NO940499L - Fremgangsmåte for fremstilling av humanproteinholdige, konserverte legemidler for infusjons- eller injeksjonsformål - Google Patents

Fremgangsmåte for fremstilling av humanproteinholdige, konserverte legemidler for infusjons- eller injeksjonsformål

Info

Publication number: NO940499L
Authority: NO; Norway
Prior art keywords: preservative; prepn; human protein; infusion; sodium
Prior art date: 1991-08-15

Application number

NO940499A

Other languages

English (en)

Other versions

NO309844B1 (no

NO940499D0 (no

Inventor

Heinrich Woog

Werner Gruber

Hans-Jorg Markl

Gerhard Winter

Fritz Demmer

Original Assignee

Boehringer Mannheim Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-08-15

Filing date

1994-02-14

Publication date

1994-02-14

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6438353&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO940499(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1994-02-14 Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh

1994-02-14 Publication of NO940499D0 publication Critical patent/NO940499D0/no

1994-02-14 Publication of NO940499L publication Critical patent/NO940499L/no

2001-04-09 Publication of NO309844B1 publication Critical patent/NO309844B1/no

Links

102000003839 Human Proteins Human genes 0.000 title abstract 4
108090000144 Human Proteins Proteins 0.000 title abstract 4
238000001802 infusion Methods 0.000 title abstract 2
238000002347 injection Methods 0.000 title abstract 2
239000007924 injection Substances 0.000 title abstract 2
239000003814 drug Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1
238000000034 method Methods 0.000 title 1
239000003755 preservative agent Substances 0.000 abstract 5
230000002335 preservative effect Effects 0.000 abstract 5
WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 abstract 3
OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 abstract 3
229960004926 chlorobutanol Drugs 0.000 abstract 2
LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 abstract 2
BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical class OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 abstract 1
CFKMVGJGLGKFKI-UHFFFAOYSA-N 4-chloro-m-cresol Chemical compound CC1=CC(O)=CC=C1Cl CFKMVGJGLGKFKI-UHFFFAOYSA-N 0.000 abstract 1
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
206010020751 Hypersensitivity Diseases 0.000 abstract 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical class C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
208000026935 allergic disease Diseases 0.000 abstract 1
230000007815 allergy Effects 0.000 abstract 1
BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 abstract 1
235000001014 amino acid Nutrition 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
229960000686 benzalkonium chloride Drugs 0.000 abstract 1
229960004217 benzyl alcohol Drugs 0.000 abstract 1
235000019445 benzyl alcohol Nutrition 0.000 abstract 1
CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 abstract 1
239000012928 buffer substance Substances 0.000 abstract 1
ZFTFAPZRGNKQPU-UHFFFAOYSA-N dicarbonic acid Chemical compound OC(=O)OC(O)=O ZFTFAPZRGNKQPU-UHFFFAOYSA-N 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
239000001630 malic acid Substances 0.000 abstract 1
235000011090 malic acid Nutrition 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
229940070805 p-chloro-m-cresol Drugs 0.000 abstract 1
WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 abstract 1
229920001184 polypeptide Polymers 0.000 abstract 1
229910000160 potassium phosphate Inorganic materials 0.000 abstract 1
235000011009 potassium phosphates Nutrition 0.000 abstract 1
159000000001 potassium salts Chemical class 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
230000009257 reactivity Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000011734 sodium Chemical class 0.000 abstract 1
229910052708 sodium Inorganic materials 0.000 abstract 1
239000001509 sodium citrate Substances 0.000 abstract 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 abstract 1
239000001488 sodium phosphate Substances 0.000 abstract 1
229910000162 sodium phosphate Inorganic materials 0.000 abstract 1
238000004448 titration Methods 0.000 abstract 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Dermatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)

NO940499A 1991-08-15 1994-02-14 Konserverte, humanproteinholdige legemidler for anvendelse som injeksjons- eller infusjonsoppløsning i form av flerdosepreparater NO309844B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE4126983A DE4126983A1 (de)	1991-08-15	1991-08-15	Verfahren zur herstellung von humanprotein-enthaltenden, konservierten arzneimitteln fuer infusions- oder injektionszwecke
PCT/EP1992/001822 WO1993003744A1 (de)	1991-08-15	1992-08-10	Verfahren zur herstellung von humanproteinhaltigen, konservierten arzneimitteln für infusions- oder injektionszwecke

