NO940499L - Fremgangsmåte for fremstilling av humanproteinholdige, konserverte legemidler for infusjons- eller injeksjonsformål - Google Patents

Fremgangsmåte for fremstilling av humanproteinholdige, konserverte legemidler for infusjons- eller injeksjonsformål

Info

Publication number: NO940499L
Authority: NO; Norway
Prior art keywords: preservative; prepn; human protein; infusion; sodium
Prior art date: 1991-08-15

Application number

NO940499A

Other languages

English (en)

Other versions

NO309844B1 (no

NO940499D0 (no

Inventor

Heinrich Woog

Werner Gruber

Hans-Jorg Markl

Gerhard Winter

Fritz Demmer

Original Assignee

Boehringer Mannheim Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-08-15

Filing date

1994-02-14

Publication date

1994-02-14

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6438353&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO940499(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1994-02-14 Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh

1994-02-14 Publication of NO940499D0 publication Critical patent/NO940499D0/no

1994-02-14 Publication of NO940499L publication Critical patent/NO940499L/no

2001-04-09 Publication of NO309844B1 publication Critical patent/NO309844B1/no

Links

102000003839 Human Proteins Human genes 0.000 title abstract 4
108090000144 Human Proteins Proteins 0.000 title abstract 4
238000001802 infusion Methods 0.000 title abstract 2
238000002347 injection Methods 0.000 title abstract 2
239000007924 injection Substances 0.000 title abstract 2
239000003814 drug Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1
238000000034 method Methods 0.000 title 1
239000003755 preservative agent Substances 0.000 abstract 5
230000002335 preservative effect Effects 0.000 abstract 5
WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 abstract 3
OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 abstract 3
229960004926 chlorobutanol Drugs 0.000 abstract 2
LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 abstract 2
BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical class OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 abstract 1
CFKMVGJGLGKFKI-UHFFFAOYSA-N 4-chloro-m-cresol Chemical compound CC1=CC(O)=CC=C1Cl CFKMVGJGLGKFKI-UHFFFAOYSA-N 0.000 abstract 1
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
206010020751 Hypersensitivity Diseases 0.000 abstract 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical class C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
208000026935 allergic disease Diseases 0.000 abstract 1
230000007815 allergy Effects 0.000 abstract 1
BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 abstract 1
235000001014 amino acid Nutrition 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
229960000686 benzalkonium chloride Drugs 0.000 abstract 1
229960004217 benzyl alcohol Drugs 0.000 abstract 1
235000019445 benzyl alcohol Nutrition 0.000 abstract 1
CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 abstract 1
239000012928 buffer substance Substances 0.000 abstract 1
ZFTFAPZRGNKQPU-UHFFFAOYSA-N dicarbonic acid Chemical compound OC(=O)OC(O)=O ZFTFAPZRGNKQPU-UHFFFAOYSA-N 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
239000001630 malic acid Substances 0.000 abstract 1
235000011090 malic acid Nutrition 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
229940070805 p-chloro-m-cresol Drugs 0.000 abstract 1
WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 abstract 1
229920001184 polypeptide Polymers 0.000 abstract 1
229910000160 potassium phosphate Inorganic materials 0.000 abstract 1
235000011009 potassium phosphates Nutrition 0.000 abstract 1
159000000001 potassium salts Chemical class 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
230000009257 reactivity Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000011734 sodium Chemical class 0.000 abstract 1
229910052708 sodium Inorganic materials 0.000 abstract 1
239000001509 sodium citrate Substances 0.000 abstract 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 abstract 1
239000001488 sodium phosphate Substances 0.000 abstract 1
229910000162 sodium phosphate Inorganic materials 0.000 abstract 1
238000004448 titration Methods 0.000 abstract 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Dermatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)

NO940499A 1991-08-15 1994-02-14 Konserverte, humanproteinholdige legemidler for anvendelse som injeksjons- eller infusjonsoppløsning i form av flerdosepreparater NO309844B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE4126983A DE4126983A1 (de)	1991-08-15	1991-08-15	Verfahren zur herstellung von humanprotein-enthaltenden, konservierten arzneimitteln fuer infusions- oder injektionszwecke
PCT/EP1992/001822 WO1993003744A1 (de)	1991-08-15	1992-08-10	Verfahren zur herstellung von humanproteinhaltigen, konservierten arzneimitteln für infusions- oder injektionszwecke

Publications (3)

Publication Number	Publication Date
NO940499D0 NO940499D0 (no)	1994-02-14
NO940499L true NO940499L (no)	1994-02-14
NO309844B1 NO309844B1 (no)	2001-04-09

