NO942825L - Polypeptider med fibronektinbindingsseter som modulatorer for sammensetting av matriks - Google Patents

Polypeptider med fibronektinbindingsseter som modulatorer for sammensetting av matriks

Info

Publication number
NO942825L
NO942825L NO942825A NO942825A NO942825L NO 942825 L NO942825 L NO 942825L NO 942825 A NO942825 A NO 942825A NO 942825 A NO942825 A NO 942825A NO 942825 L NO942825 L NO 942825L
Authority
NO
Norway
Prior art keywords
fibronectin
polypeptides
matrix composition
modulators
binding sites
Prior art date
Application number
NO942825A
Other languages
English (en)
Other versions
NO942825D0 (no
Inventor
Erkki I Ruoslahti
Alex Norla
Original Assignee
Jolla Cancer Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jolla Cancer Res Found filed Critical Jolla Cancer Res Found
Publication of NO942825D0 publication Critical patent/NO942825D0/no
Publication of NO942825L publication Critical patent/NO942825L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micromachines (AREA)
  • Mechanical Light Control Or Optical Switches (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Foreliggende oppfinnelse til- veiebringer seter for selvsammensetning av fibronektin. Oppfinnelsen tilveie- bringer et sett av polypeptider avledet fra den første type III-repetisjon i fibronektin som inneholder et fibronek- tin- f ibronektinbindingssete. Disse polypeptider er benyttet for erholdelse av et nytt polypeptidsett avledet fra de C-terminale type I-repetisjoner som inneholder et annet fibronektin-fibro- nektinbindingssete som interagerer med den første type III-repetisjon i fibro- nektin. Disse polypeptider kan hemme sammensetning av fibronektinmatriks ved å forstyrre fibronektin-fibronektinbin- ding. Disse polypeptider kan også fremme fibronektinmatrikssammensetning og indusere disulfidkryssbinding av fibronektinmolekyler in vltro. I til- legg kan polypeptidene hemme migrering av tumorceller. Polypeptidene ifølge foreliggende oppfinnelse har også en rekke beslektede anvendelser.
NO942825A 1992-01-31 1994-07-29 Polypeptider med fibronektinbindingsseter som modulatorer for sammensetting av matriks NO942825L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/829,462 US5453489A (en) 1992-01-31 1992-01-31 Polypeptide fragments of fibronectin which can modulate extracellular matrix assembly
PCT/US1993/000909 WO1993015203A2 (en) 1992-01-31 1993-02-01 Polypeptides with fibronectin binding sites as modulators for matrix assembly

Publications (2)

Publication Number Publication Date
NO942825D0 NO942825D0 (no) 1994-07-29
NO942825L true NO942825L (no) 1994-09-29

Family

ID=25254610

Family Applications (1)

Application Number Title Priority Date Filing Date
NO942825A NO942825L (no) 1992-01-31 1994-07-29 Polypeptider med fibronektinbindingsseter som modulatorer for sammensetting av matriks

Country Status (11)

Country Link
US (1) US5453489A (no)
EP (1) EP0624196B1 (no)
JP (1) JPH07506342A (no)
AT (1) ATE152173T1 (no)
AU (1) AU672967B2 (no)
CA (1) CA2129115A1 (no)
DE (1) DE69310145T2 (no)
DK (1) DK0624196T3 (no)
FI (1) FI943568A0 (no)
NO (1) NO942825L (no)
WO (1) WO1993015203A2 (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5492890A (en) * 1990-12-03 1996-02-20 The Scripps Research Institute Polypeptides for promoting cell attachment
US5629291A (en) * 1992-01-31 1997-05-13 La Jolla Cancer Research Foundation Methods of modulating fibronectin extracellular matrix assembly
US7112320B1 (en) 1995-06-07 2006-09-26 Andre Beaulieu Solid wound healing formulations containing fibronectin
US5922676A (en) * 1996-09-20 1999-07-13 The Burnham Institute Methods of inhibiting cancer by using superfibronectin
US6685943B1 (en) 1997-01-21 2004-02-03 The Texas A&M University System Fibronectin binding protein compositions and methods of use
GB9714276D0 (en) 1997-07-08 1997-09-10 Univ Dundee Peptides and related compounds
US6194378B1 (en) 1998-02-18 2001-02-27 The Research Foundation Of State University Of New York Fibronectin peptides-based extracellular matrix for wound healing
US6852318B1 (en) 1998-05-08 2005-02-08 The Regents Of The University Of California Methods for detecting and inhibiting angiogenesis
EP1420820A4 (en) * 2001-07-31 2005-04-06 Univ Texas ANTIGENIC AND ANTIBODIES TO TRANSLATED MOLECOROUS MOLECULES AND THEIR USES
US8691944B2 (en) * 2005-10-04 2014-04-08 The Research Foundation For The State University Of New York Fibronectin polypeptides and methods of use
EP2167111A4 (en) * 2007-06-14 2010-06-09 Univ New York State Res Found POLYPEPTIDES AND METHOD OF USE