Publications (3)

Publication Number	Publication Date
NO940499D0 NO940499D0 (no)	1994-02-14
NO940499L true NO940499L (no)	1994-02-14
NO309844B1 NO309844B1 (no)	2001-04-09

Family

ID=6438353

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO940499A NO309844B1 (no)	1991-08-15	1994-02-14	Konserverte, humanproteinholdige legemidler for anvendelse som injeksjons- eller infusjonsoppløsning i form av flerdosepreparater

Country Status (25)

Country	Link
US (2)	US5503827A (no)
EP (2)	EP0607156B1 (no)
JP (1)	JP3670660B2 (no)
KR (1)	KR100263282B1 (no)
AT (1)	ATE145138T1 (no)
AU (2)	AU678756B2 (no)
CA (1)	CA2115348C (no)
CZ (1)	CZ284853B6 (no)
DE (2)	DE4126983A1 (no)
DK (1)	DK0607156T3 (no)
ES (1)	ES2094923T3 (no)
FI (1)	FI112169B (no)
GE (1)	GEP19981289B (no)
GR (1)	GR3022037T3 (no)
HU (1)	HU227421B1 (no)
IL (1)	IL102775A (no)
MX (1)	MX9204636A (no)
NO (1)	NO309844B1 (no)
RU (1)	RU2091068C1 (no)
SG (1)	SG66226A1 (no)
SK (1)	SK281910B6 (no)
TW (1)	TW351677B (no)
UA (1)	UA26343C2 (no)
WO (1)	WO1993003744A1 (no)
ZA (1)	ZA926122B (no)

