NO940305D0 - Kinazolin-derivater som acetylcholin-esteraseinhibitorer - Google Patents

Kinazolin-derivater som acetylcholin-esteraseinhibitorer

Info

Publication number
NO940305D0
NO940305D0 NO940305A NO940305A NO940305D0 NO 940305 D0 NO940305 D0 NO 940305D0 NO 940305 A NO940305 A NO 940305A NO 940305 A NO940305 A NO 940305A NO 940305 D0 NO940305 D0 NO 940305D0
Authority
NO
Norway
Prior art keywords
kinazoline
derivatives
acetylcholine esterase
esterase inhibitors
inhibitors
Prior art date
Application number
NO940305A
Other languages
English (en)
Other versions
NO940305L (no
Inventor
Vlad Edward Gregor
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of NO940305D0 publication Critical patent/NO940305D0/no
Publication of NO940305L publication Critical patent/NO940305L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
NO940305A 1991-07-29 1994-01-28 Kinazolin-derivater som acetylcholinesteraseinhibitorer NO940305L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73688891A 1991-07-29 1991-07-29
US91166292A 1992-07-16 1992-07-16
PCT/US1992/005864 WO1993003034A1 (en) 1991-07-29 1992-07-22 Quinazoline derivatives as acetylcholinesterase inhibitors

Publications (2)

Publication Number Publication Date
NO940305D0 true NO940305D0 (no) 1994-01-28
NO940305L NO940305L (no) 1994-03-28

Family

ID=27113138

Family Applications (1)

Application Number Title Priority Date Filing Date
NO940305A NO940305L (no) 1991-07-29 1994-01-28 Kinazolin-derivater som acetylcholinesteraseinhibitorer

Country Status (13)

Country Link
US (1) US5486512A (no)
EP (1) EP0597956A1 (no)
JP (1) JPH06509576A (no)
AU (1) AU665207B2 (no)
CA (1) CA2113115A1 (no)
CZ (1) CZ281628B6 (no)
FI (1) FI940393A7 (no)
HU (1) HUT66324A (no)
IE (1) IE922434A1 (no)
MX (1) MX9204425A (no)
NO (1) NO940305L (no)
PT (1) PT100742A (no)
WO (1) WO1993003034A1 (no)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2133078A1 (en) * 2000-03-03 2009-12-16 Eisai R&D Management Co., Ltd. Use of a cholinesterase inhibitor for the treatment of dementia and cognitive impairments
US20030153598A1 (en) * 2000-07-25 2003-08-14 Raymond Pratt Methods for treating Parkinson's disease with cholinesterase inhibitors
JP2004508373A (ja) * 2000-09-07 2004-03-18 バイエル・フアーマシユーチカルズ・コーポレーシヨン 環式および非環式アミジンおよびプロゲステロン受容体結合剤として使用するためのそれらを含有する医薬組成物
US7022844B2 (en) 2002-09-21 2006-04-04 Honeywell International Inc. Amide-based compounds, production, recovery, purification and uses thereof
KR20080095915A (ko) * 2004-05-06 2008-10-29 워너-램버트 캄파니 엘엘씨 4-페닐아미노-퀴나졸린-6-일-아미드
US20060142186A1 (en) * 2004-12-23 2006-06-29 Voyager Pharmaceutical Corporation Leuprolide acetate and acetylcholinesterase inhibitors or NMDA receptor antagonists for the treatment of alzheimer's disease
US20070155738A1 (en) * 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
BRPI0609802A2 (pt) * 2005-05-20 2017-05-02 Alantos Pharmaceuticals Holding Inc composto, composição farmacêutica e uso de um composto
US8278345B2 (en) 2006-11-09 2012-10-02 Probiodrug Ag Inhibitors of glutaminyl cyclase
ATE554085T1 (de) 2006-11-30 2012-05-15 Probiodrug Ag Neue inhibitoren von glutaminylcyclase
JP5930573B2 (ja) 2007-03-01 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤の新規使用
EP2142514B1 (en) 2007-04-18 2014-12-24 Probiodrug AG Thiourea derivatives as glutaminyl cyclase inhibitors
CN101220043A (zh) * 2008-01-24 2008-07-16 沈阳药科大学 噻唑并[3,2-a]嘧啶类衍生物及其应用
JP5934645B2 (ja) 2009-09-11 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体
AU2011215870B2 (en) 2010-02-09 2016-01-28 The Johns Hopkins University Methods and compositions for improving cognitive function
JP6026284B2 (ja) 2010-03-03 2016-11-16 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤
NZ602312A (en) 2010-03-10 2014-02-28 Probiodrug Ag Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5)
WO2011131748A2 (en) 2010-04-21 2011-10-27 Probiodrug Ag Novel inhibitors
EP2686313B1 (en) 2011-03-16 2016-02-03 Probiodrug AG Benzimidazole derivatives as inhibitors of glutaminyl cyclase
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
EP2956138B1 (en) 2013-02-15 2022-06-22 Kala Pharmaceuticals, Inc. Therapeutic compounds and uses thereof
US9688688B2 (en) 2013-02-20 2017-06-27 Kala Pharmaceuticals, Inc. Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
MX368903B (es) 2013-02-20 2019-10-21 Kala Pharmaceuticals Inc Compuestos terapéuticos y sus usos en el tratamiento de enfermedades proliferativas.
JP6433482B2 (ja) 2013-03-15 2018-12-05 エージンバイオ， インコーポレイテッド 認知機能を改善するための方法および組成物
WO2014144663A1 (en) 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
US9890173B2 (en) 2013-11-01 2018-02-13 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
US9458169B2 (en) 2013-11-01 2016-10-04 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
WO2016191288A1 (en) 2015-05-22 2016-12-01 Agenebio, Inc. Extended release pharmaceutical compositions of levetiracetam
CA2988572A1 (en) 2015-06-26 2016-12-29 Takeda Pharmaceutical Company Limited 2,3-dihydro-4h-1,3-benzoxazin-4-one derivatives as modulators of cholinergic muscarinic m1 receptor
JP6787913B2 (ja) * 2015-10-20 2020-11-18 武田薬品工業株式会社 複素環化合物
US10336767B2 (en) 2016-09-08 2019-07-02 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
AU2017324713B2 (en) 2016-09-08 2020-08-13 KALA BIO, Inc. Crystalline forms of therapeutic compounds and uses thereof
EP3509423A4 (en) 2016-09-08 2020-05-13 Kala Pharmaceuticals, Inc. CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF
ES2812698T3 (es) 2017-09-29 2021-03-18 Probiodrug Ag Inhibidores de glutaminil ciclasa

