NO941756L - Fremgangsmåte for å skille enantiomerene av 5-metyl-tetrahydrofolsyre - Google Patents

Fremgangsmåte for å skille enantiomerene av 5-metyl-tetrahydrofolsyre

Info

Publication number: NO941756L
Authority: NO; Norway
Prior art keywords: enantiomers; separating; methyl; pct; tetrahydrofolic acid
Prior art date: 1991-11-11

Application number

NO941756A

Other languages

English (en)

Other versions

NO305175B1 (no

NO941756D0 (no

Inventor

Klaus Scheib

Peter Klein

Robert Carter

Original Assignee

Knoll Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-11-11

Filing date

1994-05-10

Publication date

1994-05-10

1994-05-10 Application filed by Knoll Ag filed Critical Knoll Ag

1994-05-10 Publication of NO941756L publication Critical patent/NO941756L/no

1994-05-10 Publication of NO941756D0 publication Critical patent/NO941756D0/no

1999-04-12 Publication of NO305175B1 publication Critical patent/NO305175B1/no

Links

229940105150 5-methyltetrahydrofolic acid Drugs 0.000 title 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title 1
ZNOVTXRBGFNYRX-ABLWVSNPSA-N levomefolic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 ZNOVTXRBGFNYRX-ABLWVSNPSA-N 0.000 title 1
UNRBEYYLYRXYCG-UHFFFAOYSA-N (1-ethylpyrrolidin-2-yl)methanamine Chemical group CCN1CCCC1CN UNRBEYYLYRXYCG-UHFFFAOYSA-N 0.000 abstract 1
ZNOVTXRBGFNYRX-OLZOCXBDSA-N (2s)-2-[[4-[[(6r)-2-amino-5-methyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioic acid Chemical compound C([C@H]1N(C=2C(=O)NC(N)=NC=2NC1)C)NC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 ZNOVTXRBGFNYRX-OLZOCXBDSA-N 0.000 abstract 1
ZNOVTXRBGFNYRX-STQMWFEESA-N (6S)-5-methyltetrahydrofolic acid Chemical compound C([C@@H]1N(C=2C(=O)N=C(N)NC=2NC1)C)NC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 ZNOVTXRBGFNYRX-STQMWFEESA-N 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Hydrogenated Pyridines (AREA)

NO941756A 1991-11-11 1994-05-10 FremgangsmÕte for Õ skille enantiomerene av 5-metyl-tetrahydrofolsyre NO305175B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE4136921A DE4136921A1 (de)	1991-11-11	1991-11-11	Verfahren zur trennung von 5-methyl-tetrahydrofolsaeure
PCT/EP1992/002515 WO1993010118A1 (de)	1991-11-11	1992-11-03	Verfahren zur trennung von 5-methyl-tetrahydrofolsäure

Publications (3)

Publication Number	Publication Date
NO941756L true NO941756L (no)	1994-05-10
NO941756D0 NO941756D0 (no)	1994-05-10
NO305175B1 NO305175B1 (no)	1999-04-12

Family

ID=6444446

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO941756A NO305175B1 (no)	1991-11-11	1994-05-10	FremgangsmÕte for Õ skille enantiomerene av 5-metyl-tetrahydrofolsyre

Country Status (16)