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4341764A (en) * 1980-03-05 1982-07-27 Cutter Laboratories, Inc. Method of preparing fibronectin and antihemophilic factor
US4578079A (en) * 1982-08-04 1986-03-25 La Jolla Cancer Research Foundation Tetrapeptide
US4589881A (en) * 1982-08-04 1986-05-20 La Jolla Cancer Research Foundation Polypeptide

Also Published As

Publication number Publication date
DK0624196T3 (da) 1997-11-03
EP0624196B1 (en) 1997-04-23
FI943568A7 (fi) 1994-07-29
NO942825D0 (no) 1994-07-29
EP0624196A1 (en) 1994-11-17
AU3656893A (en) 1993-09-01
AU672967B2 (en) 1996-10-24
WO1993015203A3 (en) 1993-09-30
ATE152173T1 (de) 1997-05-15
CA2129115A1 (en) 1993-08-05
DE69310145T2 (de) 1997-07-31
DE69310145D1 (de) 1997-05-28
JPH07506342A (ja) 1995-07-13
WO1993015203A2 (en) 1993-08-05
US5453489A (en) 1995-09-26
FI943568L (fi) 1994-07-29
FI943568A0 (fi) 1994-07-29

Similar Documents

Publication Publication Date Title
DE69534588D1 (de) Protocadherin-proteine und verwendungen davon
DE69841273D1 (de) Verfahren zur identifikation von bindestellendomänen, die ihre epitopbindefähigkeit beibehalten
NZ335396A (en) Methods and compositions for stimulating neurite growth using compounds with affinity for fkbp12 in combination with neurotrophic factors
DE69737814D1 (de) Gekürzte lösliche typ-i-rezeptoren für tumor-nekrose-faktor
ATE335748T1 (de) Thienopyrimidindione und deren verwendung bei der modulierung von autoimmunerkrankungen
DE69629181D1 (de) Wachstumsfaktor-b, spezifisch für vaskuläre endothelzellen
DE69333731D1 (de) Glialmitogene faktoren, ihre herstellung und verwendung
DK0941235T3 (da) Cykliske peptider, der binder til en plasminogenaktivatorreceptor af urokinasetypen
DE69925909D1 (de) T-zell inhibierende rezeptorzusammensetzungen sowie deren verwendung
EA200500875A1 (ru) Производные 3-аминопирролидина в качестве модуляторов рецепторов хемокинов
DE69333815D1 (de) Gentranskription und ionisierende strahlung: methoden und zusammensetzungen
DE69939327D1 (de) Funktionelle antagonisten von hedgehog-aktivität
ATE211171T1 (de) Weitgehend reine rezeptorartige, tgf-beta-1- bindende moleküle und deren verwendungen
TW200716746A (en) Methods for identifying a compound modulating the binding between polypeptides
WO1993015203A3 (en) Polypeptides with fibronectin binding sites as modulators for matrix assembly
DK0802924T3 (da) Lægemiddel til forlænget immunsuppression og eliminering af tumorceller
PT97355A (pt) Processo para a preparacao de polipeptidos recombinantes contendo uma sequencia de aminoacidos de uma proteina de celulas
BR0110087A (pt) Compostos para modular proliferação celular
DK1255829T3 (da) Inhibitor af hepatocytvækstfaktoraktivator til anvendelse i modulation af angiogenese og kardiovaskularisering
ATE202117T1 (de) Angiotensin ii rezeptor typ i spezifische monoklonale antikörper und hybridoma
DK1587526T3 (da) MNTF-peptider og sammensætninger og anvendelsesmåder
DE69402177D1 (de) Synthese von dimer-blöcken und ihre verwendung bei der zusammensetzung von oligonukleotiden
ATE359263T1 (de) Substitutierte aminosaeuren als erythropoietin- mimetica
DE69319346D1 (de) Bahandlung von tumoren mit neutrophischen faktoren und hemmern der zellproliferation
ATE389014T1 (de) Phosphorylierte glyoxalase i und deren verwendung