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2992221A (en) * 1958-07-03 1961-07-11 Petersen Siegfried Polymethylene-oxoquinazolines and their production
US3271396A (en) * 1964-08-17 1966-09-06 Squibb & Sons Inc Pyrido-quinazoline derivatives
US3745216A (en) * 1969-12-18 1973-07-10 Smith Kline French Lab Compositions and methods for producing hypotensive activity with imidazo and pyrimido(2,1-b)quinazoline compounds
BE794964A (fr) * 1972-02-04 1973-08-02 Bristol Myers Co Nouveaux agents hypotenseurs et procede pour les preparer
US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
JPS5752352B2 (no) * 1974-02-28 1982-11-06
NL7807507A (nl) * 1977-07-25 1979-01-29 Hoffmann La Roche Tricyclische verbindingen.
HU182009B (en) * 1977-08-19 1983-12-28 Chinoin Gyogyszer Es Vegyeszet Process for producing substituted pirido-square bracket-1,2-a-square bracket closed-pyrimidines, pyrrolo-square bracket-1,2-a-square bracket closed-pyrimidines
DE2845766A1 (de) * 1978-10-18 1980-04-30 Schering Ag Pyrido eckige klammer auf 2,1-b eckige klammer zu -chinazolinon-derivate, ihre herstellung und verwendung
AT377586B (de) * 1981-06-30 1985-04-10 Erba Farmitalia Verfahren zur herstellung von substituierten pyrrolo-(2,1-b)-chinazolinen und pyrido(2,1-b)chinazolinen
FR2512674B1 (fr) * 1981-09-16 1986-01-10 Sandoz Sa Nouveaux derives tricycliques de la quinazolinone, leur preparation et medicaments contenant ces derives
US4395554A (en) * 1981-12-01 1983-07-26 Mobil Oil Corporation Process for producing alpha-picoline
CA1254557A (en) * 1984-02-15 1989-05-23 Michael C. Venuti (2-oxo-1,2,3,5-tetrahydroimidazo-(2,1-b) quinazolinyl) oxyalkylamides
US4783467A (en) * 1985-06-05 1988-11-08 Pfizer Inc. Tetrahydroimidazoquinazolinone inotropic agents
US4837239A (en) * 1985-08-23 1989-06-06 Syntex (U.S.A.) Inc. Cardiotonic phosphodiesterase inhibitors complexed with water soluble vitamins
US4670434A (en) * 1985-11-14 1987-06-02 Syntex (U.S.A.) Inc. (2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors
US4766126A (en) * 1986-01-10 1988-08-23 Daiichi Seiyaku Co., Ltd. Process for treatment of nephritis with imidazoquinazolines
US4760065A (en) * 1986-02-13 1988-07-26 Hardtmann Goetz E Trifluoromethyl substituted tetracyclic quinazolin-ones having tranquilizing activity