Country	Link
US (1)	US5457202A (no)
EP (1)	EP0612322B1 (no)
JP (1)	JP3162390B2 (no)
KR (1)	KR100211915B1 (no)
AT (1)	ATE177100T1 (no)
AU (1)	AU664051B2 (no)
CA (1)	CA2121351C (no)
DE (2)	DE4136921A1 (no)
DK (1)	DK0612322T3 (no)
ES (1)	ES2127765T3 (no)
FI (1)	FI105918B (no)
GR (1)	GR3029552T3 (no)
NO (1)	NO305175B1 (no)
TW (1)	TW221293B (no)
WO (1)	WO1993010118A1 (no)
ZA (1)	ZA928643B (no)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4136921A1 (de) *	1991-11-11	1993-05-13	Knoll Ag	Verfahren zur trennung von 5-methyl-tetrahydrofolsaeure
GB9222253D0 (en) *	1992-10-23	1992-12-09	Celltech Ltd	Chemical compounds
GB9304920D0 (en) *	1993-03-10	1993-04-28	Celltech Ltd	Chemical compounds
GB9304919D0 (en) *	1993-03-10	1993-04-28	Celltech Ltd	Chemical compounds
GB9326699D0 (en) *	1993-12-22	1994-03-02	Celltech Ltd	Chemical compounds
ATE260911T1 (de) *	1993-12-22	2004-03-15	Celltech R&D Ltd	Trisubstituierte phenyl-derivate, verfahren zu deren herstellung und deren verwendung als phosphodiesterase (typ iv) hemmstoffe
IT1270185B (it) *	1994-06-08	1997-04-29	Bracco Spa	Processo per l'ottenimento e la separazione dei sali diastereoisomeri dell'acido folinico
US6245774B1 (en)	1994-06-21	2001-06-12	Celltech Therapeutics Limited	Tri-substituted phenyl or pyridine derivatives
US5786354A (en) *	1994-06-21	1998-07-28	Celltech Therapeutics, Limited	Tri-substituted phenyl derivatives and processes for their preparation
GB9412571D0 (en)	1994-06-22	1994-08-10	Celltech Ltd	Chemical compounds
GB9412573D0 (en)	1994-06-22	1994-08-10	Celltech Ltd	Chemical compounds
GB9523675D0 (en) *	1995-11-20	1996-01-24	Celltech Therapeutics Ltd	Chemical compounds
GB9526246D0 (en) *	1995-12-21	1996-02-21	Celltech Therapeutics Ltd	Chemical compounds
GB9526245D0 (en) *	1995-12-21	1996-02-21	Celltech Therapeutics Ltd	Chemical compounds
GB9608435D0 (en) *	1996-04-24	1996-06-26	Celltech Therapeutics Ltd	Chemical compounds
GB9619284D0 (en) *	1996-09-16	1996-10-30	Celltech Therapeutics Ltd	Chemical compounds
GB9622363D0 (en) *	1996-10-28	1997-01-08	Celltech Therapeutics Ltd	Chemical compounds
GB9625184D0 (en) *	1996-12-04	1997-01-22	Celltech Therapeutics Ltd	Chemical compounds
AU5330698A (en) *	1996-12-23	1998-07-17	Celltech Therapeutics Limited	Fused polycyclic 2-aminopyrimidine derivatives, their preparation and their use as protein tyrosine kinase inhibitors
GB9705361D0 (en) *	1997-03-14	1997-04-30	Celltech Therapeutics Ltd	Chemical compounds
GB9713087D0 (en) *	1997-06-20	1997-08-27	Celltech Therapeutics Ltd	Chemical compounds
CH693905A5 (de) *	1999-04-15	2004-04-15	Eprova Ag	Stabile kristalline Salze von 5-Methyltetrahydrofolsäure.
GB9914258D0 (en)	1999-06-18	1999-08-18	Celltech Therapeutics Ltd	Chemical compounds
GB9924862D0 (en)	1999-10-20	1999-12-22	Celltech Therapeutics Ltd	Chemical compounds
DE10022510A1 (de)	2000-05-10	2001-11-15	Basf Ag	Zusammensetzungen enthaltend Folsäure und reduziertes Folat
AU2002312933B2 (en)	2001-05-29	2007-12-06	Schering Ag	CDK inhibiting pyrimidines, production thereof and their use as medicaments
CN101143863B (zh) *	2006-09-13	2010-08-11	南京莱因医药科技有限公司	5-甲基四氢叶酸的拆分及其成盐方法
CH698729B1 (de)	2007-05-30	2009-10-15	Cerbios Pharma Sa	Stabile, kristalline (6S)-N(5)-Methyl-5, 6,7,8-tetrahydrofolsäure.
CN101407518A (zh) *	2007-10-11	2009-04-15	南京莱尔生物化工有限公司	(6r,s)-5-甲酰-四氢叶酸的拆分及其成盐的方法
PL2254890T3 (pl) *	2008-02-20	2015-10-30	Gnosis Spa	Sposób diastereoizomerycznego rozdzielania kwasu 5-metylotetrahydrofoliowego
JP5925381B2 (ja) *	2012-04-13	2016-05-25	▲連雲▼港金康和信▲薬業▼有限公司ＬｉａｎｙｕｎｇａｎｇＪｉｎｋａｎｇＨｅｘｉｎＰｈａｒｍａｃｅｕｔｉｃａｌＣｏ．，Ｌｔｄ．	化合物［４−（２−アミノ−１０−メチル−４−オキソ−６，７，８，９−テトラヒドロ−４ａ，７−エピミノピリミド［４，５−ｂ］［１，４］ジアゼピン−５（４Ｈ）−イル）ベンゾイル］−グルタメート及びその製造
RU2019134064A (ru)	2017-03-31	2021-04-30	Мерк Патент Гмбх	Кристаллическая натриевая соль 5-метил-(6s)-тетрагидрофолиевой кислоты
CN108358928A (zh) *	2018-05-23	2018-08-03	浙江圣达生物药业股份有限公司	一种(6s)-5-甲基四氢叶酸钙的制备方法
WO2022235566A1 (en)	2021-05-03	2022-11-10	North Carolina State University	Compositions and methods related to the treatment of ocular diseases in equines