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JP3541054B2 (ja) *	1994-04-21	2004-07-07	ユニ・チャーム株式会社	使い捨ておむつ
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ATE301675T1 (de) *	1995-06-07	2005-08-15	Chiron Corp	Methode zur lösung, reinigung und rückfaltung von protein
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US6267958B1 (en)	1995-07-27	2001-07-31	Genentech, Inc.	Protein formulation
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RU2234942C2 (ru) *	1998-07-14	2004-08-27	Корикса Корпорейшн	Выделенный опухолевый полипептид предстательной железы и кодирующий его полинуклеотид
US6207718B1 (en)	1998-08-07	2001-03-27	Ontogeny, Inc.	Pharmaceutical compositions containing hedgehog protein
US6979442B1 (en) *	1998-08-17	2005-12-27	Pfizer Inc.	Stabilized protein compositions
WO2000061169A1 (en) *	1999-04-09	2000-10-19	Ortho-Mcneil Pharmaceutical, Inc.	Pharmaceutical compositions of erythropoietin
AU777397B2 (en) *	1999-07-22	2004-10-14	Aventisub Ii Inc.	Multi-dose erythropoietin formulations
KR20070116181A (ko)	1999-07-22	2007-12-06	아벤티스 파마슈티칼스 인크.	보존 제약 제형
DK1129720T3 (da)	2000-02-29	2004-09-27	Pfizer Prod Inc	Stabiliseret granulocyt-kolonistimulerende faktor
US20020141970A1 (en) *	2001-03-05	2002-10-03	Pettit Dean K.	Stable aqueous solutions of granulocyte macrophage colony-stimulating factor
US6818613B2 (en) *	2001-11-07	2004-11-16	Ortho-Mcneil Pharmaceutical, Inc.	Aqueous sustained-release formulations of proteins
RU2218151C2 (ru) *	2001-12-11	2003-12-10	Замаев Ильяс Амсудинович	Способ консервации растворов лекарственных средств
KR20050012224A (ko) *	2002-05-21	2005-01-31	다이이찌 산토리 파마 가부시키가이샤	그렐린 함유 의약 조성물
SI21257A (sl) *	2002-07-17	2004-02-29	LEK farmacevtska dru�ba d.d.	Stabilni farmacevtski pripravek, ki vsebuje eritropoietin
US7812120B2 (en)	2003-03-21	2010-10-12	Par Pharmaceutical, Inc.	Nasal calcitonin formulations containing chlorobutanol
AU2003901515A0 (en) *	2003-04-02	2003-04-17	Norika Holdings	Sterilisation process for pharmaceutical product
EP1641486B1 (en) *	2003-06-10	2012-04-18	LG Life Sciences Ltd.	Stable, aqueous solution of human erythropoietin, not containing serum albumin
DE10333317A1 (de) *	2003-07-22	2005-02-17	Biotecon Therapeutics Gmbh	Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA)
EP1654283B1 (en) *	2003-08-13	2011-07-13	Novartis Vaccines and Diagnostics, Inc.	Improved method of purifying tfpi and tfpi analogs
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DE202005005094U1 (de) *	2005-03-31	2005-07-28	Dr. Gerhard Mann Chem.-Pharm. Fabrik Gmbh	Ophthalmische Zusammensetzung
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DE202006020194U1 (de)	2006-03-01	2007-12-06	Bioceuticals Arzneimittel Ag	G-CSF-Flüssigformulierung
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HRP20141217T1 (hr)	2007-08-27	2015-02-27	Ratiopharm Gmbh	G-csf tekuä†a formulacija
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BR112012006187A2 (pt)	2009-09-25	2019-09-24	Santen Pharmaceutical Co., Ltd.	colírio, e método para estabilizar um colírio,tendo um excelente efeito sobre a promoção da cura de um distúrbio da córnea
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1991
- 1991-08-15 DE DE4126983A patent/DE4126983A1/de not_active Withdrawn
1992
- 1992-08-05 TW TW081106209A patent/TW351677B/zh not_active IP Right Cessation
- 1992-08-10 HU HU9400416A patent/HU227421B1/hu unknown
- 1992-08-10 IL IL10277592A patent/IL102775A/en not_active IP Right Cessation
- 1992-08-10 JP JP50407293A patent/JP3670660B2/ja not_active Expired - Lifetime
- 1992-08-10 EP EP92916938A patent/EP0607156B1/de not_active Expired - Lifetime
- 1992-08-10 US US08/193,002 patent/US5503827A/en not_active Expired - Lifetime
- 1992-08-10 AU AU24094/92A patent/AU678756B2/en not_active Expired
- 1992-08-10 RU RU9294016163A patent/RU2091068C1/ru active
- 1992-08-10 AT AT92916938T patent/ATE145138T1/de active
- 1992-08-10 SK SK148-94A patent/SK281910B6/sk not_active IP Right Cessation
- 1992-08-10 DK DK92916938.1T patent/DK0607156T3/da active
- 1992-08-10 ES ES92916938T patent/ES2094923T3/es not_active Expired - Lifetime
- 1992-08-10 EP EP92113571A patent/EP0528313A1/de active Pending
- 1992-08-10 CZ CZ94287A patent/CZ284853B6/cs not_active IP Right Cessation
- 1992-08-10 WO PCT/EP1992/001822 patent/WO1993003744A1/de not_active Ceased
- 1992-08-10 DE DE59207523T patent/DE59207523C5/de not_active Expired - Lifetime
- 1992-08-10 KR KR1019940700453A patent/KR100263282B1/ko not_active Expired - Lifetime
- 1992-08-10 UA UA94005433A patent/UA26343C2/uk unknown
- 1992-08-10 CA CA002115348A patent/CA2115348C/en not_active Expired - Lifetime
- 1992-08-10 SG SG1996001887A patent/SG66226A1/en unknown
- 1992-08-11 MX MX9204636A patent/MX9204636A/es unknown
- 1992-08-14 ZA ZA926122A patent/ZA926122B/xx unknown
- 1992-10-15 GE GEAP19923057A patent/GEP19981289B/en unknown
1994
- 1994-02-14 FI FI940674A patent/FI112169B/fi not_active IP Right Cessation
- 1994-02-14 NO NO940499A patent/NO309844B1/no not_active IP Right Cessation
1996
- 1996-01-30 US US08/593,579 patent/US6303113B1/en not_active Expired - Fee Related
- 1996-12-13 GR GR960403464T patent/GR3022037T3/el unknown
1997
- 1997-03-17 AU AU16339/97A patent/AU710768B2/en not_active Expired