Also Published As

Publication number Publication date
US5486512A (en) 1996-01-23
FI940393A7 (fi) 1994-03-11
NO940305L (no) 1994-03-28
IE922434A1 (en) 1993-02-10
AU2397892A (en) 1993-03-02
HU9400258D0 (en) 1994-06-28
FI940393A0 (fi) 1994-01-26
JPH06509576A (ja) 1994-10-27
EP0597956A1 (en) 1994-05-25
MX9204425A (es) 1993-01-01
HUT66324A (en) 1994-11-28
WO1993003034A1 (en) 1993-02-18
CA2113115A1 (en) 1993-02-18
CZ281628B6 (cs) 1996-11-13
AU665207B2 (en) 1995-12-21
CZ13594A3 (en) 1994-05-18
PT100742A (pt) 1993-10-29

Similar Documents

Publication Publication Date Title
NO940305D0 (no) Kinazolin-derivater som acetylcholin-esteraseinhibitorer
FI944804A7 (fi) Pyrimidinyyliasetamideja elastaasin estäjinä
DK0606248T3 (da) Heteroarylaminer som hidtil ukendte acetylcholinesteraseinhibitorer
NO992725L (no) 6-Fenylpyridyl-2-amin-derivater anvendelige som NOS-inhibitorer
NO960371D0 (no) Piperazinderivater som ter
NO942064D0 (no) yminhibitorer
NO980467D0 (no) 4-mercaptopyrrolidin-derivater som farnesyl-transerase-inhibitorer
FI962315L (fi) Entsyymi-inhibiittorit
FI930995A7 (fi) Elektronisk spaerrcylinder som inkopplas med stiftkoppling
FI934568L (fi) Hydrofobisitet som aostadkommits med metalljonaktivering
DK0818448T3 (da) Cycloalkanopyridiner som CETP-inhibitorer
FI950893A7 (fi) Kinuklidiinijohdannaiset skvaleenisyntaasi-inhibiittoreina
FI943727A7 (fi) Piperidinyylitiasyklisiä johdannaisia
DK0593294T3 (da) Aminderivater som korrosionsinhibitorer
FI940573L (fi) Geneseriinin johdannaiset koliiniestraasin inhibiittoreina
FI945674A7 (fi) Substituoidut 2beta-morfoliini-androstaanijohdannaiset
FI953851L (fi) Silybidut asetyylikoliiniesteraase-inhibiittorit
NO922167L (no) Aminodukter som korrosjonshemmere
FI950488A7 (fi) Kinuklidiinijohdannaisia skvaleenisyntaasi-inhibiittoreina
FI960730L (fi) Indolijohdannaiset 5alfa-reduktaasi-1-inhibiittoreina
FI923555L (fi) Foerfarande foer framstaellning av mattor som bestaor av minst tvao med varandra bundna skikt
FI962010A0 (fi) Immuunivastetta heikentävinä aineina käytettäviä 6-okso-nukleosideja
FI935826A0 (fi) Kallsmoerjmedel med delvis neutraliserade fosforsyraestrar som EP-tillsatsaemnen
DE69418656D1 (de) 2-acyloxycephemderivate als elastaseinhibitoren
NO950408D0 (no) Kinuklidinderivater som skvalen-syntase-inhibitorer