NO941256L - 3-(N-isopropyl-N-n-propylamino)-5-(N-isopropyl)karbamoylkroman - Google Patents

3-(N-isopropyl-N-n-propylamino)-5-(N-isopropyl)karbamoylkroman

Info

Publication number
NO941256L
NO941256L NO941256A NO941256A NO941256L NO 941256 L NO941256 L NO 941256L NO 941256 A NO941256 A NO 941256A NO 941256 A NO941256 A NO 941256A NO 941256 L NO941256 L NO 941256L
Authority
NO
Norway
Prior art keywords
isopropyl
disorders
propylamino
karbamoylkroman
carbamoylchroman
Prior art date
Application number
NO941256A
Other languages
English (en)
Other versions
NO941256D0 (no
Inventor
Eva Maria Hammarberg
Lars George Johansson
Svante Bertil Ross
Seth Olov Thorberg
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9102905A external-priority patent/SE9102905D0/xx
Priority claimed from SE9202000A external-priority patent/SE9202000D0/xx
Application filed by Astra Ab filed Critical Astra Ab
Publication of NO941256D0 publication Critical patent/NO941256D0/no
Publication of NO941256L publication Critical patent/NO941256L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)

Abstract

3-(N-isopropyl-N-n-propylamino )-5-(N-isopropyl )karba- moylkroman som har formelen: (D som racemat, (E )-enantlomer i form av fri base eller farmasøytisk akseptable salter derav. Forbindelsene er beregnet for terapeutisk bruk, spesielt for behandling av 5-hydroksytryptamin-formidlede forstyrrelser i sentralnervesystemet, f.eks depresjon, angst, obsessiv- compulsiv forstyrrelse (OCD), anoreksi, senil demente, migrene, slag, Alzheimers sykdom, nypertensjon, termoregulatoriske og seksuelle forstyrrelser, smerte og forstyrrelser i det kardlovaskulære systemet.
NO941256A 1991-10-08 1994-04-07 3-(N-isopropyl-N-n-propylamino)-5-(N-isopropyl)karbamoylkroman NO941256L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9102905A SE9102905D0 (sv) 1991-10-08 1991-10-08 A new therapeutically active compound and a process for its preparation
SE9202000A SE9202000D0 (sv) 1992-06-29 1992-06-29 A new therapeutically active compound
PCT/SE1992/000708 WO1993007135A1 (en) 1991-10-08 1992-10-08 3-(n-isopropyl-n-n-propylamino)-5-(n-isopropyl)carbamoylchroman

Publications (2)

Publication Number Publication Date
NO941256D0 NO941256D0 (no) 1994-04-07
NO941256L true NO941256L (no) 1994-04-07

Family

ID=26661197

Family Applications (1)

Application Number Title Priority Date Filing Date
NO941256A NO941256L (no) 1991-10-08 1994-04-07 3-(N-isopropyl-N-n-propylamino)-5-(N-isopropyl)karbamoylkroman

Country Status (32)