Family

ID=6438353

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO940499A NO309844B1 (no)	1991-08-15	1994-02-14	Konserverte, humanproteinholdige legemidler for anvendelse som injeksjons- eller infusjonsoppløsning i form av flerdosepreparater

Country Status (25)

Country	Link
US (2)	US5503827A (no)
EP (2)	EP0607156B1 (no)
JP (1)	JP3670660B2 (no)
KR (1)	KR100263282B1 (no)
AT (1)	ATE145138T1 (no)
AU (2)	AU678756B2 (no)
CA (1)	CA2115348C (no)
CZ (1)	CZ284853B6 (no)
DE (2)	DE4126983A1 (no)
DK (1)	DK0607156T3 (no)
ES (1)	ES2094923T3 (no)
FI (1)	FI112169B (no)
GE (1)	GEP19981289B (no)
GR (1)	GR3022037T3 (no)
HU (1)	HU227421B1 (no)
IL (1)	IL102775A (no)
MX (1)	MX9204636A (no)
NO (1)	NO309844B1 (no)
RU (1)	RU2091068C1 (no)
SG (1)	SG66226A1 (no)
SK (1)	SK281910B6 (no)
TW (1)	TW351677B (no)
UA (1)	UA26343C2 (no)
WO (1)	WO1993003744A1 (no)
ZA (1)	ZA926122B (no)