Also Published As

Publication number	Publication date
SK14894A3 (en)	1994-11-09
IL102775A (en)	1999-12-22
JP3670660B2 (ja)	2005-07-13
EP0607156A1 (de)	1994-07-27
HUT67379A (en)	1995-04-28
GR3022037T3 (en)	1997-03-31
IL102775A0 (en)	1993-01-31
EP0607156B1 (de)	1996-11-13
US6303113B1 (en)	2001-10-16
JPH06510031A (ja)	1994-11-10
SK281910B6 (sk)	2001-09-11
CA2115348A1 (en)	1993-03-04
NO309844B1 (no)	2001-04-09
ATE145138T1 (de)	1996-11-15
ZA926122B (en)	1994-02-14
RU94016163A (ru)	1996-08-10
FI112169B (fi)	2003-11-14
HU9400416D0 (en)	1994-05-30
CZ284853B6 (cs)	1999-03-17
UA26343C2 (uk)	1999-08-30
DE59207523D1 (de)	1996-12-19
US5503827A (en)	1996-04-02
DK0607156T3 (da)	1997-04-07
EP0528313A1 (de)	1993-02-24
MX9204636A (es)	1993-02-01
WO1993003744A1 (de)	1993-03-04
HU227421B1 (en)	2011-05-30
ES2094923T3 (es)	1997-02-01
GEP19981289B (en)	1998-05-01
AU2409492A (en)	1993-03-16
RU2091068C1 (ru)	1997-09-27
AU710768B2 (en)	1999-09-30
NO940499D0 (no)	1994-02-14
KR100263282B1 (ko)	2000-08-01
CA2115348C (en)	2007-07-17
CZ28794A3 (en)	1994-08-17
AU678756B2 (en)	1997-06-12
FI940674A0 (fi)	1994-02-14
AU1633997A (en)	1997-05-22
DE4126983A1 (de)	1993-02-18
FI940674L (fi)	1994-02-14
DE59207523C5 (de)	2006-11-16
SG66226A1 (en)	1999-07-20
TW351677B (en)	1999-02-01

Legal Events

Date	Code	Title	Description
2012-09-10	MK1K	Patent expired

Publication	Publication Date	Title
NO940499D0 (no)	1994-02-14	Fremgangsmåte for fremstilling av humanproteinholdige, konserverte legemidler for infusjons- eller injeksjonsformål
NO178687C (no)	1996-05-15	Fremgangsmåte for fremstilling av forenlige, lagringsstabile erythropoietinpreparater
ES2150940T3 (es)	2000-12-16	Formulacion proteinica que comprende hormona del crecimiento.
FI875308A0 (fi)	1987-12-02	Foerfarande i tvao steg foer att hela ett saor smaertfritt och ett vattenhaltigt medium och en salva foer lokal anvaendning vid foerfarandet.
EP0747092A3 (en)	1998-04-08	Dissolution liquid for drug in iontophoresis
ES445542A1 (es)	1977-06-01	Procedimiento de obtencion de laminas de recubrimiento para aplicaciones cosmeticas.
AU3037089A (en)	1989-08-25	Lipid metabolism improving agent and method of its use
KR840008279A (ko)	1984-12-14	아미노산 함유지방유제의 지방미립자화 방법
GB918754A (en)	1963-02-20	Improvements in or relating to corticotrophin preparations
IT1243742B (it)	1994-06-21	Composizioni farmaceutiche a base di calcitonine
FR2185416A1 (en)	1974-01-04	Isotonic injectable ACTH compsns - with low content of polyphloretin phosphate, but with prolonged activity
FR2425858A1 (fr)	1979-12-14	Composition ophtalmique pour le traitement de la senescence cristallinienne
DE69423623D1 (de)	2000-04-27	Aminosäureergänzung