Country Link
EP (3) EP0538222A1 (no)
JP (1) JPH07500320A (no)
CN (2) CN1072411A (no)
AP (1) AP338A (no)
AT (1) ATE139774T1 (no)
AU (1) AU667687B2 (no)
BG (1) BG98684A (no)
CA (1) CA2118708A1 (no)
CY (1) CY1992A (no)
CZ (1) CZ51094A3 (no)
DE (1) DE69211857T2 (no)
DK (1) DK0607274T3 (no)
EE (1) EE02981B1 (no)
ES (1) ES2089571T3 (no)
FI (1) FI941616A0 (no)
GR (1) GR3020608T3 (no)
HK (1) HK55997A (no)
HR (1) HRP920935A2 (no)
HU (1) HUT68834A (no)
IL (1) IL103373A0 (no)
IS (2) IS1644B (no)
MA (1) MA22674A1 (no)
MX (1) MX9205744A (no)
MY (1) MY131174A (no)
NO (1) NO941256L (no)
NZ (2) NZ244618A (no)
PL (1) PL171013B1 (no)
SI (1) SI9200249A (no)
SK (1) SK36194A3 (no)
TN (1) TNSN92088A1 (no)
WO (1) WO1993007135A1 (no)
YU (1) YU90492A (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5420151A (en) * 1989-12-22 1995-05-30 Aktiebolaget Astra Chroman derivatives
US5990114A (en) * 1996-02-28 1999-11-23 Recordati, S.A., Chemical And Pharmaceutical Company Use of 5-HT1A receptor antagonists for the treatment of urinary incontinence
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
RU2232758C2 (ru) * 1998-09-23 2004-07-20 Рисерч Дивелопмент Фаундейшн Токоферолы, токотриенолы и другие производные хромана и боковых цепей и способы лечения с их использованием
US6235938B1 (en) * 1999-06-10 2001-05-22 Yale University Transition metal-catalyzed process for preparing N-aryl amine compounds
MX2019000982A (es) 2016-07-29 2019-07-04 Sunovion Pharmaceuticals Inc Compuestos y composiciones y usos de los mismos.
JP7191085B2 (ja) 2017-08-02 2022-12-16 サノビオン ファーマシューティカルズ インク イソクロマン化合物およびその使用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR862239B (en) * 1985-09-03 1986-12-31 Ciba Geigy Ag 3-amino-dihydro-(1)-benzopyrans and benzothiopyrans
US4801605A (en) * 1986-08-29 1989-01-31 Ciba-Geigy Corporation 3-amino-dihydro-[1]-benzopyrans and benzothiopyrans
SE8605504D0 (sv) * 1986-12-19 1986-12-19 Astra Laekemedel Ab Novel chroman derivatives
JPH021429A (ja) * 1988-06-09 1990-01-05 Toray Ind Inc 光学活性１−メチル−３−フェニルプロピルアミンの製造方法
SE8904361D0 (sv) * 1989-12-22 1989-12-22 Astra Ab New chroman and thiochroman derivatives

Also Published As

Publication number Publication date
JPH07500320A (ja) 1995-01-12
EP0607274A1 (en) 1994-07-27
SI9200249A (en) 1993-06-30
SK36194A3 (en) 1994-12-07
NO941256D0 (no) 1994-04-07
PL171013B1 (pl) 1997-02-28
CY1992A (en) 1997-09-05
MY131174A (en) 2007-07-31
HRP920935A2 (en) 1995-08-31
IS1644B (is) 1997-03-25
WO1993007135A1 (en) 1993-04-15
ATE139774T1 (de) 1996-07-15
CZ51094A3 (en) 1994-11-16
AP338A (en) 1994-04-26
CA2118708A1 (en) 1993-04-15
EP0703229A3 (en) 1996-06-26
TNSN92088A1 (fr) 1993-06-08
CN1146992A (zh) 1997-04-09
BG98684A (en) 1995-05-31
AP9200434A0 (en) 1992-10-31
NZ270595A (en) 1996-10-28
AU667687B2 (en) 1996-04-04
IS3929A (is) 1993-04-09
MX9205744A (es) 1993-04-01
AU2768492A (en) 1993-05-03
CN1072411A (zh) 1993-05-26
NZ244618A (en) 1996-10-28
HK55997A (en) 1997-05-09
ES2089571T3 (es) 1996-10-01
EP0538222A1 (en) 1993-04-21
EE02981B1 (et) 1997-04-15
EP0607274B1 (en) 1996-06-26
IL103373A0 (en) 1993-03-15
DE69211857D1 (de) 1996-08-01
HU9400993D0 (en) 1994-08-29
GR3020608T3 (en) 1996-10-31
IS4310A (is) 1993-04-09
DK0607274T3 (da) 1996-11-04
FI941616A7 (fi) 1994-04-08
FI941616A0 (fi) 1994-04-08
YU90492A (sh) 1995-12-04
MA22674A1 (fr) 1993-07-01
DE69211857T2 (de) 1996-10-24
EP0703229A2 (en) 1996-03-27
HUT68834A (en) 1995-08-28

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