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DE4242919A1 (de) *	1992-12-18	1994-06-23	Boehringer Mannheim Gmbh	Verfahren zur Herstellung von lagerstabilen wässrigen pharmazeutischen Zubereitungen von G-CSF
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JP3541054B2 (ja) *	1994-04-21	2004-07-07	ユニ・チャーム株式会社	使い捨ておむつ
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JP2000504319A (ja) *	1996-01-19	2000-04-11	イーライ・リリー・アンド・カンパニー	肥満症タンパク質製剤
TW518219B (en)	1996-04-26	2003-01-21	Chugai Pharmaceutical Co Ltd	Erythropoietin solution preparation
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US20050203187A1 (en) *	1998-06-01	2005-09-15	Verbiscar Anthony J.	Formulations useful for the treatment of varicella zoster virus infections and methods for the use thereof
RU2234942C2 (ru) *	1998-07-14	2004-08-27	Корикса Корпорейшн	Выделенный опухолевый полипептид предстательной железы и кодирующий его полинуклеотид
ES2253851T3 (es)	1998-08-07	2006-06-01	Curis, Inc.	Composicion farmaceutica estable de proteinas hedgehog y uso de la misma.
US6979442B1 (en) *	1998-08-17	2005-12-27	Pfizer Inc.	Stabilized protein compositions
KR100740794B1 (ko) *	1999-04-09	2007-07-20	오르토-맥네일 파마슈티칼, 인코퍼레이티드	에리트로포이에틴의 약제학적 제형
IL147756A (en)	1999-07-22	2005-12-18	Aventis Pharma Inc	Preserved pharmaceutical formulations
KR100693263B1 (ko) *	1999-07-22	2007-03-13	아벤티스 파마슈티칼스 인크.	다중 투여형 에리트로포이에틴 제형
ATE269716T1 (de)	2000-02-29	2004-07-15	Pfizer Prod Inc	Stabilisierter granulozyten-kolonie- stimulierender faktor
US20020141970A1 (en) *	2001-03-05	2002-10-03	Pettit Dean K.	Stable aqueous solutions of granulocyte macrophage colony-stimulating factor
US6818613B2 (en) *	2001-11-07	2004-11-16	Ortho-Mcneil Pharmaceutical, Inc.	Aqueous sustained-release formulations of proteins
RU2218151C2 (ru) *	2001-12-11	2003-12-10	Замаев Ильяс Амсудинович	Способ консервации растворов лекарственных средств
JP5000848B2 (ja) *	2002-05-21	2012-08-15	第一三共株式会社	グレリン含有医薬組成物
SI21257A (sl) *	2002-07-17	2004-02-29	LEK farmacevtska dru�ba d.d.	Stabilni farmacevtski pripravek, ki vsebuje eritropoietin
US7812120B2 (en)	2003-03-21	2010-10-12	Par Pharmaceutical, Inc.	Nasal calcitonin formulations containing chlorobutanol
AU2003901515A0 (en) *	2003-04-02	2003-04-17	Norika Holdings	Sterilisation process for pharmaceutical product
CN1802171B (zh) *	2003-06-10	2010-10-13	株式会社Lg生命科学	不包含血清白蛋白的人红细胞生成素的稳定水溶液
DE10333317A1 (de) *	2003-07-22	2005-02-17	Biotecon Therapeutics Gmbh	Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA)
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EP1532983A1 (en) *	2003-11-18	2005-05-25	ZLB Bioplasma AG	Immunoglobulin preparations having increased stability
BRPI0514408B8 (pt) *	2004-08-24	2021-05-25	Asubio Pharma Co Ltd	preparação liquida de peptídeo fisiologicamente ativo
DE202005005094U1 (de) *	2005-03-31	2005-07-28	Dr. Gerhard Mann Chem.-Pharm. Fabrik Gmbh	Ophthalmische Zusammensetzung
CA2618068C (en)	2005-08-05	2016-02-16	Amgen Inc.	Stable aqueous protein or antibody pharmaceutical formulations and their preparation
DE102006009437A1 (de)	2006-03-01	2007-09-13	Bioceuticals Arzneimittel Ag	G-CSF-Flüssigformulierung
UA100245C2 (uk)	2007-08-27	2012-12-10	Біогенерікс Аг	Рідка форма г-ксф
US8546328B2 (en) *	2007-08-27	2013-10-01	Biogenerix Ag	Liquid formulation of G-CSF conjugate
US8796206B2 (en)	2007-11-15	2014-08-05	Amgen Inc.	Aqueous formulation of erythropoiesis stimulating protein stabilised by antioxidants for parenteral administration
RS52106B (sr) *	2008-02-08	2012-08-31	Biogenerix Ag	Tečni preparat fsh
US8120369B2 (en)	2009-03-02	2012-02-21	Harris Corporation	Dielectric characterization of bituminous froth
EA022927B1 (ru) *	2009-09-25	2016-03-31	Р-Тек Уено, Лтд.	Стабильные глазные капли для заживления повреждений роговицы
DK2531218T3 (en)	2010-02-04	2019-04-01	Csl Behring Ag	immunoglobulin
EP2361636A1 (en)	2010-02-26	2011-08-31	CSL Behring AG	Immunoglobulin preparation and storage system for an immunoglobulin preparation
CN121371151A (zh)	2014-12-03	2026-01-23	瑞士杰特贝林生物制品有限公司	具有增加的稳定性的包含免疫球蛋白的药物产品
MA48047A (fr) *	2017-04-05	2020-02-12	Modernatx Inc	Réduction ou élimination de réponses immunitaires à des protéines thérapeutiques administrées par voie non intraveineuse, par exemple par voie sous-cutanée
CA3095134A1 (en)	2018-03-28	2019-10-03	Board Of Regents, The University Of Texas System	Identification of epigenetic alterations in dna isolated from exosomes
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1991
- 1991-08-15 DE DE4126983A patent/DE4126983A1/de not_active Withdrawn
1992
- 1992-08-05 TW TW081106209A patent/TW351677B/zh not_active IP Right Cessation
- 1992-08-10 EP EP92916938A patent/EP0607156B1/de not_active Expired - Lifetime
- 1992-08-10 RU RU9294016163A patent/RU2091068C1/ru active
- 1992-08-10 AU AU24094/92A patent/AU678756B2/en not_active Expired
- 1992-08-10 UA UA94005433A patent/UA26343C2/uk unknown
- 1992-08-10 SK SK148-94A patent/SK281910B6/sk not_active IP Right Cessation
- 1992-08-10 WO PCT/EP1992/001822 patent/WO1993003744A1/de not_active Ceased
- 1992-08-10 HU HU9400416A patent/HU227421B1/hu unknown
- 1992-08-10 US US08/193,002 patent/US5503827A/en not_active Expired - Lifetime
- 1992-08-10 DE DE59207523T patent/DE59207523C5/de not_active Expired - Lifetime
- 1992-08-10 IL IL10277592A patent/IL102775A/en not_active IP Right Cessation
- 1992-08-10 AT AT92916938T patent/ATE145138T1/de active
- 1992-08-10 SG SG1996001887A patent/SG66226A1/en unknown
- 1992-08-10 CA CA002115348A patent/CA2115348C/en not_active Expired - Lifetime
- 1992-08-10 JP JP50407293A patent/JP3670660B2/ja not_active Expired - Lifetime
- 1992-08-10 CZ CZ94287A patent/CZ284853B6/cs not_active IP Right Cessation
- 1992-08-10 KR KR1019940700453A patent/KR100263282B1/ko not_active Expired - Lifetime
- 1992-08-10 EP EP92113571A patent/EP0528313A1/de active Pending
- 1992-08-10 ES ES92916938T patent/ES2094923T3/es not_active Expired - Lifetime
- 1992-08-10 DK DK92916938.1T patent/DK0607156T3/da active
- 1992-08-11 MX MX9204636A patent/MX9204636A/es unknown
- 1992-08-14 ZA ZA926122A patent/ZA926122B/xx unknown
- 1992-10-15 GE GEAP19923057A patent/GEP19981289B/en unknown
1994
- 1994-02-14 NO NO940499A patent/NO309844B1/no not_active IP Right Cessation
- 1994-02-14 FI FI940674A patent/FI112169B/fi not_active IP Right Cessation
1996
- 1996-01-30 US US08/593,579 patent/US6303113B1/en not_active Expired - Fee Related
- 1996-12-13 GR GR960403464T patent/GR3022037T3/el unknown
1997
- 1997-03-17 AU AU16339/97A patent/AU710768B2/en not_active Expired

