs containing the compounds and methods of their preparation.

NO940261A 1993-01-26 1994-01-25 5-membered heterocycles, process for the preparation thereof and drugs containing these compounds NO940261L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4302051A DE4302051A1 (en) 1993-01-26 1993-01-26 5-membered heterocycles, process for their preparation and medicaments containing these compounds

Publications (2)

Publication Number Publication Date
NO940261D0 NO940261D0 (en) 1994-01-25
NO940261L true NO940261L (en) 1994-07-27

Family

ID=6478937

Family Applications (1)

Application Number Title Priority Date Filing Date
NO940261A NO940261L (en) 1993-01-26 1994-01-25 5-membered heterocycles, process for the preparation thereof and drugs containing these compounds

Country Status (18)

Country Link
EP (1) EP0608858A1 (en)
JP (1) JPH072851A (en)
KR (1) KR940018382A (en)
CN (1) CN1097753A (en)
AU (1) AU5398494A (en)
BG (1) BG98409A (en)
CA (1) CA2114178A1 (en)
CZ (1) CZ18194A3 (en)
DE (1) DE4302051A1 (en)
FI (1) FI940378A7 (en)
HU (1) HU9400217D0 (en)
IL (1) IL108436A0 (en)
NO (1) NO940261L (en)
NZ (1) NZ250762A (en)
PL (1) PL302018A1 (en)
RU (1) RU94002482A (en)
SK (1) SK8394A3 (en)
ZA (1) ZA94495B (en)