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8621268D0 (en) *	1986-09-03	1986-10-08	Univ Strathclyde	Separation of substances
CH673459A5 (no) *	1987-05-15	1990-03-15	Eprova Ag
DE3821875C1 (no) *	1988-06-29	1990-02-15	Eprova Ag, Forschungsinstitut, Schaffhausen, Ch
CH676981A5 (no) *	1988-11-11	1991-03-28	Eprova Ag
ATE139799T1 (de) *	1989-12-11	1996-07-15	American Cyanamid Co	Verfahren zur herstellung von optisch reinen diastereoisomeren von tetrahydrofolatverbindungen
FR2659330B1 (fr) *	1990-03-09	1994-02-11	Sapec Sa	Composes diastereoisomeres derivant de l'acide tetrahydrofolique, procede de preparation et utilisation dans la synthese de diastereomeres 6s et 6r de folates reduits.
CH680731A5 (no) *	1990-04-12	1992-10-30	Sapec Fine Chemicals
CH681303A5 (no) *	1991-01-16	1993-02-26	Eprova Ag
CH683261A5 (it) *	1991-10-10	1994-02-15	Applied Pharma Res	Procedimento per la preparazione dell'acido metiltetraidrofolico nella forma (6(R,S)(-))N-5 e separazione del diastereoisomero attivo (6(S)(-))N-5) sotto forma di sali.
DE4136921A1 (de) *	1991-11-11	1993-05-13	Knoll Ag	Verfahren zur trennung von 5-methyl-tetrahydrofolsaeure

1991
- 1991-11-11 DE DE4136921A patent/DE4136921A1/de not_active Withdrawn
1992
- 1992-11-03 CA CA002121351A patent/CA2121351C/en not_active Expired - Fee Related
- 1992-11-03 WO PCT/EP1992/002515 patent/WO1993010118A1/de not_active Ceased
- 1992-11-03 US US08/232,267 patent/US5457202A/en not_active Expired - Lifetime
- 1992-11-03 JP JP50892693A patent/JP3162390B2/ja not_active Expired - Fee Related
- 1992-11-03 AT AT92923141T patent/ATE177100T1/de not_active IP Right Cessation
- 1992-11-03 AU AU28983/92A patent/AU664051B2/en not_active Ceased
- 1992-11-03 DE DE59209643T patent/DE59209643D1/de not_active Expired - Lifetime
- 1992-11-03 KR KR1019940701569A patent/KR100211915B1/ko not_active Expired - Fee Related
- 1992-11-03 ES ES92923141T patent/ES2127765T3/es not_active Expired - Lifetime
- 1992-11-03 DK DK92923141T patent/DK0612322T3/da active
- 1992-11-03 EP EP92923141A patent/EP0612322B1/de not_active Expired - Lifetime
- 1992-11-10 ZA ZA928643A patent/ZA928643B/xx unknown
- 1992-11-11 TW TW081109046A patent/TW221293B/zh active
1994
- 1994-05-10 NO NO941756A patent/NO305175B1/no not_active IP Right Cessation
- 1994-05-10 FI FI942161A patent/FI105918B/fi not_active IP Right Cessation
1999
- 1999-03-04 GR GR990400523T patent/GR3029552T3/el unknown