Also Published As

Publication number	Publication date
DE4126983A1 (de)	1993-02-18
AU1633997A (en)	1997-05-22
KR100263282B1 (ko)	2000-08-01
UA26343C2 (uk)	1999-08-30
CA2115348A1 (en)	1993-03-04
US6303113B1 (en)	2001-10-16
US5503827A (en)	1996-04-02
CA2115348C (en)	2007-07-17
HUT67379A (en)	1995-04-28
TW351677B (en)	1999-02-01
GR3022037T3 (en)	1997-03-31
IL102775A0 (en)	1993-01-31
SG66226A1 (en)	1999-07-20
EP0528313A1 (de)	1993-02-24
FI940674L (fi)	1994-02-14
MX9204636A (es)	1993-02-01
AU678756B2 (en)	1997-06-12
SK281910B6 (sk)	2001-09-11
RU94016163A (ru)	1996-08-10
DE59207523D1 (de)	1996-12-19
IL102775A (en)	1999-12-22
EP0607156A1 (de)	1994-07-27
HU9400416D0 (en)	1994-05-30
JPH06510031A (ja)	1994-11-10
EP0607156B1 (de)	1996-11-13
AU710768B2 (en)	1999-09-30
RU2091068C1 (ru)	1997-09-27
AU2409492A (en)	1993-03-16
NO309844B1 (no)	2001-04-09
WO1993003744A1 (de)	1993-03-04
NO940499D0 (no)	1994-02-14
FI112169B (fi)	2003-11-14
DE59207523C5 (de)	2006-11-16
CZ284853B6 (cs)	1999-03-17
FI940674A0 (fi)	1994-02-14
JP3670660B2 (ja)	2005-07-13
SK14894A3 (en)	1994-11-09
ZA926122B (en)	1994-02-14
ATE145138T1 (de)	1996-11-15
CZ28794A3 (en)	1994-08-17
DK0607156T3 (da)	1997-04-07
ES2094923T3 (es)	1997-02-01
GEP19981289B (en)	1998-05-01
HU227421B1 (en)	2011-05-30

Legal Events

Date	Code	Title	Description
2012-09-10	MK1K	Patent expired

Publication	Publication Date	Title
NO940499D0 (no)	1994-02-14	Fremgangsmåte for fremstilling av humanproteinholdige, konserverte legemidler for infusjons- eller injeksjonsformål
NO178687C (no)	1996-05-15	Fremgangsmåte for fremstilling av forenlige, lagringsstabile erythropoietinpreparater
DE69329367D1 (de)	2000-10-12	Wachstumshormon-enthaltendeproteinformulierung
FI875308A0 (fi)	1987-12-02	Foerfarande i tvao steg foer att hela ett saor smaertfritt och ett vattenhaltigt medium och en salva foer lokal anvaendning vid foerfarandet.
ES445542A1 (es)	1977-06-01	Procedimiento de obtencion de laminas de recubrimiento para aplicaciones cosmeticas.
NO893882D0 (no)	1989-09-29	Middel til forbedring av lipidmetabolisme og fremgangsmaate ved anvendelse derav.
KR840008279A (ko)	1984-12-14	아미노산 함유지방유제의 지방미립자화 방법
DE69513635D1 (de)	2000-01-05	Wässrige zubereitung mit verzögerter wirkstofffreigabe
FR2185416A1 (en)	1974-01-04	Isotonic injectable ACTH compsns - with low content of polyphloretin phosphate, but with prolonged activity
DE69423623D1 (de)	2000-04-27	Aminosäureergänzung
van Bruchem	1976	ABOMASAL MUCOSAL BLOODFLOW IN RELATION TO ABOMASAL SECRETORY ACTIVITY IN SHEEP
JPS56115722A (en)	1981-09-11	Analgesic
IT1206281B (it)	1989-04-14	Attivatore del plasminogeno dei tessuti e suo impiego nella medicina umana ed in veterinaria
IT1247752B (it)	1994-12-30	Composizioni farmaceutiche aventi come principio attivo calcitonina da somministrarsi per via intranasale.