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ZA963391B (en) * 1995-05-24 1997-10-29 Du Pont Merck Pharma Isoxazoline fibrinogen receptor antagonists.
JPH11513382A (en) * 1995-10-20 1999-11-16 ドクトル カルル トーマエ ゲゼルシャフト ミット ベシュレンクテル ハフツング 5-membered heterocyclic compounds, pharmaceuticals containing these compounds, their use and methods for their preparation
US6083986A (en) * 1996-07-26 2000-07-04 Icagen, Inc. Potassium channel inhibitors
US6333337B1 (en) 1998-01-27 2001-12-25 Icagen, Inc. Potassium channel inhibitors
HUP0102470A3 (en) * 1998-07-01 2002-05-28 Takeda Chemical Industries Ltd 1,3-azole derivatives as retinoid-associated receptor regulators and their use
US7084279B1 (en) 1999-02-11 2006-08-01 Emisphere Technologies Inc. Oxadiazole compounds and compositions for delivering active agents
ES2251976T3 (en) * 1999-02-11 2006-05-16 Emisphere Technologies, Inc. COMPOUNDS AND COMPOSITIONS OF OXADIAZOL TO PROVIDE ACTIVE AGENTS.
AU781365B2 (en) 1999-12-21 2005-05-19 Icagen, Inc. Potassium channel inhibitors
WO2001058880A1 (en) * 2000-02-08 2001-08-16 Yamanouchi Pharmaceutical Co., Ltd. Novel triazole derivatives
SK16242002A3 (en) * 2000-05-19 2003-04-01 Merck Patent Gmbh Triazole derivative and a pharmaceutical composition containing the same
US6566380B2 (en) 2000-07-25 2003-05-20 Icagen, Inc. Potassium channel inhibitors
US6620849B2 (en) 2000-07-26 2003-09-16 Icafen, Inc. Potassium channel inhibitors
US6849634B2 (en) 2000-12-21 2005-02-01 Icagen Potassium channel inhibitors
EP1405636A4 (en) * 2001-06-26 2009-04-15 Takeda Pharmaceutical REGULATOR OF RECTINTOR FUNCTION RELATING TO RETINOIDS
US7390813B1 (en) 2001-12-21 2008-06-24 Xenon Pharmaceuticals Inc. Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents
WO2003075853A2 (en) 2002-03-08 2003-09-18 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
ATE329909T1 (en) 2002-11-27 2006-07-15 Boehringer Ingelheim Pharma 1,2,3-TRIAZOLAMIDE DERIVATIVES AS CYTOKIN INHIBITORS
US7078419B2 (en) 2003-03-10 2006-07-18 Boehringer Ingelheim Pharmaceuticals, Inc. Cytokine inhibitors
EP1622569B1 (en) 2003-04-24 2015-12-02 Incyte Corporation Aza spiro alkane derivatives as inhibitors of metallproteases
PL1648874T3 (en) 2003-07-30 2012-04-30 Xenon Pharmaceuticals Inc Piperazine derivatives and their use as therapeutic agents
ATE501128T1 (en) 2003-12-03 2011-03-15 Boehringer Ingelheim Pharma 1,2,3-TRIAZOLAMIDE DERIVATIVES AS INHIBITORS OF CYTOKINE PRODUCTION
PT1725544E (en) 2004-03-09 2009-07-02 Boehringer Ingelheim Pharma 3-[4-heterocyclyl-1,2,3-triazol-1-yl]-n-aryl-benzamides as inhibitors of the cytokines production for the treatment of chronic inflammatory diseases
EP1745036A2 (en) 2004-05-03 2007-01-24 Boehringer Ingelheim Pharmaceuticals Inc. Cytokine inhibitors
US7485657B2 (en) 2004-05-12 2009-02-03 Boehringer Ingelheim Pharmaceuticals, Inc. Anti-cytokine heterocyclic compounds
CN101084211A (en) 2004-09-20 2007-12-05 泽农医药公司 Heterocyclic derivatives and their use as therapeutic agents
BRPI0515482A (en) 2004-09-20 2008-07-22 Xenon Pharmaceuticals Inc heterocyclic derivatives and their uses as therapeutic agents
MX2007003318A (en) 2004-09-20 2007-05-18 Xenon Pharmaceuticals Inc Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes.
BRPI0515500A (en) 2004-09-20 2008-07-29 Xenon Pharmaceuticals Inc pyridazine derivatives for stearoyl coa desaturase inhibition
AU2005286728A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase
MX2007003332A (en) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors.
AU2005286647A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
US7531560B2 (en) 2004-11-10 2009-05-12 Boehringer Ingelheim Pharmaceuticals, Inc. Anti-cytokine heterocyclic compounds
AP2007004047A0 (en) 2005-01-20 2007-06-30 Pfizer Ltd Substituted triazole derivatives as oxtocin antagonists
CA2618646A1 (en) 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
TW200811164A (en) * 2006-05-12 2008-03-01 Jerini Ag New heterocyclic compounds for the inhibition of integrins and use thereof
US7910108B2 (en) 2006-06-05 2011-03-22 Incyte Corporation Sheddase inhibitors combined with CD30-binding immunotherapeutics for the treatment of CD30 positive diseases
TW200813018A (en) 2006-06-09 2008-03-16 Astrazeneca Ab Novel compounds
MX2009002019A (en) 2006-08-24 2009-03-09 Novartis Ag 2- (pyrazin-2-yl) -thiazole and 2- (1h-pyraz0l-3-yl) -thiazole derivatives as well as related compounds as stearoyl-coa desaturase (scd) inhibitors for the treatment of metabolic, cardiovascular and other disorders.
TWI386405B (en) 2006-09-05 2013-02-21 An imidazole derivative
CA2685266C (en) 2007-04-27 2014-01-28 Purdue Pharma L.P. Trpv1 antagonists and uses thereof for the treatment of prevention of pain, ui and ulcer, ibd, or ibs in an animal
US8119661B2 (en) 2007-09-11 2012-02-21 Astrazeneca Ab Piperidine derivatives and their use as muscarinic receptor modulators
WO2011153359A1 (en) 2010-06-04 2011-12-08 Albany Molecular Research, Inc. Glycine transporter-1 inhibitors, methods of making them, and uses thereof
PE20141531A1 (en) 2011-06-22 2014-10-23 Purdue Pharma Lp TRPV1 ANTAGONISTS INCLUDING DIHYDROXI SUBSTITUTES AND THEIR USES
JP6478923B2 (en) 2013-02-07 2019-03-06 ヘプタレス セラピューティクス リミテッドＨｅｐｔａｒｅｓ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ Piperidin-1-yl and azepine-1-yl carboxylate as muscarinic M4 receptor agonists
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WO2020051424A1 (en) * 2018-09-07 2020-03-12 Pic Therapeutics Eif4e inhibitors and uses thereof
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IL98757A (en) * 1990-07-18 1997-01-10 Novo Nordisk As Piperidine derivatives their preparation and pharmaceutical compositions containing them
DE4124942A1 (en) * 1991-07-27 1993-01-28 Thomae Gmbh Dr K 5-LOW HETEROCYCLES, METHOD FOR THE PRODUCTION THEREOF AND MEDICAMENTS CONTAINING SUCH COMPOUNDS

Also Published As

Publication number Publication date
HU9400217D0 (en) 1994-05-30
RU94002482A (en) 1996-08-27
KR940018382A (en) 1994-08-16
SK8394A3 (en) 1995-02-08
CA2114178A1 (en) 1994-07-27
NO940261D0 (en) 1994-01-25
PL302018A1 (en) 1994-08-08
FI940378L (en) 1994-07-27
EP0608858A1 (en) 1994-08-03
ZA94495B (en) 1995-07-25
CN1097753A (en) 1995-01-25
JPH072851A (en) 1995-01-06
FI940378A7 (en) 1994-07-27
FI940378A0 (en) 1994-01-26
IL108436A0 (en) 1994-04-12
AU5398494A (en) 1994-08-04
DE4302051A1 (en) 1994-07-28
CZ18194A3 (en) 1994-11-16
BG98409A (en) 1994-09-30
NZ250762A (en) 1995-08-28

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