Also Published As

Publication number	Publication date
AU664051B2 (en)	1995-11-02
GR3029552T3 (en)	1999-06-30
ZA928643B (en)	1994-05-11
ES2127765T3 (es)	1999-05-01
AU2898392A (en)	1993-06-15
NO305175B1 (no)	1999-04-12
FI942161L (fi)	1994-05-10
FI105918B (fi)	2000-10-31
WO1993010118A1 (de)	1993-05-27
JP3162390B2 (ja)	2001-04-25
NO941756D0 (no)	1994-05-10
US5457202A (en)	1995-10-10
EP0612322B1 (de)	1999-03-03
DE59209643D1 (de)	1999-04-08
CA2121351A1 (en)	1993-05-27
JPH07500842A (ja)	1995-01-26
DE4136921A1 (de)	1993-05-13
EP0612322A1 (de)	1994-08-31
KR100211915B1 (ko)	1999-08-02
FI942161A0 (fi)	1994-05-10
ATE177100T1 (de)	1999-03-15
CA2121351C (en)	2003-08-05
TW221293B (no)	1994-02-21
DK0612322T3 (da)	1999-09-27

Legal Events

Date	Code	Title	Description
2011-06-27	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO941756D0 (no)	1994-05-10	Fremgangsmåte for å skille enantiomerene av 5-metyl-tetrahydrofolsyre
NO944644L (no)	1995-06-09	Fremstilling av 3,4,4-trisubstituert-piperidinyl-N-alkylkarboksylater og mellomprodukter
FI910857A0 (fi)	1991-02-22	Foerfarande foer framstaellning av oxetanoner.
TNSN92022A1 (fr)	1993-06-08	Procede de preparation de nouveaux derives de l'indole
NZ225362A (en)	1990-07-26	Optical isomers of medetomidine and pharmaceutical compositions
MY107819A (en)	1996-06-29	Preparation of substituted piperidines.
NO941958D0 (no)	1994-05-26	Fremstilling av substituerte piperidiner
DE69225410D1 (de)	1998-06-10	Herstellung von n-acetylneuraminsäure-derivaten
ES2086065T3 (es)	1996-06-16	Preparacion de tetrahidropiridinas sustituidas.
ES2045215T3 (es)	1994-01-16	(+)-o (+)-1-(2-n-aminoetil sustituido) -1-metil-7-metoxi-1,2,3,4-tetrahidronaftaleno, y procedimiento para su produccion.
DE59310246D1 (de)	2002-01-24	Asymmetrische Hydrierung
AU2857492A (en)	1993-05-27	Improved fish production
AU2055188A (en)	1989-02-16	Optical isomers
HUT53103A (en)	1990-09-28	Process for the preparation of new 20,21-dinor-eburnamenine derivatives, new intermediates thereof, as well as pharmaceutical compositions containing said compounds as active ingredients
EP0474250A3 (en)	1993-04-07	Enzymatic process for separating the optical isomers of racemic 1,2-diols
CA2112981A1 (fr)	1993-01-21	Procede de preparation des isomeres optiques d'un derive de l'amino-2 naphtyridine
AU1866192A (en)	1993-01-07	New process for the synthesis of enantiomers of 3-aminochroman compounds